PTM - CPLM Gene Name UniProt ID Type Position Code DHX36; DDX36; KIAA1488; MLEL1; RHAU Q9H2U1 Acetylation 947 K DHX36; DDX36; KIAA1488; MLEL1; RHAU Q9H2U1 Ubiquitination 152 K DHX36; DDX36; KIAA1488; MLEL1; RHAU Q9H2U1 Ubiquitination 153 K DHX36; DDX36; KIAA1488; MLEL1; RHAU Q9H2U1 Ubiquitination 845 K DHX36; DDX36; KIAA1488; MLEL1; RHAU Q9H2U1 Ubiquitination 440 K DHX36; DDX36; KIAA1488; MLEL1; RHAU Q9H2U1 Ubiquitination 206 K DHX36; DDX36; KIAA1488; MLEL1; RHAU Q9H2U1 Ubiquitination 682 K DHX36; DDX36; KIAA1488; MLEL1; RHAU Q9H2U1 Ubiquitination 947 K DHX36; DDX36; KIAA1488; MLEL1; RHAU Q9H2U1 Ubiquitination 951 K DHX36; DDX36; KIAA1488; MLEL1; RHAU Q9H2U1 Ubiquitination 973 K DHX36; DDX36; KIAA1488; MLEL1; RHAU Q9H2U1 Ubiquitination 191 K DHX36; DDX36; KIAA1488; MLEL1; RHAU Q9H2U1 Ubiquitination 858 K DHX36; DDX36; KIAA1488; MLEL1; RHAU Q9H2U1 Ubiquitination 108 K DHX36; DDX36; KIAA1488; MLEL1; RHAU Q9H2U1 Ubiquitination 817 K DHX36; DDX36; KIAA1488; MLEL1; RHAU Q9H2U1 Ubiquitination 139 K DHX36; DDX36; KIAA1488; MLEL1; RHAU Q9H2U1 Ubiquitination 146 K DHX36; DDX36; KIAA1488; MLEL1; RHAU Q9H2U1 Ubiquitination 862 K

PTM - dbPAF Gene Name UniProt ID Position Type Species DHX36; DDX36; KIAA1488; MLEL1; RHAU Q9H2U1 1006 Y Homo sapiens(Human) DHX36; DDX36; KIAA1488; MLEL1; RHAU Q9H2U1 1007 Y Homo sapiens(Human) DHX36; DDX36; KIAA1488; MLEL1; RHAU Q9H2U1 1008 S Homo sapiens(Human) DHX36; DDX36; KIAA1488; MLEL1; RHAU Q9H2U1 133 T Homo sapiens(Human) DHX36; DDX36; KIAA1488; MLEL1; RHAU Q9H2U1 136 S Homo sapiens(Human) DHX36; DDX36; KIAA1488; MLEL1; RHAU Q9H2U1 161 S Homo sapiens(Human) DHX36; DDX36; KIAA1488; MLEL1; RHAU Q9H2U1 162 Y Homo sapiens(Human) DHX36; DDX36; KIAA1488; MLEL1; RHAU Q9H2U1 167 S Homo sapiens(Human) DHX36; DDX36; KIAA1488; MLEL1; RHAU Q9H2U1 169 Y Homo sapiens(Human) DHX36; DDX36; KIAA1488; MLEL1; RHAU Q9H2U1 18 S Homo sapiens(Human) DHX36; DDX36; KIAA1488; MLEL1; RHAU Q9H2U1 2 S Homo sapiens(Human) DHX36; DDX36; KIAA1488; MLEL1; RHAU Q9H2U1 22 Y Homo sapiens(Human) DHX36; DDX36; KIAA1488; MLEL1; RHAU Q9H2U1 283 S Homo sapiens(Human) DHX36; DDX36; KIAA1488; MLEL1; RHAU Q9H2U1 3 Y Homo sapiens(Human) DHX36; DDX36; KIAA1488; MLEL1; RHAU Q9H2U1 36 S Homo sapiens(Human) DHX36; DDX36; KIAA1488; MLEL1; RHAU Q9H2U1 534 T Homo sapiens(Human) DHX36; DDX36; KIAA1488; MLEL1; RHAU Q9H2U1 621 S Homo sapiens(Human) DHX36; DDX36; KIAA1488; MLEL1; RHAU Q9H2U1 626 Y Homo sapiens(Human) DHX36; DDX36; KIAA1488; MLEL1; RHAU Q9H2U1 656 S Homo sapiens(Human) DHX36; DDX36; KIAA1488; MLEL1; RHAU Q9H2U1 66 Y Homo sapiens(Human) DHX36; DDX36; KIAA1488; MLEL1; RHAU Q9H2U1 860 Y Homo sapiens(Human) DHX36; DDX36; KIAA1488; MLEL1; RHAU Q9H2U1 963 S Homo sapiens(Human)

PTM - PhosSNP Gene Name dbSNP ID Gene Mutation AA Mutation Mutation Position Code Peptide Score Modification Type DHX36; DDX36; KIAA1488; MLEL1; RHAU rs61757598 AGC->AAC S->N 993 Y PRFQDGYYS****** 1007 Phosphorylation TypeIII- DHX36; DDX36; KIAA1488; MLEL1; RHAU rs61757598 AGC->AAC S->N 1007 Y PRFQDGYYS****** 1007 Phosphorylation TypeIII-

PTM - PhosphositePlus UniProt ID MOD_RSD Type SITE_+/-7_AA Q9H2U1 K139-ac Acetylation NtPCsENkLDIQEKK Q9H2U1 K845-ac Acetylation GLYPKVAkIRLNLGK Q9H2U1 K853-ac Acetylation IRLNLGKkRKMVKVy Q9H2U1 K947-ac Acetylation ARIAHLVkELRKELD Q9H2U1 R11-m1 Methylation DYHQNWGrDGGPRSs Q9H2U1 R34-m1 Methylation AGGHGGNrGsGGGGG Q9H2U1 R47-m1 Methylation GGGGGGGrGGrGrHP Q9H2U1 R50-m1 Methylation GGGGrGGrGrHPGHL Q9H2U1 R52-m1 Methylation GGrGGrGrHPGHLKG Q9H2U1 R90-m1 Methylation AVVHMDErREEQIVQ Q9H2U1 S2-p Phosphorylation ______MsyDYHQNW Q9H2U1 Y3-p Phosphorylation _____MsyDYHQNWG Q9H2U1 S18-p Phosphorylation rDGGPRSsGGGyGGG Q9H2U1 Y22-p Phosphorylation PRSsGGGyGGGPAGG Q9H2U1 S36-p Phosphorylation GHGGNrGsGGGGGGG Q9H2U1 Y66-p Phosphorylation GREIGMWyAKKQGQK Q9H2U1 T126-p Phosphorylation PEDHGYGtEVSTKNt Q9H2U1 T133-p Phosphorylation tEVSTKNtPCsENkL Q9H2U1 S136-p Phosphorylation STKNtPCsENkLDIQ Q9H2U1 S161-p Phosphorylation MFRIRNRsyIDRDSE Q9H2U1 Y162-p Phosphorylation FRIRNRsyIDRDSEy Q9H2U1 Y169-p Phosphorylation yIDRDSEyLLQENEP Q9H2U1 Y248-p Phosphorylation TQFILDNyIERGKGS Q9H2U1 S283-p Phosphorylation VAAERAEsCGsGNST Q9H2U1 S286-p Phosphorylation ERAEsCGsGNSTGYQ Q9H2U1 T534-p Phosphorylation LMPTVNQtQVFKRTP Q9H2U1 Y626-p Phosphorylation RASLLDDyQLPEILR Q9H2U1 S656-p Phosphorylation GGIAYFLsRLMDPPS Q9H2U1 Y860-p Phosphorylation kRKMVKVyTKTDGLV Q9H2U1 S963-p Phosphorylation LLQEKIEsPHPVDWN Q9H2U1 Y1006-p Phosphorylation PPRFQDGyys_____ Q9H2U1 Y1007-p Phosphorylation PRFQDGyys______ Q9H2U1 S1008-p Phosphorylation RFQDGyys_______ Q9H2U1 K139-ub Ubiquitination NtPCsENkLDIQEKK Q9H2U1 K152-ub Ubiquitination KKLINQEkkMFRIRN Q9H2U1 K153-ub Ubiquitination KLINQEkkMFRIRNR Q9H2U1 K817-ub Ubiquitination FVSSRNPkDPESNIN Q9H2U1 K973-ub Ubiquitination PVDWNDTkSRDCAVL

PTM - dbPTM UniProt ID Position Code Type Resources References Q9H2U1 947 K Acetylation Swiss-Prot 1010711 19608861 Q9H2U1 161 S Phosphorylation PhosphoELM.10011 18669648 Q9H2U1 167 S Phosphorylation PhosphoELM.10011 18669648 Q9H2U1 1008 S Phosphorylation PhosphoELM.10011 18669648 Q9H2U1 162 Y Phosphorylation PhosphoELM.10011 18669648 Q9H2U1 152 K Ubiquitylation Phosphositeplus.1010730 21890473 Q9H2U1 153 K Ubiquitylation Phosphositeplus.1010730 21890473 Q9H2U1 973 K Ubiquitylation Phosphositeplus.1010730 21906983 Q9H2U1 947 K Acetylation Phosphositeplus.1010730 19608861 Q9H2U1 1008 S Phosphorylation Phosphositeplus.1010730 21659604 Q9H2U1 161 S Phosphorylation Phosphositeplus.1010730 20736484 Q9H2U1 2 S Phosphorylation Phosphositeplus.1010730 22115753 Q9H2U1 947 K Acetylation HPRD 9.0 19608861 Q9H2U1 161 S Phosphorylation HPRD 9.0 18669648 Q9H2U1 167 S Phosphorylation HPRD 9.0 18669648 Q9H2U1 1008 S Phosphorylation HPRD 9.0 15144186,18669648 Q9H2U1 162 Y Phosphorylation HPRD 9.0 18669648

PTM - HPRD Symbol Position Code Type References DHX36 1008 S Phosphorylation 15144186,18669648 DHX36 161 S Phosphorylation 18669648 DHX36 162 Y Phosphorylation 18669648 DHX36 167 S Phosphorylation 18669648 DHX36 947 K Acetylation 19608861

PTM - Phospho.ELM UniProt Position Code PMIDs Kinase Source Type Q9H2U1 162 Y 18669648 HTP Phosphorylation Q9H2U1 167 S 18669648 HTP Phosphorylation Q9H2U1 161 S 18669648 HTP Phosphorylation Q9H2U1 1008 S 18669648 HTP Phosphorylation

PTM - UniProt UniProt ID Position Type PMIDs Q9H2U1 161 Phosphoserine 23186163 Q9H2U1 947 N6-acetyllysine 19608861 Q9H2U1 963 Phosphoserine 23186163

PTM - PHOSIDA Symbol Accession Code Position Surrounding Sequence Type DHX36 IPI00027415 K 947 RIAHLVaKELRKEL acetylation DHX36 IPI00027415 S 621 YNGLRApSLLDDYQ phosphorylation

PTM - BioGRID Entrez Gene BioGRID ID Position Code Type PMIDs 170506 128022 - K Ubiquitination 18781797 170506 128022 - K Ubiquitination 21139048 170506 128022 - K Ubiquitination 21890473 170506 128022 - K Ubiquitination 21906983 170506 128022 - K Sumoylation 21252943 170506 128022 - K Ubiquitination 21963094 170506 128022 - K Ubiquitination 24816145 170506 128022 - K Sumoylation 25027693

PTM - mUbiSiDa Gene Name Species Ubiquitination Site Ubiquitination Sequence Evidence PMID DHX36 Homo sapiens (Human) 66; 67 "66,KLINQEKKMFRIR; 67,LINQEKKMFRIRN" 66:21890473; 67:21890473 DHX36 Homo sapiens (Human) 152; 153; 959 "152,KLINQEKKMFRIR; 153,LINQEKKMFRIRN; 959,VDWNDTKSRDCAV" 152:21890473; 153:21890473; 959:21906983 DHX36 Homo sapiens (Human) 152; 153; 973 "152,KLINQEKKMFRIR; 153,LINQEKKMFRIRN; 973,VDWNDTKSRDCAV" 152:21890473; 153:21890473; 973:21906983 DHX36 Homo sapiens (Human) 152; 153; 944 "152,KLINQEKKMFRIR; 153,LINQEKKMFRIRN; 944,VDWNDTKSRDCAV" 152:21890473; 153:21890473; 944:21906983 DHX36 Homo sapiens (Human) 66; 67 "66,KLINQEKKMFRIR; 67,LINQEKKMFRIRN" 66:21890473; 67:21890473 DHX36 Homo sapiens (Human) 152; 153 "152,KLINQEKKMFRIR; 153,LINQEKKMFRIRN" 152:21890473; 153:21890473