PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus ENC1 NUDCD3 25036637 intact exp GP GP G G G GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP G GP GP GP GP G ENC1 HSP90AB1 25036637,22939624 intact exp GP GP G G G GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP G GP GP GP GP G ENC1 TGFBR1 15761153 hprd,i2d exp GP G G G G GP G GP GP G GP G GP G G GP GP G G G G G G G GP G GP G G ENC1 CUL3 15983046,21145461 biogrid exp GP GP G G G GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP G GP GP GP GP G ENC1 CSNK1A1 19888210 i2d exp G G G G G G G G G G G G G G G G G G GP G G G G G G G G G G ENC1 AXIN2 19888210 i2d exp GP GP G G G GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP G GP GP GP GP G ENC1 HSP90AA1 22939624 biogrid exp GP GP G G G GP G G GP G G G G G G G GP G G G GP G G G G G G GP G ENC1 AXIN1 19888210 i2d exp GP GP G G GP G P GP G GP G GP GP G GP GP G GP G GP GP GP G GP GP GP GP G ENC1 NKD1 19888210 i2d exp G G G G G P G G G G GP ENC1 NFE2L2 20511222,17875699,18981988 biogrid exp GP GP G G G GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP G GP GP GP GP G ENC1 CSNK1E 19888210 i2d exp GP GP G G G GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP G GP GP GP GP G ENC1 RB1 9566959,16306221 hprd,biogrid,bci exp GP GP G G G GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP G GP GP GP GP G ENC1 RBX1 15983046 biogrid exp G G G G G GP G GP G G G G GP G G G GP G GP G GP GP G G G G G GP G ENC1 SNCA 17893145 biogrid exp G G G G G GP G GP GP G GP G G G G GP G G G G G G G G GP G GP G ENC1 KEAP1 19424503 biogrid exp GP GP G G G GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP G GP GP GP GP G ENC1 NACC1 19121354 biogrid exp GP GP G G G GP G GP GP G GP G GP G G GP GP G GP G GP GP GP G GP GP GP GP G ENC1 HSPA8 25036637 intact exp P P P P P P P P P P P P P P P ENC1 ACTB 15208678 biogrid exp GP GP G G G GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP G GP GP GP GP G ENC1 HSPA6 25036637 intact exp GP GP G G G P G GP GP GP G G G G GP GP G GP G GP GP GP G GP G GP GP G ENC1 ENC1 15983046,16306221 biogrid exp GP GP G G G GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP G GP GP GP GP G ENC1 KBTBD11 23023127 pred GP GP G G G GP G P GP G GP G GP GP G GP GP P G P GP P G GP GP P P G ENC1 KLHL2 23023127 pred G G G G G G G G G G GP G G G G GP G G G G G GP G G GP G G GP G ENC1 KLHL18 23023127 pred G GP G G G GP G GP GP G GP G GP G G GP GP G GP G G GP G GP G GP GP G ENC1 KLHL38 23023127 pred P P P P P P P P P P P P P P P P P P ENC1 BTRC 23023127 pred GP GP G G G GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP G GP G GP GP G ENC1 PSMB1 21836163 pred GP GP G G G GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP G GP GP GP GP G ENC1 CCT5 21836163 pred G GP G G G GP G G GP G GP G GP GP G GP GP G GP G GP GP GP G GP GP GP GP G ENC1 SNCB 21836163 pred G GP G P G GP G ENC1 FBXW7 23023127 pred GP GP G G G GP G GP GP G GP G GP GP G GP GP G GP G P GP GP G GP GP GP GP ENC1 KLHL4 23023127 pred P GP G GP P G P P G P GP G P P P P ENC1 KLHL11 23023127 pred P P P P P P P P P P P P P GP ENC1 BTBD3 23023127 pred GP GP G G G GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP G GP GP GP GP G ENC1 KLHL26 23023127 pred GP P G GP G P GP G GP P GP G GP GP GP G P GP GP G GP GP GP G ENC1 BTBD2 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G ENC1 UBQLN2 23023127 pred GP GP G G G GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP G GP GP GP GP G ENC1 BTBD6 23023127 pred G G G G G G G G GP G G G G GP G GP G G G G G G G G GP G G G G ENC1 SARNP 21836163 pred GP GP G G G GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP G GP GP GP GP G ENC1 SMURF1 21836163 pred G GP G G G GP G G GP G GP G GP G G G GP G G G GP G G G G GP G GP G ENC1 BTBD9 23023127 pred P G G G G GP G G GP G G G GP GP G G GP GP G G GP G G GP GP GP G ENC1 GATA6 16082366 pred GP GP P GP GP P G GP GP G GP P G GP GP GP P GP GP GP GP G ENC1 KLHL3 23023127 pred G GP G G G GP G GP GP G GP G GP G G GP GP G GP G GP G GP G GP G GP GP G ENC1 BTBD10 23023127 pred GP GP G G G GP G GP GP G GP G GP GP G G GP G GP G GP GP GP G G GP G GP G ENC1 KLHL1 23023127 pred P G P G P G P P P P

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants O14682 A0A024R475 affinity chromatography technology 21145461 physical association X 2 O14682 P07900-2 affinity chromatography technology 22939624 physical association X 2 O14682 A0A024R475 enzymatic study 15983046 direct interaction X 2 O14682 A0A024R475 affinity chromatography technology 15983046 physical association X 2 P60709 O14682 far western blotting 15208678 direct interaction X 2 P60709 O14682 affinity chromatography technology 15208678 physical association X 2 Q16236-3 O14682 affinity chromatography technology 17875699 physical association X 2 Q16236-3 O14682 pull down 17875699 direct interaction X 2 Q16236-3 O14682 imaging technique 18981988 colocalization X 2 Q16236-3 O14682 pull down 18981988 direct interaction X 2 Q16236-3 O14682 affinity chromatography technology 18981988 physical association X 2 Q16236-3 O14682 affinity chromatography technology 20511222 physical association X 2 Q16236-3 O14682 affinity chromatography technology 20511222 physical association X 2 A0A024R7E0 O14682 two hybrid 19121354 direct interaction X 2 A0A024R7E0 O14682 affinity chromatography technology 19121354 physical association X 2 A0A024R7C0 O14682 affinity chromatography technology 19424503 physical association X 2 P0CG48 O14682 affinity chromatography technology 23000965 physical association X 2 P0CG48 O14682 affinity chromatography technology 21139048 physical association X 2 P0CG48 O14682 affinity chromatography technology 21906983 physical association X 2 O14682 H6UYS5 unspecified method 17893145 direct interaction X 2 O14682 O14682 pull down 16306221 direct interaction X 2 O14682 A0A024RDV3 affinity chromatography technology 16306221 physical association X 2 O14682 P62877 enzymatic study 15983046 direct interaction X 2 O14682 A0A024RDV3 affinity chromatography technology 9566959 physical association X 2 O14682 A0A024RDV3 pull down 9566959 direct interaction X 2 O14682 P62877 affinity chromatography technology 15983046 physical association X 2 O14682 A0A024RDV3 in vivo 9566959 - X 2 O14682 A0A024RDV3 in vitro 9566959 - X 2 O14682 A0A024RDV3 in vitro 9566959 - X 2 O14682 A0A024RDV3 in vivo 9566959 - X 2 P36897-3 O14682 in vivo 15761153 - X 2 P36897-3 O14682 in vivo 15761153 - X 2 Q53FC7 O14682 luminescence based mammalian interactome mapping 25036637 physical association X 2 Q8IVD9 O14682 luminescence based mammalian interactome mapping 25036637 physical association X 2 O14682 A0A024RD80 luminescence based mammalian interactome mapping 22939624 physical association X 2 O14682 Q6PK50 luminescence based mammalian interactome mapping 25036637 physical association X 2 O14682 Q96BE0 luminescence based mammalian interactome mapping 25036637 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B ENC1 NFE2L2 MI:0004(affinity chromatography technology)|MI:0428(imaging technique)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0428(imaging technique)|MI:0428(imaging technique)|MI:0004(affinity chromatography technology) 17875699,18981988,20511222 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0403(colocalization)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_213200|BIOGRID_221212|BIOGRID_213201|BIOGRID_283560|BIOGRID_221215|BIOGRID_221214|BIOGRID_283561 prey|prey|prey|bait|prey|prey|prey bait|bait|bait|prey|bait|bait|bait ENC1 ACTB MI:0047(far western blotting)|MI:0047(far western blotting) 15208678 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid) BIOGRID_281095|BIOGRID_281094 bait|bait prey|prey ENC1 RBX1 MI:0004(affinity chromatography technology) 15983046 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_127422 bait prey ENC1 HSP90AA1 MI:0004(affinity chromatography technology) 22939624 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_255386 prey bait ENC1 SNCA MI:0686(unspecified method) 17893145 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_227081 prey bait ENC1 HSP90AB1 MI:0729(luminescence based mammalian interactome mapping) 22939624 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_124979 bait prey ENC1 NACC1 MI:0018(two hybrid)|MI:0018(two hybrid) 19121354 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_211836|BIOGRID_211838 prey|prey bait|bait ENC1 RB1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0492(in vitro)|MI:0096(pull down) 16306221,9566959 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|-|MI:0915(physical association) (biogrid)|(biogrid)|MI:0468(hprd)|(biogrid) BIOGRID_103881|BIOGRID_103882|HPRD_2631|BIOGRID_285181 prey|prey|-|prey bait|bait|-|bait ENC1 TGFBR1 MI:0493(in vivo) 15761153 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_17686 - - ENC1 KEAP1 MI:0004(affinity chromatography technology) 19424503 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_197127 prey bait ENC1 UBC MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 15983046,21139048,21906983,23000965 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_127427|BIOGRID_181517|BIOGRID_269188|BIOGRID_172431 bait|prey|prey|prey prey|bait|bait|bait ENC1 CUL3 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 15983046,21145461 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_127421|BIOGRID_202083 bait|prey prey|bait

PPI - HINT Gene A Gene B PMID Method Quality ENC1 RB1 16306221,9566959,9566959 0004,0004,0096 LC ENC1 CUL3 21145461,15983046 0004,0004 HT,LC ENC1 NFE2L2 18981988,18981988,20511222,17875699,18981988,17875699 0096,0428,0004,0004,0004,0096 LC ENC1 CUL3 21145461 0004 HT ENC1 RB1 16306221,9566959,9566959 0004,0004,0096 LC ENC1 CUL3 15983046 0004 LC ENC1 NFE2L2 18981988,18981988,20511222,17875699,18981988,17875699 0096,0428,0004,0004,0004,0096 LC ENC1 ENC1 15983046 0415 LC ENC1 HSP90AB1 25036637,22939624 0729,0729 HT ENC1 TGFBR1 15761153 0019 HT ENC1 PS1TP5BP1 15208678,15208678 0004,0047 LC ENC1 Q53FC7 25036637 0729 HT ENC1 NUDCD3 25036637 0729 HT ENC1 Q96BE0 25036637 0729 HT ENC1 NACC1 19121354,19121354 0018,0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID P08238 O14682 HSP90AB1 ENC1 0.126 22939624 P62877 O14682 RBX1 ENC1 0.21 15983046 Q16236 O14682 NFE2L2 ENC1 0.837 20511222,17875699,18981988 P07900 O14682 HSP90AA1 ENC1 0.126 22939624 Q96RE7 O14682 NACC1 ENC1 0.454 19121354 P60709 O14682 ACTB ENC1 0.454 15208678 O14682 O14682 ENC1 ENC1 0.554 16306221,15983046 P06400 O14682 RB1 ENC1 0.569 16306221,9566959 P37840 O14682 SNCA ENC1 0.309 17893145 Q13618 O14682 CUL3 ENC1 0.309 15983046,21145461 Q14145 O14682 KEAP1 ENC1 0.21 19424503 Q13501 O14682 SQSTM1 ENC1 0.376 26637326

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 ENC1 RB1 MI:0045 experimental interaction detection MI:0461 interaction database ENC1 HSP90AA1 MI:0045 experimental interaction detection MI:0461 interaction database ENC1 HSP90AB1 MI:0045 experimental interaction detection MI:0461 interaction database ENC1 UBC MI:0045 experimental interaction detection MI:0461 interaction database ENC1 TGFBR1 MI:0045 experimental interaction detection MI:0461 interaction database ENC1 SNCA MI:0362 inference MI:0461 interaction database ENC1 HNF4A MI:0045 experimental interaction detection MI:0461 interaction database ENC1 ACTB MI:0045 experimental interaction detection MI:0461 interaction database ENC1 RBX1 MI:0045 experimental interaction detection MI:0461 interaction database ENC1 SQSTM1 MI:0045 experimental interaction detection MI:0461 interaction database ENC1 CUL3 MI:0045 experimental interaction detection MI:0461 interaction database ENC1 KEAP1 MI:0045 experimental interaction detection MI:0461 interaction database ENC1 NFE2L2 MI:0045 experimental interaction detection MI:0461 interaction database ENC1 NACC1 MI:0045 experimental interaction detection MI:0461 interaction database