PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus XIAP DTX3 22493164 biogrid,intact exp GP GP G G G GP G GP GP G GP GP G G G GP GP G P G G G GP G GP G GP GP G UBE2L6 DTX3 19549727 biogrid,intact exp GP GP G G GP GP G G GP G GP GP G G G GP GP GP P G G G GP G GP GP GP GP G USP1 DTX3 23105109 biogrid exp GP GP G G GP GP G G GP G GP GP G G G GP GP G G G G GP GP GP GP GP GP G MAPK9 DTX3 26186194 biogrid exp G GP G G G GP G G GP G GP GP G G G GP GP GP P G G G GP GP GP GP GP GP G UBE2D3 DTX3 19549727 biogrid,intact exp GP G G G GP GP G G GP G GP GP G G G G GP GP P G G G G GP G GP GP GP G DTX3 RNF38 22493164 biogrid,intact exp GP GP G G G GP G G GP G GP GP G G G GP GP GP P G G G GP GP GP G GP GP G UBE2K DTX3 25416956,19549727 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP G G G GP GP GP P G G G GP GP GP GP GP GP G DTX3 UBE2E3 19549727 biogrid,intact exp GP GP G G G GP G G GP G GP G G G G GP GP GP G G G G GP GP G GP GP G UBE2DNL DTX3 19549727 intact exp DTX3 TRAF4 22493164 biogrid,intact exp G GP G GP G P GP G GP GP G G G GP GP G P G G G GP P GP G GP GP G USP2 DTX3 23105109 biogrid exp GP G P GP G GP P G GP GP G G P GP GP P G G GP GP GP P P GP G UBE2D2 DTX3 19549727 biogrid,intact exp GP G G G GP GP G G GP G GP GP G G G G GP GP P G G G G GP G GP GP GP G UEVLD DTX3 19549727 biogrid,intact exp GP GP G G G GP G GP GP G GP GP G G G GP GP G P G G G GP GP GP GP GP GP G ZDHHC17 DTX3 24705354 biogrid,intact exp G GP G G GP GP G G GP G GP GP G G G GP GP G P G G G GP G GP GP GP GP G UBE2V1 DTX3 19549727 biogrid,intact exp DTX3 NARFL 26186194 biogrid exp GP P G G GP GP GP P G GP GP G G GP GP P G G GP GP P P P GP NDUFS6 DTX3 26186194 biogrid exp GP GP G G GP GP G GP GP G GP GP G G G GP GP GP P G G G GP GP GP GP GP GP G NDUFAF5 DTX3 26186194 biogrid exp G GP G G G GP G GP GP G GP GP G G G GP GP GP G G G GP G GP G GP GP G DTX3 FARSB 26186194 biogrid exp G G G G G GP G GP GP G GP G G G G GP GP GP P G G G G GP GP G GP GP G DTX3 USP21 23105109 biogrid exp GP GP G G G GP G GP GP G GP GP G G G GP GP G P G G G GP G GP G GP GP G UBE2L3 DTX3 19549727 biogrid,intact exp GP G G G G GP G GP GP G GP G G G G GP GP G P G G G GP GP GP G GP GP G UBE2E1 DTX3 19549727 biogrid,intact exp GP GP G G G GP G G GP G GP G G G G GP GP GP G G G G GP GP G GP GP G UBE2D1 DTX3 19549727 biogrid,intact exp GP G G G GP GP G G GP G GP GP G G G G GP GP P G G G G GP G GP GP GP G DTX3 UBE2E2 19549727 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP G G G GP GP GP P G G G GP GP GP GP GP GP G DTX3 NMD3 26186194 biogrid exp G GP G G G GP G GP GP G GP G G G G GP GP G G G G GP G GP G G G G LYN DTX3 23503679 biogrid exp GP G G G GP GP G G GP G G G G G G GP GP G P G G G GP GP GP GP G G DTX3 UBE2W 19549727 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP G G G GP GP GP P G G G GP GP GP GP GP GP G ITSN1 DTX3 26186194 biogrid exp G GP G G G GP G GP GP G GP GP G G G GP GP G G G G GP GP GP G GP GP G DTX3 CHFR 26186194 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2H DTX3 19549727 biogrid,intact exp GP GP G G GP GP G GP G G GP GP G G G GP GP GP P G G G GP GP GP GP GP GP G DTX3 RNF114 26186194 biogrid exp GP GP G G GP GP G GP GP G GP GP G G G GP GP GP P G G G GP GP GP GP GP GP G DTX3 RNF141 22493164 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP G G G GP GP GP P G G G GP GP GP GP GP GP G DTX3 UBE2D4 19549727 biogrid,intact exp GP G G G GP GP G G GP G GP GP G G G G GP GP P G G G G GP G GP GP GP G DTX3 DTX3 11226752 hprd exp, ortho GP GP G G GP GP G GP GP G GP GP G G G GP GP GP P G G G GP GP GP GP GP GP G DTX2 DTX3 11226752, 25402006, 23023127 hprd exp, ortho, pred GP P P P GP GP P GP G G GP P G P G G G GP GP P G GP GP G DTX1 DTX3 11226752, 23023127 hprd exp, pred GP G G G G GP G G GP G GP GP G G GP GP P G GP G GP G GP GP G NOTCH1 DTX3 23023127 pred GP GP G G GP GP G GP GP G GP GP G G G GP GP GP P G G G GP GP GP GP GP GP G CFD DTX3 23023127 pred G G G G G G GP GP GP G G G G G G G G G G G G G G GP G SPATA21 DTX3 23023127 pred P P P P P P P P P P P P P P P P MIB1 DTX3 23023127 pred GP GP G G GP GP G G GP G GP GP G G G GP GP GP P G G G GP G GP G GP GP G DHDDS DTX3 21836163 pred GP GP G G G GP G GP GP G GP GP G G G GP GP GP P G G G GP GP GP G GP GP G

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B UBE2H DTX3 MI:0018(two hybrid)|MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_101358|BIOGRID_124318 bait|bait prey|prey DTX3 UBE2D4 MI:0018(two hybrid)|MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_124062|UniProt_101165 prey|prey bait|bait UBE2V1 DTX3 MI:0018(two hybrid)|MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_101409|BIOGRID_124320 bait|bait prey|prey DTX2 DTX3 MI:0018(two hybrid) 11226752 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_16308 - - UBE2K DTX3 MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_124064 bait prey DTX3 RNF38 MI:0415(enzymatic study)|MI:0397(two hybrid array) 22493164 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_284112|UniProt_122613 prey|prey bait|bait USP1 DTX3 MI:0018(two hybrid) 23105109 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_248199 bait prey DTX1 DTX3 MI:0018(two hybrid) 11226752 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_11096 - - DTX3 HIP2 MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_100982 prey bait USP2 DTX3 MI:0018(two hybrid) 23105109 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_248179 bait prey UBE2D3 DTX3 MI:0018(two hybrid)|MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_101068|BIOGRID_124061 bait|bait prey|prey UBE2D2 DTX3 MI:0018(two hybrid)|MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_124060|UniProt_101046 bait|bait prey|prey DTX3 DTX3 MI:0018(two hybrid) 11226752 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_19842 - - UBE2L3 DTX3 MI:0018(two hybrid)|MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_101384|BIOGRID_124319 bait|bait prey|prey ZDHHC17 DTX3 MI:0397(two hybrid array)|MI:0397(two hybrid array) 24705354 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (intact)|(intact) UniProt_133272|UniProt_176503 bait|bait prey|prey DTX3 RNF141 MI:0397(two hybrid array) 22493164 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_122545 prey bait DTX3 UBE2E3 MI:0018(two hybrid)|MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_124317|UniProt_101435 prey|prey bait|bait UEVLD DTX3 MI:0018(two hybrid)|MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_124323|UniProt_101498 bait|bait prey|prey DTX3 UBE2E2 MI:0018(two hybrid)|MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_124322|UniProt_101329 prey|prey bait|bait UBE2E1 DTX3 MI:0018(two hybrid)|MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_124316|UniProt_101314 bait|bait prey|prey DTX3 UBE2W MI:0018(two hybrid)|MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_124321|UniProt_101495 prey|prey bait|bait LYN DTX3 MI:0004(affinity chromatography technology) 23503679 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_279518 bait prey UBE2DNL DTX3 MI:0018(two hybrid)|MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_124324|UniProt_101526 bait|bait prey|prey DTX3 TRAF4 MI:0397(two hybrid array)|MI:0415(enzymatic study) 22493164 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_122517|BIOGRID_284158 prey|prey bait|bait UBE2D1 DTX3 MI:0018(two hybrid)|MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_101020|BIOGRID_124059 bait|bait prey|prey DTX3 USP21 MI:0018(two hybrid) 23105109 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_248221 prey bait UBE2L6 DTX3 MI:0018(two hybrid)|MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_124063|UniProt_101127 bait|bait prey|prey XIAP DTX3 MI:0397(two hybrid array)|MI:0415(enzymatic study) 22493164 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_122460|BIOGRID_284100 bait|bait prey|prey

PPI - HINT Gene A Gene B PMID Method Quality NDUFS6 DTX3 26186194 0004 HT MAPK9 DTX3 26186194 0004 HT ITSN1 DTX3 26186194 0004 HT NDUFAF5 DTX3 26186194 0004 HT DTX3 NMD3 26186194 0004 HT DTX3 CHFR 26186194 0004 HT DTX3 NARFL 26186194 0004 HT DTX3 FARSB 26186194 0004 HT DTX3 RNF114 26186194 0004 HT NDUFS6 DTX3 26186194 0004 HT MAPK9 DTX3 26186194 0004 HT ITSN1 DTX3 26186194 0004 HT NDUFAF5 DTX3 26186194 0004 HT DTX3 NMD3 26186194 0004 HT DTX3 CHFR 26186194 0004 HT DTX3 NARFL 26186194 0004 HT DTX3 FARSB 26186194 0004 HT DTX3 RNF114 26186194 0004 HT HIP2 DTX3 19549727 0397 HT UBE2L6 DTX3 19549727,19549727 0397,0018 HT USP2 DTX3 23105109 0018 LC USP1 DTX3 23105109 0018 LC UBE2D1 DTX3 19549727,19549727 0397,0018 HT UBE2E1 DTX3 19549727,19549727 0397,0018 HT UBE2D3 DTX3 19549727,19549727 0397,0018 HT UBE2K DTX3 25416956,25416956,25416956,19549727,25416956 1356,1112,0397,0018,0018 HT UBE2H DTX3 19549727,19549727 0397,0018 HT UBE2D2 DTX3 19549727,19549727 0397,0018 HT UBE2L3 DTX3 19549727,19549727 0397,0018 HT XIAP DTX3 22493164,22493164 0018,0397 HT UBE2V1 DTX3 19549727,19549727 0397,0018 HT DTX2 DTX3 11226752 0018 LC DTX1 DTX3 11226752 0018 LC ZDHHC17 DTX3 24705354,24705354 0397,0018 HT UBE2DNL DTX3 19549727,19549727 0397,0018 HT UEVLD DTX3 19549727,19549727 0397,0018 HT DTX3 DTX3 11226752 0018 LC DTX3 RNF141 22493164,22493164 0018,0397 HT DTX3 UBE2E3 19549727,19549727 0397,0018 HT DTX3 UBE2W 19549727,19549727 0397,0018 HT DTX3 UBE2E2 19549727,19549727 0397,0018 HT DTX3 TRAF4 22493164,22493164 0018,0397 HT DTX3 RNF38 22493164,22493164 0018,0397 HT DTX3 USP21 23105109 0018 LC DTX3 UBE2D4 19549727,19549727 0397,0018 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q8N9I9 B3KSH4 DTX3 HIP2 0.126 19549727 Q8N9I9 P61077 DTX3 UBE2D3 0.286 19549727 Q8N9I9 O43639 DTX3 NCK2 0.236 unassigned1304 Q8N9I9 O75380 DTX3 NDUFS6 0.126 26186194 Q8N9I9 P45984 DTX3 MAPK9 0.126 26186194 Q8N9I9 P51668 DTX3 UBE2D1 0.523 19549727,unassigned1304 Q8N9I9 P51965 DTX3 UBE2E1 0.376 19549727 Q8N9I9 P62256 DTX3 UBE2H 0.376 19549727 Q8N9I9 Q13404 DTX3 UBE2V1 0.376 19549727 Q8N9I9 Q15811 DTX3 ITSN1 0.126 26186194 Q8N9I9 Q5TEU4 DTX3 NDUFAF5 0.126 26186194 Q8N9I9 Q8IUH5 DTX3 ZDHHC17 0.286 24705354 Q969T4 Q8N9I9 UBE2E3 DTX3 0.376 19549727 Q96B02 Q8N9I9 UBE2W DTX3 0.376 19549727 Q96D46 Q8N9I9 NMD3 DTX3 0.126 26186194 Q96EP1 Q8N9I9 CHFR DTX3 0.126 26186194 Q96LR5 Q8N9I9 UBE2E2 DTX3 0.376 19549727 Q9H0F5 Q8N9I9 RNF38 DTX3 0.286 22493164 Q9H6Q4 Q8N9I9 NARFL DTX3 0.126 26186194 Q9NSD9 Q8N9I9 FARSB DTX3 0.126 26186194 Q9Y2X8 Q8N9I9 UBE2D4 DTX3 0.376 19549727 Q9Y508 Q8N9I9 RNF114 DTX3 0.126 26186194 Q8N9I9 Q8IWF7 DTX3 UBE2DNL 0.126 19549727 Q8N9I9 P07948 DTX3 LYN 0.126 23503679 Q8N9I9 O75604 DTX3 USP2 0.183 23105109 Q8N9I9 O94782 DTX3 USP1 0.183 23105109 Q9NR21 Q8N9I9 PARP11 DTX3 0.236 unassigned1304 Q8N9I9 Q8IX04 DTX3 UEVLD 0.286 19549727 Q8N9I9 Q13882 DTX3 PTK6 0.236 unassigned1304 Q8N9I9 J3QRU1 DTX3 YES1 {ECO:0000313|ENSEMBL:ENSP00000464380} 0.236 unassigned1304 Q8N9I9 O95817 DTX3 BAG3 0.236 unassigned1304 Q96E35 Q8N9I9 ZMYND19 DTX3 0.236 unassigned1304 Q8N9I9 Q7L775 DTX3 EPM2AIP1 0.236 unassigned1304 Q8N9I9 Q86YD7 DTX3 FAM90A1 0.236 unassigned1304 Q8NI38 Q8N9I9 NFKBID DTX3 0.236 unassigned1304 Q8N9I9 P06241 DTX3 FYN 0.236 unassigned1304 Q8N9I9 P98170 DTX3 XIAP 0.286 22493164 Q8N9I9 P62837 DTX3 UBE2D2 0.286 19549727 Q8N9I9 P62993 DTX3 GRB2 0.236 unassigned1304 Q8N9I9 P57075 DTX3 UBASH3A 0.236 unassigned1304 Q8N9I9 P61086 DTX3 UBE2K 0.659 25416956,19549727,unassigned1304 Q9BUZ4 Q8N9I9 TRAF4 DTX3 0.454 unassigned1304,22493164 Q8N9I9 O14933 DTX3 UBE2L6 0.454 19549727,unassigned1304 Q8WVD5 Q8N9I9 RNF141 DTX3 0.286 22493164 Q9UK80 Q8N9I9 USP21 DTX3 0.183 23105109 Q8N9I9 P68036 DTX3 UBE2L3 0.286 19549727

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 UBE2L6 DTX3 MI:0045 experimental interaction detection MI:0461 interaction database NDUFS6 DTX3 MI:0045 experimental interaction detection MI:0461 interaction database USP2 DTX3 MI:0045 experimental interaction detection MI:0461 interaction database USP1 DTX3 MI:0045 experimental interaction detection MI:0461 interaction database LYN DTX3 MI:0045 experimental interaction detection MI:0461 interaction database MAPK9 DTX3 MI:0045 experimental interaction detection MI:0461 interaction database UBE2D1 DTX3 MI:0045 experimental interaction detection MI:0461 interaction database UBE2E1 DTX3 MI:0045 experimental interaction detection MI:0461 interaction database UBE2D3 DTX3 MI:0045 experimental interaction detection MI:0461 interaction database UBE2K DTX3 MI:0045 experimental interaction detection MI:0461 interaction database UBE2H DTX3 MI:0045 experimental interaction detection MI:0461 interaction database UBE2D2 DTX3 MI:0045 experimental interaction detection MI:0461 interaction database UBE2L3 DTX3 MI:0045 experimental interaction detection MI:0461 interaction database XIAP DTX3 MI:0045 experimental interaction detection MI:0461 interaction database UBE2V1 DTX3 MI:0045 experimental interaction detection MI:0461 interaction database ITSN1 DTX3 MI:0045 experimental interaction detection MI:0461 interaction database NDUFAF5 DTX3 MI:0045 experimental interaction detection MI:0461 interaction database DTX2 DTX3 MI:0362 inference MI:0461 interaction database DTX1 DTX3 MI:0362 inference MI:0461 interaction database ZDHHC17 DTX3 MI:0045 experimental interaction detection MI:0461 interaction database UBE2DNL DTX3 MI:0045 experimental interaction detection MI:0461 interaction database UEVLD DTX3 MI:0045 experimental interaction detection MI:0461 interaction database DTX3 RNF141 MI:0045 experimental interaction detection MI:0461 interaction database DTX3 UBE2E3 MI:0045 experimental interaction detection MI:0461 interaction database DTX3 UBE2W MI:0045 experimental interaction detection MI:0461 interaction database DTX3 NMD3 MI:0045 experimental interaction detection MI:0461 interaction database DTX3 CHFR MI:0045 experimental interaction detection MI:0461 interaction database DTX3 UBE2E2 MI:0045 experimental interaction detection MI:0461 interaction database DTX3 TRAF4 MI:0045 experimental interaction detection MI:0461 interaction database DTX3 RNF38 MI:0045 experimental interaction detection MI:0461 interaction database DTX3 NARFL MI:0045 experimental interaction detection MI:0461 interaction database DTX3 FARSB MI:0045 experimental interaction detection MI:0461 interaction database DTX3 USP21 MI:0045 experimental interaction detection MI:0461 interaction database DTX3 DTX4 MI:0362 inference MI:0461 interaction database DTX3 UBE2D4 MI:0045 experimental interaction detection MI:0461 interaction database DTX3 RNF114 MI:0045 experimental interaction detection MI:0461 interaction database