PTM - CPLM Gene Name UniProt ID Type Position Code PHF8; KIAA1111; ZNF422 Q9UPP1 Ubiquitination 732 K PHF8; KIAA1111; ZNF422 Q9UPP1 Ubiquitination 486 K PHF8; KIAA1111; ZNF422 Q9UPP1 Ubiquitination 100 K PHF8; KIAA1111; ZNF422 Q9UPP1 Ubiquitination 36 K PHF8; KIAA1111; ZNF422 Q9UPP1 Ubiquitination 191 K PHF8; KIAA1111; ZNF422 Q9UPP1 Ubiquitination 665 K PHF8; KIAA1111; ZNF422 Q9UPP1 Ubiquitination 117 K PHF8; KIAA1111; ZNF422 Q9UPP1 Ubiquitination 166 K PHF8; KIAA1111; ZNF422 Q9UPP1 Ubiquitination 446 K PHF8; KIAA1111; ZNF422 Q9UPP1 Ubiquitination 213 K PHF8; KIAA1111; ZNF422 Q9UPP1 Ubiquitination 523 K PHF8; KIAA1111; ZNF422 Q9UPP1 Ubiquitination 528 K PHF8; KIAA1111; ZNF422 Q9UPP1 Ubiquitination 207 K PHF8; KIAA1111; ZNF422 Q9UPP1 Ubiquitination 467 K PHF8; KIAA1111; ZNF422 Q9UPP1 Ubiquitination 915 K PHF8; KIAA1111; ZNF422 Q9UPP1 Ubiquitination 219 K

PTM - dbPAF Gene Name UniProt ID Position Type Species PHF8; KIAA1111; ZNF422 Q9UPP1 1007 T Homo sapiens(Human) PHF8; KIAA1111; ZNF422 Q9UPP1 1021 S Homo sapiens(Human) PHF8; KIAA1111; ZNF422 Q9UPP1 1024 S Homo sapiens(Human) PHF8; KIAA1111; ZNF422 Q9UPP1 1026 S Homo sapiens(Human) PHF8; KIAA1111; ZNF422 Q9UPP1 104 S Homo sapiens(Human) PHF8; KIAA1111; ZNF422 Q9UPP1 105 S Homo sapiens(Human) PHF8; KIAA1111; ZNF422 Q9UPP1 120 S Homo sapiens(Human) PHF8; KIAA1111; ZNF422 Q9UPP1 214 Y Homo sapiens(Human) PHF8; KIAA1111; ZNF422 Q9UPP1 215 Y Homo sapiens(Human) PHF8; KIAA1111; ZNF422 Q9UPP1 216 Y Homo sapiens(Human) PHF8; KIAA1111; ZNF422 Q9UPP1 22 T Homo sapiens(Human) PHF8; KIAA1111; ZNF422 Q9UPP1 23 T Homo sapiens(Human) PHF8; KIAA1111; ZNF422 Q9UPP1 303 Y Homo sapiens(Human) PHF8; KIAA1111; ZNF422 Q9UPP1 359 T Homo sapiens(Human) PHF8; KIAA1111; ZNF422 Q9UPP1 373 S Homo sapiens(Human) PHF8; KIAA1111; ZNF422 Q9UPP1 383 Y Homo sapiens(Human) PHF8; KIAA1111; ZNF422 Q9UPP1 522 S Homo sapiens(Human) PHF8; KIAA1111; ZNF422 Q9UPP1 582 T Homo sapiens(Human) PHF8; KIAA1111; ZNF422 Q9UPP1 589 S Homo sapiens(Human) PHF8; KIAA1111; ZNF422 Q9UPP1 593 S Homo sapiens(Human) PHF8; KIAA1111; ZNF422 Q9UPP1 603 S Homo sapiens(Human) PHF8; KIAA1111; ZNF422 Q9UPP1 614 T Homo sapiens(Human) PHF8; KIAA1111; ZNF422 Q9UPP1 621 S Homo sapiens(Human) PHF8; KIAA1111; ZNF422 Q9UPP1 651 S Homo sapiens(Human) PHF8; KIAA1111; ZNF422 Q9UPP1 685 S Homo sapiens(Human) PHF8; KIAA1111; ZNF422 Q9UPP1 69 S Homo sapiens(Human) PHF8; KIAA1111; ZNF422 Q9UPP1 704 Y Homo sapiens(Human) PHF8; KIAA1111; ZNF422 Q9UPP1 705 T Homo sapiens(Human) PHF8; KIAA1111; ZNF422 Q9UPP1 706 T Homo sapiens(Human) PHF8; KIAA1111; ZNF422 Q9UPP1 722 S Homo sapiens(Human) PHF8; KIAA1111; ZNF422 Q9UPP1 751 S Homo sapiens(Human) PHF8; KIAA1111; ZNF422 Q9UPP1 753 S Homo sapiens(Human) PHF8; KIAA1111; ZNF422 Q9UPP1 790 S Homo sapiens(Human) PHF8; KIAA1111; ZNF422 Q9UPP1 802 S Homo sapiens(Human) PHF8; KIAA1111; ZNF422 Q9UPP1 804 S Homo sapiens(Human) PHF8; KIAA1111; ZNF422 Q9UPP1 807 S Homo sapiens(Human) PHF8; KIAA1111; ZNF422 Q9UPP1 810 T Homo sapiens(Human) PHF8; KIAA1111; ZNF422 Q9UPP1 826 S Homo sapiens(Human) PHF8; KIAA1111; ZNF422 Q9UPP1 834 S Homo sapiens(Human) PHF8; KIAA1111; ZNF422 Q9UPP1 852 Y Homo sapiens(Human) PHF8; KIAA1111; ZNF422 Q9UPP1 854 S Homo sapiens(Human) PHF8; KIAA1111; ZNF422 Q9UPP1 857 S Homo sapiens(Human) PHF8; KIAA1111; ZNF422 Q9UPP1 866 S Homo sapiens(Human) PHF8; KIAA1111; ZNF422 Q9UPP1 874 S Homo sapiens(Human) PHF8; KIAA1111; ZNF422 Q9UPP1 880 S Homo sapiens(Human) PHF8; KIAA1111; ZNF422 Q9UPP1 886 T Homo sapiens(Human) PHF8; KIAA1111; ZNF422 Q9UPP1 888 T Homo sapiens(Human) PHF8; KIAA1111; ZNF422 Q9UPP1 904 S Homo sapiens(Human) PHF8; KIAA1111; ZNF422 Q9UPP1 907 T Homo sapiens(Human) PHF8; KIAA1111; ZNF422 Q9UPP1 967 S Homo sapiens(Human) PHF8; KIAA1111; ZNF422 Q9UPP1 968 S Homo sapiens(Human) PHF8; KIAA1111; ZNF422 Q9UPP1 969 S Homo sapiens(Human)

PTM - PhosphositePlus UniProt ID MOD_RSD Type SITE_+/-7_AA Q9UPP1 K219-ac Acetylation VKyyySGkREKVLNV Q9UPP1 K244-m1 Methylation SNLVETPkIVRKLSW Q9UPP1 T22-p Phosphorylation PPPAPLDttNLAGRR Q9UPP1 T23-p Phosphorylation PPAPLDttNLAGRRT Q9UPP1 S69-p Phosphorylation CQDWFHGsCVGVEEE Q9UPP1 S104-p Phosphorylation IMKKRRGssKGHDTH Q9UPP1 S105-p Phosphorylation MKKRRGssKGHDTHK Q9UPP1 S120-p Phosphorylation GKPVKTGsPTFVREL Q9UPP1 S175-p Phosphorylation GLGMTLPsPSFTVRD Q9UPP1 Y214-p Phosphorylation KLGDFVKyyySGkRE Q9UPP1 Y215-p Phosphorylation LGDFVKyyySGkREK Q9UPP1 Y216-p Phosphorylation GDFVKyyySGkREKV Q9UPP1 T359-p Phosphorylation GWIHAVLtPVDCLAF Q9UPP1 S373-p Phosphorylation FGGNFLHsLNIEMQL Q9UPP1 Y383-p Phosphorylation IEMQLKAyEIEKRLS Q9UPP1 S522-p Phosphorylation MSRLSLPsKNGSKKK Q9UPP1 T614-p Phosphorylation LLMSNGStKRVKSLS Q9UPP1 S651-p Phosphorylation EDEFDLDsDDELQID Q9UPP1 S685-p Phosphorylation LPRAKPCsDPNRVRE Q9UPP1 Y704-p Phosphorylation EFDIEEDyttDEDMV Q9UPP1 T705-p Phosphorylation FDIEEDyttDEDMVE Q9UPP1 T706-p Phosphorylation DIEEDyttDEDMVEG Q9UPP1 S722-p Phosphorylation EGKLGNGsGAGGILD Q9UPP1 S802-p Phosphorylation SSGLGTVsNsPAsQR Q9UPP1 S804-p Phosphorylation GLGTVsNsPAsQRTP Q9UPP1 S807-p Phosphorylation TVsNsPAsQRTPGKR Q9UPP1 S826-p Phosphorylation PAYWRTEsEEEEENA Q9UPP1 S834-p Phosphorylation EEEEENAsLDEQDSL Q9UPP1 Y852-p Phosphorylation FKDAEYIyPsLEsDD Q9UPP1 S854-p Phosphorylation DAEYIyPsLEsDDDD Q9UPP1 S857-p Phosphorylation YIyPsLEsDDDDPAL Q9UPP1 S866-p Phosphorylation DDDPALKsRPKKKKN Q9UPP1 S874-p Phosphorylation RPKKKKNsDDAPWsP Q9UPP1 S880-p Phosphorylation NsDDAPWsPKARVtP Q9UPP1 T886-p Phosphorylation WsPKARVtPTLPKQD Q9UPP1 T900-p Phosphorylation DRPVREGtRVAsIEt Q9UPP1 S904-p Phosphorylation REGtRVAsIEtGLAA Q9UPP1 T907-p Phosphorylation tRVAsIEtGLAAAAA Q9UPP1 T1007-p Phosphorylation AQANRSTtPMAPGVF Q9UPP1 S1021-p Phosphorylation FLTQRRPsVGsQSNQ Q9UPP1 S1024-p Phosphorylation QRRPsVGsQSNQAGQ Q9UPP1 K1043-sm Sumoylation KKGLATAkQRLGRIL Q9UPP1 K1051-sm Sumoylation QRLGRILkIHRNGKL Q9UPP1 K446-ub Ubiquitination AFRAWTRkEALPDHE Q9UPP1 K486-ub Ubiquitination IFQQNVGkTSNIFGL

PTM - dbPTM UniProt ID Position Code Type Resources References Q9UPP1 69 S Phosphorylation Swiss-Prot 1010711 20622854 Q9UPP1 120 S Phosphorylation Swiss-Prot 1010711 15302935;19413330;19690332;20622854 Q9UPP1 705 T Phosphorylation Swiss-Prot 1010711 18669648;19690332 Q9UPP1 706 T Phosphorylation Swiss-Prot 1010711 18669648;19690332 Q9UPP1 722 S Phosphorylation Swiss-Prot 1010711 18669648 Q9UPP1 804 S Phosphorylation Swiss-Prot 1010711 19413330;19690332 Q9UPP1 854 S Phosphorylation Swiss-Prot 1010711 18669648;19690332 Q9UPP1 857 S Phosphorylation Swiss-Prot 1010711 17081983;18669648;19413330;19690332 Q9UPP1 880 S Phosphorylation Swiss-Prot 1010711 18669648;19413330;19690332 Q9UPP1 120 S Phosphorylation PhosphoELM.10011 15302935 Q9UPP1 722 S Phosphorylation PhosphoELM.10011 18669648 Q9UPP1 854 S Phosphorylation PhosphoELM.10011 18669648 Q9UPP1 857 S Phosphorylation PhosphoELM.10011 18669648;17081983 Q9UPP1 880 S Phosphorylation PhosphoELM.10011 18669648 Q9UPP1 705 T Phosphorylation PhosphoELM.10011 18669648 Q9UPP1 706 T Phosphorylation PhosphoELM.10011 18669648 Q9UPP1 704 Y Phosphorylation PhosphoELM.10011 18669648 Q9UPP1 1021 S Phosphorylation Phosphositeplus.1010730 22115753 Q9UPP1 120 S Phosphorylation Phosphositeplus.1010730 15302935;19690332;19691289;20622854;22115753 Q9UPP1 651 S Phosphorylation Phosphositeplus.1010730 19690332 Q9UPP1 69 S Phosphorylation Phosphositeplus.1010730 20622854 Q9UPP1 722 S Phosphorylation Phosphositeplus.1010730 18669648 Q9UPP1 804 S Phosphorylation Phosphositeplus.1010730 19664995;19690332;20068231 Q9UPP1 826 S Phosphorylation Phosphositeplus.1010730 21659604 Q9UPP1 834 S Phosphorylation Phosphositeplus.1010730 21659604 Q9UPP1 854 S Phosphorylation Phosphositeplus.1010730 18669648;19690332;20363803;20393185;21406692;21659604;22115753 Q9UPP1 857 S Phosphorylation Phosphositeplus.1010730 18669648;19415658;19664994;19690332;20068231;20363803;20393185;21406692;21659604;22115753 Q9UPP1 880 S Phosphorylation Phosphositeplus.1010730 18669648;19664994;19690332;20068231;20363803;21406692;22115753 Q9UPP1 904 S Phosphorylation Phosphositeplus.1010730 19690332 Q9UPP1 705 T Phosphorylation Phosphositeplus.1010730 18669648;19690332 Q9UPP1 706 T Phosphorylation Phosphositeplus.1010730 18669648;19690332 Q9UPP1 907 T Phosphorylation Phosphositeplus.1010730 19690332 Q9UPP1 303 Y Phosphorylation Phosphositeplus.1010730 18083107 Q9UPP1 704 Y Phosphorylation Phosphositeplus.1010730 19690332 Q9UPP1 852 Y Phosphorylation Phosphositeplus.1010730 20393185 Q9UPP1 790 S Phosphorylation HPRD 9.0 18452278 Q9UPP1 621 S Phosphorylation SysPTM 1.1 18669648 Q9UPP1 753 S Phosphorylation SysPTM 1.1 18669648 Q9UPP1 857 S Phosphorylation SysPTM 1.1 17322306 Q9UPP1 857 S Phosphorylation SysPTM 1.1 18669648;17081983 Q9UPP1 880 S Phosphorylation SysPTM 1.1 18669648 Q9UPP1 705 T Phosphorylation SysPTM 1.1 18669648 Q9UPP1 706 T Phosphorylation SysPTM 1.1 18669648

PTM - HPRD Symbol Position Code Type References PHF8 486 S Phosphorylation 20068231 PHF8 668 Y Phosphorylation 18669648 PHF8 669 T Phosphorylation 18669648 PHF8 670 T Phosphorylation 18669648 PHF8 686 S Phosphorylation 18669648 PHF8 768 S Phosphorylation 19413330,19664995,20068231 PHF8 790 S Phosphorylation 18452278 PHF8 818 S Phosphorylation 18669648 PHF8 821 S Phosphorylation 17322306,18669648,19413330,19415658,19651622,19664994,18452278,20068231 PHF8 84 S Phosphorylation 15302935,19691289 PHF8 844 S Phosphorylation 18669648,19413330,19664994,20068231

PTM - Phospho.ELM UniProt Position Code PMIDs Kinase Source Type Q9UPP1 704 Y 18669648 HTP Phosphorylation Q9UPP1 705 T 18669648 HTP Phosphorylation Q9UPP1 706 T 18669648 HTP Phosphorylation Q9UPP1 880 S 18669648 HTP Phosphorylation Q9UPP1 722 S 18669648 HTP Phosphorylation Q9UPP1 854 S 18669648 HTP Phosphorylation Q9UPP1 120 S 15302935 HTP Phosphorylation Q9UPP1 857 S 18669648 HTP Phosphorylation Q9UPP1 857 S 17081983 HTP Phosphorylation

PTM - UniProt UniProt ID Position Type PMIDs Q9UPP1 69 Phosphoserine; by CDK1 20622854 Q9UPP1 120 Phosphoserine; by CDK1 23186163;20622854 Q9UPP1 651 Phosphoserine 19690332 Q9UPP1 705 Phosphothreonine 18669648;19690332 Q9UPP1 706 Phosphothreonine 18669648;19690332 Q9UPP1 722 Phosphoserine 23186163 Q9UPP1 804 Phosphoserine 20068231;23186163 Q9UPP1 854 Phosphoserine 18669648;19690332;21406692 Q9UPP1 857 Phosphoserine 17081983;18669648;19690332;20068231;21406692;23186163 Q9UPP1 880 Phosphoserine 18669648;20068231;21406692;23186163

PTM - PHOSIDA Symbol Accession Code Position Surrounding Sequence Type PHF8 IPI00183302 S 756 IYPSLEpSDDDDPA phosphorylation

PTM - BioGRID Entrez Gene BioGRID ID Position Code Type PMIDs 23133 116751 - K Ubiquitination 21139048 23133 116751 - K Ubiquitination 22505724 23133 116751 - K Ubiquitination 21963094 23133 116751 - K Ubiquitination 23979597 23133 116751 - K Ubiquitination 24816145 23133 116751 - K Ubiquitination 25147182