PTM - CPLM Gene Name UniProt ID Type Position Code SART1 O43290 Sumoylation 94 K SART1 O43290 Sumoylation 141 K SART1 O43290 Ubiquitination 129 K SART1 O43290 Ubiquitination 657 K SART1 O43290 Ubiquitination 524 K SART1 O43290 Ubiquitination 699 K SART1 O43290 Ubiquitination 648 K SART1 O43290 Ubiquitination 758 K SART1 O43290 Ubiquitination 183 K SART1 O43290 Ubiquitination 723 K SART1 O43290 Ubiquitination 684 K SART1 O43290 Ubiquitination 188 K SART1 O43290 Ubiquitination 530 K SART1 O43290 Ubiquitination 302 K

PTM - dbPAF Gene Name UniProt ID Position Type Species SART1 O43290 102 Y Homo sapiens(Human) SART1 O43290 108 S Homo sapiens(Human) SART1 O43290 110 T Homo sapiens(Human) SART1 O43290 111 S Homo sapiens(Human) SART1 O43290 112 S Homo sapiens(Human) SART1 O43290 119 S Homo sapiens(Human) SART1 O43290 123 T Homo sapiens(Human) SART1 O43290 17 T Homo sapiens(Human) SART1 O43290 189 T Homo sapiens(Human) SART1 O43290 200 T Homo sapiens(Human) SART1 O43290 207 S Homo sapiens(Human) SART1 O43290 22 T Homo sapiens(Human) SART1 O43290 249 Y Homo sapiens(Human) SART1 O43290 258 T Homo sapiens(Human) SART1 O43290 271 T Homo sapiens(Human) SART1 O43290 275 T Homo sapiens(Human) SART1 O43290 316 Y Homo sapiens(Human) SART1 O43290 321 S Homo sapiens(Human) SART1 O43290 348 S Homo sapiens(Human) SART1 O43290 356 T Homo sapiens(Human) SART1 O43290 388 S Homo sapiens(Human) SART1 O43290 390 Y Homo sapiens(Human) SART1 O43290 392 T Homo sapiens(Human) SART1 O43290 42 S Homo sapiens(Human) SART1 O43290 430 T Homo sapiens(Human) SART1 O43290 437 S Homo sapiens(Human) SART1 O43290 448 S Homo sapiens(Human) SART1 O43290 45 S Homo sapiens(Human) SART1 O43290 463 S Homo sapiens(Human) SART1 O43290 466 T Homo sapiens(Human) SART1 O43290 474 S Homo sapiens(Human) SART1 O43290 48 S Homo sapiens(Human) SART1 O43290 486 S Homo sapiens(Human) SART1 O43290 521 S Homo sapiens(Human) SART1 O43290 591 S Homo sapiens(Human) SART1 O43290 596 S Homo sapiens(Human) SART1 O43290 598 S Homo sapiens(Human) SART1 O43290 621 S Homo sapiens(Human) SART1 O43290 623 S Homo sapiens(Human) SART1 O43290 667 S Homo sapiens(Human) SART1 O43290 673 Y Homo sapiens(Human) SART1 O43290 685 Y Homo sapiens(Human) SART1 O43290 686 S Homo sapiens(Human) SART1 O43290 695 T Homo sapiens(Human) SART1 O43290 712 Y Homo sapiens(Human) SART1 O43290 716 T Homo sapiens(Human) SART1 O43290 721 T Homo sapiens(Human) SART1 O43290 730 S Homo sapiens(Human) SART1 O43290 760 S Homo sapiens(Human) SART1 O43290 761 S Homo sapiens(Human) SART1 O43290 762 S Homo sapiens(Human) SART1 O43290 764 T Homo sapiens(Human) SART1 O43290 768 T Homo sapiens(Human) SART1 O43290 781 T Homo sapiens(Human) SART1 O43290 783 Y Homo sapiens(Human) SART1 O43290 787 S Homo sapiens(Human) SART1 O43290 789 S Homo sapiens(Human) SART1 O43290 84 S Homo sapiens(Human)

PTM - PhosphositePlus UniProt ID MOD_RSD Type SITE_+/-7_AA O43290 K133-ac Acetylation LRAkLGLkPLEVNAI O43290 R385-m1 Methylation SLSTVGPrLAsEyLt O43290 R692-m1 Methylation ysRREEYrGFtQDFk O43290 K757-m1 Methylation LDEEALLkkMsssDt O43290 K758-m1 Methylation DEEALLkkMsssDtP O43290 T22-p Phosphorylation GTTAAAGtGGATEQP O43290 S42-p Phosphorylation HKKHKHRsGGsGGsG O43290 S45-p Phosphorylation HKHRsGGsGGsGGER O43290 S48-p Phosphorylation RsGGsGGsGGERRKR O43290 S84-p Phosphorylation STHGRERsQAEPSER O43290 Y102-p Phosphorylation REKRDDGyEAAASsK O43290 S108-p Phosphorylation GyEAAASsKTssGDA O43290 S111-p Phosphorylation AAASsKTssGDASSL O43290 S112-p Phosphorylation AASsKTssGDASSLs O43290 S119-p Phosphorylation sGDASSLsIEEtNKL O43290 T123-p Phosphorylation SSLsIEEtNKLRAkL O43290 T189-p Phosphorylation QkLGKIktLGEDDPW O43290 T200-p Phosphorylation DDPWLDDtAAWIERS O43290 Y249-p Phosphorylation GQRRQDLysARDLQG O43290 S250-p Phosphorylation QRRQDLysARDLQGL O43290 T258-p Phosphorylation ARDLQGLtVEHAIDS O43290 T271-p Phosphorylation DSFREGEtMILtLKD O43290 T275-p Phosphorylation EGEtMILtLKDKGVL O43290 Y316-p Phosphorylation KKPDYLPyAEDEsVD O43290 S321-p Phosphorylation LPyAEDEsVDDLAQQ O43290 S332-p Phosphorylation LAQQKPRsILsKYDE O43290 S335-p Phosphorylation QKPRsILsKYDEELE O43290 S348-p Phosphorylation LEGERPHsFRLEQGG O43290 S388-p Phosphorylation TVGPrLAsEyLtPEE O43290 Y390-p Phosphorylation GPrLAsEyLtPEEMV O43290 T392-p Phosphorylation rLAsEyLtPEEMVTF O43290 T430-p Phosphorylation LLPLGDQtQDGDFGs O43290 S437-p Phosphorylation tQDGDFGsRLRGRGR O43290 S448-p Phosphorylation GRGRRRVsEVEEEKE O43290 S463-p Phosphorylation PVPQPLPsDDtRVEN O43290 T466-p Phosphorylation QPLPsDDtRVENMDI O43290 S474-p Phosphorylation RVENMDIsDEEEGGA O43290 S486-p Phosphorylation GGAPPPGsPQVLEED O43290 S521-p Phosphorylation QLQQLRDsGEKVVEI O43290 S591-p Phosphorylation FERDEERsANGGsEs O43290 S596-p Phosphorylation ERsANGGsEsDGEEN O43290 S598-p Phosphorylation sANGGsEsDGEENIG O43290 S621-p Phosphorylation EKQQQDFsAsSTTIL O43290 S623-p Phosphorylation QQQDFsAsSTTILDE O43290 S667-p Phosphorylation RVKAPNKsLPSAVyC O43290 Y673-p Phosphorylation KsLPSAVyCIEDKMA O43290 Y685-p Phosphorylation KMAIDDKysRREEYr O43290 S686-p Phosphorylation MAIDDKysRREEYrG O43290 T695-p Phosphorylation REEYrGFtQDFkEKD O43290 Y712-p Phosphorylation KPDVkIEyVDETGRK O43290 T721-p Phosphorylation DETGRKLtPkEAFRQ O43290 S730-p Phosphorylation kEAFRQLsHRFHGKG O43290 S760-p Phosphorylation EALLkkMsssDtPLG O43290 S761-p Phosphorylation ALLkkMsssDtPLGt O43290 S762-p Phosphorylation LLkkMsssDtPLGtV O43290 T764-p Phosphorylation kkMsssDtPLGtVAL O43290 T768-p Phosphorylation ssDtPLGtVALLQEK O43290 T781-p Phosphorylation EKQKAQKtPyIVLSG O43290 Y783-p Phosphorylation QKAQKtPyIVLSGsG O43290 S789-p Phosphorylation PyIVLSGsGKSMNAN O43290 K94-sm Sumoylation EPSERRVkREKRDDG O43290 K141-sm Sumoylation PLEVNAIkKEAGTkE O43290 K147-sm Sumoylation IkKEAGTkEEPVTAD O43290 K188-sm Sumoylation NQkLGKIktLGEDDP O43290 K709-sm Sumoylation DGYKPDVkIEyVDET O43290 K742-sm Sumoylation GKGSGKMkTERRMKK O43290 K758-sm Sumoylation DEEALLkkMsssDtP O43290 K129-ub Ubiquitination EtNKLRAkLGLkPLE O43290 K183-ub Ubiquitination EKRLLNQkLGKIktL O43290 K188-ub Ubiquitination NQkLGKIktLGEDDP O43290 K302-ub Ubiquitination VDKERAEkNVELRKK O43290 K657-ub Ubiquitination LLETTVQkVARVKAP O43290 K699-ub Ubiquitination rGFtQDFkEKDGYKP O43290 K723-ub Ubiquitination TGRKLtPkEAFRQLs

PTM - dbPTM UniProt ID Position Code Type Resources References O43290 392 T Phosphorylation Swiss-Prot 1010711 15302935;18669648 O43290 430 T Phosphorylation Swiss-Prot 1010711 17525332;19690332 O43290 448 S Phosphorylation Swiss-Prot 1010711 17081983;18220336;18669648;19367720;19690332 O43290 474 S Phosphorylation Swiss-Prot 1010711 18669648 O43290 486 S Phosphorylation Swiss-Prot 1010711 18669648 O43290 591 S Phosphorylation Swiss-Prot 1010711 17081983 O43290 596 S Phosphorylation Swiss-Prot 1010711 17081983 O43290 598 S Phosphorylation Swiss-Prot 1010711 17081983 O43290 695 T Phosphorylation Swiss-Prot 1010711 17525332 O43290 764 T Phosphorylation Swiss-Prot 1010711 19413330;19690332 O43290 448 S Phosphorylation PhosphoELM.10011 18669648;18220336;17081983 O43290 463 S Phosphorylation PhosphoELM.10011 18669648;18220336 O43290 474 S Phosphorylation PhosphoELM.10011 18669648 O43290 486 S Phosphorylation PhosphoELM.10011 18669648 O43290 591 S Phosphorylation PhosphoELM.10011 17081983 O43290 596 S Phosphorylation PhosphoELM.10011 17081983;15302935 O43290 598 S Phosphorylation PhosphoELM.10011 17081983 O43290 392 T Phosphorylation PhosphoELM.10011 18669648;15302935 O43290 430 T Phosphorylation PhosphoELM.10011 17525332 O43290 466 T Phosphorylation PhosphoELM.10011 18669648 O43290 695 T Phosphorylation PhosphoELM.10011 17525332 O43290 141 K Sumoylation Phosphositeplus.1010730 15175327;20346425;20797634 O43290 709 K Sumoylation Phosphositeplus.1010730 15175327;20346425 O43290 742 K Sumoylation Phosphositeplus.1010730 20346425 O43290 94 K Sumoylation Phosphositeplus.1010730 15175327;20346425 O43290 129 K Ubiquitylation Phosphositeplus.1010730 21890473 O43290 188 K Ubiquitylation Phosphositeplus.1010730 21906983 O43290 321 S Phosphorylation Phosphositeplus.1010730 19276368 O43290 448 S Phosphorylation Phosphositeplus.1010730 17081983;18220336;18669648;18707149;19276368;19367720;19664995;19690332;20044836;20068231;20164059;20166139;20363803;20562096;20815410;21060948;21406692;22115753 O43290 463 S Phosphorylation Phosphositeplus.1010730 18220336;19276368 O43290 474 S Phosphorylation Phosphositeplus.1010730 18669648 O43290 486 S Phosphorylation Phosphositeplus.1010730 18669648 O43290 521 S Phosphorylation Phosphositeplus.1010730 20068231 O43290 591 S Phosphorylation Phosphositeplus.1010730 20068231;22115753 O43290 596 S Phosphorylation Phosphositeplus.1010730 15302935;20068231;22115753 O43290 598 S Phosphorylation Phosphositeplus.1010730 20068231;21659604;22115753 O43290 760 S Phosphorylation Phosphositeplus.1010730 20044836 O43290 761 S Phosphorylation Phosphositeplus.1010730 20044836 O43290 762 S Phosphorylation Phosphositeplus.1010730 20044836 O43290 123 T Phosphorylation Phosphositeplus.1010730 18491316 O43290 258 T Phosphorylation Phosphositeplus.1010730 20044836 O43290 275 T Phosphorylation Phosphositeplus.1010730 20044836 O43290 392 T Phosphorylation Phosphositeplus.1010730 15302935;18669648;20068231;22067460 O43290 430 T Phosphorylation Phosphositeplus.1010730 17525332;19690332 O43290 466 T Phosphorylation Phosphositeplus.1010730 19276368 O43290 695 T Phosphorylation Phosphositeplus.1010730 17525332 O43290 764 T Phosphorylation Phosphositeplus.1010730 19690332;20044836 O43290 768 T Phosphorylation Phosphositeplus.1010730 20044836 O43290 783 Y Phosphorylation Phosphositeplus.1010730 17360941 O43290 448 S Phosphorylation HPRD 9.0 17081983,18669648,19664995,18212344,19651622,18707149,18452278,20166139,20068231 O43290 463 S Phosphorylation HPRD 9.0 17081983,18669648,18452278 O43290 474 S Phosphorylation HPRD 9.0 18669648,18452278 O43290 486 S Phosphorylation HPRD 9.0 18669648,18452278 O43290 521 S Phosphorylation HPRD 9.0 20068231 O43290 591 S Phosphorylation HPRD 9.0 17081983,18452278,20068231 O43290 596 S Phosphorylation HPRD 9.0 17081983,18452278,20068231 O43290 598 S Phosphorylation HPRD 9.0 17081983,18452278,20068231 O43290 789 S Phosphorylation HPRD 9.0 20068231 O43290 123 T Phosphorylation HPRD 9.0 18491316 O43290 392 T Phosphorylation HPRD 9.0 15302935,18669648,20068231 O43290 430 T Phosphorylation HPRD 9.0 17525332 O43290 466 T Phosphorylation HPRD 9.0 17081983,18669648 O43290 695 T Phosphorylation HPRD 9.0 17525332 O43290 764 T Phosphorylation HPRD 9.0 19413330 O43290 94 K Sumoylation HPRD 9.0 17000644 O43290 141 K Sumoylation HPRD 9.0 17000644 O43290 709 K Sumoylation HPRD 9.0 17000644 O43290 742 K Sumoylation HPRD 9.0 17000644 O43290 448 S Phosphorylation SysPTM 1.1 18707149;18669648;17081983;18212344 O43290 463 S Phosphorylation SysPTM 1.1 17081983 O43290 474 S Phosphorylation SysPTM 1.1 18669648 O43290 486 S Phosphorylation SysPTM 1.1 18669648 O43290 591 S Phosphorylation SysPTM 1.1 17081983 O43290 596 S Phosphorylation SysPTM 1.1 17081983 O43290 598 S Phosphorylation SysPTM 1.1 17081983 O43290 123 T Phosphorylation SysPTM 1.1 18491316 O43290 392 T Phosphorylation SysPTM 1.1 18669648 O43290 466 T Phosphorylation SysPTM 1.1 17081983

PTM - HPRD Symbol Position Code Type References SART1 123 T Phosphorylation 18491316 SART1 141 K Sumoylation 17000644 SART1 392 T Phosphorylation 15302935,18669648,20068231 SART1 430 T Phosphorylation 17525332 SART1 448 S Phosphorylation 17081983,18669648,19664995,18212344,19651622,18707149,18452278,20166139,20068231 SART1 463 S Phosphorylation 17081983,18669648,18452278 SART1 466 T Phosphorylation 17081983,18669648 SART1 474 S Phosphorylation 18669648,18452278 SART1 486 S Phosphorylation 18669648,18452278 SART1 521 S Phosphorylation 20068231 SART1 591 S Phosphorylation 17081983,18452278,20068231 SART1 596 S Phosphorylation 17081983,18452278,20068231 SART1 598 S Phosphorylation 17081983,18452278,20068231 SART1 695 T Phosphorylation 17525332 SART1 709 K Sumoylation 17000644 SART1 742 K Sumoylation 17000644 SART1 764 T Phosphorylation 19413330 SART1 789 S Phosphorylation 20068231 SART1 94 K Sumoylation 17000644

PTM - Phospho.ELM UniProt Position Code PMIDs Kinase Source Type O43290 695 T 17525332 HTP Phosphorylation O43290 486 S 18669648 HTP Phosphorylation O43290 596 S 17081983 HTP Phosphorylation O43290 596 S 15302935 HTP Phosphorylation O43290 463 S 18669648 HTP Phosphorylation O43290 463 S 18220336 HTP Phosphorylation O43290 466 T 18669648 HTP Phosphorylation O43290 430 T 17525332 HTP Phosphorylation O43290 474 S 18669648 HTP Phosphorylation O43290 591 S 17081983 HTP Phosphorylation O43290 392 T 18669648 HTP Phosphorylation O43290 392 T 15302935 HTP Phosphorylation O43290 598 S 17081983 HTP Phosphorylation O43290 448 S 18669648 HTP Phosphorylation O43290 448 S 18220336 HTP Phosphorylation O43290 448 S 17081983 HTP Phosphorylation

PTM - UniProt UniProt ID Position Type PMIDs O43290 321 Phosphoserine 23186163 O43290 348 Phosphoserine 23186163 O43290 392 Phosphothreonine 18669648;23186163 O43290 430 Phosphothreonine 17525332;19690332;23186163 O43290 448 Phosphoserine 17081983;18220336;18669648;19690332;20068231;21406692;23186163 O43290 474 Phosphoserine 24275569 O43290 486 Phosphoserine 18669648 O43290 521 Phosphoserine 20068231 O43290 591 Phosphoserine 17081983;20068231 O43290 596 Phosphoserine 20068231 O43290 598 Phosphoserine 20068231 O43290 621 Phosphoserine 24275569 O43290 695 Phosphothreonine 17525332 O43290 761 Phosphoserine 23186163 O43290 764 Phosphothreonine 19690332 O43290 789 Phosphoserine 23186163

PTM - PHOSIDA Symbol Accession Code Position Surrounding Sequence Type SART1 IPI00021417 S 448 RGRRRVpSEVEEEK phosphorylation SART1 IPI00021417 S 591 ERDEERpSANGGSE phosphorylation SART1 IPI00021417 S 596 RSANGGpSESDGEE phosphorylation SART1 IPI00021417 S 598 ANGGSEpSDGEENI phosphorylation SART1 IPI00021417 T 356 RLEQGGpTADGLRE phosphorylation SART1 IPI00021417 T 392 LASEYLpTPEEMVT phosphorylation

PTM - BioGRID Entrez Gene BioGRID ID Position Code Type PMIDs 9092 114546 - K Sumoylation 21693764 9092 114546 - K Ubiquitination 21139048 9092 114546 - K Ubiquitination 21890473 9092 114546 - K Ubiquitination 21906983 9092 114546 - K Sumoylation 19471022 9092 114546 - K Sumoylation 21252943 9092 114546 - K Sumoylation 20797634 9092 114546 - K Sumoylation 15175327 9092 114546 - K Sumoylation 17000644 9092 114546 - K Ubiquitination 23000965 9092 114546 - K Neddylation 24654937 9092 114546 - K Sumoylation 24654937 9092 114546 - K Ubiquitination 24816145 9092 114546 - K Sumoylation 25027693

PTM - mUbiSiDa Gene Name Species Ubiquitination Site Ubiquitination Sequence Evidence PMID SART1 Homo sapiens (Human) 188; 129 "188,QKLGKIKTLGEDD; 129,TNKLRAKLGLKPL" 188:21906983; 129:21890473 SART1 Homo sapiens (Human) 129 "129,TNKLRAKLGLKPL" 129:21890473