PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus APP MARCH3 21832049 biogrid exp G G G G GP GP G G GP G G G G G G GP GP G GP G G GP G G GP G G GP G MARCH3 UBE2D4 19549727 biogrid,intact exp G G G G GP GP G G GP G GP G G G G G GP G GP G G GP G GP G GP GP GP G MARCH3 UBE2E2 19549727 biogrid,intact exp G G G G GP GP G G GP G GP G G G G GP GP G GP G G GP GP GP GP GP GP GP G UBE2D3 MARCH3 19549727 biogrid,intact exp G G G G GP GP G G GP G GP G G G G G GP G GP G G GP G GP G GP GP GP G UBE2D2 MARCH3 19549727 biogrid,intact exp G G G G GP GP G G GP G GP G G G G G GP G GP G G GP G GP G GP GP GP G MARCH3 UBE2W 19549727 biogrid,intact exp G G G G GP GP G G GP G GP G G G G GP GP G GP G G GP GP GP GP GP GP GP G UBE2E1 MARCH3 19549727 biogrid,intact exp G G G G G GP G G GP G GP G G G G GP GP G G G G G G GP GP G GP GP G UBE2K MARCH3 19549727 biogrid,intact exp G G G G GP GP G G GP G GP G G G G GP GP G GP G G GP GP GP GP GP GP GP G MARCH3 MARCH2 ortho G G G G GP GP G G GP G GP G G G G GP GP GP G G GP GP GP GP GP GP GP G UBC MARCH3 ortho G G G G GP GP G G GP G GP G G G G GP GP G GP G G GP GP GP GP GP GP GP G MARCH8 MARCH3 25402006 pred G G G G GP GP G G GP G GP G G G G GP GP G GP G G GP GP GP GP G GP GP G LMNB1 MARCH3 21836163 pred G G GP P GP P G G G GP P G GP G P P P GP GP GP P MARCH3 MARCH1 25402006 pred G G G GP GP G GP G P G G G G GP GP P G P P P GP GP GP P G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P61086 Q86UD3 two hybrid 19549727 direct interaction X 2 Q86UD3 A0A024RA90 two hybrid 19549727 direct interaction X 2 P61077-3 Q86UD3 two hybrid 19549727 direct interaction X 2 A0A024R2K3 Q86UD3 two hybrid 19549727 direct interaction X 2 Q86UD3 P05067-7 pull down 21832049 direct interaction X 2 Q86UD3 P62837 two hybrid 19549727 direct interaction X 2 Q86UD3 Q96FI0 two hybrid 19549727 direct interaction X 2 Q86UD3 A0A024R2Q2 two hybrid 19549727 direct interaction X 2 Q86UD3 A0A024RA90 two hybrid array 19549727 physical association X 2 B3KSH4 Q86UD3 two hybrid array 19549727 physical association X 2 Q96B02 Q86UD3 two hybrid array 19549727 physical association X 2 A0A024RDH2 Q86UD3 two hybrid array 19549727 physical association X 2 A0A024R2K3 Q86UD3 two hybrid array 19549727 physical association X 2 Q86UD3 P62837 two hybrid array 19549727 physical association X 2 Q86UD3 A0A024R2Q2 two hybrid array 19549727 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B MARCH3 UBE2E2 MI:0018(two hybrid)|MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_124313|UniProt_101328 prey|prey bait|bait MARCH3 UBE2W MI:0018(two hybrid)|MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_124312|UniProt_101493 prey|prey bait|bait UBE2E1 MARCH3 MI:0018(two hybrid)|MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_124310|UniProt_101315 bait|bait prey|prey UBE2K MARCH3 MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_124311 bait prey MARCH3 UBE2D4 MI:0018(two hybrid)|MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_124309|UniProt_101464 prey|prey bait|bait APP MARCH3 MI:0096(pull down) 21832049 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_229307 prey bait MARCH3 HIP2 MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_101212 prey bait UBE2D2 MARCH3 MI:0018(two hybrid)|MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_101271|BIOGRID_124307 bait|bait prey|prey UBE2D3 MARCH3 MI:0018(two hybrid)|MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_101295|BIOGRID_124308 bait|bait prey|prey

PPI - HINT Gene A Gene B PMID Method Quality HIP2 MARCH3 19549727 0397 HT UBE2E1 MARCH3 19549727,19549727 0397,0018 HT UBE2D3 MARCH3 19549727,19549727 0397,0018 HT UBE2K MARCH3 19549727 0018 HT UBE2D2 MARCH3 19549727,19549727 0397,0018 HT MARCH3 UBE2W 19549727,19549727 0397,0018 HT MARCH3 UBE2E2 19549727,19549727 0397,0018 HT MARCH3 UBE2D4 19549727,19549727 0397,0018 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q86UD3 B3KSH4 MARCH3 HIP2 0.236 19549727 Q86UD3 P61077 MARCH3 UBE2D3 0.286 19549727 Q86UD3 P61086 MARCH3 UBE2K 0.183 19549727 Q86UD3 P05067 MARCH3 APP 0.183 21832049 Q86UD3 P62837 MARCH3 UBE2D2 0.376 19549727 Q86UD3 Q12959 MARCH3 DLG1 0.126 24550280 Q9Y2X8 Q86UD3 UBE2D4 MARCH3 0.286 19549727 Q969F0 Q86UD3 FATE1 MARCH3 0.236 unassigned1304 Q96B02 Q86UD3 UBE2W MARCH3 0.286 19549727 Q9BQE5 Q86UD3 APOL2 MARCH3 0.236 unassigned1304 Q96LR5 Q86UD3 UBE2E2 MARCH3 0.286 19549727 Q86UD3 P51965 MARCH3 UBE2E1 0.286 19549727

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 APP MARCH3 MI:0045 experimental interaction detection MI:0461 interaction database UBC MARCH3 MI:0362 inference MI:0461 interaction database UBE2E1 MARCH3 MI:0045 experimental interaction detection MI:0461 interaction database UBE2D3 MARCH3 MI:0045 experimental interaction detection MI:0461 interaction database UBE2K MARCH3 MI:0045 experimental interaction detection MI:0461 interaction database UBE2D2 MARCH3 MI:0045 experimental interaction detection MI:0461 interaction database MARCH3 UBE2W MI:0045 experimental interaction detection MI:0461 interaction database MARCH3 UBE2E2 MI:0045 experimental interaction detection MI:0461 interaction database MARCH3 MARCH2 MI:0362 inference MI:0461 interaction database MARCH3 UBE2D4 MI:0045 experimental interaction detection MI:0461 interaction database