PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus APP MARCH10 21832049 biogrid exp P P P P P P P P P P GP MARCH10 WDYHV1 25416956 biogrid,intact exp P P P P P P P P P P P P P P P P P P P GP MARCH10 ANLN 25416956 biogrid,intact exp P P P P P P P P P P P P P GP MARCH10 UNC45A 25416956 biogrid,intact exp P P P P P P P P P P P P P P P P P P P P P GP UBE2H MARCH10 19549727 biogrid,intact exp P P P P P P P P P P P P P P P P P P P P GP SRPK2 MARCH10 23602568 biogrid,intact exp P P P P P P P P P P P GP CTBP1 MARCH10 24722188 biogrid exp P P P P P P P P P P P P P P P P P P P P P GP

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q8NA82 P78362-2 enzymatic study 23602568 direct interaction X 2 Q13363-2 Q8NA82 two hybrid 24722188 direct interaction X 2 P05067-7 Q8NA82 pull down 21832049 direct interaction X 2 Q9H3U1-3 Q8NA82 two hybrid 25416956 direct interaction X 2 Q8NA82 unspecified method 20467438 direct interaction X 2 A0A024RA49 Q8NA82 two hybrid 25416956 direct interaction X 2 Q96HA8 Q8NA82 two hybrid 25416956 direct interaction X 2 Q8NA82 two hybrid 19549727 direct interaction X 2 Q9H3U1 Q8NA82 two hybrid prey pooling approach 25416956 physical association X 2 Q9H3U1 Q8NA82 two hybrid array 25416956 physical association X 2 Q9H3U1 Q8NA82 validated two hybrid 25416956 physical association X 2 A0A024R704 Q8NA82 protein kinase assay 23602568 phosphorylation reaction X 2 A4D1L5 Q8NA82 two hybrid array 19549727 physical association X 2 P31016 Q8NA82 peptide array 20467438 direct interaction X 2 Q9NQW6-2 Q8NA82 two hybrid prey pooling approach 25416956 physical association X 2 Q9NQW6-2 Q8NA82 two hybrid array 25416956 physical association X 2 Q9NQW6-2 Q8NA82 validated two hybrid 25416956 physical association X 2 Q96HA8 Q8NA82 two hybrid prey pooling approach 25416956 physical association X 2 Q96HA8 Q8NA82 two hybrid array 25416956 physical association X 2 Q96HA8 Q8NA82 validated two hybrid 25416956 physical association X 2

PPI - HINT Gene A Gene B PMID Method Quality UBE2H MARCH10 19549727,19549727 0397,0018 HT SRPK2 MARCH10 23602568,23602568 0415,0424 LC CTBP1 MARCH10 24722188 0018 HT MARCH10 WDYHV1 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT MARCH10 UNC45A 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT MARCH10 ANLN 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q8NA82 P62256 MARCH10 UBE2H 0.286 19549727 Q8NA82 P05067 MARCH10 APP 0.183 21832049 Q96HA8 Q8NA82 WDYHV1 MARCH10 0.454 25416956 Q9NQW6 Q8NA82 ANLN MARCH10 0.454 25416956 Q9H3U1 Q8NA82 UNC45A MARCH10 0.583 25416956,unassigned1304 Q8NA82 P31016 MARCH10 DLG4 0.183 20467438 Q8NA82 P32502 MARCH10 GCD7 0.332 27107014 Q8NA82 P78362 MARCH10 SRPK2 0.21 23602568 Q8NA82 Q13363 MARCH10 CTBP1 0.183 24722188

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 APP MARCH10 MI:0045 experimental interaction detection MI:0461 interaction database EIF2B2 MARCH10 MI:0362 inference MI:0461 interaction database UBE2H MARCH10 MI:0045 experimental interaction detection MI:0461 interaction database DLG4 MARCH10 MI:0362 inference MI:0461 interaction database SRPK2 MARCH10 MI:0045 experimental interaction detection MI:0461 interaction database CTBP1 MARCH10 MI:0045 experimental interaction detection MI:0461 interaction database MARCH10 WDYHV1 MI:0045 experimental interaction detection MI:0461 interaction database MARCH10 UNC45A MI:0045 experimental interaction detection MI:0461 interaction database MARCH10 ANLN MI:0045 experimental interaction detection MI:0461 interaction database