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GP GP G GP GP G G G G GP G GP G GP G GP P G G G P G SOCS5 MED8 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G SOCS5 IGBP1 16082366 pred GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G SOCS5 IL2 16082366 pred P P P P P P P P P P P P P P P P P P P SOCS5 FER 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G SOCS5 RELB 23023127 pred GP GP G G GP GP GP G GP GP GP GP G GP GP G G G G G G G GP G GP GP G SOCS5 CD86 23023127 pred GP G G G GP GP G G P G GP GP GP G GP GP G P G GP P GP G P G GP P SOCS5 EPOR 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SOCS5 RAPGEFL1 16082366 pred G G GP P G P P P GP GP P P P P P P SOCS5 PTK2 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G SOCS5 SHC4 23023127 pred G G G G G G G G G SOCS5 FEM1B 25402006 pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP GP GP G GP GP GP GP GP G GP GP G SOCS5 ARF4 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SOCS5 MAP3K12 25402006 pred GP GP G G GP GP G G GP G GP G GP GP G GP GP GP GP G GP GP GP G GP G GP GP G SOCS5 ABL2 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G RGL2 SOCS5 16082366 pred GP GP G G G GP G GP GP G GP GP G G G GP GP G GP G G GP G GP GP G GP GP G SOCS5 VRK3 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP G GP GP G IRS4 SOCS5 25402006 pred GP GP G G G GP G GP GP G GP P P GP G GP GP G GP G GP P GP GP GP G GP GP G SOCS5 NEBL 23023127 pred GP GP G G G G G GP GP G GP GP GP GP G GP G G GP G G G G G GP GP G G KALRN SOCS5 23023127 pred P P G P GP G P P G P P P P P GP P P P P P P G P P SOCS5 ACVR1C 23023127 pred G GP G G GP G GP GP G P G GP G G G G G G GP P G G GP P SOCS5 VAV2 25402006, 23023127 pred GP GP G G GP GP G G GP G GP GP GP G G GP GP GP GP G GP GP GP GP G GP GP G SOCS5 CRKL 23023127 pred GP G G G GP GP G G GP G G G GP GP G GP GP G GP G GP GP G G GP G GP G G SOCS5 YES1 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G SOCS5 IL21R 16082366 pred P P P P P P P P GP P P P P P P P P G P P SOCS5 ITCH 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G SOCS5 TNK2 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G SOCS5 RASGEF1C 16082366 pred P P G P GP P P G P P P P P GP P GP P P P P P P GP SOCS5 ANKS1A 25402006 pred GP GP G G GP G G G GP G GP GP GP GP G GP G G GP G GP GP GP G GP G GP GP G SOCS5 UBASH3A 23023127 pred P P G P P P G SOCS5 KLHL3 23023127 pred G GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP G GP GP GP G GP GP G SOCS5 CPLX2 23023127 pred G G G G G G G SOCS5 IL12B 16082366 pred P P P P P P P P P P P P P SOCS5 LCK 23023127 pred G G GP G G G G G G GP G G G G G G G SOCS5 RGL4 16082366 pred P G G P P P P G P P P P P P G P SOCS5 PIK3R3 25402006, 23023127 pred GP GP G G GP GP G G GP G GP GP GP GP G GP GP G GP G GP G GP G GP G GP GP G SOCS5 INHA 16082366 pred GP G G G G G G G GP P G G GP G G GP G G GP G SOCS5 SH2D5 23023127 pred P P G G GP GP GP GP G P P P G GP GP P P G GP P GP P P P GP SOCS5 ERBB4 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP G SOCS5 SOS2 25402006, 16082366 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G SOCS5 PIAS1 16082366 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G SOCS5 TWIST2 16082366 pred G G G G G G G G G G G G G G G G G G G G G G SH2B2 SOCS5 23023127 pred GP GP G G GP GP G G GP G GP GP GP G G GP GP G GP G GP GP GP G GP G GP GP G SOCS5 CDH13 23023127 pred GP G G GP G P G G GP G G SOCS5 INPP5D 23023127 pred G GP G G GP GP G GP G G GP G G GP G G GP GP G G G G GP GP G G G G G SOCS5 CMTM8 25402006 pred GP GP G G G P G GP GP GP GP GP G G G P GP GP G GP G G GP G GP P G SOCS5 IL10RA 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SOCS5 LRRC41 25402006 pred G G G G GP G G GP GP G GP G GP GP G GP G G GP G GP G G GP GP G GP GP G SOCS5 SLC5A1 25402006 pred G G G G G G G GP GP GP G G GP G G G G G G G G GP G G G SOCS5 CBLB 25402006, 23023127 pred GP GP G G G GP G G GP G GP GP GP GP G GP GP GP GP G GP GP G G GP G GP GP G SOCS5 SOS1 16082366 pred GP G G G GP G G GP GP G GP G GP GP G GP G G GP G GP GP GP GP GP G GP G G SOCS5 AOX1 16082366 pred GP GP G G G P G GP GP GP GP GP G G GP GP GP GP G GP GP G GP GP G GP GP G SOCS5 CNTN4 23023127 pred GP G GP G G G G P G G GP G G GP P G G G TLR4 SOCS5 16082366 pred G GP G G GP GP G G G G G GP G GP G G G GP G G G SOCS5 ACVR1B 23023127 pred G G G G G GP G G GP G GP GP GP G G GP GP G GP G GP G G G GP G GP GP G SOCS5 RUSC2 23023127 pred GP GP G P GP G GP GP G GP GP GP GP G P GP GP P G P P GP GP GP G GP GP G SOCS5 RGL1 16082366 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G SOCS5 STAM2 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G SOCS5 ZAP70 23023127 pred G G GP G G G GP G G G G SOCS5 EPHA5 23023127 pred G G G G G G G G G G G G G G G G G G SOCS5 PTPN2 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G SOCS5 SNX1 25402006 pred GP GP G G GP GP G G GP G GP GP GP GP G GP GP G GP G G GP GP G GP G GP GP G SOCS5 PTPRF 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP G GP GP G SOCS5 IGFBP5 16082366 pred GP GP G G GP GP G G GP G GP GP GP GP G GP GP G GP G GP GP GP G GP G GP GP G SOCS5 TLN1 25402006 pred GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G SOCS5 GRB14 25402006, 23023127 pred P GP P P G GP GP GP G P GP P P G GP GP P P GP P GP SOCS5 FLT3 23023127 pred GP P G G GP GP G GP GP G GP GP P GP P GP GP GP G GP P GP GP GP P GP G SOCS5 PLCG1 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G SOCS5 MATK 23023127 pred P P G G GP GP P P P GP GP GP GP GP P P P P P P P G P P SOCS5 MIA3 23023127 pred GP GP G G GP GP G GP GP G GP GP G GP G GP GP GP GP G GP GP GP G GP G GP GP G SOCS5 HSH2D 23023127 pred P P G G P P P P P P G P P P P P P P G GP P SOCS5 ACIN1 16082366 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G SOCS5 IRF4 23023127 pred G G G G GP G G G G G G GP GP GP G G G G G G G G G G G G G G G SOCS5 MINK1 23023127 pred GP G G G G GP G G GP G GP G GP GP G GP GP GP GP G GP GP GP G GP G GP GP G SOCS5 PPP1R13B 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G SOCS5 RARA 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G SOCS5 PTPRN 23023127 pred G GP G G G GP G G G G G G G G G GP G GP G GP G G G G G GP G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants O75159 P05067-7 pull down 21832049 direct interaction X 2 Q969X1 O75159 two hybrid 21988832 direct interaction X 2 P0CG48 O75159 pull down 23314748 direct interaction X 2 O75159 affinity chromatography technology 12242343 physical association X 2 O75159 pull down 12242343 direct interaction X 2 O75159 P42574 two hybrid 21988832 direct interaction X 2 O75159 P00533 affinity chromatography technology 15590694 physical association X 2 Q96GG9 O75159 affinity chromatography technology 21145461 physical association X 2 Q9UM73 O75159 affinity chromatography technology 14968112 physical association X 2 O75159 P00533 in vivo 15695332 - X 2 O75159 P24394-2 in vitro 12242343 - X 2 O75159 P10721-2 in vivo 14707129 - X 2 O75159 P24394-2 in vitro 12242343 - X 2 O75159 P10721-2 in vivo 14707129 - X 2 O75159 P00533 in vivo 15695332 - X 2 O75159 Q9BPW0 luminescence based mammalian interactome mapping 25036637 physical association X 2 A0A024R7Y5 O75159 two hybrid array 16643902 physical association X 2 O75159 P42574 two hybrid array 21988832 physical association X 2 O75159 A0A024R759 fluorescence polarization spectroscopy 24728074 direct interaction X 2 O75159 A0A024R759 fluorescence polarization spectroscopy 24728074 direct interaction X 2 A0A024RDA0 O75159 fluorescence polarization spectroscopy 24728074 direct interaction X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B SOCS5 EGFR MI:0493(in vivo) 15695332 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_31386 - - SOCS5 UBC MI:0096(pull down) 23314748 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_248051 prey bait SOCS5 IL4R MI:0004(affinity chromatography technology)|MI:0492(in vitro)|MI:0004(affinity chromatography technology) 12242343 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|-|MI:0915(physical association) (biogrid)|MI:0468(hprd)|(biogrid) BIOGRID_214954|HPRD_24744|BIOGRID_214953 prey|-|prey bait|-|bait SOCS5 MET MI:0053(fluorescence polarization spectroscopy)|MI:0053(fluorescence polarization spectroscopy) 24728074 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction) (intact)|(intact) UniProt_133140|UniProt_133063 neutral component|neutral component neutral component|neutral component SOCS5 KIT MI:0493(in vivo)|MI:0053(fluorescence polarization spectroscopy) 14707129,24728074 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0407(direct interaction) MI:0468(hprd)|(intact) HPRD_24955|UniProt_132874 -|neutral component -|neutral component SOCS5 APP MI:0096(pull down) 21832049 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_228200 bait prey SOCS5 TCEB1 MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation) 16643902 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|MI:0471(mint)|(intact)|(intact) MINT_82039|MINT_49820|UniProt_167599|UniProt_85141 bait|bait|bait|bait prey|prey|prey|prey SOCS5 ALK MI:0004(affinity chromatography technology) 14968112 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_122265 prey bait SOCS5 CASP3 MI:0397(two hybrid array)|MI:0004(affinity chromatography technology) 21988832 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_116872|BIOGRID_287141 unspecified role|prey unspecified role|bait SOCS5 TMBIM1 MI:0004(affinity chromatography technology)|MI:0397(two hybrid array) 21988832 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_286783|UniProt_119925 bait|unspecified role prey|unspecified role SOCS5 DCUN1D1 MI:0004(affinity chromatography technology) 21145461 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_206071 prey bait

PPI - HINT Gene A Gene B PMID Method Quality SOCS5 APP 21832049,21244100 0096,0096 LC SOCS5 DCUN1D1 21145461 0004 HT SOCS5 DCUN1D1 21145461 0004 HT SOCS5 APP 21832049,21244100 0096,0096 LC SOCS5 MET 24728074 0053 HT SOCS5 KIT 24728074 0053 HT SOCS5 CASP3 21988832,21988832 0397,0018 HT SOCS5 PPP5C 25036637 0729 HT SOCS5 TCEB1 16643902 0397 LC SOCS5 TMBIM1 21988832 0018 HT

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 JAK2 SOCS5 MI:0362 inference MI:0461 interaction database SOCS5 EGFR MI:0045 experimental interaction detection MI:0461 interaction database SOCS5 APP MI:0045 experimental interaction detection MI:0461 interaction database SOCS5 MET MI:0045 experimental interaction detection MI:0461 interaction database SOCS5 UBC MI:0045 experimental interaction detection MI:0461 interaction database SOCS5 KIT MI:0045 experimental interaction detection MI:0461 interaction database SOCS5 JAK1 MI:0362 inference MI:0461 interaction database SOCS5 IL4R MI:0045 experimental interaction detection MI:0461 interaction database SOCS5 SHC1 MI:0362 inference MI:0461 interaction database SOCS5 TYK2 MI:0362 inference MI:0461 interaction database SOCS5 CASP3 MI:0045 experimental interaction detection MI:0461 interaction database SOCS5 JAK3 MI:0362 inference MI:0461 interaction database SOCS5 TCEB1 MI:0045 experimental interaction detection MI:0461 interaction database SOCS5 TCEB2 MI:0362 inference MI:0461 interaction database SOCS5 CUL5 MI:0362 inference MI:0461 interaction database SOCS5 TMBIM1 MI:0045 experimental interaction detection MI:0461 interaction database SOCS5 DCUN1D1 MI:0045 experimental interaction detection MI:0461 interaction database SOCS5 ALK MI:0045 experimental interaction detection MI:0461 interaction database