PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus KCTD2 SMC1A 26496610 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G KCTD2 TDRD3 24778252 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G KCTD2 MIS12 26496610 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G KCTD2 HUWE1 26496610 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G NPM1 KCTD2 23402259 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G KCTD2 TMEM255A 26186194 biogrid exp G G G G G G G G G G G KCTD2 DLG3 26496610 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G KCTD2 GTPBP4 24778252 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G KCTD2 ARRDC1 26186194 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G CUL3 KCTD2 21145461 biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G KCTD2 KCTD17 26186194, 25402006, 16082366 biogrid exp, pred G G G G G G G CALR KCTD2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SCRIB KCTD2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G KCTD2 KCTD2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PAX6 KCTD2 ortho G G G G G G G G G G KCTD2 KLHL8 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G RAPSN KCTD2 ortho G G PSMA7 KCTD2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G KCTD2 RAB3IL1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PSMD2 KCTD2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G KCTD2 JMJD6 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G KCTD2 GTPBP2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G KCTD2 KCTD5 25402006, 16082366 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G KCTD2 GORASP2 16082366 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P0CG48 Q14681 affinity chromatography technology 21906983 physical association X 2 Q14681 D2CFK9 affinity chromatography technology 24778252 physical association X 2 Q14681 affinity chromatography technology 24778252 physical association X 2 Q14681 affinity chromatography technology 20360068 physical association X 2 Q14681 A0A024R475 affinity chromatography technology 21145461 physical association X 2 Q14681 P06748-2 affinity chromatography technology 23402259 physical association X 2 Q14681 tandem affinity purification 20360068 physical association C 4

PPI - HINT Gene A Gene B PMID Method Quality CUL3 KCTD2 21145461 0004 HT KCTD2 SMC1A 26496610,26496610 0007,0004 HT KCTD2 Q7Z4S8 26186194 0004 HT KCTD2 HUWE1 26496610,26496610 0007,0004 HT KCTD2 ARRDC1 26186194 0004 HT KCTD2 KCTD17 26186194 0004 HT KCTD2 DLG3 26496610,26496610 0007,0004 HT KCTD2 MIS12 26496610,26496610 0007,0004 HT CUL3 KCTD2 21145461 0004 HT KCTD2 SMC1A 26496610,26496610 0007,0004 HT KCTD2 Q7Z4S8 26186194 0004 HT KCTD2 HUWE1 26496610,26496610 0007,0004 HT KCTD2 ARRDC1 26186194 0004 HT KCTD2 KCTD17 26186194 0004 HT KCTD2 DLG3 26496610,26496610 0007,0004 HT KCTD2 MIS12 26496610,26496610 0007,0004 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q5JRV8 Q14681 TMEM255A KCTD2 0.126 26186194 Q8N5I2 Q14681 ARRDC1 KCTD2 0.126 26186194 Q8N5Z5 Q14681 KCTD17 KCTD2 0.126 26186194 Q9H7E2 Q14681 TDRD3 KCTD2 0.126 24778252 Q14681 P06748 KCTD2 NPM1 0.126 23402259 Q92796 Q14681 DLG3 KCTD2 0.236 26496610 Q14683 Q14681 SMC1A KCTD2 0.236 26496610 Q9H081 Q14681 MIS12 KCTD2 0.236 26496610 Q7Z6Z7 Q14681 HUWE1 KCTD2 0.236 26496610 Q14681 A2AUM9 KCTD2 CEP152 0.236 26496610 Q8VC57 Q14681 KCTD5 KCTD2 0.416 26496610,20360068 Q9BZE4 Q14681 GTPBP4 KCTD2 0.126 24778252 Q14681 Q13618 KCTD2 CUL3 0.126 21145461

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 PSMA7 KCTD2 MI:0362 inference MI:0461 interaction database HPGDS KCTD2 MI:0362 inference MI:0461 interaction database CEP152 KCTD2 MI:0362 inference MI:0461 interaction database NPM1 KCTD2 MI:0045 experimental interaction detection MI:0461 interaction database UBC KCTD2 MI:0045 experimental interaction detection MI:0461 interaction database CALR KCTD2 MI:0362 inference MI:0461 interaction database PSMD2 KCTD2 MI:0362 inference MI:0461 interaction database CUL3 KCTD2 MI:0045 experimental interaction detection MI:0461 interaction database RAPSN KCTD2 MI:0362 inference MI:0461 interaction database GIT2 KCTD2 MI:0362 inference MI:0461 interaction database KCTD2 SMC1A MI:0045 experimental interaction detection MI:0461 interaction database KCTD2 TMEM255A MI:0045 experimental interaction detection MI:0461 interaction database KCTD2 JMJD6 MI:0362 inference MI:0461 interaction database KCTD2 HUWE1 MI:0045 experimental interaction detection MI:0461 interaction database KCTD2 ARRDC1 MI:0045 experimental interaction detection MI:0461 interaction database KCTD2 KCTD17 MI:0045 experimental interaction detection MI:0461 interaction database KCTD2 PSMA8 MI:0362 inference MI:0461 interaction database KCTD2 RAB3IL1 MI:0362 inference MI:0461 interaction database KCTD2 DLG3 MI:0045 experimental interaction detection MI:0461 interaction database KCTD2 RAB3IP MI:0362 inference MI:0461 interaction database KCTD2 GTPBP4 MI:0045 experimental interaction detection MI:0461 interaction database KCTD2 MIS12 MI:0045 experimental interaction detection MI:0461 interaction database KCTD2 TDRD3 MI:0045 experimental interaction detection MI:0461 interaction database KCTD2 THUMPD1 MI:0362 inference MI:0461 interaction database KCTD2 KCTD5 MI:0362 inference MI:0461 interaction database KCTD2 ANAPC11 MI:0362 inference MI:0461 interaction database KCTD2 GIT1 MI:0362 inference MI:0461 interaction database