PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus HSPB1 ZNF131 25277244 biogrid,intact exp P P P P P P P P P P P P P P P P P P ZNF131 BAP1 20805357 biogrid exp P P P P P P P P P P P P P P P P P P P P P P CREB1 ZNF131 25609649 intact exp P P P P P P P P P P P P P P P P P P P P P P ZNF131 FHL2 25416956,21516116 biogrid,intact exp P P P P P P P P P P P P P P P P P P CDK8 ZNF131 26496610 biogrid,intact exp ZNF131 MBIP 26186194 biogrid exp P P P P P P P P P P P P P P P P ZNF131 UHRF2 23404503 biogrid exp P P P P P P P P P P P P P P P P P P P P P P ZNF131 FOXJ2 25609649 intact exp P P P P P P P P P P P P P P P P P P P P P CTNNB1 ZNF131 19888210 i2d exp P P P P P P P P P P P P P P P P P P P ZNF131 WDR26 22939629 biogrid exp P P P P P P P P P P P P P P P P P P P P P KPNA2 ZNF131 17306895 biogrid exp P P P P P P P P P P P P P P P P P P P P ZNF131 PRKCD 26496610 biogrid,intact exp P P P P P P P P P P P P P P P P P P P P P P ZNF131 FHL5 26186194 biogrid exp P P P P P P P P P P P P P P P P P P P P ZNF131 FOXB1 25609649 intact exp ESR1 ZNF131 23159625 biogrid exp P CBX4 ZNF131 22467880 biogrid exp P P P P P P P P P P P P P P P P P P P P P ZNF131 MORF4L2 17573780 biogrid exp P P P P P P P P P P P P P P P P P P P P P P KPNA6 ZNF131 17306895 biogrid exp P P P P P P P P P P P P P P P P P P P P P P ZNF131 MORF4L1 17573780 biogrid exp P P P P P P P P P P P P P P P P P P P P KPNA3 ZNF131 17306895 biogrid exp, ortho P P P P P P P P P P P P P P P P P P P P P P BCL6 ZNF131 23023127 pred P P P P VHL ZNF131 23023127 pred P P P P P P P ZNF131 BACH2 23023127 pred P P P P P P P P P P P P P P P P P P P P P P ZBTB48 ZNF131 23023127 pred P P P P P P P P P P P P P P P BACH1 ZNF131 23023127 pred P P P P P P P P P P P P P P P P P P P

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P52739 P04792 reverse ras recruitment system 25277244 physical association X 2 P52739 P04792 reverse ras recruitment system 25277244 physical association X 2 P52739 Q8D1Q7 two hybrid pooling approach 20711500 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B ZNF131 BAP1 MI:0401(biochemical) 20805357 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0914(association) (biogrid) BIOGRID_160707 prey bait UBC ZNF131 MI:0004(affinity chromatography technology)|MI:0415(enzymatic study)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 21963094,21987572,22467880,23404503 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_250849|BIOGRID_163999|BIOGRID_205023|BIOGRID_265267 prey|bait|prey|bait bait|prey|bait|prey ZNF131 MORF4L2 MI:0004(affinity chromatography technology) 17573780 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_138031 prey bait KPNA6 ZNF131 MI:0096(pull down) 17306895 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_218833 bait prey KPNA2 ZNF131 MI:0096(pull down) 17306895 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_218834 bait prey ZNF131 MORF4L1 MI:0004(affinity chromatography technology) 17573780 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_137998 prey bait ZNF131 SUMO1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 22467880,23404503 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid) BIOGRID_205019|BIOGRID_205020|BIOGRID_250850 bait|prey|bait prey|bait|prey ZNF131 SUMO3 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 22467880 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_205027|BIOGRID_205025 bait|prey prey|bait CBX4 ZNF131 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 22467880 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_205018|BIOGRID_204748 prey|bait bait|prey ZNF131 SUMO2 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 21252943,21693764,22467880 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_205026|BIOGRID_205024|BIOGRID_165537|BIOGRID_184009 bait|prey|prey|prey prey|bait|bait|bait ZNF131 UHRF2 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 23404503 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_250847|BIOGRID_250848 prey|bait bait|prey ZNF131 WDR26 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_237567 prey bait KPNA3 ZNF131 MI:0096(pull down) 17306895 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_218832 bait prey

PPI - HINT Gene A Gene B PMID Method Quality CREB1 ZNF131 25609649,25609649 0676,0004 HT CDK8 ZNF131 26496610,26496610 0007,0004 HT ZNF131 PRKCD 26496610,26496610 0007,0004 HT ZNF131 FHL5 26186194 0004 HT ZNF131 FOXB1 25609649,25609649 0676,0004 HT ZNF131 WDR26 22939629 0401 HT ZNF131 MBIP 26186194 0004 HT ZNF131 FOXJ2 25609649,25609649 0676,0004 HT CREB1 ZNF131 25609649,25609649 0676,0004 HT CDK8 ZNF131 26496610,26496610 0007,0004 HT ZNF131 PRKCD 26496610,26496610 0007,0004 HT ZNF131 FHL5 26186194 0004 HT ZNF131 FOXB1 25609649,25609649 0676,0004 HT ZNF131 WDR26 22939629 0401 HT ZNF131 MBIP 26186194 0004 HT ZNF131 FOXJ2 25609649,25609649 0676,0004 HT HSPB1 ZNF131 25277244 0097 LC ZNF131 FHL2 25416956,25416956,25416956,21516116,25416956 1112,0397,0018,0018,1356 HT ZNF131 BAP1 20805357 0401 LC ZNF131 WDR26 22939629 0401 LC ZNF131 HEL-S-102 25277244 0018 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q8D1Q7 P52739 Q8D1Q7 ZNF131 0.126 20711500 P52739 O60684 ZNF131 KPNA6 0.309 17306895 Q9H7D7 P52739 WDR26 ZNF131 0.081 22939629 Q9NS73 P52739 MBIP ZNF131 0.126 26186194 P52739 P06932 ZNF131 E7 {ECO:0000255|HAMAP-RULE:MF_04004} 0.126 22810586 Q9JJR9 P52739 NRIP3 ZNF131 0.236 26496610 Q9P0K8 P52739 FOXJ2 ZNF131 0.236 25609649 Q99853 P52739 FOXB1 ZNF131 0.236 25609649 P52739 P16220 ZNF131 CREB1 0.236 25609649 P52739 J3KNW4 ZNF131 FHL2 {ECO:0000313|ENSEMBL:ENSP00000344266} 0.236 unassigned1304 Q05655 P52739 PRKCD ZNF131 0.236 26496610 Q14192 P52739 FHL2 ZNF131 0.554 25416956,21516116 P52739 P49336 ZNF131 CDK8 0.236 26496610 Q5TD97 P52739 FHL5 ZNF131 0.332 unassigned1304,26186194 Q92560 P52739 BAP1 ZNF131 0.21 20805357 Q96PU4 P52739 UHRF2 ZNF131 0.376 23404503 Q9UBU8 P52739 MORF4L1 ZNF131 0.126 17573780 Q15014 P52739 MORF4L2 ZNF131 0.126 17573780 Q13469 P52739 NFATC2 ZNF131 0.126 27637333 P52739 P52292 ZNF131 KPNA2 0.309 17306895 P52739 O00257 ZNF131 CBX4 0.376 22467880 P52739 O00505 ZNF131 KPNA3 0.309 17306895 P52739 P04792 ZNF131 HSPB1 0.376 25277244 P52739 P03372 ZNF131 ESR1 0.376 23159625

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 CBX4 ZNF131 MI:0045 experimental interaction detection MI:0461 interaction database KPNA3 ZNF131 MI:0045 experimental interaction detection MI:0461 interaction database KPNA6 ZNF131 MI:0045 experimental interaction detection MI:0461 interaction database ESR1 ZNF131 MI:0045 experimental interaction detection MI:0461 interaction database HSPB1 ZNF131 MI:0045 experimental interaction detection MI:0461 interaction database UBC ZNF131 MI:0045 experimental interaction detection MI:0461 interaction database CREB1 ZNF131 MI:0045 experimental interaction detection MI:0461 interaction database CDK8 ZNF131 MI:0045 experimental interaction detection MI:0461 interaction database KPNA2 ZNF131 MI:0045 experimental interaction detection MI:0461 interaction database ZNF131 SUMO3 MI:0045 experimental interaction detection MI:0461 interaction database ZNF131 SUMO2 MI:0045 experimental interaction detection MI:0461 interaction database ZNF131 SUMO1 MI:0045 experimental interaction detection MI:0461 interaction database ZNF131 PRKCD MI:0045 experimental interaction detection MI:0461 interaction database ZNF131 FHL2 MI:0045 experimental interaction detection MI:0461 interaction database ZNF131 MORF4L2 MI:0045 experimental interaction detection MI:0461 interaction database ZNF131 FHL5 MI:0045 experimental interaction detection MI:0461 interaction database ZNF131 BAP1 MI:0045 experimental interaction detection MI:0461 interaction database ZNF131 UHRF2 MI:0045 experimental interaction detection MI:0461 interaction database ZNF131 FOXB1 MI:0045 experimental interaction detection MI:0461 interaction database ZNF131 NRIP3 MI:0362 inference MI:0461 interaction database ZNF131 MBIP MI:0045 experimental interaction detection MI:0461 interaction database ZNF131 FOXJ2 MI:0045 experimental interaction detection MI:0461 interaction database ZNF131 MORF4L1 MI:0045 experimental interaction detection MI:0461 interaction database