PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus COPS6 FBXL14 21145461 biogrid exp GP GP G G GP GP G GP GP G GP G GP GP G GP GP G G G GP G GP G GP GP GP GP G FBXL14 COPS5 21145461 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G G G GP G GP GP GP GP GP GP G SNAI1 FBXL14 19955572,25203322 biogrid,intact exp GP GP G GP P P P P P GP P P P GP P GP P P P P HSP90AA1 FBXL14 22939624 biogrid exp GP GP G G G GP G G GP G G G G G G G GP G G G GP G G G G G G GP G FKBP5 FBXL14 25036637 intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G G G GP G GP GP GP GP GP GP G FBXL14 SUGT1 25036637 intact exp G G G G G G G GP GP G GP G G G G GP G G G G G G G GP GP G GP GP G HSP90AB1 FBXL14 25036637,22939624 intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G G G GP G GP GP GP GP GP GP G FBXL14 AARSD1 25036637 intact exp P P P P P P P P P P P P P P P FBXL14 MTA3 26028330 intact exp GP GP G P GP G G GP G GP GP GP GP G GP GP G G G GP G GP GP GP GP GP GP G FBXL14 DICER1 24035498 biogrid exp GP G G G GP GP G GP GP G GP G G GP G GP GP G G G GP G GP GP GP GP GP GP G CUL1 FBXL14 21145461 biogrid exp GP G G G G GP G GP GP G GP GP GP G G GP GP G G G GP G GP GP GP GP GP GP G SKP1 FBXL14 25402006, 16082366 bci exp, ortho, pred GP GP G G GP GP G G GP G GP GP GP GP G GP GP G G G GP G GP G GP GP GP GP G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q8N1E6 A0A090N7U0 affinity chromatography technology 21145461 physical association X 2 Q8N1E6 Q7L5N1 affinity chromatography technology 21145461 physical association X 2 A0A024R7W9 Q8N1E6 affinity chromatography technology 21145461 physical association X 2 Q8N1E6 P07900-2 affinity chromatography technology 22939624 physical association X 2 Q8N1E6 Q9UPY3-2 affinity chromatography technology 24035498 physical association X 2 Q8N1E6 O95863 pull down 19955572 direct interaction X 2 Q8N1E6 O95863 affinity chromatography technology 19955572 physical association X 2 Q8N1E6 O95863 pull down 19955572 direct interaction X 2 Q8N1E6 Q02085 affinity chromatography technology 19955572 physical association X 2 Q8N1E6 A0A024RD80 luminescence based mammalian interactome mapping 22939624 physical association X 2 Q8N1E6 Q13451 luminescence based mammalian interactome mapping 25036637 physical association X 2 Q8N1E6 Q6PK50 luminescence based mammalian interactome mapping 25036637 physical association X 2 Q8N1E6 Q9BTE6-2 luminescence based mammalian interactome mapping 25036637 physical association X 2 Q8K2C9 Q8N1E6 luminescence based mammalian interactome mapping 25036637 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B FBXL14 COPS5 MI:0004(affinity chromatography technology) 21145461 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_205196 prey bait HSP90AB1 FBXL14 MI:0729(luminescence based mammalian interactome mapping) 22939624 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_124983 prey bait SNAI1 FBXL14 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 19955572 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid) BIOGRID_153389|BIOGRID_153390|BIOGRID_153391 bait|bait|prey prey|prey|bait CUL1 FBXL14 MI:0004(affinity chromatography technology) 21145461 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_204539 bait prey COPS6 FBXL14 MI:0004(affinity chromatography technology) 21145461 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_205729 bait prey HSP90AA1 FBXL14 MI:0004(affinity chromatography technology) 22939624 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_255390 bait prey FBXL14 DICER1 MI:0004(affinity chromatography technology) 24035498 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_289809 bait prey

PPI - HINT Gene A Gene B PMID Method Quality SNAI1 FBXL14 25203322,19955572,19955572 0007,0096,0004 LC CUL1 FBXL14 21145461 0004 HT COPS6 FBXL14 21145461 0004 HT FBXL14 COPS5 21145461 0004 HT CUL1 FBXL14 21145461 0004 HT COPS6 FBXL14 21145461 0004 HT FBXL14 COPS5 21145461 0004 HT SNAI1 FBXL14 25203322,19955572,19955572 0007,0096,0004 LC B4DYC6 FBXL14 25036637 0729 HT HSP90AB1 FBXL14 25036637,22939624 0729,0729 HT FKBP5 FBXL14 25036637 0729 HT FBXL14 AARSD1 25036637 0729 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q8N1E6 Q8K2C9 FBXL14 PTPLAD1 0.126 25036637 Q8N1E6 B4DYC6 FBXL14 B4DYC6 0.126 25036637 Q8N1E6 P08238 FBXL14 HSP90AB1 0.126 22939624 Q8N1E6 Q13451 FBXL14 FKBP5 0.126 25036637 Q8N1E6 Q6PK50 FBXL14 HSP90AB1 0.126 25036637 Q9BTE6 Q8N1E6 AARSD1 FBXL14 0.126 25036637 Q9UPY3 Q8N1E6 DICER1 FBXL14 0.21 24035498 Q8N1E6 P07900 FBXL14 HSP90AA1 0.126 22939624 Q8N1E6 Q7L5N1 FBXL14 COPS6 0.126 21145461 Q8N1E6 O95863 FBXL14 SNAI1 0.702 19955572,25203322 Q92905 Q8N1E6 COPS5 FBXL14 0.126 21145461 Q9BTC8 Q8N1E6 MTA3 FBXL14 0.126 26028330 Q8N1E6 Q13616 FBXL14 CUL1 0.126 21145461 Q8N1E6 P63208 FBXL14 SKP1 0.126 27705803 Q8N1E6 Q02085 FBXL14 SNAI1 0.21 19955572

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 SIAH2 FBXL14 MI:0362 inference MI:1106 pathways database SPRY2 FBXL14 MI:0362 inference MI:0461 interaction database SPRY3 FBXL14 MI:0362 inference MI:0461 interaction database FBXO21 FBXL14 MI:0362 inference MI:1106 pathways database SNAI1 FBXL14 MI:0045 experimental interaction detection MI:0461 interaction database HSP90AA1 FBXL14 MI:0045 experimental interaction detection MI:0461 interaction database HSP90AB1 FBXL14 MI:0045 experimental interaction detection MI:0461 interaction database UBB FBXL14 MI:0362 inference MI:1106 pathways database UBC FBXL14 MI:0362 inference MI:1106 pathways database TRIM21 FBXL14 MI:0362 inference MI:1106 pathways database CCNF FBXL14 MI:0362 inference MI:1106 pathways database UBE2A FBXL14 MI:0362 inference MI:1106 pathways database FBXW4 FBXL14 MI:0362 inference MI:1106 pathways database RBX1 FBXL14 MI:0362 inference MI:1106 pathways database RPS27A FBXL14 MI:0362 inference MI:1106 pathways database UBA52 FBXL14 MI:0362 inference MI:1106 pathways database SKP1 FBXL14 MI:0362 inference MI:0461,MI:1106 interaction database,pathways database SKP2 FBXL14 MI:0362 inference MI:1106 pathways database FKBP5 FBXL14 MI:0045 experimental interaction detection MI:0461 interaction database CUL1 FBXL14 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database TRIP12 FBXL14 MI:0362 inference MI:1106 pathways database LONRF1 FBXL14 MI:0362 inference MI:1106 pathways database HECTD2 FBXL14 MI:0362 inference MI:1106 pathways database HACD4 FBXL14 MI:0362 inference MI:0461 interaction database FBXO31 FBXL14 MI:0362 inference MI:1106 pathways database FBXW9 FBXL14 MI:0362 inference MI:1106 pathways database FBXW10 FBXL14 MI:0362 inference MI:1106 pathways database RNF213 FBXL14 MI:0362 inference MI:1106 pathways database FBXL22 FBXL14 MI:0362 inference MI:1106 pathways database FBXL19 FBXL14 MI:0362 inference MI:1106 pathways database FBXW12 FBXL14 MI:0362 inference MI:1106 pathways database RNF19B FBXL14 MI:0362 inference MI:1106 pathways database COPS6 FBXL14 MI:0045 experimental interaction detection MI:0461 interaction database RNF144B FBXL14 MI:0362 inference MI:1106 pathways database RBBP6 FBXL14 MI:0362 inference MI:1106 pathways database HUWE1 FBXL14 MI:0362 inference MI:1106 pathways database TRIM69 FBXL14 MI:0362 inference MI:1106 pathways database SIAH1 FBXL14 MI:0362 inference MI:1106 pathways database HERC6 FBXL14 MI:0362 inference MI:1106 pathways database UBR2 FBXL14 MI:0362 inference MI:1106 pathways database FBXL14 FBXW8 MI:0362 inference MI:1106 pathways database FBXL14 FBXL16 MI:0362 inference MI:1106 pathways database FBXL14 FBXO15 MI:0362 inference MI:1106 pathways database FBXL14 ZNRF1 MI:0362 inference MI:1106 pathways database FBXL14 FBXL13 MI:0362 inference MI:1106 pathways database FBXL14 FBXO22 MI:0362 inference MI:1106 pathways database FBXL14 ZNRF2 MI:0362 inference MI:1106 pathways database FBXL14 FBXO27 MI:0362 inference MI:1106 pathways database FBXL14 FBXO30 MI:0362 inference MI:1106 pathways database FBXL14 RNF217 MI:0362 inference MI:1106 pathways database FBXL14 DTX3L MI:0362 inference MI:1106 pathways database FBXL14 FBXO41 MI:0362 inference MI:1106 pathways database FBXL14 LMO7 MI:0362 inference MI:1106 pathways database FBXL14 MYLIP MI:0362 inference MI:1106 pathways database FBXL14 COPS5 MI:0045 experimental interaction detection MI:0461 interaction database FBXL14 FBXW7 MI:0362 inference MI:1106 pathways database FBXL14 FBXO32 MI:0362 inference MI:1106 pathways database FBXL14 FBXW5 MI:0362 inference MI:1106 pathways database FBXL14 MIB2 MI:0362 inference MI:1106 pathways database FBXL14 SPSB1 MI:0362 inference MI:1106 pathways database FBXL14 FBXL8 MI:0362 inference MI:1106 pathways database FBXL14 FBXO17 MI:0362 inference MI:1106 pathways database FBXL14 FBXL20 MI:0362 inference MI:1106 pathways database FBXL14 FBXL18 MI:0362 inference MI:1106 pathways database FBXL14 NEDD4L MI:0362 inference MI:1106 pathways database FBXL14 MTA3 MI:0045 experimental interaction detection MI:0461 interaction database FBXL14 AARSD1 MI:0045 experimental interaction detection MI:0461 interaction database FBXL14 RBCK1 MI:0362 inference MI:1106 pathways database FBXL14 FBXL15 MI:0362 inference MI:1106 pathways database FBXL14 FBXO44 MI:0362 inference MI:1106 pathways database FBXL14 UNKL MI:0362 inference MI:1106 pathways database FBXL14 SMURF2 MI:0362 inference MI:1106 pathways database FBXL14 TRIM36 MI:0362 inference MI:1106 pathways database FBXL14 FBXO6 MI:0362 inference MI:1106 pathways database FBXL14 RNF19A MI:0362 inference MI:1106 pathways database FBXL14 RLIM MI:0362 inference MI:1106 pathways database FBXL14 FBXL12 MI:0362 inference MI:1106 pathways database FBXL14 HACD3 MI:0362 inference MI:0461 interaction database FBXL14 FBXO40 MI:0362 inference MI:1106 pathways database FBXL14 HERC5 MI:0362 inference MI:1106 pathways database FBXL14 FBXL7 MI:0362 inference MI:1106 pathways database FBXL14 FBXO2 MI:0362 inference MI:1106 pathways database FBXL14 FBXO10 MI:0362 inference MI:1106 pathways database FBXL14 FBXO9 MI:0362 inference MI:1106 pathways database FBXL14 FBXL5 MI:0362 inference MI:1106 pathways database FBXL14 FBXL4 MI:0362 inference MI:1106 pathways database FBXL14 FBXW11 MI:0362 inference MI:1106 pathways database FBXL14 FBXO4 MI:0362 inference MI:1106 pathways database FBXL14 FBXL21 MI:0362 inference MI:1106 pathways database FBXL14 FBXL3 MI:0362 inference MI:1106 pathways database FBXL14 FBXW2 MI:0362 inference MI:1106 pathways database FBXL14 DICER1 MI:0045 experimental interaction detection MI:0461 interaction database FBXL14 BTRC MI:0362 inference MI:1106 pathways database FBXL14 FBXO7 MI:0362 inference MI:1106 pathways database FBXL14 RNF115 MI:0362 inference MI:1106 pathways database FBXL14 RNF114 MI:0362 inference MI:1106 pathways database FBXL14 WSB1 MI:0362 inference MI:1106 pathways database