PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus CUL5 ASB8 26186194,24337577 biogrid exp GP GP G G GP GP G GP G G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G TCEB1 ASB8 19159283,21988832,24337577,12559969 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G ZC3H6 ASB8 24337577 biogrid exp GP GP G G GP GP G GP G G GP GP GP GP G GP GP G GP G GP GP GP GP GP G GP GP G ASB8 SERTAD1 21988832 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G KIF26B ASB8 24337577 biogrid exp P P GP P G P P P P P GP P P P P P P P P P TRIM11 ASB8 26186194 biogrid exp GP GP G G GP GP G GP G G GP GP GP GP G GP GP GP GP G GP GP GP P GP GP GP GP G RIN3 ASB8 25814554 biogrid,intact exp G GP G G G GP G GP G G G G GP GP G G GP G G G G G G GP G GP G GP G TUBB3 ASB8 24337577 biogrid exp GP GP G G GP GP G G G G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G ASB8 SLC25A13 24337577 biogrid exp G GP G G GP GP G GP G G GP GP GP GP G GP GP G GP G G G GP G GP GP GP GP G SLC25A6 ASB8 24337577 biogrid exp G GP G G GP GP G G G G GP GP G G G GP GP G GP G G G GP G GP G GP GP G RCN1 ASB8 21988832 biogrid,intact exp GP GP G G G GP G G G G GP G GP G G GP GP GP GP G GP GP GP G GP G G GP G ASB8 MOV10 22658674 biogrid exp G G G G G G G G G G G G G G G G G G G G G G MCM7 ASB8 21988832 biogrid,intact exp GP GP G G GP G G G G G G G G GP G GP G GP G G GP GP GP G GP G GP GP G ASB8 HIF1AN 26186194,24337577 biogrid exp GP GP G G GP GP G GP G G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G NPAT ASB8 26186194 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G TMED10 ASB8 24337577 biogrid exp GP GP G G GP GP G GP G G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G PCNA ASB8 24337577 biogrid exp GP GP G G GP G G G G G GP G G GP G GP G G GP G GP GP GP G GP GP GP GP G AMBRA1 ASB8 26186194,24337577 biogrid exp GP GP G G GP GP G GP G G GP GP GP G G GP GP G P G GP GP GP GP GP G GP GP G NEDD8 ASB8 24337577 biogrid exp GP GP G G GP GP G GP G G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G HOXD4 ASB8 20211142 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G ASB8 NXF1 22658674 biogrid exp GP GP G G GP GP G GP G G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G TCEB2 ASB8 24337577,12559969, 21836163 hprd,biogrid exp, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G RGL2 ASB8 16082366 pred GP GP G G G GP G GP G G GP GP G G G GP GP G GP G G GP G GP GP G GP GP G RGL4 ASB8 16082366 pred P G G P P P G P P P P P P G P PSMD10 ASB8 23023127 pred GP G G G G GP G G G G G G GP GP G GP GP GP GP G GP GP GP G GP G GP GP G RASGEF1B ASB8 16082366 pred P P P G P P P P P P P P P RALGDS ASB8 16082366 pred GP GP G G GP GP G GP G G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G ANKRD39 ASB8 23023127 pred GP GP G G GP GP G GP G G GP GP GP GP GP GP GP GP G P GP GP GP GP G GP GP G BCAR3 ASB8 16082366 pred GP GP G P GP G GP G G GP GP GP GP G GP GP G P G GP GP GP GP GP G GP GP G SOS1 ASB8 16082366 pred GP G G G GP G G GP G G GP G GP GP G GP G G GP G GP GP GP GP GP GP GP G G SOS2 ASB8 16082366 pred GP GP G G GP GP G GP G G GP G GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G RASGRP2 ASB8 16082366 pred G GP G G GP GP GP G G GP GP GP GP G GP GP P GP G P GP GP GP GP P G RAPGEF3 ASB8 16082366 pred GP P G P GP G GP G G GP P GP GP G P GP G GP GP GP GP GP P GP GP P G ASB8 RAPGEFL1 16082366 pred G G GP G P P P GP GP P P P P P P RALGPS2 ASB8 16082366 pred GP GP G GP P G P G GP GP P GP G GP P GP P GP P P GP GP GP GP RASGRP1 ASB8 16082366 pred G G G G G G G G G G G G G G G G G G G RASGEF1C ASB8 16082366 pred P P G P GP P G P P P P P GP P GP P P P P P P GP RASGRF2 ASB8 16082366 pred GP GP G G GP GP G GP G G GP P GP GP G GP GP GP GP G GP GP P GP GP GP GP GP G SH2D3C ASB8 16082366 pred GP G G G GP G G GP G G GP G G GP G G G G G GP G G G G GP GP GP G RNF103 ASB8 23023127 pred G GP G G GP GP G G G G GP G GP GP G GP GP GP GP G G GP G G GP G GP GP G RAPGEF1 ASB8 16082366 pred G GP G G GP GP G G G G GP G GP GP G GP GP G GP G GP GP G GP GP GP GP GP G ASB8 RGL1 16082366 pred GP GP G G GP GP G GP G G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P61129 Q9H765 affinity chromatography technology 24337577 physical association X 2 A0A024R6I3 Q9H765 affinity chromatography technology 24337577 physical association X 2 P12236 Q9H765 affinity chromatography technology 24337577 physical association X 2 Q9H765 Q15369-2 two hybrid 19159283 direct interaction X 2 Q9H765 C6EMX8 two hybrid 21988832 direct interaction X 2 Q9H765 Q15369-2 two hybrid 21988832 direct interaction X 2 Q9H765 Q93034 affinity chromatography technology 24337577 physical association X 2 Q9H765 Q9NWT6 affinity chromatography technology 24337577 physical association X 2 Q9H765 Q15369-2 affinity chromatography technology 24337577 physical association X 2 Q9H765 Q15369-2 pull down 12559969 direct interaction X 2 P12004 Q9H765 affinity chromatography technology 24337577 physical association X 2 Q53GC0 Q9H765 two hybrid 21988832 direct interaction X 2 Q9H765 Q15293 two hybrid 21988832 direct interaction X 2 Q9H765 Q15843 affinity chromatography technology 24337577 physical association X 2 Q9H765 Q15370-2 affinity chromatography technology 24337577 physical association X 2 Q9H765 Q53G92 affinity chromatography technology 24337577 physical association X 2 Q9H765 Q2KJY2 affinity chromatography technology 24337577 physical association X 2 Q9H765 affinity chromatography technology 24337577 physical association X 2 Q9H765 Q15370-2 pull down 12559969 direct interaction X 2 Q9H765 P09016 two hybrid 20211142 direct interaction X 2 Q9C0C7-4 Q9H765 affinity chromatography technology 24337577 physical association X 2 Q9H765 in vivo 12559969 - C 3 Q9H765 in vivo 12559969 - C 3 Q9H765 in vivo 12559969 - C 3 Q9H765 Q15370-2 in vitro 12559969 - X 2 Q9H765 Q15370-2 in vitro 12559969 - X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B HOXD4 ASB8 MI:0018(two hybrid) 20211142 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_128511 bait prey KIF26B ASB8 MI:0004(affinity chromatography technology) 24337577 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_309737 prey bait ASB8 SLC25A13 MI:0004(affinity chromatography technology) 24337577 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_309738 bait prey ASB8 SERTAD1 MI:0397(two hybrid array)|MI:0004(affinity chromatography technology) 21988832 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_120190|BIOGRID_286122 unspecified role|bait unspecified role|prey NRF1 ASB8 MI:0428(imaging technique) 24250222 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_295391 bait prey TCEB1 ASB8 MI:0492(in vitro)|MI:0096(pull down)|MI:0397(two hybrid array)|MI:0018(two hybrid)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 12559969,19159283,21988832,24337577 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction) MI:0468(hprd)|(biogrid)|(intact)|(biogrid)|(biogrid)|(biogrid) HPRD_40528|BIOGRID_100491|UniProt_120079|BIOGRID_197015|BIOGRID_309731|BIOGRID_286121 -|prey|unspecified role|bait|prey|prey -|bait|unspecified role|prey|bait|bait ZC3H6 ASB8 MI:0004(affinity chromatography technology) 24337577 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_309727 prey bait CUL5 ASB8 MI:0004(affinity chromatography technology) 24337577 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_309728 prey bait TMED10 ASB8 MI:0004(affinity chromatography technology) 24337577 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_309734 prey bait TCEB2 ASB8 MI:0492(in vitro)|MI:0096(pull down)|MI:0004(affinity chromatography technology)|MI:0492(in vitro) 12559969,24337577 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0407(direct interaction)|MI:0915(physical association)|- MI:0468(hprd)|(biogrid)|(biogrid)|MI:0468(hprd) HPRD_40528|BIOGRID_100490|BIOGRID_309732|HPRD_20032 -|prey|prey|- -|bait|bait|- AMBRA1 ASB8 MI:0004(affinity chromatography technology) 24337577 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_309736 prey bait TUBB3 ASB8 MI:0004(affinity chromatography technology) 24337577 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_309735 prey bait MCM7 ASB8 MI:0397(two hybrid array)|MI:0004(affinity chromatography technology) 21988832 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_120077|BIOGRID_286119 unspecified role|prey unspecified role|bait RCN1 ASB8 MI:0397(two hybrid array)|MI:0004(affinity chromatography technology) 21988832 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_120078|BIOGRID_286120 unspecified role|prey unspecified role|bait SLC25A6 ASB8 MI:0004(affinity chromatography technology) 24337577 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_309739 prey bait NEDD8 ASB8 MI:0004(affinity chromatography technology) 24337577 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_309730 prey bait PCNA ASB8 MI:0004(affinity chromatography technology) 24337577 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_309733 prey bait ASB8 HIF1AN MI:0004(affinity chromatography technology) 24337577 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_309729 bait prey

PPI - HINT Gene A Gene B PMID Method Quality NPAT ASB8 26186194 0004 HT TCEB1 ASB8 24337577,12559969 0004,0096 LC TCEB2 ASB8 12559969,24337577 0096,0004 LC CUL5 ASB8 24337577,26186194 0004,0004 LC,HT TRIM11 ASB8 26186194 0004 HT AMBRA1 ASB8 24337577,26186194 0004,0004 LC,HT ASB8 HIF1AN 26972000,24337577,26186194 0007,0004,0004 LC,HT NPAT ASB8 26186194 0004 HT CUL5 ASB8 26186194 0004 HT TRIM11 ASB8 26186194 0004 HT AMBRA1 ASB8 26186194 0004 HT ASB8 HIF1AN 26186194 0004 HT TCEB1 ASB8 24337577,12559969 0004,0096 LC TCEB2 ASB8 12559969,24337577 0096,0004 LC CUL5 ASB8 24337577 0004 LC AMBRA1 ASB8 24337577 0004 LC ASB8 HIF1AN 26972000,24337577 0007,0004 LC HOXD4 ASB8 20211142 0018 HT MCM7 ASB8 21988832 0018 HT RCN1 ASB8 21988832 0018 HT TCEB1 ASB8 21988832,19159283 0018,0018 HT,LC RIN3 ASB8 25814554,25814554 0397,0018 HT ASB8 SERTAD1 21988832 0018 HT ASB8 HEL-S-84 21988832 0018 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9HCE1 Q9H765 MOV10 ASB8 0.126 22658674 Q9H765 P12004 ASB8 PCNA 0.126 24337577 Q9H765 Q2KJY2 ASB8 KIF26B 0.126 24337577 Q9H765 Q13509 ASB8 TUBB3 0.126 24337577 Q9H765 P61129 ASB8 ZC3H6 0.126 24337577 Q9H765 P12236 ASB8 SLC25A6 0.126 24337577 Q9H765 P49755 ASB8 TMED10 0.126 24337577 Q9H765 Q14207 ASB8 NPAT 0.126 26186194 Q9H765 Q15843 ASB8 NEDD8 0.126 24337577 Q9H765 Q96F44 ASB8 TRIM11 0.126 26186194 Q9UJS0 Q9H765 SLC25A13 ASB8 0.126 24337577 Q9NWT6 Q9H765 HIF1AN ASB8 0.332 26972000,24337577,26186194 Q9H765 P09016 ASB8 HOXD4 0.183 20211142 Q9H765 Q93034 ASB8 CUL5 0.236 24337577,26186194 Q9H765 P33993 ASB8 MCM7 0.332 21988832 Q9H765 Q15370 ASB8 TCEB2 0.396 12559969,24337577 Q9H765 Q9C0C7 ASB8 AMBRA1 0.236 24337577,26186194 Q9H765 Q8TB24 ASB8 RIN3 0.286 25814554 Q9UBU9 Q9H765 NXF1 ASB8 0.126 22658674 Q9UHV2 Q9H765 SERTAD1 ASB8 0.332 21988832 Q9H765 Q15293 ASB8 RCN1 0.332 21988832 Q9H765 Q15369 ASB8 TCEB1 0.722 12559969,19159283,21988832,24337577

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 HOXD4 ASB8 MI:0045 experimental interaction detection MI:0461 interaction database PCNA ASB8 MI:0045 experimental interaction detection MI:0461 interaction database SLC25A6 ASB8 MI:0045 experimental interaction detection MI:0461 interaction database MCM7 ASB8 MI:0045 experimental interaction detection MI:0461 interaction database TMED10 ASB8 MI:0045 experimental interaction detection MI:0461 interaction database ZC3H6 ASB8 MI:0045 experimental interaction detection MI:0461 interaction database TUBB3 ASB8 MI:0045 experimental interaction detection MI:0461 interaction database NPAT ASB8 MI:0045 experimental interaction detection MI:0461 interaction database RCN1 ASB8 MI:0045 experimental interaction detection MI:0461 interaction database TCEB1 ASB8 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database TCEB2 ASB8 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database NEDD8 ASB8 MI:0045 experimental interaction detection MI:0461 interaction database KIF26B ASB8 MI:0045 experimental interaction detection MI:0461 interaction database RIN3 ASB8 MI:0045 experimental interaction detection MI:0461 interaction database CUL5 ASB8 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database TRIM11 ASB8 MI:0045 experimental interaction detection MI:0461 interaction database AMBRA1 ASB8 MI:0045 experimental interaction detection MI:0461 interaction database ASB8 MOV10 MI:0045 experimental interaction detection MI:0461 interaction database ASB8 HIF1AN MI:0045 experimental interaction detection MI:0461 interaction database ASB8 RNF7 MI:0362 inference MI:1106 pathways database ASB8 NXF1 MI:0045 experimental interaction detection MI:0461 interaction database ASB8 SERTAD1 MI:0045 experimental interaction detection MI:0461 interaction database ASB8 SLC25A13 MI:0045 experimental interaction detection MI:0461 interaction database