PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus MMS19 MSL2 22678362 biogrid exp GP GP G G G GP G GP GP G GP G GP GP G GP GP G GP G GP GP G GP GP G GP GP G TRIM8 MSL2 22493164 biogrid,intact exp GP GP G G G GP G GP GP G GP GP GP GP G GP GP G GP G GP GP G GP GP G GP GP G WNK1 MSL2 20936779 intact exp G GP G G G GP G GP GP G GP GP GP GP G G GP G GP G G G G GP G G G GP G HIST2H2BE MSL2 24837678,21726816 biogrid exp GP GP G G G GP G GP GP G GP GP GP GP G GP GP G GP G GP GP G GP GP G GP GP G RNF20 MSL2 24837678 biogrid exp GP GP G G G GP G GP GP G GP GP GP GP G GP GP G GP G GP GP G GP GP G GP GP G YWHAG MSL2 20936779 biogrid,i2d,intact exp GP GP G G G GP G GP GP G GP GP GP GP G GP GP G GP G GP GP G GP GP G GP GP G PAF1 MSL2 24837678 biogrid exp GP GP G G G GP G GP GP G GP G GP GP G GP GP G GP G GP GP G GP GP G GP GP G TP53 MSL2 19033443 biogrid exp G G G G G G G G G G G G G G G GP G G G G GP G G G GP G G GP G YWHAE MSL2 20936779 biogrid,i2d,intact exp GP GP G G G GP G GP GP G GP GP GP GP G GP GP G GP G GP GP G GP GP G GP GP G KAT8 MSL2 16227571,20479123 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G MSL2 FAM96B 23891004 biogrid exp GP GP G G G GP G GP GP G GP GP GP GP G GP GP G GP G GP GP G GP GP G GP GP G CDK9 MSL2 24837678 biogrid exp GP GP G G G GP G GP GP G GP GP GP GP G GP GP G GP G GP GP G GP GP G GP GP G RNF40 MSL2 24837678 biogrid exp GP GP G G G GP G GP GP G GP GP GP GP G GP GP G GP G GP GP G GP GP G GP GP G HIST2H2AC MSL2 21726816 biogrid exp P P P P P P P P P P P P P P P P P P SREBF2 MSL2 20936779 i2d exp GP GP G G G GP G G GP G GP G GP GP G GP GP G G G GP G G GP GP G GP GP G HIST2H3A, HIST2H3C, HIST2H3D MSL2 21726816 biogrid exp P P P P P P P P P P P P P P P P P P UBE2D3 MSL2 24837678,21726816 biogrid exp GP G G G G GP G G GP G GP GP GP GP G G GP G GP G GP GP G GP G G GP GP G HIST1H4A, HIST1H4B, HIST1H4C, HIST1H4D, HIST1H4E, HIST1H4F, HIST1H4H, HIST1H4I, HIST1H4J, HIST1H4K, HIST1H4L, HIST2H4A, HIST2H4B, HIST4H4 MSL2 21726816 biogrid exp P P P P P P P P P P P P P P P P P P YWHAZ MSL2 20936779 biogrid,i2d exp GP GP G G G GP G GP GP G GP GP GP GP G GP GP G GP G GP GP G GP GP G GP GP G HIST2H2AA3, HIST2H2AA4 MSL2 21726816 biogrid exp P P G G P P GP P P P GP P P GP P GP P GP G GP GP MSL1 MSL2 16227571,23084835, 25402006, 21836163 biogrid exp, pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP G GP G GP GP G GP GP G GP GP G MSL3 MSL2 16227571, 21836163 biogrid exp, pred GP GP G G G GP G GP GP G GP G G GP G GP GP G G G GP GP G G GP G GP GP G MSL2 ING4 25402006 pred GP GP G G G GP G GP G G GP GP GP GP G GP GP G P G GP GP G GP GP G GP GP G MSL2 RUVBL1 25402006 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP G GP G GP GP G GP G GP GP G MEAF6 MSL2 25402006 pred GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP G GP GP G GP GP G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q9HCI7 coimmunoprecipitation 16227571 association C 4 Q9HCI7 tandem affinity purification 20360068 physical association C 15 Q9H4A3 Q9HCI7 two hybrid pooling approach 20936779 physical association X 2 Q9HCI7 P62258 two hybrid pooling approach 20936779 physical association X 2 Q9BZR9 Q9HCI7 two hybrid array 22493164 physical association X 2 Q81P54 Q9HCI7 two hybrid pooling approach 20711500 physical association X 2 Q7CKV2 Q9HCI7 two hybrid pooling approach 20711500 physical association X 2 Q9HCI7 P61981 two hybrid pooling approach 20936779 physical association X 2

PPI - HINT Gene A Gene B PMID Method Quality UBE2D3 MSL2 24837678,21726816 0096,0096 LC MSL1 MSL2 16227571 0004 LC KAT8 MSL2 20479123,16227571 0004,0004 LC UBE2D3 MSL2 24837678,21726816 0096,0096 LC MSL1 MSL2 16227571 0004 LC KAT8 MSL2 20479123,16227571 0004,0004 LC RNF40 MSL2 24837678 0401 LC CDK9 MSL2 24837678 0401 LC YWHAG MSL2 20936779,20936779 0398,0018 HT YWHAE MSL2 20936779,20936779 0398,0018 HT HIST1H4A|HIST1H4B|HIST1H4C|HIST1H4D|HIST1H4E|HIST1H4F|HIST1H4H|HIST1H4I|HIST1H4J|HIST1H4K|HIST1H4L|HIST2H4A|HIST2H4B|HIST4H4 MSL2 21726816 0415 LC YWHAZ MSL2 20936779 0018 HT HIST2H2AC MSL2 21726816 0415 LC HIST2H2BE MSL2 24837678,21726816 0415,0415 LC RNF20 MSL2 24837678 0401 LC MSL1 MSL2 23084835 0114 LC HIST2H2AA3|HIST2H2AA4 MSL2 21726816 0415 LC HIST2H3A|HIST2H3C|HIST2H3D MSL2 21726816 0415 LC PAF1 MSL2 24837678,24837678 0096,0401 LC TRIM8 MSL2 22493164,22493164 0018,0397 HT WNK1 MSL2 20936779 0398 HT MSL2 HEL2 20936779 0018 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9HCI7 Q5VTR2 MSL2 RNF20 0.236 24837678 Q9HCI7 P61981 MSL2 YWHAG 0.286 20936779 Q9HCI7 Q8N5Y2 MSL2 MSL3 0.21 16227571 Q9HCI7 O75150 MSL2 RNF40 0.236 24837678 Q9HCI7 P04637 MSL2 TP53 0.569 19033443 Q9HCI7 P62805 MSL2 HIST4H4 0.309 21726816 Q9HCI7 Q16777 MSL2 HIST2H2AC 0.309 21726816 Q9HCI7 Q6FI13 MSL2 HIST2H2AA4 0.309 21726816 Q9HCI7 Q71DI3 MSL2 HIST2H3D 0.309 21726816 Q9HCI7 Q7CKV2 MSL2 Q7CKV2 0.126 20711500 Q9HCI7 Q81P54 MSL2 Q81P54 0.126 20711500 Q9HCI7 Q9H4A3 MSL2 WNK1 0.126 20936779 Q9Y3D0 Q9HCI7 FAM96B MSL2 0.126 23891004 Q9HCI7 Q9H7Z6 MSL2 KAT8 0.376 16227571,20479123 Q9HCI7 Q8N7H5 MSL2 PAF1 0.636 24837678 Q9HCI7 P61077 MSL2 UBE2D3 0.523 24837678,21726816 Q9HCI7 Q16778 MSL2 HIST2H2BE 0.523 24837678,21726816 Q9HCI7 Q9BZR9 MSL2 TRIM8 0.286 22493164 Q9HCI7 Q9CY25 MSL2 MIS12 0.236 26496610 Q9HCI7 Q68DK7 MSL2 MSL1 0.454 16227571,23084835 Q9HCI7 P62258 MSL2 YWHAE 0.286 20936779 Q9HCI7 Q9D1P2 MSL2 KAT8 0.416 26496610,20360068 Q9HCI7 Q96T76 MSL2 MMS19 0.126 22678362 Q9HCI7 P50750 MSL2 CDK9 0.236 24837678 Q9HCI7 P63104 MSL2 YWHAZ 0.183 20936779

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 TP53 MSL2 MI:0045 experimental interaction detection MI:0461 interaction database SUMO3 MSL2 MI:0045 experimental interaction detection MI:0461 interaction database UBE2D3 MSL2 MI:0045 experimental interaction detection MI:0461 interaction database YWHAG MSL2 MI:0045 experimental interaction detection MI:0461 interaction database YWHAE MSL2 MI:0045 experimental interaction detection MI:0461 interaction database HIST1H4A MSL2 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database YWHAZ MSL2 MI:0045 experimental interaction detection MI:0461 interaction database HIST2H2AC MSL2 MI:0045 experimental interaction detection MI:0461 interaction database HIST2H2BE MSL2 MI:0045 experimental interaction detection MI:0461 interaction database MSL1 MSL2 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database HIST2H2AA3 MSL2 MI:0045 experimental interaction detection MI:0461 interaction database HIST2H3A MSL2 MI:0045 experimental interaction detection MI:0461 interaction database MSL3 MSL2 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database PAF1 MSL2 MI:0045 experimental interaction detection MI:0461 interaction database MMS19 MSL2 MI:0045 experimental interaction detection MI:0461 interaction database TRIM8 MSL2 MI:0045 experimental interaction detection MI:0461 interaction database MIS12 MSL2 MI:0362 inference MI:0461 interaction database WNK1 MSL2 MI:0045 experimental interaction detection MI:0461 interaction database KAT8 MSL2 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database MSL2 FAM96B MI:0045 experimental interaction detection MI:0461 interaction database