PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus ENO1 LONRF3 23414517 intact exp G G G G G G G G G G G G G G G GP G G G G GP G G G GP G G GP G LONRF3 AGO3 26186194 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G LONRF3 APPBP2 25416956 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G LONRF3 NOTCH2NL 25416956 biogrid,intact exp G G G G G G G G G G G G G G G GP G G G G GP G G G GP G G GP G LONRF3 RFPL4B 26186194 biogrid exp P P P LONRF3 SMURF1 15761153 hprd,i2d exp G G G G G G G G G G G G G G G G G G G G GP G G G G G G GP G PHB LONRF3 20195357 biogrid,intact exp G G G G G G G G G G G G G G G GP G G G G GP G G G GP G G GP G LONRF3 LONRF3 23023127 pred G G G G G G G G G G G G G G G GP G G G G GP G G G GP G G GP G SMARCA2 LONRF3 25402006 pred G G G G G G G G G G G G G G G GP G G G G GP G G G GP G G GP G UBE2D3 LONRF3 23023127 pred G G G G G G G G G G G G G G G G G G G G GP G G G G G G GP G LONRF3 A1CF 25402006 pred G G G G G G G G G G G G G G G GP G G G G G G G G GP G G G ANXA2 LONRF3 25402006 pred G G G G G G G G G G G G G G G G G G G G GP G G G G G G GP G UBE2N LONRF3 23023127 pred G G G G G G G G G G G G G G G GP G G G G GP G G G GP G G GP G UBE2D2 LONRF3 23023127 pred G G G G G G G G G G G G G G G G G G G G GP G G G G G G GP G LONRF3 CRBN 23023127 pred G G G G G G G G G G G G G G G GP G G G G GP G G G GP G G GP G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q496Y0 A8K401 display technology 20195357 physical association X 2 Q496Y0 A8K401 tandem affinity purification 20195357 physical association X 2 Q7Z3S9 Q496Y0 two hybrid prey pooling approach 25416956 physical association X 2 Q7Z3S9 Q496Y0 two hybrid array 25416956 physical association X 2 Q7Z3S9 Q496Y0 validated two hybrid 25416956 physical association X 2 Q496Y0 A0A024R4F1 two hybrid fragment pooling approach 23414517 physical association X 2 Q496Y0 A0A024QZ47 two hybrid prey pooling approach 25416956 physical association X 2 Q496Y0 A0A024QZ47 two hybrid array 25416956 physical association X 2 Q496Y0 A0A024QZ47 validated two hybrid 25416956 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B LONRF3 SMURF1 MI:0493(in vivo) 15761153 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_17789 - - ENO1 LONRF3 MI:0663(confocal microscopy) 23414517 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_127050 bait prey PHB LONRF3 MI:0034(display technology)|MI:0034(display technology)|MI:0096(pull down) 20195357 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (intact)|(intact)|(biogrid) UniProt_105404|UniProt_105154|BIOGRID_290329 bait|bait|bait prey|prey|prey

PPI - HINT Gene A Gene B PMID Method Quality LONRF3 RFPL4B 26186194 0004 HT LONRF3 AGO3 26186194 0004 HT LONRF3 RFPL4B 26186194 0004 HT LONRF3 AGO3 26186194 0004 HT ENO1 LONRF3 23414517 0399 HT PHB LONRF3 20195357,20195357 0034,0676 LC LONRF3 NOTCH2NL 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT LONRF3 APPBP2 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT LONRF3 SMURF1 15761153 0019 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9H9G7 Q496Y0 AGO3 LONRF3 0.126 26186194 Q6ZWI9 Q496Y0 RFPL4B LONRF3 0.126 26186194 Q92624 Q496Y0 APPBP2 LONRF3 0.454 25416956 Q496Y0 P78358 LONRF3 CTAG1B 0.236 unassigned1304 Q496Y0 P17661 LONRF3 DES 0.236 unassigned1304 Q496Y0 B8A4K4 LONRF3 CYSRT1 {ECO:0000313|ENSEMBL:ENSP00000386453} 0.236 unassigned1304 Q7Z3S9 Q496Y0 NOTCH2NL LONRF3 0.454 25416956 Q496Y0 P06733 LONRF3 ENO1 0.126 23414517 Q496Y0 P35232 LONRF3 PHB 0.376 20195357

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 ENO1 LONRF3 MI:0045 experimental interaction detection MI:0461 interaction database PHB LONRF3 MI:0045 experimental interaction detection MI:0461 interaction database LONRF3 RFPL4B MI:0045 experimental interaction detection MI:0461 interaction database LONRF3 NOTCH2NL MI:0045 experimental interaction detection MI:0461 interaction database LONRF3 APPBP2 MI:0045 experimental interaction detection MI:0461 interaction database LONRF3 AGO3 MI:0045 experimental interaction detection MI:0461 interaction database LONRF3 SMURF1 MI:0045 experimental interaction detection MI:0461 interaction database