PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus HSPA8 WSB2 25036637 intact exp P P P P P P P P P P NUDCD3 WSB2 25036637 intact exp GP G G G G GP G GP GP G GP G G G G GP GP GP GP G G GP G GP GP G GP GP G HSP90AB1 WSB2 25036637,22939624 intact exp GP G G G G GP G GP GP G GP G G G G GP GP GP GP G G GP G GP GP G GP GP G HSF2 WSB2 25036637 intact exp G G G G G G G G G G G G G G G G G G G G G G G G G GP G AARSD1 WSB2 25036637 intact exp P P P P P P P P P P P P PPP5C WSB2 25036637 intact exp GP G G G G GP G GP GP G GP G G G G GP GP GP GP G G GP G GP GP G GP GP G CUL4A WSB2 17079684 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SGTA WSB2 25036637 intact exp GP G G G G GP G GP GP G GP G G G G GP GP GP GP G G GP G GP GP G GP GP G ELAVL1 WSB2 19322201 biogrid exp GP G G G G GP G GP GP G GP G G G G GP GP GP GP G G GP G GP GP G GP GP G IL21R WSB2 20059963 biogrid exp P P P P P G P P P P P P G P P WSB2 PFDN2 25036637 intact exp GP G G G G GP G GP GP G GP G G G G GP GP GP GP G G GP G GP GP G GP GP G EZH2 WSB2 16169070 hprd,biogrid,i2d,mint,intact exp GP G G GP G G GP G P GP G GP GP HSP90AA1 WSB2 22939624 biogrid exp GP G G G G GP G G GP G G G G G G G GP G G G G G G G G G G GP G FKBP5 WSB2 25036637 intact exp GP G G G G GP G GP GP G GP G G G G GP GP GP GP G G GP G GP GP G GP GP G WSB2 NUDC 25036637 intact exp GP G G G G GP G G GP G GP G G G G GP GP GP GP G G GP G G GP G GP GP G STIP1 WSB2 25036637 intact exp GP G G G G GP G GP GP G GP G G G G GP GP GP GP G G GP G GP GP G GP GP G PFDN5 WSB2 25036637 intact exp GP G G G G GP G GP GP G GP G G G G GP GP GP GP G G GP G GP GP G GP GP G CUL5 WSB2 21145461 biogrid exp GP G G G G GP G GP GP G GP G G G G GP GP GP GP G G GP G GP GP G GP GP G RPN1 WSB2 16169070 hprd,i2d,mint,intact exp G G G G G GP G GP GP G G G G G G GP GP G GP G G GP G GP GP G GP GP G WSB2 SUGT1 25036637 intact exp G G G G G G G GP GP G GP G G G G GP G G GP G G G G GP GP G GP GP G DDB1 WSB2 17079684 biogrid exp GP G G G G GP G GP GP G GP G G G G GP GP GP GP G G GP G GP GP G GP GP G NUDCD2 WSB2 25036637 intact exp GP G G G G GP G GP GP G GP G G G G GP GP GP GP G G GP G GP GP G GP GP G WSB2 FKBPL 25036637 intact exp P G GP P P G P P GP P P P G P P GP GP G CACYBP WSB2 25036637 intact exp GP G G G G GP G G GP G GP G G G G GP GP GP GP G G GP G G GP G GP GP G CSF3R WSB2 17001306 biogrid exp, ortho G G G G G GP G GP G G G G G G G G GP G G G G G G G G G GP G RALGPS2 WSB2 16082366 pred GP G G G P G P GP GP G G G GP P GP P GP P GP G GP GP PAFAH1B1 WSB2 23023127 pred GP G G G G GP G GP GP G GP G G G G GP GP GP GP G G GP G GP GP G GP GP G VPS26A WSB2 25402006 pred GP G G G G GP G G GP G GP G G G G GP GP GP GP G G GP G G GP G GP GP G BCAR3 WSB2 16082366 pred GP G G GP G GP GP G GP G G G G GP GP G P G G GP G GP GP G GP GP G NBEA WSB2 23023127 pred GP G G GP G G GP G GP G G G GP GP G GP G GP G G GP G GP GP G SERINC5 WSB2 25402006 pred GP G G G G GP G GP GP G GP G G G G GP GP G GP G G GP G GP GP G GP GP G WSB2 RAPGEFL1 16082366 pred G G GP P G P GP GP P P P P P SOS1 WSB2 16082366 pred GP G G G G G G GP GP G GP G G G G GP G G GP G G GP G GP GP G GP G G RASGRP2 WSB2 16082366 pred G G G G G GP GP GP G GP G G G G GP GP P G G GP GP G GP P G WSB2 RGL1 16082366 pred GP G G G G GP G GP GP G GP G G G G GP GP GP GP G G GP G GP GP G GP GP G RGL2 WSB2 16082366 pred GP G G G G GP G GP GP G GP G G G G GP GP G GP G G GP G GP GP G GP GP G GNGT1 WSB2 23023127 pred P P G P P GNG2 WSB2 23023127 pred G G G G G GP G G GP G GP G G G G G GP GP GP G G G G G G G GP GP G GNB1 WSB2 23023127 pred G G G G G GP G GP GP G GP G G G G GP GP GP GP G G G G G GP G GP GP G TWF1 WSB2 25402006 pred GP G G G G G G GP GP G GP G G G G GP G G GP G G GP G G GP G GP GP G SKP1 WSB2 25402006 pred GP G G G G GP G G GP G GP G G G G GP GP GP GP G G GP G G GP G GP GP G RASGEF1B WSB2 16082366 pred P P P P G P P P P P P P SH2D3C WSB2 16082366 pred GP G G G G G G GP G G GP G G G G G G G G G G G G G G GP GP G SOS2 WSB2 16082366 pred GP G G G G GP G GP GP G GP G G G G GP GP GP GP G G GP G GP GP G GP GP G GNAL WSB2 23023127 pred GP G GP G GP GP G P G G P GP P P G GP G GP GP G GP GP G WSB2 FBXW11 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PDC WSB2 23023127 pred P P P P P P P P P P P P P GNB5 WSB2 23023127 pred GP G G G G GP G GP GP G GP G G G G GP GP G GP G G G G GP GP G GP GP G RASGRP1 WSB2 16082366 pred G G G G G G G G G G G G G G G G G G G ARPC3 WSB2 25402006 pred G G G G G GP G G GP G GP G G G G GP GP G GP G G GP G GP GP G GP GP G WDR5B WSB2 23023127 pred GP G G G G GP G G GP G GP G G G G GP GP G GP G G G G GP GP G GP GP G RAPGEF3 WSB2 16082366 pred GP G GP G GP GP G GP G G G P GP G GP G GP G GP P G GP P G RAPGEF1 WSB2 16082366 pred G G G G G GP G G GP G GP G G G G GP GP G GP G G GP G GP GP G GP GP G GNAT1 WSB2 23023127 pred RGL4 WSB2 16082366 pred P G G P P P G P P P P G P RASGRF2 WSB2 16082366 pred GP G G G G GP G GP GP G GP G G G GP GP GP GP G G GP GP GP G GP GP G MDH1 WSB2 25402006 pred G G G G G GP G GP G G GP G G G G G GP G GP G G G G GP G G GP GP G RASGEF1C WSB2 16082366 pred P G GP P P G P P GP P GP P P P P GP RALGDS WSB2 16082366 pred GP G G G G GP G GP GP G GP G G G G GP GP GP GP G G GP G GP GP G GP GP G CSF3 WSB2 21836163 pred P P P G P P P GP P P P P

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q9NYS7 Q16531 affinity chromatography technology 17079684 physical association X 2 Q9NYS7 B2RBV7 affinity chromatography technology 17079684 physical association X 2 Q9NYS7 Q99062-4 affinity chromatography technology 17001306 physical association X 2 Q9NYS7 Q99062-4 imaging technique 17001306 colocalization X 2 Q9NYS7 Q99062-4 protein complementation assay 17001306 direct interaction X 2 Q9NYS7 Q93034 affinity chromatography technology 21145461 physical association X 2 Q9NYS7 affinity chromatography technology 20059963 physical association X 2 Q9NYS7 affinity chromatography technology 20059963 physical association X 2 Q9NYS7 P07900-2 affinity chromatography technology 22939624 physical association X 2 Q9NYS7 two hybrid 16169070 direct interaction X 2 Q15910-3 Q9NYS7 two hybrid 16169070 - X 2 Q15910-3 Q9NYS7 two hybrid 16169070 - X 2 Q9NYS7 P04843 two hybrid 16169070 - X 2 Q9NYS7 P04843 two hybrid 16169070 - X 2 Q9NYS7 Q96BE0 luminescence based mammalian interactome mapping 25036637 physical association X 2 Q9NYS7 Q9BPW0 luminescence based mammalian interactome mapping 25036637 physical association X 2 Q03933 Q9NYS7 luminescence based mammalian interactome mapping 25036637 physical association X 2 P31948 Q9NYS7 luminescence based mammalian interactome mapping 25036637 physical association X 2 A0A024R904 Q9NYS7 luminescence based mammalian interactome mapping 25036637 physical association X 2 Q13451 Q9NYS7 luminescence based mammalian interactome mapping 25036637 physical association X 2 A0A024RCQ6 Q9NYS7 luminescence based mammalian interactome mapping 25036637 physical association X 2 Q99471 Q9NYS7 luminescence based mammalian interactome mapping 25036637 physical association X 2 Q8WVJ2 Q9NYS7 luminescence based mammalian interactome mapping 25036637 physical association X 2 Q9Y266 Q9NYS7 luminescence based mammalian interactome mapping 25036637 physical association X 2 Q15910 Q9NYS7 two hybrid pooling approach 16169070 physical association X 2 Q9NYS7 P04843 two hybrid pooling approach 16169070 physical association X 2 Q9NYS7 A0A024RD80 luminescence based mammalian interactome mapping 22939624 physical association X 2 Q9NYS7 Q6PK50 luminescence based mammalian interactome mapping 25036637 physical association X 2 Q9NYS7 B1AQP2 luminescence based mammalian interactome mapping 25036637 physical association X 2 Q9NYS7 O43765 luminescence based mammalian interactome mapping 25036637 physical association X 2 Q8IVD9 Q9NYS7 luminescence based mammalian interactome mapping 25036637 physical association X 2 Q9BTE6-2 Q9NYS7 luminescence based mammalian interactome mapping 25036637 physical association X 2 Q8K2C9 Q9NYS7 luminescence based mammalian interactome mapping 25036637 physical association X 2 Q3UJD6 Q9NYS7 luminescence based mammalian interactome mapping 25036637 physical association X 2

PPI - HINT Gene A Gene B PMID Method Quality CUL5 WSB2 21145461 0004 HT CUL5 WSB2 21145461 0004 HT B4DYC6 WSB2 25036637 0729 HT B7Z8L6 WSB2 16169070 0018 HT SGTA WSB2 25036637 0729 HT RPN1 WSB2 16169070,16169070 0018,0398 HT HSP90AB1 WSB2 25036637,22939624 0729,0729 HT STIP1 WSB2 25036637 0729 HT PPP5C WSB2 25036637 0729 HT HSF2 WSB2 25036637 0729 HT FKBP5 WSB2 25036637 0729 HT EZH2 WSB2 16169070,16169070 0018,0398 HT NUDCD3 WSB2 25036637 0729 HT NUDCD2 WSB2 25036637 0729 HT Q96BE0 WSB2 25036637 0729 HT CSF3R WSB2 17001306,17001306,17001306 0004,0428,0090 LC PFDN5 WSB2 25036637 0729 HT AARSD1 WSB2 25036637 0729 HT CACYBP WSB2 25036637 0729 HT WSB2 PFDN2 25036637 0729 HT WSB2 FKBPL 25036637 0729 HT WSB2 NUDC 25036637 0729 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9NYS7 O43765 WSB2 SGTA 0.126 25036637 Q9NYS7 Q8K2C9 WSB2 PTPLAD1 0.126 25036637 Q9NYS7 Q9HBE5 WSB2 IL21R 0.376 20059963 Q9NYS7 B4DYC6 WSB2 B4DYC6 0.126 25036637 Q9NYS7 P04843 WSB2 RPN1 0.126 16169070 Q9NYS7 P08238 WSB2 HSP90AB1 0.126 22939624 Q9NYS7 P31948 WSB2 STIP1 0.126 25036637 Q9NYS7 Q6PK50 WSB2 HSP90AB1 0.126 25036637 Q9NYS7 Q96BE0 WSB2 Q96BE0 0.126 25036637 Q9NYS7 Q9HB71 WSB2 CACYBP 0.126 25036637 Q9UIM3 Q9NYS7 FKBPL WSB2 0.126 25036637 Q9Y266 Q9NYS7 NUDC WSB2 0.126 25036637 Q9NYS7 Q8IVD9 WSB2 NUDCD3 0.126 25036637 Q9NYS7 P07900 WSB2 HSP90AA1 0.126 22939624 Q9NYS7 Q99062 WSB2 CSF3R 0.523 17001306 Q9NYS7 Q93034 WSB2 CUL5 0.126 21145461 Q9NYS7 Q8WVJ2 WSB2 NUDCD2 0.126 25036637 Q9NYS7 Q9BPW0 WSB2 PPP5C 0.126 25036637 Q9NYS7 Q9BTE6 WSB2 AARSD1 0.126 25036637 Q9NYS7 Q99471 WSB2 PFDN5 0.126 25036637 Q9UHV9 Q9NYS7 PFDN2 WSB2 0.126 25036637 Q9NYS7 Q13619 WSB2 CUL4A 0.21 17079684 Q9NYS7 Q13451 WSB2 FKBP5 0.126 25036637 Q9NYS7 Q15717 WSB2 ELAVL1 0.126 19322201 Q9NYS7 Q15910 WSB2 EZH2 0.286 16169070 Q9NYS7 Q16531 WSB2 DDB1 0.21 17079684 Q9NYS7 Q03933 WSB2 HSF2 0.126 25036637 Q9NYS7 Q3UJD6 WSB2 USP19 0.126 25036637

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 SGTA WSB2 MI:0045 experimental interaction detection MI:0461 interaction database USP19 WSB2 MI:0362 inference MI:0461 interaction database RPN1 WSB2 MI:0045 experimental interaction detection MI:0461 interaction database HSP90AA1 WSB2 MI:0045 experimental interaction detection MI:0461 interaction database HSP90AB1 WSB2 MI:0045 experimental interaction detection MI:0461 interaction database UBC WSB2 MI:0362 inference MI:0461 interaction database STIP1 WSB2 MI:0045 experimental interaction detection MI:0461 interaction database HSF2 WSB2 MI:0045 experimental interaction detection MI:0461 interaction database FKBP5 WSB2 MI:0045 experimental interaction detection MI:0461 interaction database CUL4A WSB2 MI:0045 experimental interaction detection MI:0461 interaction database ELAVL1 WSB2 MI:0045 experimental interaction detection MI:0461 interaction database EZH2 WSB2 MI:0045 experimental interaction detection MI:0461 interaction database DDB1 WSB2 MI:0045 experimental interaction detection MI:0461 interaction database HACD4 WSB2 MI:0362 inference MI:0461 interaction database NUDCD3 WSB2 MI:0045 experimental interaction detection MI:0461 interaction database NUDCD2 WSB2 MI:0045 experimental interaction detection MI:0461 interaction database CUL5 WSB2 MI:0045 experimental interaction detection MI:0461 interaction database CSF3R WSB2 MI:0045 experimental interaction detection MI:0461 interaction database PFDN5 WSB2 MI:0045 experimental interaction detection MI:0461 interaction database AARSD1 WSB2 MI:0045 experimental interaction detection MI:0461 interaction database CACYBP WSB2 MI:0045 experimental interaction detection MI:0461 interaction database IL21R WSB2 MI:0045 experimental interaction detection MI:0461 interaction database WSB2 HACD3 MI:0362 inference MI:0461 interaction database WSB2 PFDN2 MI:0045 experimental interaction detection MI:0461 interaction database WSB2 FKBPL MI:0045 experimental interaction detection MI:0461 interaction database WSB2 NUDC MI:0045 experimental interaction detection MI:0461 interaction database