PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus KLHL6 NUDC 25036637 intact exp GP P G GP P GP P P GP GP GP P P P P P GP GP GP P KLHL6 PPP1R1B 25416956 biogrid,intact exp G G G P GP GP G GP P P P P GP G GP NUDCD3 KLHL6 25036637 intact exp GP P G GP P P GP P P GP GP GP P P P P P P GP GP GP P HSP90AA1 KLHL6 22939624 biogrid exp GP P G G P GP G G G P P G G G P HSP90AB1 KLHL6 22939624 intact exp GP P G GP P P GP P P GP GP GP P P P P P P GP GP GP P C7 KLHL6 23023127 pred GP P G G P GP P P GP GP GP P P P P GP GP GP P TLR2 KLHL6 23023127 pred G G G G G G G G G AXIN1 KLHL6 23023127 pred GP P G GP P P GP P P GP GP GP P P P P P P GP GP GP P KLHL6 NOD2 23023127 pred P G GP P P P GP P P P P P P P P P GP P SOCS5 KLHL6 23023127 pred GP P G GP P P GP P P GP GP GP P P P P P P GP G GP P BCL6 KLHL6 23023127 pred G G GP G G GP G P G GP G NCF2 KLHL6 23023127 pred G G GP GP GP G GP G ZBTB7A KLHL6 23023127 pred GP P G GP P P GP P P GP GP GP P P P P P P GP GP GP P CBLB KLHL6 23023127 pred GP P G G P GP P P GP GP GP P P P P GP GP GP P PTPRC KLHL6 23023127 pred G G GP G G GP G G GP G TCEB2 KLHL6 23023127 pred G G G G G G G G G G C3AR1 KLHL6 23023127 pred G G GP P GP GP GP GP P P P GP G GP P BCAR1 KLHL6 23023127 pred GP P P P P GP P P GP GP GP P P P P P P GP GP GP P ELF1 KLHL6 23023127 pred GP P G GP P GP P P GP GP GP P P P P P GP GP GP P KLHL6 SLA2 23023127 pred G G G G G G G G G G KLHL6 BIN2 23023127 pred G GP P GP GP P GP G PLCG2 KLHL6 23023127, 21836163 pred G P G GP P P GP P GP GP GP P P P GP GP GP P LCK KLHL6 23023127 pred G G GP G G GP G G GP G ZAP70 KLHL6 23023127 pred G G GP G G GP G GP G NFAM1 KLHL6 23023127 pred GP P G GP P P GP P P GP GP GP P P P P P P GP GP GP P IL15 KLHL6 23023127 pred GP P P P GP P P GP GP GP P P P P P GP GP GP P KLHL6 TNFSF13B 23023127 pred GP P G GP P P GP P P GP GP GP P P P P P P GP GP GP P KLHL6 LAT2 23023127 pred G G GP G GP GP G P G GP G A2M KLHL6 23023127 pred G G G P GP P G G G P P G G G IKZF1 KLHL6 23023127 pred G G GP G G GP G G GP G ZBTB16 KLHL6 23023127 pred G P G G P GP GP G GP P P P P GP G G P BCL10 KLHL6 23023127 pred GP P G GP P P GP P P GP GP GP P P P P P P GP GP GP P CD86 KLHL6 23023127 pred GP G GP P P P GP GP GP P P P P P P GP GP P PRKCB KLHL6 23023127 pred GP P G GP P GP P GP GP G P P P P G GP GP P SOCS3 KLHL6 23023127 pred GP P G GP P P GP P P GP G GP P P P P P GP G GP P KLHL6 BTBD6 23023127 pred G G GP GP G GP GP P GP G G UNC13D KLHL6 23023127 pred G G G G KLHL6 TRAF6 23023127 pred GP P G GP P GP P P GP G GP P P P GP GP GP P KLHL6 RNF31 23023127 pred P P G GP P P P P P GP P GP P P P P P P GP GP P P SYK KLHL6 23023127 pred GP G GP P GP P GP GP GP P P GP GP GP P KLHL6 VSIG4 23023127 pred G G G P G GP GP G P P G G GP P BCL3 KLHL6 23023127 pred G G GP P GP G GP GP P GP G GP

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q8WZ60 P0CG48 affinity chromatography technology 22505724 physical association X 2 Q8WZ60 P0CG48 pull down 19850743 direct interaction X 2 Q8WZ60 P0CG48 affinity chromatography technology 21906983 physical association X 2 Q8WZ60 P07900-2 affinity chromatography technology 22939624 physical association X 2 Q8WZ60 A0A024R1R3 two hybrid 25416956 direct interaction X 2 Q8WZ60 A0A024RD80 luminescence based mammalian interactome mapping 22939624 physical association X 2 Q8WZ60 Q9Y266 luminescence based mammalian interactome mapping 25036637 physical association X 2 Q8WZ60 Q8IVD9 luminescence based mammalian interactome mapping 25036637 physical association X 2 Q8WZ60 B3KVQ9 two hybrid prey pooling approach 25416956 physical association X 2 Q8WZ60 B3KVQ9 two hybrid array 25416956 physical association X 2 Q8WZ60 B3KVQ9 validated two hybrid 25416956 physical association X 2

PPI - HINT Gene A Gene B PMID Method Quality HSP90AB1 KLHL6 22939624 0729 HT NUDCD3 KLHL6 25036637 0729 HT KLHL6 PPP1R1B 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT KLHL6 NUDC 25036637 0729 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q8WZ60 P07900 KLHL6 HSP90AA1 0.126 22939624 Q8WZ60 Q8IVD9 KLHL6 NUDCD3 0.126 25036637 Q8WZ60 P08238 KLHL6 HSP90AB1 0.126 22939624 Q9Y266 Q8WZ60 NUDC KLHL6 0.126 25036637 Q9UD71 Q8WZ60 PPP1R1B KLHL6 0.454 25416956

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 HSP90AA1 KLHL6 MI:0045 experimental interaction detection MI:0461 interaction database HSP90AB1 KLHL6 MI:0045 experimental interaction detection MI:0461 interaction database UBC KLHL6 MI:0045 experimental interaction detection MI:0461 interaction database HNF4A KLHL6 MI:0045 experimental interaction detection MI:0461 interaction database NUDCD3 KLHL6 MI:0045 experimental interaction detection MI:0461 interaction database KLHL6 PPP1R1B MI:0045 experimental interaction detection MI:0461 interaction database KLHL6 NUDC MI:0045 experimental interaction detection MI:0461 interaction database