PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus MAP3K11 TRIM5 22078707 biogrid exp GP GP G GP P G GP GP GP GP GP GP G GP P GP GP G GP GP GP P GP GP GP P G SCNN1B MAP3K11 20936779 i2d exp GP GP G G P G GP G GP GP GP P G P P GP GP GP GP GP GP GP P G PKM MAP3K11 24606918 intact exp GP GP G G GP GP G G GP G GP GP GP GP G GP GP G GP G GP GP GP G GP GP GP GP G MAP3K11 COPS5 20936779 biogrid,i2d,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G GSK3B MAP3K11 20368287 biogrid exp G G G G G GP G G GP G G G G G G G GP G G G GP G G G G G G G G MAP3K11 DAXX bci exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G EPS8 MAP3K11 21988832 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G HSPA4 MAP3K11 24912674 biogrid exp GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G MAP3K11 SMG1 bci exp GP GP G G GP GP G GP GP G GP GP G GP G GP GP G GP G GP GP GP GP GP G GP GP G APP MAP3K11 12917434 innatedb,biogrid exp G GP G G GP GP G G GP G G G G G G GP GP G GP G GP GP G G GP G G GP G MAP3K11 KIFAP3 9427749 biogrid,bci exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G NF2 MAP3K11 20890305 i2d,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G MAP3K11 CLEC4G 18624398 biogrid,intact exp G G G G G G G G TRAF5 MAP3K11 19918265 innatedb exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G MAP3K11 STUB1 24912674 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G NR3C2 MAP3K11 bci exp GP GP G P GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G CBL MAP3K11 19546888 biogrid exp, ortho G GP G G GP GP G G GP G GP G GP GP G G GP GP G G G G G G G GP G GP G KIF3B MAP3K11 9427749, 21836163 biogrid exp, ortho, pred GP G G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP G G GP GP G GP GP G MAP3K11 MAP4K1 11053428,9346925, 25402006, 23023127, 21836163 hprd,biogrid,mint,intact,bci exp, ortho, pred G G G GP G G G G G G GP GP G G G G GP G GP G G MAP4K2 MAP3K11 11784851, 23023127 hprd,biogrid,intact,bci exp, ortho, pred P P P P P P P P P P P P P P P P P P P P P P TRAF2 MAP3K11 19918265,19586614, 25402006, 23023127 innatedb,biogrid exp, ortho, pred P P P P P P P P P P P P P P P P P P P GP GP P MAP3K11 KIF3A 9427749, 21836163 hprd,biogrid,bci exp, ortho, pred G GP G G GP GP G G GP G G G G G G G GP G GP G G G GP G G G GP GP G MAP3K11 SH3RF1 14504284, 25402006, 23023127, 21836163 hprd,biogrid exp, ortho, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G MAP3K11 KIF17 9427749, 21836163 biogrid exp, pred P P G P GP P P G P P P P GP P P P P P P P GP P GP PIN1 MAP3K11 21988832,20936779, 23023127 biogrid,i2d,intact exp, pred G GP G G GP GP G G GP G G G G GP G G GP G P G P GP G G G G GP GP G HSP90AB1 MAP3K11 15001580, 25402006 biogrid exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G TNK1 MAP3K11 23023127 bci exp, pred G GP G G GP GP G GP GP G GP GP GP G G GP GP GP G G GP GP GP GP GP G GP GP G MAPK8 MAP3K11 25284480, 25402006, 23023127 intact,bci exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G CDC37 MAP3K11 15001580, 25402006 biogrid exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G MAP3K11 CAMKK2 23023127 bci exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G MAP3K12 MAP3K11 10187804, 25402006, 23023127, 21836163 hprd,bci exp, pred GP GP G G GP GP G G GP G GP G GP GP G GP GP GP GP G GP GP GP G GP G GP GP G MAP3K11 MAP4K5 25402006, 23023127 bci exp, pred GP G G G GP GP G G GP G GP G G G G G GP GP GP G G G G GP G G GP GP G RAC1 MAP3K11 9427749, 21836163 hprd,biogrid,bci exp, pred GP GP G G GP G G G GP G G G GP G G GP G G GP G GP GP G GP GP G GP GP G PKN1 MAP3K11 23023127, 16082366 bci exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G CDC42 MAP3K11 16253996,25241761,20890305,9427749,10799501, 25402006, 21836163 hprd,biogrid,i2d,intact,bci exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G DLG4 MAP3K11 11152698, 21836163 biogrid exp, pred G GP G G G G GP G G G G G G G G MAP2K1 MAP3K11 23023127 i2d,bci exp, pred G GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G AKT1 MAP3K11 12458207, 25402006, 23023127, 21836163 innatedb,hprd,biogrid,bci exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G IGF1R MAP3K11 23023127 bci exp, pred GP GP G G G G G GP GP G GP GP GP GP G GP G G GP G GP GP GP G GP GP GP GP G IRAK1 MAP3K11 25402006, 23023127 bci exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G CHUK MAP3K11 10713178, 25402006 innatedb,hprd,biogrid,bci exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G ABL1 MAP3K11 25402006, 23023127 bci exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G PIK3R1 MAP3K11 25284480, 25402006 intact exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G CDKN1C MAP3K11 23023127 bci exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G MAPK8IP2 MAP3K11 10490659, 25402006, 23023127, 21836163 hprd,biogrid,bci exp, pred G GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G MAP3K11 MAP3K5 25402006, 23023127, 16082366 bci exp, pred G GP G G GP GP G G GP G GP G GP GP G G GP GP GP G G GP G G G GP GP GP G HSP90AA1 MAP3K11 15001580,24912674, 25402006 biogrid exp, pred GP GP G G G GP G G GP G G G G G G G GP G G G GP G G G G G G GP G MAP3K11 TRAF6 19918265,19586614,23172226, 23023127 innatedb,biogrid exp, pred GP GP G G GP G G GP GP G GP GP GP G G GP G GP G G GP GP GP G GP GP GP GP G MAP3K11 MAPK8IP1 10490659,16456539,23172226, 25402006, 23023127, 21836163 hprd,biogrid,bci exp, pred P P G P GP G P P G P P P P P GP P G P P P P P P P GP MAP2K4 MAP3K11 10187804, 25402006, 23023127 biogrid exp, pred GP GP G G GP GP G G GP G GP G GP G G G GP G G G GP G G G G G GP GP G MAP3K11 TAOK3 25402006, 23023127 bci exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G MAP3K10 MAP3K11 25402006, 23023127 bci exp, pred P P P P P P P P P P P P P P P P P P P P P RHOG MAP3K11 12376551, 23023127 hprd,biogrid,bci exp, pred GP GP G G GP GP G G G G GP G GP GP G G GP G G G G G G G G GP G G G MAP2K7 MAP3K11 15001580,10187804, 25402006, 23023127 hprd,biogrid,i2d exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G E2F1 MAP3K11 23023127 bci exp, pred P GP G G GP GP G GP GP G GP GP GP GP GP GP GP GP G P P GP P GP P GP GP G MAP3K11 MAPK8IP3 10629060, 25402006, 21836163, 16082366 hprd,biogrid,bci exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G MAP3K11 CDK12 23023127 bci exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G MAP3K11 MAP3K11 11053428,12376551,11590155,17721511,23172226, 23023127 hprd,biogrid,intact exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G IKBKB MAP3K11 10713178, 25402006 innatedb,hprd,biogrid,bci exp, pred GP GP G G GP GP G G GP G GP G GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G MAP3K9 MAP3K11 25402006, 23023127 bci exp, pred P GP G P GP G GP G GP GP P G G GP GP P GP G GP GP GP GP GP GP GP GP G MAP3K11 TTN 23023127 bci exp, pred GP GP G G GP GP G GP GP G P G G GP G GP GP G G G P G G GP GP G G G G GSK3A MAP3K11 20368287, 23023127 biogrid,intact exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G CDK6 MAP3K11 23023127 bci exp, pred G GP G G GP GP G G GP G GP G GP GP G GP GP G GP G GP GP G G GP GP GP GP G SMAD4 MAP3K11 23023127 bci exp, pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP GP GP G GP GP GP G GP GP GP GP G GRIK2 MAP3K11 ortho P P G P GP G GP GP G P P P P P GP P P G P P P P P P P P PLCG2 MAP3K11 23023127 pred G GP G G GP GP G GP GP G GP G GP GP G GP GP GP G G GP G G GP GP GP GP GP G EFNA1 MAP3K11 23023127 pred GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP GP GP GP GP GP GP P G PRKACB MAP3K11 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G MAP3K13 MAP3K11 25402006, 23023127 pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP GP GP G GP GP G GP GP GP GP GP G MAP3K11 STK24 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G KLK8 MAP3K11 23023127 pred GP G G G G G G G G G GP G G G G G G G G G G G G G G G G G MAP3K11 CENPK 21836163 pred G G G G G G G G MAP3K11 CIDEC 23023127 pred G GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G INSRR MAP3K11 23023127 pred P P G GP P P P P P P P P P P P P P GP P P P P SNUPN MAP3K11 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP G GP GP G MAP3K11 PEX13 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G CFLAR MAP3K11 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G MAP3K11 PHLDA3 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G MAP3K11 SH3GL3 23023127 pred G G G G GP G G G G G G G G G GP G GP G G G G G G GP GP G MAP3K11 NOXO1 23023127 pred G G G SRC MAP3K11 25402006 pred GP GP G GP GP G G GP G G G G GP GP G G G GP GP G GP GP GP GP G MAP3K11 NSFL1C 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G MAP3K11 BAIAP2L2 23023127 pred P P G P P GP GP P P P GP P P P P P P P GP P GP P ABL2 MAP3K11 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G MAP3K11 CEP250 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G MAP3K11 SUMO4 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G G GP GP GP G GP GP GP GP G GP GP GP G MAP3K11 PDCD4 23023127 pred P P P P P P P P P P P P P GP GP P P P P P P P MAP3K11 KIF20B 21836163 pred GP P G G GP GP G P GP P P P G GP GP GP P P G GP GP P G GP GP MAP3K11 MAP9 21836163 pred GP G G GP G GP GP G GP GP G G GP GP G P G P GP P P GP G GP GP EGF MAP3K11 23023127 pred P P P P GP P GP P P P G P P GP P GP GP GP GP P P P GABARAP MAP3K11 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G AKT2 MAP3K11 23023127 pred GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G MAP3K11 STAM 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP G GP GP G CXCL12 MAP3K11 23023127 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP G GP G GP G G G GP GP G GP G MAP3K11 MARK1 23023127 pred GP GP G G GP GP G GP GP G GP P GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G MAP3K11 STK26 23023127 pred GP P G G P GP G G GP G G GP P P G G GP G P GP G GP P G BTK MAP3K11 23023127 pred G G GP G G GP GP G G GP G RAF1 MAP3K11 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G MAP3K11 SGK3 23023127 pred P P P P P P P P P P P P P P P P P P P P P P MAP3K11 MAD1L1 21836163 pred GP P G P GP G P P P GP GP GP G GP GP P P G P GP P GP GP GP P GP MAP3K11 DBNL 23023127 pred GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G CIDEA MAP3K11 23023127 pred G G G G G G G G MAP3K11 SH3RF2 23023127 pred P P P GP P P P P P P P P P P P GP MAP3K11 NCOA3 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G ARHGEF6 MAP3K11 23023127 pred G GP G G GP GP G G GP G GP GP GP GP G GP GP G GP G G G G G GP G GP G G EFS MAP3K11 23023127 pred GP G G G G GP G G GP G GP P GP G G G GP GP GP G GP GP GP G G G G G G CLK3 MAP3K11 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G NCF4 MAP3K11 23023127 pred G G G GP G GP GP G G G G GP G NCF4 MAP3K11 23023127 pred G G G GP G GP GP G G G G GP G NCK2 MAP3K11 23023127 pred G GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G RHOA MAP3K11 23023127 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G MAP3K11 CCAR2 25402006 pred P P G P GP P GP G GP P P P GP P P G P P GP GP P P P GP MAP3K11 TBK1 25402006 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G MAP3K11 RGL1 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G MAPK4 MAP3K11 25402006 pred P P P P P P P GP P P P P P GP P P P P P P P P MAP3K11 TNIK 23023127 pred GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G MAP3K11 MAP3K14 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G MAP3K11 KIF2C 21836163 pred GP G G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G ULK1 MAP3K11 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SPTAN1 MAP3K11 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SMC1A MAP3K11 21836163 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G MAP3K11 RUSC2 23023127 pred GP GP G P GP G GP GP G GP GP GP GP G P GP GP P G P P GP GP GP GP GP GP G MAP3K11 SPRED3 23023127 pred G G G G G G G G G G G G G G G G G G G G MAP3K11 BAG1 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G MAP3K11 SMARCAD1 21836163 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP P G GP GP GP GP GP GP GP GP G MAP3K11 ALK 23023127 pred GP GP G P GP G GP GP G P G GP GP G GP GP GP GP G GP P GP GP GP P GP GP G ARHGEF9 MAP3K11 23023127 pred GP GP G P GP G GP GP G GP GP G G G G GP G GP G GP G GP P G GP G P G MAP3K6 MAP3K11 25402006, 23023127 pred GP GP P P G GP GP GP P GP GP G GP P GP GP P GP GP GP GP GP GP P G BAG6 MAP3K11 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G MAP3K11 STRADA 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G LCK MAP3K11 23023127 pred G G GP G G G G G G GP G G G G G GP G YES1 MAP3K11 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G LRP1 MAP3K11 25402006 pred G G G G G GP G G G G G GP GP G G G GP GP G G GP G G G G G G GP G PTPN11 MAP3K11 23023127 pred GP GP G G G GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G EPHA2 MAP3K11 23023127 pred GP GP G P P G GP GP G GP GP GP GP G GP GP P GP G GP GP GP GP GP GP GP GP G CDK13 MAP3K11 23023127 pred G G G G G G G GP G G GP G G G G GP G G G G GP G G G GP G GP GP G ACVR1B MAP3K11 23023127 pred G G G G G GP G G GP G GP GP GP G G GP GP G GP G GP G G G GP G GP GP G MAP3K11 FAF1 23023127 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G ITK MAP3K11 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G RDX MAP3K11 23023127 pred G GP G G G GP G G G G GP GP G GP G G GP GP GP G GP GP GP G G G GP GP G PDGFRA MAP3K11 23023127 pred G G G G GP GP G G G G GP G G G G G GP GP G G GP G G G G G GP G G MAP3K1 MAP3K11 25402006, 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G AURKA MAP3K11 25402006, 23023127, 21836163 pred G GP P G G G G GP G P G P G G G G GP MAP3K11 TMUB2 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G MAP3K11 EPS8L2 23023127 pred GP GP G GP P GP G GP GP GP G G GP GP G GP G GP GP GP P GP P GP GP G BRAF MAP3K11 25402006, 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP P GP GP GP G GP GP GP GP P GP GP GP G EPHB4 MAP3K11 23023127 pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP GP GP G GP GP GP G GP G GP GP G MAPRE1 MAP3K11 21836163 pred GP GP G G G GP G G GP G GP G GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G SRGAP3 MAP3K11 23023127 pred GP G G G G GP G GP GP G GP G G G G G GP G G G G G G GP G G G MAP3K7 MAP3K11 25402006, 23023127 pred GP GP G G G GP G G GP G G GP GP G G G GP G GP G GP GP G G G G GP GP G MAP3K11 CAMKK1 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G NFKB1 MAP3K11 25402006 pred GP G G G GP G G G GP G G G GP GP G GP G G G G GP GP GP G GP GP G GP G PTPRF MAP3K11 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP G FER MAP3K11 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G MAP3K11 SH2D3C 23023127 pred GP G G G GP G G GP G G GP G G GP G G G G G GP G G G G GP GP GP G ARL2 MAP3K11 21836163 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G MAP3K11 STAC2 23023127 pred GP GP G G GP GP G G GP G GP G GP GP G GP GP GP GP G GP P GP G GP GP GP GP G FES MAP3K11 23023127 pred GP P G GP P GP GP P GP GP GP P P P P GP P GP P GP P P VAV1 MAP3K11 25402006, 23023127 pred GP GP G GP GP G P P G P GP GP GP G GP GP G GP G GP G GP P P GP GP GP G MAP3K11 MAP3K15 25402006 pred P P P P P P P P P P P P P P P P P P P P P TNK2 MAP3K11 25402006, 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G MAP3K11 TESK2 23023127 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G MAP3K11 BAIAP2L1 23023127 pred P GP P P G P GP GP GP GP P G GP P P GP G GP GP GP P GP P GP GP TESK1 MAP3K11 23023127 pred G G G G GP GP G GP G G G GP GP GP G G GP G G G G G G G G G G G G MAP3K11 ARHGAP26 23023127 pred GP GP G G G GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP G GP G GP GP G NEB MAP3K11 23023127 pred G P G G G G P G G G G G GP G P G MAP3K11 CENPH 21836163 pred P G G P P P P P P P GP P P GP P P P P GP G PSTPIP1 MAP3K11 23023127 pred G G GP G GP G GP GP G G G G GP G G MAP3K11 VRK2 25402006, 23023127 pred GP GP G G G G G GP GP G GP GP GP G G GP G G GP G GP GP GP GP GP G GP GP G MAP3K11 CUEDC2 25402006 pred G G G G GP GP G G G G GP G GP G G GP GP G G G G G G G GP G G G G TROAP MAP3K11 21836163 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G MAP3K11 NUDC 21836163 pred GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G GAK MAP3K11 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G TEK MAP3K11 23023127 pred G GP G P GP G GP GP G G G GP GP G GP GP G GP G G G GP GP GP GP P G MAP3K11 MYLIP 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G CDC16 MAP3K11 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G PPM1B MAP3K11 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G PRKCZ MAP3K11 25402006, 23023127 pred G GP G GP G GP GP G GP GP GP GP G GP GP GP G GP GP GP P GP GP GP GP ERF MAP3K11 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G MAP3K11 NDE1 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G MAP3K11 IKBKG 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G CDK4 MAP3K11 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G ARAF MAP3K11 25402006, 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G IQGAP1 MAP3K11 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G MAP3K11 NLRC5 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SH3D21 MAP3K11 23023127 pred P GP G G GP P G GP GP G GP GP P GP GP GP P GP G GP P GP GP GP P P GP G PIK3CA MAP3K11 23023127 pred GP GP G P GP G GP GP G 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G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G DVL1 MAP3K11 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G CCND1 MAP3K11 23023127 pred GP GP G P GP G G GP G GP GP G G G GP GP G G G G G GP G GP GP GP P G CDK5 MAP3K11 23023127 pred P GP G P GP G P P G GP GP P GP GP GP P P G P G P P P P P RGS14 MAP3K11 23023127, 21836163 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G MOS MAP3K11 21836163 pred GP GP G G GP GP G GP P G GP GP GP P G P GP GP GP G GP P GP GP P P P GP G RPS6KA1 MAP3K11 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G TPM3 MAP3K11 25402006 pred G P GP G GP G G GP G GP G G G BUB1B MAP3K11 21836163 pred P P G GP P GP GP P P P GP GP P GP P GP P P P GP P GP GP G TEC MAP3K11 23023127 pred P P P P P P P P P P P P P P P P P P P MAP3K11 DNMT3B 23023127 pred GP P G G GP GP G GP P GP GP GP P G GP GP GP GP G GP P GP GP GP GP GP GP PRKCH MAP3K11 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G MAP3K11 SUGT1 21836163 pred G G G G G G G GP GP G GP G G G G GP G G GP G G G G GP GP G GP GP G MAP3K11 ABI3 23023127 pred G G G G GP GP G GP GP G GP G GP GP G GP GP G G G G G GP GP GP G G SKI MAP3K11 23023127 pred GP GP G G GP GP G GP GP G GP G GP G G GP GP GP GP G GP GP GP GP GP GP GP GP G MAP3K11 BMPER 23023127 pred P P P P P P P P GP P P P P P P P P P P P P RAD23A MAP3K11 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G HSPB1 MAP3K11 25402006 pred GP GP G G GP G G GP GP G GP GP GP G G GP G GP GP G GP GP GP GP GP G GP GP G FGFR4 MAP3K11 23023127 pred P GP P P P GP GP GP GP GP GP P GP GP P P P GP GP GP GP P ARHGEF7 MAP3K11 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP G GP GP GP GP GP G MAP3K11 SGK2 23023127 pred G GP G G G GP G G GP G GP GP G G GP GP GP GP G GP G G GP GP P GP GP G RAE1 MAP3K11 21836163 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP G G GP GP GP GP GP G RANGAP1 MAP3K11 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G MAP3K11 ARHGEF16 23023127 pred GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G MAP3K11 CLIP4 23023127 pred G G G P G G GP GP G GP GP G G GP G G P G GP GP G GP GP G GP GP G MAP3K11 LZTS2 21836163 pred GP GP G G G GP G G GP G GP GP G G G GP GP G GP G GP GP GP G GP G GP GP G PRKCB MAP3K11 23023127 pred GP GP G G GP GP G G GP G GP G GP GP G G GP GP GP G G GP GP G G GP GP GP G PAK3 MAP3K11 25402006 pred G G G G G GP G G G G G G GP G G GP G GP G GP G G G G G G G G ZEB2 MAP3K11 23023127 pred G G G G GP GP G GP G G GP GP GP GP G G GP G G G G G G GP G G G VEGFC MAP3K11 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G MAP2K3 MAP3K11 25402006, 23023127 pred P P P P P P P P P P P P P P P P P P P P P MAP3K11 PLEKHF1 23023127 pred GP GP GP G G G G G GP G G G GP G G GP G G GP G G GP G G MAP3K11 SGSM3 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G NEBL MAP3K11 23023127 pred GP GP G G G G G GP GP G GP GP GP GP G GP G G GP G G G G G GP P GP G G EGFR MAP3K11 25402006, 23023127 pred GP GP G GP G G GP G GP GP G G G GP GP G G G GP GP G GP GP G GP GP G CLK1 MAP3K11 23023127 pred GP GP G G G GP G G GP G GP GP GP G G GP GP GP GP G GP GP GP G GP GP GP GP G MAP3K11 MAPK15 23023127 pred GP GP G G G GP GP GP G GP GP GP P GP GP P GP G GP P GP GP GP GP GP G MAP3K11 STAG2 21836163 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G MAP3K11 PPP1R13B 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G HERPUD1 MAP3K11 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G MAP3K11 UBQLN1 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G MAP2K6 MAP3K11 25402006, 23023127 pred GP G G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP G G MAP3K11 DOK1 25402006 pred GP GP G G GP GP G G G G GP G GP GP G GP GP G GP G GP G G GP GP G GP GP G MAP3K11 PAK6 25402006 pred GP G G G G GP G GP GP G GP G GP G GP GP P GP G GP G GP P GP GP GP EREG MAP3K11 23023127 pred P G G P P P P P P P P GP P P P P P P P P P LTK MAP3K11 23023127 pred P G G P G GP P GP GP GP GP P GP P GP GP G GP G GP GP MAP3K11 VAV3 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G RASA1 MAP3K11 23023127 pred GP G G G GP GP G G G G G G G G G G GP G G G GP G G G G G GP G G MAP3K11 UHRF2 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SASH1 MAP3K11 23023127 pred GP GP G G GP GP G GP GP G GP GP GP G G G GP G GP G GP GP GP GP G G GP GP G PLAU MAP3K11 23023127 pred G G G GP P G G GP GP GP GP G GP GP GP GP G GP GP G G GP GP GP GP G BMX MAP3K11 23023127 pred GP P G GP P G GP GP P P P G GP P GP P P P GP P P NFKBIA MAP3K11 25402006 pred G GP G G GP GP G GP GP G G G GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G IL18 MAP3K11 23023127 pred GP G GP G P GP P GP GP GP P P P P G GP GP GP P GRB14 MAP3K11 23023127 pred P GP P P G GP GP GP G P GP P P G GP GP P P GP P P GP ILK MAP3K11 23023127 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G ACVR2A MAP3K11 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G CAMK2B MAP3K11 23023127 pred G G G G GP G GP G G G G G GP G G G GP GP G G GP G FANCA MAP3K11 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G MAP3K11 SRMS 23023127 pred P P P P P P P P P P P P P P P P P P P P P P TUBB4A MAP3K11 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP GP GP GP GP G GP P GP GP GP GP GP GP G INSR MAP3K11 23023127 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G MAP3K11 SMURF1 23023127 pred G GP G G GP GP G G GP G GP G GP G G G GP GP G G GP G G G G GP G GP G CDK10 MAP3K11 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G CDK2 MAP3K11 23023127 pred GP GP G G GP GP G GP GP G GP G G GP G GP GP G G G GP GP G G GP G GP GP G MAP3K11 UBL7 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G TNF MAP3K11 23023127 pred G G G G G GP G G GP G G G GP G GP GP G GP G G G G GP G GP G G MYLK MAP3K11 23023127 pred G G G G G G G G GP G GP G G G G G G G G G G G G G G G G G G TUBA3C, TUBA3D MAP3K11 25402006 pred P P P P P P P P P P P P P P TXK MAP3K11 23023127 pred P G G G P G G G G P G MAPT MAP3K11 25402006 pred G GP G G G GP G GP GP G GP GP G GP G G GP G GP G G GP GP GP G G GP GP G MAP3K11 CNTRL 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G P GP G GP G P GP GP P GP GP GP GP SOCS3 MAP3K11 23023127 pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP GP GP G GP G GP GP GP G GP GP G CSNK1D MAP3K11 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G MAP3K11 TACC3 21836163 pred P G GP P GP P P GP GP P P P P P GP GP GP GP SOCS6 MAP3K11 23023127 pred GP GP G P GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP P GP GP G MAP3K11 SH3BP4 23023127 pred GP GP G P GP G G GP G GP G GP GP G GP GP G GP G GP GP GP G GP GP GP GP G RAD23B MAP3K11 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G CDC42EP2 MAP3K11 25402006 pred GP GP G G GP GP G GP GP G P GP G G GP GP GP GP GP GP P GP G GP P G NFKBIB MAP3K11 25402006 pred GP P G GP GP G GP P G GP GP GP GP G GP GP P GP G GP GP GP GP GP GP GP GP G CYTH1 MAP3K11 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G G GP G G GP GP GP GP G NRAS MAP3K11 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G MERTK MAP3K11 23023127 pred G GP G G G GP G GP G G GP GP GP G G G GP GP GP G G GP GP G G G GP GP G ACVR2B MAP3K11 23023127 pred GP GP G G GP GP G GP GP G GP G G G G GP GP GP GP G GP G G G GP G GP GP G SH2D1A MAP3K11 23023127 pred G G MAP3K11 SH3GLB1 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G TBCE MAP3K11 23023127 pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP GP GP G GP GP GP GP GP GP GP GP G MAP3K11 CD2AP 23023127 pred GP GP G GP P G G GP GP GP GP GP G GP GP G GP G GP GP GP G GP GP GP GP MAP3K11 DLC1 23023127 pred G G G G G GP G G GP G GP G G G G GP GP G G G G G G G GP G G GP G MAP3K11 CENPJ 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G CTGF MAP3K11 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G PRKCA MAP3K11 23023127 pred G GP G G GP GP G GP GP G GP G G GP G GP GP G GP G GP G G GP GP G GP GP G IQGAP2 MAP3K11 25402006 pred GP GP G GP P G GP GP GP GP GP G G GP P GP GP G GP GP GP GP G GP GP G GOLGA3 MAP3K11 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G STK11 MAP3K11 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G MAP3K11 BAIAP2 25402006, 23023127 pred P P G G GP GP G GP P G GP GP GP GP P GP GP GP G GP GP P P P P GP GP G CSNK1G2 MAP3K11 23023127 pred G G G G G G G G GP G G G G G G GP G G GP G G G G G GP G GP G G VAV2 MAP3K11 23023127 pred GP GP G G GP GP G G GP G GP GP GP G G GP GP GP GP G GP GP GP GP GP GP GP G MSLN MAP3K11 21836163 pred GP G GP P MAP3K11 TBC1D2 23023127 pred P P P G G GP P G GP P P GP P P P P MAP3K11 ITCH 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G PAK2 MAP3K11 25402006, 23023127 pred GP GP G G G GP G G GP G GP GP GP GP G GP GP GP G G GP G GP GP GP GP GP G G PDGFRB MAP3K11 23023127 pred G G G G G GP G G G G GP G G G G G GP GP G G GP GP G G G G GP GP G MAP3K11 ZAK 25402006, 23023127 pred GP GP G G G GP G GP GP G GP G GP G G GP GP G GP G GP GP GP G GP G GP GP G BCAR1 MAP3K11 23023127 pred GP GP G P GP G GP GP G GP GP GP GP GP GP GP GP G GP GP GP GP GP GP GP GP G DLGAP5 MAP3K11 21836163 pred G GP P G P P P GP P P GP P P P GP RIMBP3C MAP3K11 23023127 pred P P P P

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B RAC1 MAP3K11 MI:0492(in vitro) 9427749 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_6154 - - CDC37 MAP3K11 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 15001580 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid) BIOGRID_271491|BIOGRID_271493|BIOGRID_271488 prey|bait|prey bait|prey|bait MAP2K4 MAP3K11 MI:0415(enzymatic study) 10187804 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_108969 prey bait MAP3K11 KIF17 MI:0018(two hybrid) 9427749 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_97969 bait prey CBL MAP3K11 MI:0004(affinity chromatography technology) 19546888 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_220335 bait prey MAP3K11 TRAF6 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 19586614,23172226 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid) BIOGRID_248103|BIOGRID_146874|BIOGRID_248102 prey|prey|bait bait|bait|prey MAP3K11 KIF3A MI:0018(two hybrid)|MI:0492(in vitro) 9427749 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|- (biogrid)|MI:0468(hprd) BIOGRID_97970|HPRD_6159 bait|- prey|- MAP3K11 SIRT1 MI:0004(affinity chromatography technology) 22318606 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0799(additive genetic interaction defined by inequality) (biogrid) BIOGRID_193230 prey bait AKT1 MAP3K11 MI:0493(in vivo)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 12458207 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0915(physical association)|MI:0407(direct interaction) MI:0468(hprd)|(biogrid)|(biogrid) HPRD_38783|BIOGRID_104909|BIOGRID_104910 -|prey|prey -|bait|bait RHOG MAP3K11 MI:0096(pull down)|MI:0492(in vitro) 12376551 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|- (biogrid)|MI:0468(hprd) BIOGRID_103548|HPRD_2326 bait|- prey|- GSK3B MAP3K11 MI:0415(enzymatic study) 20368287 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_258008 bait prey EPS8 MAP3K11 MI:0004(affinity chromatography technology)|MI:0397(two hybrid array) 21988832 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_287307|UniProt_118832 bait|unspecified role prey|unspecified role MAP4K2 MAP3K11 MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0492(in vitro)|MI:0004(affinity chromatography technology) 11784851 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|-|MI:0915(physical association) (intact)|(intact)|MI:0468(hprd)|(biogrid) UniProt_70073|UniProt_180929|HPRD_6157|BIOGRID_211531 bait|bait|-|bait prey|prey|-|prey NF2 MAP3K11 MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation) 20890305 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0217(phosphorylation reaction) (intact)|(intact)|(intact)|(intact) UniProt_108905|UniProt_108904|UniProt_108903|UniProt_108908 prey|bait|bait|unspecified role bait|prey|prey|unspecified role MAP3K11 CLEC4G MI:0018(two hybrid)|MI:0018(two hybrid) 18624398 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_96738|BIOGRID_155362 prey|prey bait|bait MAP3K11 MAPK8IP1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0493(in vivo) 10490659,16456539,23172226 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|- (biogrid)|(biogrid)|(biogrid)|(biogrid)|MI:0468(hprd) BIOGRID_248106|BIOGRID_248107|BIOGRID_99198|BIOGRID_99206|HPRD_32491 bait|bait|bait|bait|- prey|prey|prey|prey|- MAP3K11 MAPK8IP3 MI:0096(pull down)|MI:0493(in vivo) 10629060 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|- (biogrid)|MI:0468(hprd) BIOGRID_107587|HPRD_6160 prey|- bait|- CDC42 MAP3K11 MI:0006(anti bait coimmunoprecipitation)|MI:0018(two hybrid)|MI:0006(anti bait coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0492(in vitro) 10799501,20890305,9427749 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|- (intact)|(biogrid)|(intact)|(biogrid)|MI:0468(hprd) UniProt_108907|BIOGRID_97958|UniProt_108906|BIOGRID_100021|HPRD_17214 bait|bait|bait|bait|- prey|prey|prey|prey|- UBC MAP3K11 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0415(enzymatic study)|MI:0004(affinity chromatography technology) 19586614,22118674,23172226 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_248104|BIOGRID_146877|BIOGRID_160467|BIOGRID_248101 prey|prey|bait|prey bait|bait|prey|bait CHUK MAP3K11 MI:0493(in vivo)|MI:0415(enzymatic study) 10713178 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0407(direct interaction) MI:0468(hprd)|(biogrid) HPRD_6152|BIOGRID_108438 -|prey -|bait KIF3B MAP3K11 MI:0018(two hybrid) 9427749 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_97972 prey bait MAP3K11 TRIM5 MI:0018(two hybrid) 22078707 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_190560 prey bait TRAF2 MAP3K11 MI:0004(affinity chromatography technology) 19586614 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_146873 bait prey HSP90AA1 MAP3K11 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 15001580 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_271490|BIOGRID_271487 prey|prey bait|bait MAP3K11 SH3RF1 MI:0493(in vivo)|MI:0018(two hybrid)|MI:0018(two hybrid) 14504284 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0915(physical association)|MI:0407(direct interaction) MI:0468(hprd)|(biogrid)|(biogrid) HPRD_6161|BIOGRID_88020|BIOGRID_88019 -|prey|prey -|bait|bait IKBKB MAP3K11 MI:0493(in vivo)|MI:0415(enzymatic study) 10713178 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0407(direct interaction) MI:0468(hprd)|(biogrid) HPRD_6158|BIOGRID_108437 -|prey -|bait GSK3A MAP3K11 MI:0398(two hybrid pooling approach)|MI:0398(two hybrid pooling approach)|MI:0415(enzymatic study) 20368287 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(intact)|(biogrid) UniProt_107051|UniProt_170449|BIOGRID_257935 bait|bait|bait prey|prey|prey DLG4 MAP3K11 MI:0004(affinity chromatography technology) 11152698 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_109018 bait prey MAP3K11 SIRT2 MI:0004(affinity chromatography technology) 22318606 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0799(additive genetic interaction defined by inequality) (biogrid) BIOGRID_193323 prey bait MAP3K11 KIFAP3 MI:0018(two hybrid) 9427749 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_97971 bait prey MAP3K11 MAP4K1 MI:0107(surface plasmon resonance)|MI:0107(surface plasmon resonance)|MI:0096(pull down)|MI:0492(in vitro)|MI:0415(enzymatic study) 11053428,9346925 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|-|MI:0407(direct interaction) MI:0471(mint)|MI:0471(mint)|(intact)|MI:0468(hprd)|(biogrid) MINT_71789|MINT_41843|UniProt_135366|HPRD_6153|BIOGRID_104600 bait|bait|bait|-|prey prey|prey|prey|-|bait MAP3K11 COPS5 MI:0018(two hybrid)|MI:0096(pull down) 20936779 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_127004|UniProt_110523 bait|bait prey|prey MAP3K12 MAP3K11 MI:0492(in vitro) 10187804 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_6151 - - APP MAP3K11 MI:0415(enzymatic study) 12917434 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_273725 bait prey MAP2K7 MAP3K11 MI:0004(affinity chromatography technology)|MI:0415(enzymatic study)|MI:0492(in vitro) 10187804,15001580 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction)|- (biogrid)|(biogrid)|MI:0468(hprd) BIOGRID_271494|BIOGRID_108970|HPRD_6156 prey|prey|- bait|bait|- HSP90AB1 MAP3K11 MI:0004(affinity chromatography technology) 15001580 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_271489 prey bait MAPK8IP2 MAP3K11 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0493(in vivo)|MI:0004(affinity chromatography technology) 10490659 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|-|MI:0407(direct interaction) (biogrid)|(biogrid)|MI:0468(hprd)|(biogrid) BIOGRID_99199|BIOGRID_99207|HPRD_16882|BIOGRID_99221 prey|prey|-|bait bait|bait|-|prey PIN1 MAP3K11 MI:0397(two hybrid array)|MI:0004(affinity chromatography technology) 21988832 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_119114|BIOGRID_287598 unspecified role|prey unspecified role|bait

PPI - HINT Gene A Gene B PMID Method Quality UBC MAP3K11 19586614,22118674 0004,0004 LC CDC42 MAP3K11 20890305,25241761,10799501,25241761 0007,0813,0004,0428 LC TRAF2 MAP3K11 19586614,19918265 0004,0007 LC MAP3K11 Q86SX1 24912674,15001580 0004,0004 LC MAP3K11 MAPK8IP1 10490659,10490659,23172226,23172226 0004,0096,0004,0096 LC MAP3K11 TRAF6 19918265,19586614,23172226,23172226 0007,0004,0004,0415 LC UBC MAP3K11 19586614,22118674 0004,0004 LC CDC42 MAP3K11 20890305,25241761,10799501,25241761 0007,0813,0004,0428 LC TRAF2 MAP3K11 19586614,19918265 0004,0007 LC MAP3K11 Q86SX1 24912674,15001580 0004,0004 LC MAP3K11 MAPK8IP1 10490659,10490659,23172226,23172226 0004,0096,0004,0096 LC MAP3K11 TRAF6 19918265,19586614,23172226,23172226 0007,0004,0004,0415 LC MAP2K7 MAP3K11 10187804,15001580,15001580 0415,0045,0415 LC IKBKB MAP3K11 10713178,10713178,10713178 0423,0415,0007 LC KIF3B MAP3K11 9427749 0018 LC CHUK MAP3K11 10713178,10713178,10713178 0423,0415,0007 LC PKM MAP3K11 24606918 0424 LC NF2 MAP3K11 20890305,20890305,20890305 0096,0006,0424 LC MAP2K4 MAP3K11 10187804 0415 LC CDC42 MAP3K11 9427749 0018 LC RAC1 MAP3K11 9427749 0018 LC MAP2K1 MAP3K11 15258589 0045 LC Q08G24 MAP3K11 18624398 0018 HT EPS8 MAP3K11 21988832 0018 HT PIN1 MAP3K11 21988832 0018 HT MAP3K11 CLEC4G 18624398 0018 HT MAP3K11 Q6XYD1 18624398 0018 HT MAP3K11 SH3RF1 14504284,14504284,14504284 0096,0019,0004 LC MAP3K11 KIFAP3 9427749 0018 LC MAP3K11 COPS5 20936779,20936779 0398,0018 HT MAP3K11 MAP4K1 11053428,9346925 0415,0018 LC MAP3K11 B-RAF 15258589 0019 LC MAP3K11 KIF17 9427749 0018 LC MAP3K11 STUB1 24912674,24912674,24912674 0004,0415,0096 LC MAP3K11 KIF3A 9427749 0018 LC MAP3K11 TRAF6 23172226,23172226 0004,0415 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q16584 P22681 MAP3K11 CBL 0.21 19546888 Q81PD4 Q16584 Q81PD4 MAP3K11 0.126 20711500 Q16584 P05067 MAP3K11 APP 0.309 12917434 Q16584 P06930 MAP3K11 E6 0.126 22810586 Q16584 O14733 MAP3K11 MAP2K7 0.523 15001580,10187804 Q16584 P07900 MAP3K11 HSP90AA1 0.376 24912674,15001580 Q16584 P31749 MAP3K11 AKT1 0.454 12458207 Q92905 Q16584 COPS5 MAP3K11 0.286 20936779 Q16584 Q12929 MAP3K11 EPS8 0.332 21988832 Q16584 P27986 MAP3K11 PIK3R1 0.376 25284480 Q7Z6J0 Q16584 SH3RF1 MAP3K11 0.454 14504284 Q9UQF2 Q16584 MAPK8IP1 MAP3K11 0.702 10490659,23172226 Q16584 P60953 MAP3K11 CDC42 0.561 9427749,25241761,10799501 Q92918 Q16584 MAP4K1 MAP3K11 0.523 11053428,9346925 Q9C035 Q16584 TRIM5 MAP3K11 0.21 22078707 Q9UPT6 Q16584 MAPK8IP3 MAP3K11 0.309 10629060 Q16584 P45983 MAP3K11 MAPK8 0.21 25284480 Q16584 P70218 MAP3K11 MAP4K1 0.569 9003777 Q9R237 Q16584 MAPK8IP1 MAP3K11 0.21 16456539 Q16584 P78352 MAP3K11 DLG4 0.21 11152698 Q16584 P84095 MAP3K11 RHOG 0.309 12376551 Q16584 Q12851 MAP3K11 MAP4K2 0.376 11784851 Q16584 P63000 MAP3K11 RAC1 0.309 9427749 Q16584 P49840 MAP3K11 GSK3A 0.236 20368287 Q16584 Q12933 MAP3K11 TRAF2 0.21 19586614 Q16584 P49841 MAP3K11 GSK3B 0.126 20368287 Q16584 P42260 MAP3K11 GRIK2 0.21 22483987 Q16584 Q13387 MAP3K11 MAPK8IP2 0.623 10490659 Q16584 Q13526 MAP3K11 PIN1 0.332 21988832 Q16584 Q16543 MAP3K11 CDC37 0.376 15001580 Q9Y496 Q16584 KIF3A MAP3K11 0.309 9427749 Q16584 O15111 MAP3K11 CHUK 0.309 10713178 Q16584 O15066 MAP3K11 KIF3B 0.309 9427749 Q16584 O14920 MAP3K11 IKBKB 0.309 10713178 Q16584 P14618 MAP3K11 PKM 0.033 24606918 Q9UNE7 Q16584 STUB1 MAP3K11 0.623 24912674 Q16584 P08238 MAP3K11 HSP90AB1 0.21 15001580 Q16584 P34932 MAP3K11 HSPA4 0.21 24912674 Q16584 P45985 MAP3K11 MAP2K4 0.309 10187804 Q16584 Q16584 MAP3K11 MAP3K11 0.236 23172226 Q9P2E2 Q16584 KIF17 MAP3K11 0.309 9427749 Q92845 Q16584 KIFAP3 MAP3K11 0.309 9427749 Q6UXB4 Q16584 CLEC4G MAP3K11 0.332 18624398 Q9Y4K3 Q16584 TRAF6 MAP3K11 0.569 23172226,19586614

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 MAP2K7 MAP3K11 MI:0045 experimental interaction detection MI:0461 interaction database IKBKB MAP3K11 MI:0045 experimental interaction detection MI:0461 interaction database KIF3B MAP3K11 MI:0045 experimental interaction detection MI:0461 interaction database CHUK MAP3K11 MI:0045 experimental interaction detection MI:0461 interaction database APP MAP3K11 MI:0045 experimental interaction detection MI:0461 interaction database HSP90AA1 MAP3K11 MI:0045 experimental interaction detection MI:0461 interaction database HSP90AB1 MAP3K11 MI:0045 experimental interaction detection MI:0461 interaction database UBC MAP3K11 MI:0045 experimental interaction detection MI:0461 interaction database PKM MAP3K11 MI:0045 experimental interaction detection MI:0461 interaction database CBL MAP3K11 MI:0045 experimental interaction detection MI:0461 interaction database PIK3R1 MAP3K11 MI:0045 experimental interaction detection MI:0461 interaction database AKT1 MAP3K11 MI:0045 experimental interaction detection MI:0461 interaction database HSPA4 MAP3K11 MI:0045 experimental interaction detection MI:0461 interaction database NF2 MAP3K11 MI:0045 experimental interaction detection MI:0461 interaction database HNF4A MAP3K11 MI:0045 experimental interaction detection MI:0461 interaction database MAPK8 MAP3K11 MI:0045 experimental interaction detection MI:0461 interaction database MAPK9 MAP3K11 MI:0362 inference MI:0461 interaction database MAP2K4 MAP3K11 MI:0045 experimental interaction detection MI:0461 interaction database GSK3A MAP3K11 MI:0045 experimental interaction detection MI:0461 interaction database GSK3B MAP3K11 MI:0045 experimental interaction detection MI:0461 interaction database CDC42 MAP3K11 MI:0045 experimental interaction detection MI:0461 interaction database RAC1 MAP3K11 MI:0045 experimental interaction detection MI:0461 interaction database DLG4 MAP3K11 MI:0045 experimental interaction detection MI:0461 interaction database RHOG MAP3K11 MI:0045 experimental interaction detection MI:0461 interaction database MAP2K1 MAP3K11 MI:0045 experimental interaction detection MI:0461 interaction database MAP4K2 MAP3K11 MI:0045 experimental interaction detection MI:0461 interaction database EPS8 MAP3K11 MI:0045 experimental interaction detection MI:0461 interaction database TRAF2 MAP3K11 MI:0045 experimental interaction detection MI:0461 interaction database GRIK2 MAP3K11 MI:0362 inference MI:0461 interaction database MAPK8IP2 MAP3K11 MI:0045 experimental interaction detection MI:0461 interaction database PIN1 MAP3K11 MI:0045 experimental interaction detection MI:0461 interaction database CDC37 MAP3K11 MI:0045 experimental interaction detection MI:0461 interaction database MAP3K11 CLEC4G MI:0045 experimental interaction detection MI:0461 interaction database MAP3K11 SH3RF1 MI:0045 experimental interaction detection MI:0461 interaction database MAP3K11 KIFAP3 MI:0045 experimental interaction detection MI:0461 interaction database MAP3K11 COPS5 MI:0045 experimental interaction detection MI:0461 interaction database MAP3K11 MAP4K1 MI:0045 experimental interaction detection MI:0461 interaction database MAP3K11 TRIM5 MI:0045 experimental interaction detection MI:0461 interaction database MAP3K11 KIF17 MI:0045 experimental interaction detection MI:0461 interaction database MAP3K11 STUB1 MI:0045 experimental interaction detection MI:0461 interaction database MAP3K11 MAPK8IP3 MI:0045 experimental interaction detection MI:0461 interaction database MAP3K11 MAPK8IP1 MI:0045 experimental interaction detection MI:0461 interaction database MAP3K11 KIF3A MI:0045 experimental interaction detection MI:0461 interaction database MAP3K11 TRAF6 MI:0045 experimental interaction detection MI:0461 interaction database