PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus FBXO45 USP11 19615732 biogrid,intact exp G GP G G G GP G G GP G GP G G G G G GP G G G G G G G G G G GP G MYCBP2 FBXO45 24992930,19398581,25143387 biogrid exp G GP G G G GP G G GP G G G GP GP G GP GP G G G G GP G G GP G G GP G FBXO45 CTNNB1 25143387 biogrid exp GP GP G G GP GP G G GP G GP G GP G G GP GP GP G G GP GP GP G GP G GP GP G FBXO45 CDH2 25143387 biogrid exp GP G GP G G GP G GP G G G GP G G G G G GP GP G FBXO45 LGALS3BP 26496610 biogrid,intact exp GP G G G G GP G G GP G GP G GP G G GP GP GP G G GP GP G G GP G GP GP G FBXO45 YWHAH 26496610 biogrid,intact exp GP GP G G GP GP G G GP G GP G GP G G GP GP GP G G GP GP GP GP GP G GP GP G TP73 FBXO45 19581926 biogrid exp G G G G G FBXO45 PAWR 24992930 biogrid exp GP GP G G GP GP G G GP G GP G GP GP G GP GP GP G G GP GP GP GP GP G GP GP G FBXO45 NOS2 23438482 biogrid exp P P G G P G GP P P P GP GP G G G P P P P GP P P G FBXO45 SKP1 24992930,19398581,25143387, 25402006, 23023127, 21836163 biogrid exp, ortho, pred GP GP G G GP GP G G GP G GP G GP GP G GP GP GP G G GP GP GP G GP G GP GP G FBXO45 CUL1 ortho GP G G G G GP G G GP G GP G GP G G GP GP GP G G GP GP GP GP GP G GP GP G FBXO45 RCHY1 23023127 pred G GP G G G GP G G GP G GP G GP G G GP GP G G G G G GP G GP G GP G G FBXO45 TCEB1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G FBXO45 FBXL2 23023127 pred G G G G G G G G G G G G G G G G G G G G G FBXO45 FBXO9 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G FBXO45 KLHL1 23023127 pred P G G P G P P P P FBXO45 HUWE1 23023127 pred GP GP G G GP GP G G GP G GP G GP GP G GP GP GP G G GP GP GP GP GP G GP GP G FBXO45 BCL6 23023127 pred G G G G GP G G G G G G G G GP G G G G G G GP G G G G G G G G FBXO45 FAF1 23023127 pred GP GP G G GP GP G G GP G GP G GP GP G GP GP GP G G GP GP GP GP GP G GP GP G PARK2 FBXO45 23023127 pred P GP G P GP G G GP G GP P G P GP GP G P GP GP GP P GP G FBXO45 TRIM9 23023127 pred G G G G G G G G G G G FBXO45 CUL3 23023127 pred GP GP G G GP GP G G GP G GP G GP GP G GP GP GP G G GP GP GP GP GP G GP GP G FBXO45 LNX1 23023127 pred GP G G GP G G GP G GP G GP GP G GP GP G G G GP GP GP G GP GP GP FOXP2 FBXO45 23023127 pred GP GP G P GP G G GP G GP G GP P G GP GP GP G G GP GP GP GP GP G GP P G FBXO45 UBQLN1 23023127 pred GP GP G G GP GP G G GP G GP G GP GP G GP GP GP G G GP GP GP GP GP G GP GP G FBXO45 TRIM32 23023127 pred GP GP G G G GP G G GP G GP G G GP G GP GP GP G G GP GP GP GP GP G GP GP G FBXO45 RNF11 23023127 pred GP GP G G GP GP G G GP G GP G GP GP G GP GP GP G G GP GP GP GP GP G GP GP G FBXO45 FBXW7 23023127 pred GP GP G G GP GP G G GP G GP G GP GP G GP GP G G G P GP GP GP GP G GP GP FBXO45 KCTD13 23023127 pred GP GP G G G GP G G GP G GP G GP G G GP GP GP G G GP GP GP GP GP G GP GP G FBXO45 PTK2B 23023127 pred GP GP G G G GP G G GP G GP G GP GP G GP GP G G G P GP G G GP G GP GP G FBXO45 TERF2IP 23023127 pred GP GP G G GP GP G G GP G GP G GP GP G GP GP GP G G GP GP GP GP GP G GP GP G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P0C2W1 O15205 affinity chromatography technology 22797925 physical association X 2 P0C2W1 A0A024RC42 affinity chromatography technology 25143387 physical association X 2 P0C2W1 A0A024RC42 affinity chromatography technology 25143387 physical association X 2 P0C2W1 A0A024RC42 affinity chromatography technology 25143387 physical association X 2 Q96IZ0 P0C2W1 affinity chromatography technology 24992930 physical association X 2 Q96IZ0 P0C2W1 affinity chromatography technology 24992930 physical association X 2 Q96IZ0 P0C2W1 affinity chromatography technology 24992930 physical association X 2 Q96IZ0 P0C2W1 pull down 24992930 direct interaction X 2 Q96IZ0 P0C2W1 enzymatic study 24992930 direct interaction X 2 P0CG48 P0C2W1 affinity chromatography technology 22505724 physical association X 2 P0CG48 P0C2W1 affinity chromatography technology 24816145 physical association X 2 P0CG48 P0C2W1 affinity chromatography technology 21139048 physical association X 2 P0CG48 P0C2W1 affinity chromatography technology 21906983 physical association X 2 P63208 P0C2W1 affinity chromatography technology 19398581 physical association X 2 P63208 P0C2W1 affinity chromatography technology 24992930 physical association X 2 P63208 P0C2W1 affinity chromatography technology 24992930 physical association X 2 P63208 P0C2W1 two hybrid 24992930 direct interaction X 2 P63208 P0C2W1 affinity chromatography technology 25143387 physical association X 2 P63208 P0C2W1 affinity chromatography technology 25143387 physical association X 2 O75592 P0C2W1 affinity chromatography technology 19398581 physical association X 2 O75592 P0C2W1 affinity chromatography technology 19398581 physical association X 2 O75592 P0C2W1 affinity chromatography technology 24992930 physical association X 2 O75592 P0C2W1 affinity chromatography technology 24992930 physical association X 2 O75592 P0C2W1 two hybrid 24992930 direct interaction X 2 O75592 P0C2W1 affinity chromatography technology 25143387 physical association X 2 O75592 P0C2W1 affinity chromatography technology 25143387 physical association X 2 O75592 P0C2W1 affinity chromatography technology 25143387 physical association X 2 A0A024R2Q3 P0C2W1 affinity chromatography technology 25143387 physical association X 2 A0A024R2Q3 P0C2W1 affinity chromatography technology 25143387 physical association X 2 P35228 P0C2W1 affinity chromatography technology 23438482 physical association X 2 P35228 P0C2W1 affinity chromatography technology 23438482 physical association X 2 P35228 P0C2W1 affinity chromatography technology 23438482 physical association X 2 P0C2W1 O15350-4 affinity chromatography technology 19581926 physical association X 2 P0C2W1 O15350-4 enzymatic study 19581926 direct interaction X 2 P51784 P0C2W1 affinity chromatography technology 19615732 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B FBXO45 NOS2 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 23438482 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid) BIOGRID_258323|BIOGRID_258347|BIOGRID_258348 prey|bait|prey bait|prey|bait FBXO45 USP11 MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid) UniProt_100658|BIOGRID_120843 prey|prey bait|bait UBD FBXO45 MI:0004(affinity chromatography technology) 22797925 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_226785 bait prey FBXO45 SKP1 MI:0004(affinity chromatography technology) 19398581 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_199612 bait prey MYCBP2 FBXO45 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 19398581 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_199614|BIOGRID_199613 bait|prey prey|bait FBXO45 UBC MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 21139048,21906983,22505724 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid) BIOGRID_223645|BIOGRID_169474|BIOGRID_178786 prey|prey|prey bait|bait|bait TP73 FBXO45 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 19581926 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_141209|BIOGRID_141208 prey|bait bait|prey

PPI - HINT Gene A Gene B PMID Method Quality MYCBP2 FBXO45 24992930,24992930,19398581,25143387 0004,0018,0004,0004 LC FBXO45 USP11 19615732,19615732 0004,0007 HT FBXO45 SKP1 24992930,24992930,19398581,25143387 0004,0018,0004,0004 LC FBXO45 YWHAH 26496610 0007 HT FBXO45 LGALS3BP 26496610,26496610 0007,0004 HT FBXO45 Q9H4N8 26496610 0004 HT FBXO45 USP11 19615732,19615732 0004,0007 HT FBXO45 YWHAH 26496610 0007 HT FBXO45 LGALS3BP 26496610,26496610 0007,0004 HT FBXO45 Q9H4N8 26496610 0004 HT MYCBP2 FBXO45 24992930,24992930,19398581,25143387 0004,0018,0004,0004 LC FBXO45 SKP1 24992930,24992930,19398581,25143387 0004,0018,0004,0004 LC TP73 FBXO45 19581926,19581926 0415,0004 LC MYCBP2 FBXO45 24992930,24992930 0004,0018 LC FBXO45 SKP1 24992930,24992930 0004,0018 LC FBXO45 PAWR 24992930,24992930,24992930 0004,0415,0096 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID P0C2W1 O15350 FBXO45 TP73 0.454 19581926 Q9NQ87 P0C2W1 HEYL FBXO45 0.21 26068074 P0C2W1 P03372 FBXO45 ESR1 0.376 26487511 P35222 P0C2W1 CTNNB1 FBXO45 0.21 25143387 Q9Y5J3 P0C2W1 HEY1 FBXO45 0.309 26068074 Q9WTX5 P0C2W1 SKP1 FBXO45 0.236 26496610 Q07797 P0C2W1 LGALS3BP FBXO45 0.236 26496610 Q08380 P0C2W1 LGALS3BP FBXO45 0.236 26496610 Q04917 P0C2W1 YWHAH FBXO45 0.236 26496610 P51784 P0C2W1 USP11 FBXO45 0.236 19615732 P0C2W1 O75592 FBXO45 MYCBP2 0.814 25143387,19398581,unassigned1312,24992930 Q969H0 P0C2W1 FBXW7 FBXO45 0.126 25720964 P35228 P0C2W1 NOS2 FBXO45 0.236 23438482 Q96IZ0 P0C2W1 PAWR FBXO45 0.702 24992930 Q96JN8 P0C2W1 NEURL4 FBXO45 0.126 unassigned1312 P35249 P0C2W1 RFC4 FBXO45 0.126 unassigned1312 Q9UBP5 P0C2W1 HEY2 FBXO45 0.21 26068074 P19022 P0C2W1 CDH2 FBXO45 0.376 25143387 P63208 P0C2W1 SKP1 FBXO45 0.702 27705803,25143387,19398581,24992930 P54803 P0C2W1 GALC FBXO45 0.126 unassigned1312

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 UBD FBXO45 MI:0045 experimental interaction detection MI:0461 interaction database TP73 FBXO45 MI:0045 experimental interaction detection MI:0461 interaction database MYCBP2 FBXO45 MI:0045 experimental interaction detection MI:0461 interaction database ESR1 FBXO45 MI:0045 experimental interaction detection MI:0461 interaction database FBXO45 UBC MI:0045 experimental interaction detection MI:0461 interaction database FBXO45 CDH2 MI:0045 experimental interaction detection MI:0461 interaction database FBXO45 LTK MI:0362 inference MI:0461 interaction database FBXO45 CTNNB1 MI:0045 experimental interaction detection MI:0461 interaction database FBXO45 NOS2 MI:0045 experimental interaction detection MI:0461 interaction database FBXO45 USP11 MI:0045 experimental interaction detection MI:0461 interaction database FBXO45 SKP1 MI:0045 experimental interaction detection MI:0461 interaction database FBXO45 YWHAH MI:0045 experimental interaction detection MI:0461 interaction database FBXO45 LGALS3BP MI:0045 experimental interaction detection MI:0461 interaction database FBXO45 CUL1 MI:0362 inference MI:0461 interaction database FBXO45 FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database FBXO45 SPSB4 MI:0362 inference MI:0461 interaction database FBXO45 SPSB1 MI:0362 inference MI:0461 interaction database FBXO45 PAWR MI:0045 experimental interaction detection MI:0461 interaction database FBXO45 HEYL MI:0045 experimental interaction detection MI:0461 interaction database FBXO45 HEY2 MI:0045 experimental interaction detection MI:0461 interaction database FBXO45 ALK MI:0362 inference MI:0461 interaction database FBXO45 UNC13A MI:0362 inference MI:0461 interaction database FBXO45 HEY1 MI:0045 experimental interaction detection MI:0461 interaction database