PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus PELI3 PIK3R3 25814554 biogrid,intact exp GP GP G P GP G G GP G GP GP GP GP G GP GP G P G P G GP G GP GP GP GP G UBE2N PELI3 23892723 biogrid exp GP GP G P GP G GP GP G GP GP GP GP G GP GP G P G P GP GP GP GP GP GP GP G UQCRFS1 PELI3 25027698 biogrid exp GP GP G P GP G GP GP G GP GP GP GP G GP GP GP P G P GP GP GP GP GP GP GP G PELI3 STUB1 26186194 biogrid exp GP GP G P GP G GP GP G GP GP GP GP G GP GP GP P G P GP GP GP GP GP GP GP G KANK2 PELI3 26186194 biogrid exp GP GP G P GP G GP GP G GP GP GP GP G GP GP GP G P GP GP GP GP GP G GP G APP PELI3 21832049 biogrid exp G GP G P GP G G GP G G G G G G GP GP G P G P GP G G GP G G GP G PELI3 DNAJB4 26186194 biogrid exp GP GP G GP G GP GP G GP GP GP GP G GP GP GP P G P GP GP GP GP GP GP GP G UBE2V1 PELI3 23892723 biogrid exp PELI3 MAP3K14 12874243, 25402006, 21836163 hprd,biogrid,intact exp, pred G G G G G G G G G G G G G G G G G G G G G G G G G PELI3 IRAK4 17675297, 25402006 hprd,biogrid exp, pred GP GP G P GP G GP GP G GP GP GP GP G GP GP GP P G P GP GP GP GP GP GP GP G RIPK2 PELI3 23892723, 25402006 innatedb,biogrid exp, pred GP GP G P GP G GP GP G GP G GP GP G GP GP GP P G P GP GP GP GP G G GP G PELI3 TRAF6 18326498,25027698,23042151,15917247,12874243, 25402006 hprd,biogrid,intact exp, pred GP GP G P G G GP GP G GP GP GP G G GP G GP G P GP GP G GP GP GP GP G IRAK2 PELI3 17675297, 25402006 hprd,biogrid exp, pred GP GP G P GP G P P G GP GP GP GP GP GP G G GP GP GP G GP P MAP3K7 PELI3 18326498,15917247,12874243, 25402006, 21836163 hprd,biogrid,intact exp, pred GP GP G GP G G GP G G GP GP G G G GP G P G P GP G G G G GP GP G IRAK1 PELI3 19081057,25027698,16884718,17675297,18326498,12874243,15917247,17997719, 25402006, 21836163 innatedb,hprd,biogrid,mint,intact,dip exp, pred GP GP G P GP G GP GP G GP GP GP GP G GP GP GP P G P GP GP G GP GP GP GP G UBC PELI3 ortho GP GP G P GP G GP GP G GP GP GP GP G GP GP GP P G P GP GP GP GP GP GP GP G SQSTM1 PELI3 25402006 ortho, pred GP GP G P G G G GP G GP GP GP GP G GP G GP P G P GP GP GP GP GP GP GP G TLR3 PELI3 25402006 pred GP GP P G P GP GP GP GP G GP P GP P P GP G GP G GP GP G ACTG1 PELI3 25402006 pred GP GP G P GP G GP GP G GP GP GP GP G GP GP GP P G P GP GP GP GP GP GP GP G PELI3 TUBB2B 25402006 pred P P G P GP G GP G GP P P P G GP GP P P G GP GP GP P GP P G HSPA1L PELI3 25402006 pred GP P G G G G G G P G G G G GP G IL1R1 PELI3 25402006 pred GP GP G P GP G G GP G GP GP GP GP G GP GP G P G P GP GP GP GP GP GP GP G SMAD6 PELI3 25402006 pred G G G G G G G G G G G G G G G G G G G G G RPL32 PELI3 25402006 pred GP GP G P GP G GP GP G GP GP GP GP G GP GP G P G P GP GP G GP GP GP GP G TRAF2 PELI3 25402006 pred P P P P P P P P P P P P P P P P P P P GP GP P CALM1, CALM2, CALM3 PELI3 25402006 pred GP GP G P GP G GP GP G GP GP GP GP G GP GP GP P G P GP GP GP GP GP GP GP G MAP3K8 PELI3 25402006 pred GP GP P P G GP GP GP GP GP GP G P P GP P P GP P P GP GP GP P G PELI3 MYD88 25402006 pred GP GP G P GP G GP GP G GP GP GP GP G GP GP GP P G P GP GP GP GP GP GP GP G BIRC2 PELI3 25402006 pred GP GP G P GP G GP GP G GP GP GP GP G GP GP G P G P G GP GP GP GP GP GP G RIPK1 PELI3 25402006 pred GP GP G P GP G GP GP G GP GP GP GP G GP GP GP P G P GP GP GP GP GP GP GP G TUBB4A PELI3 25402006 pred GP GP G P GP G GP GP G GP GP GP GP GP GP GP P G P P GP GP GP GP GP GP G DDX5 PELI3 25402006 pred GP GP G P GP G GP GP G GP GP GP GP G GP GP GP P G P GP GP GP GP GP GP GP G PELI3 IRAK3 25402006 pred GP GP P P GP GP P P GP GP G P P P G P GP P P GP GP GP P PELI3 WDR34 25402006 pred GP GP G P GP G GP GP G GP GP GP GP G GP GP G P G P GP GP GP GP GP GP GP G MAPK14 PELI3 25402006 pred GP GP G P GP G GP GP G GP GP GP GP G GP GP GP P G P G GP GP GP GP GP GP G PELI3 MAP3K5 25402006 pred G GP G P GP G G GP G GP G GP GP G G GP GP P G GP G G G GP GP GP G IRAK1BP1 PELI3 25402006 pred P P P P P GP GP P P P G P P G P G P GP GP P P P P GP HSPA5 PELI3 25402006 pred GP GP G P GP G GP GP G GP GP GP GP G GP GP GP P G P GP GP GP GP GP GP GP G CAD PELI3 25402006 pred GP GP G P GP G GP GP G GP GP GP GP G GP GP GP P G P GP G P GP GP GP GP G CHUK PELI3 25402006 pred GP GP G P GP G GP GP G GP GP GP GP G GP GP GP P G P GP GP GP GP GP GP GP G PELI3 STRADB 25402006 pred G G G GP G GP GP G GP GP G G G G GP G P G G G GP G G G GP G PELI3 RUVBL2 25402006 pred GP GP G P GP G GP GP G GP GP GP GP G GP GP GP P G P GP GP GP GP GP GP GP G SMAD7 PELI3 25402006 pred GP GP G P GP G GP GP G GP GP GP GP G GP GP GP P G P GP GP GP GP GP GP P G EPRS PELI3 25402006 pred GP GP G P GP G G GP G GP GP GP GP G GP GP GP P G P GP GP GP GP GP GP GP G PELI3 PELI1 25402006 pred GP GP G P GP G GP GP G GP GP GP G G GP GP GP P G P GP GP GP GP GP GP GP G TUBB PELI3 25402006 pred GP GP G P GP G GP GP G GP GP GP GP G GP GP GP P G P GP GP GP GP GP GP GP G PELI3 TNFRSF11A 25402006 pred GP P P P P GP P P GP G GP P P G P G G P GP GP P G HSP90AB1 PELI3 25402006 pred GP GP G P GP G GP GP G GP GP GP GP G GP GP GP P G P GP GP GP GP GP GP GP G STAT3 PELI3 25402006 pred GP GP G P GP G GP GP G GP GP GP GP G GP GP GP P G P GP GP GP GP GP GP GP G NLRP12 PELI3 25402006 pred GP G P GP G GP GP G GP GP GP GP G GP GP GP P G P GP GP GP GP GP GP P CDC37 PELI3 25402006 pred GP GP G P GP G GP GP G GP GP GP GP G GP GP GP P G P GP GP GP GP GP GP GP G HSPA9 PELI3 25402006 pred GP GP G P GP G GP GP G GP GP GP GP G GP GP GP P G P GP GP GP GP GP GP GP G HSPA8 PELI3 25402006 pred P P P P P P P P P P P P P P P P PELI3 TAB3 25402006 pred GP GP G P GP G GP GP G GP GP GP GP G GP GP GP P G P GP GP GP GP GP GP GP G TRAF3IP2 PELI3 25402006 pred GP GP P P G P GP GP GP GP GP G GP P GP P G P GP GP P GP GP GP P G TUBA3C, TUBA3D PELI3 25402006 pred P P P P P P P P P P P P P P PELI3 IKBKG 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G PELI3 TAB2 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G RPS3 PELI3 25402006 pred GP GP G P GP G GP GP G GP GP GP GP G GP GP G P G P GP GP G GP GP GP GP G IKBKB PELI3 25402006 pred GP GP G P GP G G GP G GP G GP GP G GP GP GP P G P GP GP G GP GP GP GP G PELI3 RUVBL1 25402006 pred GP GP G P GP G GP GP G GP GP GP GP G GP GP GP P G P GP G GP G GP GP G MAVS PELI3 25402006 pred GP GP G P GP G GP GP G GP GP GP GP G GP GP GP P G P GP GP GP GP GP GP GP G SIGIRR PELI3 25402006 pred GP GP G P GP G GP GP G GP GP GP GP G GP GP G P G GP GP G GP GP GP GP G PELI3 PELI2 25402006 pred GP P G P GP G GP GP G GP P GP G G GP GP GP P G P GP GP GP GP GP GP GP G IARS PELI3 25402006 pred GP GP G GP G G GP G GP GP GP G G G GP G P G P G GP GP G G GP GP G JAZF1 PELI3 25402006 pred GP GP G P GP G GP GP G GP GP GP GP G GP GP GP P G P GP G GP GP GP GP GP G DNAJA1 PELI3 25402006 pred GP GP G P GP G G GP G GP GP GP GP G GP GP GP P G P GP GP G GP GP GP GP G PELI3 TRAF4 25402006 pred G GP G GP G P GP G GP GP GP G G GP GP G P G P G GP P GP G GP GP G

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B PELI3 IRAK4 MI:0004(affinity chromatography technology)|MI:0492(in vitro) 17675297 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|- (biogrid)|MI:0468(hprd) BIOGRID_117952|HPRD_33351 prey|- bait|- UBE2V1 PELI3 MI:0004(affinity chromatography technology) 23892723 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_283721 prey bait RIPK2 PELI3 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 23892723 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid) BIOGRID_283717|BIOGRID_283719|BIOGRID_283718 bait|prey|prey prey|bait|bait IRAK2 PELI3 MI:0004(affinity chromatography technology)|MI:0492(in vitro) 17675297 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|- (biogrid)|MI:0468(hprd) BIOGRID_117955|HPRD_33349 bait|- prey|- APP PELI3 MI:0096(pull down) 21832049 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_229338 prey bait UBC PELI3 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 17675297,18326498 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_117946|BIOGRID_117263 prey|prey bait|bait IRAK1 PELI3 MI:0004(affinity chromatography technology)|MI:0006(anti bait coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0096(pull down)|MI:0493(in vivo)|MI:0004(affinity chromatography technology)|MI:0415(enzymatic study)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0415(enzymatic study) 12874243,15917247,16884718,17675297,18326498,19081057 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|-|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|MI:0471(mint)|(biogrid)|(intact)|(intact)|MI:0465(dip)|MI:0468(hprd)|(biogrid)|(biogrid)|(intact)|MI:0471(mint)|(biogrid)|(biogrid) BIOGRID_117947|MINT_82263|BIOGRID_117266|UniProt_71891|UniProt_71890|DIP_54070|HPRD_5519|BIOGRID_257471|BIOGRID_212619|UniProt_87064|MINT_49975|BIOGRID_216050|BIOGRID_212615 prey|bait|prey|prey|-|-|-|bait|bait|bait|bait|prey|prey bait|prey|bait|null|-|-|-|prey|prey|prey|prey|bait|bait MAP3K7 PELI3 MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0493(in vivo)|MI:0007(anti tag coimmunoprecipitation)|MI:0415(enzymatic study)|MI:0004(affinity chromatography technology)|MI:0415(enzymatic study) 12874243,15917247,18326498 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|-|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid)|MI:0468(hprd)|(intact)|(biogrid)|(biogrid)|(biogrid) UniProt_71895|BIOGRID_216049|HPRD_11158|UniProt_71894|BIOGRID_212621|BIOGRID_117268|BIOGRID_212617 prey|prey|-|prey|bait|prey|prey null|bait|-|null|prey|bait|bait PELI3 MAP3K14 MI:0007(anti tag coimmunoprecipitation)|MI:0493(in vivo)|MI:0415(enzymatic study)|MI:0007(anti tag coimmunoprecipitation)|MI:0415(enzymatic study) 12874243 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|-|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|MI:0468(hprd)|(biogrid)|(intact)|(biogrid) UniProt_71896|HPRD_13200|BIOGRID_212622|UniProt_71897|BIOGRID_212618 null|-|prey|null|bait prey|-|bait|prey|prey UBE2N PELI3 MI:0004(affinity chromatography technology) 23892723 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_283720 prey bait PELI3 TRAF6 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0493(in vivo)|MI:0415(enzymatic study)|MI:0004(affinity chromatography technology)|MI:0415(enzymatic study)|MI:0007(anti tag coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation) 12874243,15917247,18326498,23042151 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|-|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(intact)|(biogrid)|MI:0468(hprd)|(biogrid)|(biogrid)|(biogrid)|(intact)|(intact) BIOGRID_216048|BIOGRID_217830|UniProt_71893|BIOGRID_217831|HPRD_10686|BIOGRID_212620|BIOGRID_117267|BIOGRID_212616|UniProt_71892|UniProt_124305 bait|prey|null|bait|-|prey|bait|bait|null|prey prey|bait|prey|prey|-|bait|prey|prey|prey|bait

PPI - HINT Gene A Gene B PMID Method Quality MAP3K7 PELI3 15917247,12874243,12874243,18326498 0004,0007,0004,0004 LC UBC PELI3 18326498,17675297 0004,0004 LC IRAK1 PELI3 19081057,15917247,16884718,25027698,12874243,12874243,18326498,17675297,16884718 0096,0004,0006,0004,0007,0004,0004,0004,0004 LC KANK2 PELI3 26186194 0004 HT PELI3 DNAJB4 26186194 0004 HT PELI3 STUB1 26186194 0004 HT PELI3 TRAF6 15917247,23042151,25027698,12874243,23042151,12874243,18326498,23042151 0004,0006,0004,0007,0004,0004,0004,0415 LC KANK2 PELI3 26186194 0004 HT PELI3 DNAJB4 26186194 0004 HT PELI3 STUB1 26186194 0004 HT MAP3K7 PELI3 15917247,12874243,12874243,18326498 0004,0007,0004,0004 LC UBC PELI3 18326498,17675297 0004,0004 LC IRAK1 PELI3 19081057,15917247,16884718,25027698,12874243,12874243,18326498,17675297,16884718 0096,0004,0006,0004,0007,0004,0004,0004,0004 LC PELI3 TRAF6 15917247,23042151,25027698,12874243,23042151,12874243,18326498,23042151 0004,0006,0004,0007,0004,0004,0004,0415 LC RIPK2 PELI3 23892723,23892723 0415,0004 LC IRAK1 PELI3 17997719 0424 LC PELI3 PIK3R3 25814554,25814554,25814554,25814554,25814554 0729,1356,0397,0018,0004 HT PELI3 TRAF6 23042151,23042151,23042151 0006,0004,0415 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q8N2H9 O43187 PELI3 IRAK2 0.21 17675297 Q8N2H9 O43353 PELI3 RIPK2 0.569 23892723 Q8N2H9 P05067 PELI3 APP 0.183 21832049 Q8N2H9 P47985 PELI3 UQCRFS1 0.21 25027698 Q8N2H9 P61088 PELI3 UBE2N 0.309 23892723 Q8N2H9 Q13404 PELI3 UBE2V1 0.309 23892723 Q8N2H9 Q63ZY3 PELI3 KANK2 0.126 26186194 Q9UDY4 Q8N2H9 DNAJB4 PELI3 0.126 26186194 Q9UNE7 Q8N2H9 STUB1 PELI3 0.126 26186194 Q9NWZ3 Q8N2H9 IRAK4 PELI3 0.21 17675297 Q99558 Q8N2H9 MAP3K14 PELI3 0.61 12874243 Q8N2H9 O43318 PELI3 MAP3K7 0.692 15917247,12874243,18326498 Q9Y4K3 Q8N2H9 TRAF6 PELI3 0.895 15917247,25027698,12874243,18326498,23042151 Q8N2H9 P51617 PELI3 IRAK1 0.925 15917247,19081057,25027698,12874243,18326498,17675297,16884718 Q92569 Q8N2H9 PIK3R3 PELI3 0.523 25814554

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 IRAK2 PELI3 MI:0045 experimental interaction detection MI:0461 interaction database MAP3K7 PELI3 MI:0045 experimental interaction detection MI:0461 interaction database RIPK2 PELI3 MI:0045 experimental interaction detection MI:0461 interaction database APP PELI3 MI:0045 experimental interaction detection MI:0461 interaction database UBC PELI3 MI:0045 experimental interaction detection MI:0461 interaction database PHB PELI3 MI:0362 inference MI:0461 interaction database RANGAP1 PELI3 MI:0362 inference MI:0461 interaction database UQCRFS1 PELI3 MI:0045 experimental interaction detection MI:0461 interaction database RPL34 PELI3 MI:0362 inference MI:0461 interaction database IRAK1 PELI3 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database UBE2N PELI3 MI:0045 experimental interaction detection MI:0461 interaction database RPL32 PELI3 MI:0362 inference MI:0461 interaction database UBE2V1 PELI3 MI:0045 experimental interaction detection MI:0461 interaction database SQSTM1 PELI3 MI:0362 inference MI:0461 interaction database KANK2 PELI3 MI:0045 experimental interaction detection MI:0461 interaction database PELI3 CARNMT1 MI:0362 inference MI:0461 interaction database PELI3 UXS1 MI:0362 inference MI:0461 interaction database PELI3 PIK3R3 MI:0045 experimental interaction detection MI:0461 interaction database PELI3 MAP3K14 MI:0045 experimental interaction detection MI:0461 interaction database PELI3 MAPKAP1 MI:0362 inference MI:0461 interaction database PELI3 IRAK4 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database PELI3 DNAJB4 MI:0045 experimental interaction detection MI:0461 interaction database PELI3 STUB1 MI:0045 experimental interaction detection MI:0461 interaction database PELI3 TRAF6 MI:0045 experimental interaction detection MI:0461 interaction database