PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus NOTCH1 NBEA 23022380 biogrid exp GP GP G GP G G GP G GP GP G G GP GP G GP G P GP G G GP G GP GP G VCP NBEA 23383273 biogrid exp GP GP G GP G G GP G GP GP G G GP GP G GP G P GP G G GP G GP GP G ABL1 NBEA 17474147 i2d,mint,intact exp GP GP G GP G G GP G GP GP G G GP GP G GP G P GP G G GP G GP GP G FOSL2 NBEA 26186194 biogrid exp GP GP G GP G G GP GP GP G G GP GP G G G P GP G G GP G GP G RD3 NBEA 26186194 biogrid exp G G NBEA DTNBP1 17043677 biogrid,intact exp GP GP G GP G G GP G GP GP G G GP GP G GP G P GP G G GP G GP GP G PRKAR2A NBEA 11102458 hprd exp GP GP G GP G G GP G GP GP G G GP GP G GP G P GP G G GP G GP GP G FYN NBEA 17474147 i2d,intact exp G GP G GP G G GP G GP G G G G GP G G G G G G G G G G G NBEA STRN4 16169070 hprd,biogrid,i2d,mint,intact exp G G G GP G G GP G G GP G G GP GP G G G GP G G GP G GP GP G PRKAR2B NBEA 11102458 hprd exp G GP G GP G G GP G GP GP G G G GP G GP G P GP G G G G GP GP G TMEM17 NBEA 26638075 biogrid,intact exp P GP G GP G P G GP P G G P GP GP G P GP G P P GP BMPR2 NBEA 15188402, 25402006 hprd exp, ortho, pred G GP G GP G G GP G GP GP G G GP GP G GP G GP G G GP G GP GP G NBEA EIF3K ortho GP GP G GP G G GP G GP GP G G GP GP G GP G P GP G G GP G GP GP G YWHAE NBEA ortho GP GP G GP G G GP G GP GP G G GP GP G GP G P GP G G GP G GP GP G YWHAB NBEA 25402006 ortho, pred GP GP G GP G G GP G GP GP G G GP GP G GP G P GP G G GP G GP GP G NBEA NAP1L2 25402006 pred G GP G GP G G GP G GP P G G GP GP G GP G GP G GP G GP GP G SNAPIN NBEA 25402006 pred GP GP G GP G G GP G GP GP G G GP GP G GP G P GP G G GP G GP GP G NBEAL1 NBEA 23023127 pred GP GP G GP G G GP G GP GP G G GP GP G GP G P GP G G GP G GP GP G NBEA WSB2 23023127 pred GP G G GP G G GP G GP G G G GP GP G GP G GP G G GP G GP GP G PPP3CA NBEA 23023127 pred GP GP G GP G G GP G GP G G G GP GP G G G GP G G GP G GP GP G DCLK1 NBEA 21836163 pred G G G GP G G GP G G G GP GP G GP G P G G G GP G GP P G STXBP1 NBEA 25402006 pred G G G GP G G GP G G G G G G GP G GP G G G G G G G G G NBEA RBSN 25402006 pred GP GP G GP G G GP G GP GP G G GP GP G GP G P GP G G GP G GP GP G NBEA ZNF490 25402006 pred GP GP G GP G G GP G GP GP G G GP GP G GP G P GP G G GP G GP GP G NBEA INPP5F 25402006 pred GP G G G G G GP G G GP G G G G G G G G G G G G GP G G NBEA MACF1 25402006 pred GP GP G GP G G GP G GP GP G G GP GP G GP G P GP G G GP G GP GP G NBEA SYBU 25402006 pred GP GP G GP G G GP G G GP G G GP GP G GP G P G G G GP GP GP G NBEA DHTKD1 21836163 pred GP GP G GP G G GP G GP GP G G GP GP G GP G P GP G G GP G GP GP G OSBP NBEA 23023127 pred GP GP G GP G G GP G GP GP G G GP GP G GP G P GP G G GP G GP GP G IPO5 NBEA 25402006 pred GP GP G GP G G GP G GP GP G G GP GP G GP G P GP G G GP G GP GP G DCAF12L2 NBEA 23023127 pred P P P P G P P P P P P P GP G RORA NBEA 21836163 pred GP GP G GP G G GP G GP GP G G GP GP G GP G P GP G G GP G GP GP G NBEA MOAP1 25402006 pred G G G GP G G G G G G G G G GP G G G G G G G G G GP G SMAD9 NBEA 21836163 pred GP GP G GP G G GP G GP GP G G GP GP G P G P GP G G GP G GP GP G NBEA BLOC1S5 25402006 pred P P P P P P P P P P P P P P NBEA DMXL1 23023127 pred GP GP G GP G G GP G GP GP G G GP GP G GP G P GP G G GP G GP GP G NBEA TSPYL4 25402006 pred GP GP G GP G G GP G GP GP G G GP GP G GP G P GP G G GP G GP GP G NBEA IPCEF1 23023127 pred GP P G GP GP G GP GP G G GP GP G P G P GP G GP G GP P GPRASP1 NBEA 25402006 pred GP GP G GP G G GP G GP GP G G GP GP G GP G P GP G G GP G GP GP G WDR17 NBEA 23023127 pred G GP G P G P GP P G NBEA NAP1L3 25402006 pred GP G GP G G GP G GP G G GP GP G P G P GP GP G GP GP G NBEA KIDINS220 23023127 pred GP GP G GP G G GP G GP GP G G GP GP G GP G P GP G G GP G GP GP G GLTSCR1L NBEA 25402006 pred GP GP G GP G G GP G GP GP G G GP GP G GP G P GP G G GP G GP GP G WDR5B NBEA 23023127 pred GP GP G GP G G GP G GP G G G GP GP G GP G G G G GP G GP GP G BLOC1S3 NBEA 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G KIAA0408 NBEA 25402006 pred P P G GP P P P P GP P P P P P P AKAP6 NBEA 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G GP G PAFAH1B1 NBEA 23023127 pred GP GP G GP G G GP G GP GP G G GP GP G GP G P GP G G GP G GP GP G NBEA BRF1 25402006 pred G G G G G G G G G G G ANK3 NBEA 23023127 pred GP G G GP G G GP G GP GP G G GP GP G GP G GP G G GP G GP GP G NBEA CAMTA1 25402006 pred GP GP G GP G G GP G GP GP G G GP GP G P G P GP G G GP G GP GP

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q8NFP9 in vitro 11102458 - X 2 Q8NFP9 in vivo 11102458 - X 2 Q8NFP9 in vitro 11102458 - X 2 Q8NFP9 in vivo 11102458 - X 2 Q9NRL3 Q8NFP9 two hybrid 16169070 - X 2 Q9NRL3 Q8NFP9 two hybrid 16169070 - X 2 Q13873-2 Q8NFP9 in vitro 15188402 - X 2 Q13873-2 Q8NFP9 in vitro 15188402 - X 2 A0A024R712 Q8NFP9 in vivo 11102458 - X 2 A0A024R712 Q8NFP9 in vitro 11102458 - X 2 A0A024R712 Q8NFP9 in vivo 11102458 - X 2 A0A024R712 Q8NFP9 in vitro 11102458 - X 2 Q8NFP9 A0A024R8E2 peptide array 17474147 physical association X 2 P06241 Q8NFP9 peptide array 17474147 physical association X 2 Q8CWG4 Q8NFP9 two hybrid pooling approach 20711500 physical association X 2 Q96EV8 Q8NFP9 two hybrid 17043677 physical association X 2 Q9NRL3 Q8NFP9 two hybrid pooling approach 16169070 physical association X 2 Q81V23 Q8NFP9 two hybrid pooling approach 20711500 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B PRKAR2B NBEA MI:0492(in vitro) 11102458 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_1640 - - VCP NBEA MI:0004(affinity chromatography technology) 23383273 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_249863 bait prey ABL1 NBEA MI:0081(peptide array)|MI:0096(pull down)|MI:0081(peptide array) 17474147 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction) MI:0471(mint)|(intact)|MI:0471(mint) MINT_42458|UniProt_91101|MINT_72501 prey|prey|prey bait|bait|bait RPS27AB NBEA MI:0018(two hybrid) 21798944 taxid:3702(Arabidopsis thaliana) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_9928 prey bait RPS27AC NBEA MI:0018(two hybrid) 21798944 taxid:3702(Arabidopsis thaliana) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_10499 prey bait NBEA STRN4 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0007(anti tag coimmunoprecipitation)|MI:0492(in vitro) 16169070 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|- MI:0471(mint)|(biogrid)|MI:0471(mint)|(intact)|MI:0468(hprd) MINT_36230|BIOGRID_94010|MINT_65346|UniProt_156584|HPRD_29443 prey|prey|prey|prey|- bait|bait|bait|bait|- UBC NBEA MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 21139048,21890473,21906983 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid) BIOGRID_169098|BIOGRID_263447|BIOGRID_178409 bait|bait|bait prey|prey|prey NRF1 NBEA MI:0428(imaging technique) 24250222 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_294564 bait prey NOTCH1 NBEA MI:0004(affinity chromatography technology) 23022380 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_246757 bait prey NBEA DTNBP1 MI:0018(two hybrid)|MI:0018(two hybrid) 17043677 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_154223|UniProt_87823 prey|prey bait|bait PRKAR2A NBEA MI:0492(in vitro) 11102458 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_1617 - - BMPR2 NBEA MI:0492(in vitro) 15188402 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_7751 - - FYN NBEA MI:0081(peptide array)|MI:0081(peptide array)|MI:0096(pull down) 17474147 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association) MI:0471(mint)|MI:0471(mint)|(intact) MINT_42689|MINT_72732|UniProt_91450 prey|prey|prey bait|bait|bait

PPI - HINT Gene A Gene B PMID Method Quality FOSL2 NBEA 26186194 0004 HT RD3 NBEA 26186194 0004 HT TMEM17 NBEA 26638075,26638075 1314,1313 HT FOSL2 NBEA 26186194 0004 HT RD3 NBEA 26186194 0004 HT TMEM17 NBEA 26638075,26638075 1314,1313 HT ABL1 NBEA 17474147 0081 HT FYN NBEA 17474147 0081 HT VCL NBEA 15163412 0019 LC NBEA NBEA 12234919 0114 LC NBEA DTNBP1 17043677 0018 HT NBEA STRN4 16169070,16169070 0018,0398 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q8NFP9 P06241 NBEA FYN 0.236 17474147 Q8NFP9 Q8CWG4 NBEA GLPD 0.126 20711500 Q9NRL3 Q8NFP9 STRN4 NBEA 0.286 16169070 Q8NFP9 Q7Z3Z2 NBEA RD3 0.126 26186194 Q8NFP9 Q81V23 NBEA Q81V23 0.126 20711500 Q8NFP9 P00519 NBEA ABL1 0.126 17474147 Q96EV8 Q8NFP9 DTNBP1 NBEA 0.332 17043677 Q8NFP9 Q86X19 NBEA TMEM17 0.236 26638075 Q8NFP9 P46531 NBEA NOTCH1 0.126 23022380 Q8NFP9 P15408 NBEA FOSL2 0.126 26186194 Q8NFP9 P55072 NBEA VCP 0.126 23383273

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 ABL1 NBEA MI:0045 experimental interaction detection MI:0461 interaction database FYN NBEA MI:0045 experimental interaction detection MI:0461 interaction database UBC NBEA MI:0045 experimental interaction detection MI:0461 interaction database FOSL2 NBEA MI:0045 experimental interaction detection MI:0461 interaction database VCL NBEA MI:0045 experimental interaction detection MI:0461 interaction database NOTCH1 NBEA MI:0045 experimental interaction detection MI:0461 interaction database VCP NBEA MI:0045 experimental interaction detection MI:0461 interaction database BMPR2 NBEA MI:0362 inference MI:0461 interaction database RD3 NBEA MI:0045 experimental interaction detection MI:0461 interaction database TMEM17 NBEA MI:0045 experimental interaction detection MI:0461 interaction database NBEA DTNBP1 MI:0045 experimental interaction detection MI:0461 interaction database NBEA STRN4 MI:0045 experimental interaction detection MI:0461 interaction database NBEA TLN1 MI:0045 experimental interaction detection MI:0461 interaction database