PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus KIAA0753 PJA1 24613305 biogrid exp GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G PJA1 OTUB1 22626734 biogrid exp GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G JOSD1 PJA1 22626734 biogrid exp GP GP G G G GP G GP GP G GP G GP G G GP GP GP GP G GP GP GP GP GP G GP G G PJA1 OTUB2 22626734 biogrid exp P P P P P P P P GP HNRNPL PJA1 16169070 hprd,i2d,mint,intact exp GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G PJA1 PJA1 21513699,12036302 biogrid exp GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G XPO1 PJA1 26673895 biogrid exp GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G PJA1 RNF126 26186194 biogrid exp GP G G G GP GP G G GP G GP G GP GP G GP GP GP P G GP GP G G GP GP GP GP G PJA1 ASCC2 16169070 hprd,biogrid,i2d,mint,intact exp GP GP G G P GP GP GP G GP GP G GP P GP P G GP GP GP GP GP GP GP GP G BCAT1 PJA1 26186194 biogrid exp GP GP G G GP GP G G GP G GP G G G GP GP GP GP G GP GP GP G GP GP GP G PJA1 USP7 22626734 biogrid exp GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G PJA1 FAF2 26186194 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G ATP5C1 PJA1 16169070 hprd,biogrid,i2d,mint,intact exp G GP G G GP GP G GP GP G GP G GP G G GP GP G GP G G G GP G GP G GP GP G PJA1 USP20 22626734 biogrid exp GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G PJA1 ATXN3L 22626734 biogrid exp P P G GP P G P P P P P P P GP P P GP GP P P GP G GSR PJA1 16169070 innatedb,hprd,biogrid,i2d,mint,intact exp GP GP G G GP GP G G GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G ATXN3 PJA1 22626734 biogrid exp GP GP G G GP GP G GP GP G GP G GP GP G P GP GP P G GP GP GP GP GP GP GP GP G MORC1 PJA1 26186194 biogrid exp P P P P P GP PJA1 SFXN3 26186194 biogrid exp G GP G GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G EED PJA1 21513699 biogrid exp GP GP G G G GP G GP GP G GP G GP GP G GP GP GP GP G GP G GP GP GP GP GP GP G PJA1 AP2M1 26186194 biogrid exp GP GP G G G GP G GP GP G GP G GP GP G GP GP G GP G GP G G G GP G GP GP G PNKD PJA1 26186194 biogrid exp GP GP G G G GP G GP GP G GP G GP G G GP GP G GP G G GP GP GP GP G GP GP G SMAD3 PJA1 18729074 innatedb,biogrid,intact exp GP GP G G G GP G G G G G G GP GP G G GP G GP G GP G G G G G G G G IRAK1 PJA1 21903422 innatedb,biogrid exp GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G ZNF440 PJA1 16169070 hprd,i2d,mint,intact exp P GP P G P GP GP G P GP GP GP GP P G GP GP GP G GP GP GP GP G UBE2U PJA1 19690564 biogrid,intact exp P P P P P P P P P P P P P P P P P P P GP SUZ12 PJA1 21513699 biogrid exp G G G G GP G G G GP G GP G G GP G GP G G G G GP G G G GP G GP G G PJA1 NDNL2 20864041 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G STAMBP PJA1 22626734 biogrid exp GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G RBFOX2 PJA1 26186194 biogrid exp G GP G G GP GP G G GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G UCHL3 PJA1 22626734 biogrid exp GP GP G G GP GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G PJA1 USP28 22626734 biogrid exp GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G TALDO1 PJA1 26186194 biogrid exp GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G UBC PJA1 16196087 biogrid exp GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G PJA1 RIBC2 16169070 hprd,biogrid,i2d,intact exp P P P P P P P P GP EZH2 PJA1 23688634,21513699 biogrid exp GP P G GP GP P GP G GP G P P P GP GP GP GP ESPL1 PJA1 22626734 biogrid exp GP GP G G GP GP GP GP G GP G GP GP G GP GP GP GP G GP P GP GP GP GP GP GP G KIF22 PJA1 16169070 hprd,biogrid,i2d,mint,intact exp GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G DNAJB2 PJA1 26186194 biogrid exp GP GP G G GP GP G G GP G GP G GP G G GP GP GP GP G GP GP GP GP GP GP GP GP G SPTBN1 PJA1 16247473 biogrid exp GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G PJA1 STAM 22626734 biogrid exp GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP G GP G GP GP G F12 PJA1 26186194 biogrid exp G G G G P G P G G G G G G G G P G GP G G G P G USP8 PJA1 22626734 biogrid exp, ortho G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G USP5 PJA1 22626734 biogrid exp, ortho GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP G GP GP GP GP GP G PJA1 USP36 26186194 biogrid exp, ortho G G G G G GP G G GP G GP G G GP G G GP G G G G GP G GP G G G G G PJA1 USP9X 22544753 biogrid exp, ortho GP GP G G GP GP G G GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G USP51 PJA1 22626734 biogrid exp, ortho GP GP G G GP GP G GP P G GP P GP G P GP GP GP G GP GP P P GP P GP PJA1 UCHL5 22626734 biogrid exp, ortho GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G PJA1 MAGED1 11959851,20864041, 25402006 hprd,biogrid,intact exp, ortho, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PJA1 NDN 11959851, 25402006 hprd exp, ortho, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G MDM2 PJA1 10722742, 21836163 hprd exp, pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G UBE2L3 PJA1 21513699, 23023127 biogrid exp, pred GP G G G G GP G GP GP G GP G G G G GP GP G GP G G G GP GP GP G GP GP G UBE2D3 PJA1 22626734, 21836163 biogrid exp, pred GP G G G GP GP G G GP G GP G GP GP G G GP GP GP G GP GP G GP G GP GP GP G UBE2D2 PJA1 12036302, 21836163 hprd,biogrid exp, pred GP G G G GP GP G G GP G GP G GP GP G G GP GP GP G GP GP G GP G GP GP GP G MSX2 PJA1 25402006 ortho, pred P P P P P P P P G P P P GP P P P P P GP G PJA1 TRIM5 21836163 pred GP GP G GP P G GP GP GP G GP GP G GP P GP GP G GP GP GP P GP GP GP P G UBE2N PJA1 23023127 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G PJA1 MYLIP 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G TTC19 PJA1 21836163 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G PJA1 LNX1 23023127, 21836163 pred GP G G GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP G GP P GP GP RNF103 PJA1 23023127 pred G GP G G GP GP G G GP G GP G GP GP G GP GP GP GP G G GP G G GP G GP GP G PRKCG PJA1 23023127 pred G G G G G GP G G G G G G G GP G G G G G G G G RNF144B PJA1 21836163 pred G GP G G G GP G GP GP G GP G GP G G GP GP GP GP G GP G G G GP G G GP G PJA1 AMFR 21836163 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G LRSAM1 PJA1 21836163 pred P GP G P GP G P GP G GP G P GP P GP GP GP G P GP P P P GP P P G PJA1 RCHY1 23023127 pred G GP G G G GP G GP GP G GP G GP G G GP GP G GP G G G GP G GP G GP G G RNF20 PJA1 21836163 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G CD2BP2 PJA1 25402006 pred GP GP G G GP GP G GP GP G GP GP GP G GP GP G GP G GP GP GP G GP GP GP GP G UBE3C PJA1 21836163 pred G GP G G GP GP G GP GP G GP G GP G G GP GP G GP G GP GP GP GP GP GP GP GP G PJA1 STUB1 23023127 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G PJA1 TRIM11 21836163 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP P GP GP GP GP G CNOT4 PJA1 21836163 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G XIAP PJA1 25402006 pred GP GP G G G GP G GP GP G GP G GP GP G GP GP G GP G G GP GP G GP G GP GP G PJA1 FANCL 21836163 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G UCHL1 PJA1 23023127 pred G G G G G GP G G GP G GP G G G G G GP G GP G G G G G G G G GP G PJA1 UHRF1 21836163 pred G G G G G G G G G G G G G G G SPTAN1 PJA1 25402006 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G NGFR PJA1 25402006 pred GP G G P P G G G G G G P G G G TRAF7 PJA1 21836163 pred GP GP G G G GP G GP GP G GP G GP G G GP GP G G G G G GP GP GP G GP GP G OPHN1 PJA1 21836163 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G PJA1 CHFR 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PJA1 TRIM9 23023127 pred G G G G G G G G G G G TTC3 PJA1 23023127 pred P P P P P PJA1 RNF11 23023127 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G PJA1 MAP3K3 25402006 pred G G G G GP GP G GP G G GP G GP GP G GP GP G G G GP G G G GP GP GP G G MIB1 PJA1 21836163 pred GP GP G G GP GP G G GP G GP G G GP G GP GP GP GP G GP GP GP G GP G GP GP G UBE2K PJA1 23023127 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G PJA1 RNF25 21836163 pred P G P P P P P P P P P P P P GP P P BRAP PJA1 21836163 pred P P G GP P GP P P P P G GP P P G GP P GP GP GP P P GP GOLGA7 PJA1 21836163 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G NFX1 PJA1 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q93009 Q8NG27 enzymatic study 22626734 direct interaction X 2 Q70EK9 Q8NG27 enzymatic study 22626734 direct interaction X 2 Q8NG27 affinity chromatography technology 22544753 physical association X 2 Q8NG27 C9JQV6 enzymatic study 22626734 direct interaction X 2 Q8NG27 Q15040 enzymatic study 22626734 direct interaction X 2 Q8NG27 enzymatic study 22626734 direct interaction X 2 Q8NG27 Q96RU2 enzymatic study 22626734 direct interaction X 2 Q8NG27 Q14674 enzymatic study 22626734 direct interaction X 2 Q8NG27 P61077-3 pull down 22626734 direct interaction X 2 Q8NG27 affinity chromatography technology 23688634 physical association X 2 Q8NG27 two hybrid 16169070 direct interaction X 2 Q8NG27 two hybrid 19690564 direct interaction X 2 Q8NG27 B2ZZ89 pull down 16247473 direct interaction X 2 Q8NG27 B2ZZ89 affinity chromatography technology 16247473 physical association X 2 Q8NG27 B2ZZ89 pull down 16247473 direct interaction X 2 Q8NG27 P51617-3 affinity chromatography technology 21903422 physical association X 2 Q8NG27 enzymatic study 21513699 direct interaction X 2 Q8NG27 E9PJK2 enzymatic study 21513699 direct interaction X 2 P0CG48 Q8NG27 affinity chromatography technology 22053931 physical association X 2 P0CG48 Q8NG27 affinity chromatography technology 21890473 physical association X 2 P0CG48 Q8NG27 affinity chromatography technology 16247473 physical association X 2 P0CG48 Q8NG27 affinity chromatography technology 16196087 physical association X 2 P0CG48 Q8NG27 affinity chromatography technology 20972266 physical association X 2 P0CG48 Q8NG27 affinity chromatography technology 21139048 physical association X 2 Q14807 Q8NG27 two hybrid 16169070 direct interaction X 2 Q9Y2K6 Q8NG27 enzymatic study 22626734 direct interaction X 2 Q96DC9 Q8NG27 enzymatic study 22626734 direct interaction X 2 Q92783 Q8NG27 enzymatic study 22626734 direct interaction X 2 A0A024R1A4 Q8NG27 pull down 21513699 direct interaction X 2 Q9Y5V3 Q8NG27 two hybrid 11959851 direct interaction X 2 Q9Y5V3 Q8NG27 affinity chromatography technology 11959851 physical association X 2 Q9Y5V3 Q8NG27 pull down 11959851 direct interaction X 2 Q9Y5V3 Q8NG27 enzymatic study 11959851 direct interaction X 2 Q9Y5V3 Q8NG27 affinity chromatography technology 20864041 physical association X 2 Q9Y5V3 Q8NG27 pull down 20864041 direct interaction X 2 Q8NG27 affinity chromatography technology 18729074 physical association X 2 Q8NG27 Q96FW1 enzymatic study 22626734 direct interaction X 2 Q8NG27 P15374 enzymatic study 22626734 direct interaction X 2 Q8NG27 enzymatic study 22626734 direct interaction X 2 Q8NG27 Q8NG27 enzymatic study 12036302 direct interaction X 2 Q8NG27 A0A087X0F7 two hybrid 16169070 direct interaction X 2 Q8NG27 P00390-5 two hybrid 16169070 direct interaction X 2 Q8NG27 P36542 two hybrid 16169070 direct interaction X 2 Q8NG27 P62837 pull down 12036302 direct interaction X 2 Q8NG27 P62837 affinity chromatography technology 12036302 physical association X 2 Q8NG27 P62837 affinity chromatography technology 12036302 physical association X 2 Q8NG27 Q96MG7 affinity chromatography technology 20864041 physical association X 2 Q8NG27 Q96MG7 pull down 20864041 direct interaction X 2 Q8NG27 Q8NG27 enzymatic study 21513699 direct interaction X 2 Q15022 Q8NG27 enzymatic study 21513699 direct interaction X 2 P55854 Q8NG27 affinity chromatography technology 25391492 physical association X 2 Q9H3M9 Q8NG27 enzymatic study 22626734 direct interaction X 2 O95630 Q8NG27 enzymatic study 22626734 direct interaction X 2 P45974-2 Q8NG27 enzymatic study 22626734 direct interaction X 2 Q8NG27 anti tag coimmunoprecipitation 21903422 association C 15 Q8NG27 tandem affinity purification 18729074 physical association C 48 Q8NG27 P14866 two hybrid pooling approach 16169070 physical association X 2 Q8NG27 Q8IYI8 two hybrid pooling approach 16169070 physical association X 2 Q9H4K1 Q8NG27 two hybrid pooling approach 16169070 physical association X 2 Q14807 Q8NG27 two hybrid pooling approach 16169070 physical association X 2 Q8NG27 tandem affinity purification 20864041 association C 3 Q9Y5V3 Q8NG27 anti bait coimmunoprecipitation 20864041 physical association X 2 Q9Y5V3 Q8NG27 pull down 20864041 physical association X 2 Q9Y5V3 Q8NG27 anti tag coimmunoprecipitation 20864041 physical association X 2 Q9Y5V3 Q8NG27 fluorescence microscopy 20864041 colocalization X 2 P00390 Q8NG27 two hybrid pooling approach 16169070 physical association X 2 Q8NG27 A0A024R1F9 two hybrid pooling approach 16169070 physical association X 2 Q8NG27 P36542 two hybrid pooling approach 16169070 physical association X 2 Q8NG27 Q5VVX9 two hybrid array 19690564 physical association X 2 Q8NG27 Q96MG7 pull down 20864041 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B SUZ12 PJA1 MI:0415(enzymatic study) 21513699 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_167121 prey bait MDM2 PJA1 MI:0493(in vivo) 10722742 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_39053 - - STAMBP PJA1 MI:0415(enzymatic study) 22626734 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_222985 prey bait EED PJA1 MI:0415(enzymatic study) 21513699 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_167122 prey bait ESPL1 PJA1 MI:0415(enzymatic study) 22626734 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_222994 prey bait PJA1 OTUB1 MI:0415(enzymatic study) 22626734 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_222986 bait prey PJA1 OTUB2 MI:0415(enzymatic study) 22626734 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_222991 bait prey ATXN3 PJA1 MI:0415(enzymatic study) 22626734 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_222983 prey bait PJA1 NDNL2 MI:0004(affinity chromatography technology)|MI:0676(tandem affinity purification)|MI:0004(affinity chromatography technology)|MI:0676(tandem affinity purification) 20864041 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0914(association) (biogrid)|(intact)|(biogrid)|(intact) BIOGRID_164395|UniProt_108248|BIOGRID_164427|UniProt_108223 prey|prey|prey|prey bait|bait|bait|bait HNRNPL PJA1 MI:0018(two hybrid)|MI:0007(anti tag coimmunoprecipitation)|MI:0492(in vitro)|MI:0018(two hybrid) 16169070 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|-|MI:0915(physical association) MI:0471(mint)|(intact)|MI:0468(hprd)|MI:0471(mint) MINT_35272|UniProt_157069|HPRD_29213|MINT_64274 prey|prey|-|prey bait|bait|-|bait PJA1 USP28 MI:0415(enzymatic study) 22626734 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_222993 bait prey USP8 PJA1 MI:0415(enzymatic study) 22626734 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_222989 prey bait EZH2 PJA1 MI:0415(enzymatic study)|MI:0004(affinity chromatography technology) 21513699,23688634 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_167120|BIOGRID_289392 prey|bait bait|prey SMAD3 PJA1 MI:0676(tandem affinity purification)|MI:0004(affinity chromatography technology) 18729074 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid) UniProt_97032|BIOGRID_218585 bait|bait prey|prey ZNF440 PJA1 MI:0018(two hybrid)|MI:0492(in vitro)|MI:0007(anti tag coimmunoprecipitation)|MI:0018(two hybrid) 16169070 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|-|MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|MI:0468(hprd)|(intact)|MI:0471(mint) MINT_35273|HPRD_28609|UniProt_157070|MINT_64275 prey|-|prey|prey bait|-|bait|bait SPTBN1 PJA1 MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down) 16247473 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid) BIOGRID_126290|BIOGRID_126288|BIOGRID_126289 bait|prey|prey prey|bait|bait USP51 PJA1 MI:0415(enzymatic study) 22626734 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_222981 prey bait UBE2D3 PJA1 MI:0415(enzymatic study) 22626734 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_223059 prey bait GSR PJA1 MI:0018(two hybrid)|MI:0007(anti tag coimmunoprecipitation)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0492(in vitro) 16169070 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|- MI:0471(mint)|(intact)|(biogrid)|MI:0471(mint)|MI:0468(hprd) MINT_62437|UniProt_156199|BIOGRID_93629|MINT_33496|HPRD_28205 bait|bait|bait|bait|- prey|prey|prey|prey|- IRAK1 PJA1 MI:0004(affinity chromatography technology) 21903422 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_155504 bait prey UBE2L3 PJA1 MI:0415(enzymatic study) 21513699 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_223184 prey bait PJA1 USP7 MI:0415(enzymatic study) 22626734 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_222984 bait prey PJA1 USP9X MI:0415(enzymatic study) 22544753 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_201625 prey bait UBE2D2 PJA1 MI:0096(pull down)|MI:0492(in vitro)|MI:0096(pull down)|MI:0096(pull down) 12036302 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|-|MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|MI:0468(hprd)|(biogrid)|(biogrid) BIOGRID_136336|HPRD_5721|BIOGRID_114161|BIOGRID_114160 prey|-|bait|bait bait|-|prey|prey UBC PJA1 MI:0004(affinity chromatography technology)|MI:0096(pull down)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0096(pull down)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 12036302,16196087,16247473,20972266,21139048,21890473,22053931 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_167910|BIOGRID_126292|BIOGRID_143262|BIOGRID_222177|BIOGRID_136338|BIOGRID_263589|BIOGRID_164254 bait|prey|bait|bait|prey|bait|bait prey|bait|prey|prey|bait|prey|prey UCHL3 PJA1 MI:0415(enzymatic study) 22626734 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_222988 prey bait NRF1 PJA1 MI:0428(imaging technique) 24250222 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_294802 bait prey PJA1 STAM MI:0415(enzymatic study) 22626734 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_222995 bait prey USP5 PJA1 MI:0415(enzymatic study) 22626734 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_222982 prey bait PJA1 USP20 MI:0415(enzymatic study) 22626734 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_222980 bait prey PJA1 MAGED1 MI:0676(tandem affinity purification)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0676(tandem affinity purification)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0493(in vivo)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0676(tandem affinity purification)|MI:0676(tandem affinity purification) 11959851,20864041 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|-|MI:0915(physical association)|MI:0407(direct interaction)|MI:0403(colocalization)|MI:0915(physical association) (intact)|(biogrid)|(biogrid)|(intact)|(biogrid)|(biogrid)|MI:0468(hprd)|(biogrid)|(biogrid)|(intact)|(intact) UniProt_108234|BIOGRID_164405|BIOGRID_164432|UniProt_108272|BIOGRID_115407|BIOGRID_115406|HPRD_5418|BIOGRID_115405|BIOGRID_115404|UniProt_108244|UniProt_108245 bait|prey|prey|prey|bait|bait|-|prey|prey|neutral component|prey prey|bait|bait|bait|prey|prey|-|bait|bait|neutral component|bait PJA1 UCHL5 MI:0415(enzymatic study) 22626734 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_222990 bait prey KIF22 PJA1 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0492(in vitro)|MI:0007(anti tag coimmunoprecipitation)|MI:0018(two hybrid) 16169070 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|-|MI:0915(physical association)|MI:0915(physical association) (biogrid)|MI:0471(mint)|MI:0468(hprd)|(intact)|MI:0471(mint) BIOGRID_94480|MINT_34523|HPRD_29229|UniProt_155412|MINT_63479 bait|bait|-|bait|bait prey|prey|-|prey|prey ATP5C1 PJA1 MI:0492(in vitro)|MI:0018(two hybrid)|MI:0007(anti tag coimmunoprecipitation)|MI:0018(two hybrid)|MI:0018(two hybrid) 16169070 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) MI:0468(hprd)|(biogrid)|(intact)|MI:0471(mint)|MI:0471(mint) HPRD_28003|BIOGRID_94169|UniProt_155082|MINT_33871|MINT_62813 -|bait|bait|bait|bait -|prey|prey|prey|prey JOSD1 PJA1 MI:0415(enzymatic study) 22626734 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_222987 prey bait UBE2U PJA1 MI:0397(two hybrid array)|MI:0018(two hybrid) 19690564 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_102646|BIOGRID_123657 bait|bait prey|prey PJA1 NDN MI:0493(in vivo) 11959851 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_5720 - - PJA1 RIBC2 MI:0018(two hybrid)|MI:0492(in vitro)|MI:0007(anti tag coimmunoprecipitation) 16169070 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|-|MI:0915(physical association) (biogrid)|MI:0468(hprd)|(intact) BIOGRID_93496|HPRD_29976|UniProt_156061 prey|-|prey bait|-|bait PJA1 ATXN3L MI:0415(enzymatic study) 22626734 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_222992 bait prey PJA1 ASCC2 MI:0492(in vitro)|MI:0018(two hybrid)|MI:0007(anti tag coimmunoprecipitation)|MI:0018(two hybrid)|MI:0018(two hybrid) 16169070 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) MI:0468(hprd)|MI:0471(mint)|(intact)|(biogrid)|MI:0471(mint) HPRD_28610|MINT_36058|UniProt_155070|BIOGRID_94157|MINT_65148 -|prey|prey|prey|prey -|bait|bait|bait|bait

PPI - HINT Gene A Gene B PMID Method Quality RBFOX2 PJA1 26186194 0004 HT UBC PJA1 20972266,12036302,16247473 0004,0096,0004 LC DNAJB2 PJA1 26186194 0004 HT TALDO1 PJA1 26186194 0004 HT BCAT1 PJA1 26186194 0004 HT MORC1 PJA1 26186194 0004 HT Q8IZZ5 PJA1 26186194 0004 HT PNKD PJA1 26186194 0004 HT PJA1 FAF2 26186194 0004 HT PJA1 AP2M1 26186194 0004 HT PJA1 RNF126 26186194 0004 HT PJA1 SFXN3 26186194 0004 HT PJA1 USP36 26186194 0004 HT PJA1 MAGED1 11959851,20864041,20864041,20864041,11959851,11959851,20864041,20864041,11959851 0096,0004,0096,0416,0004,0415,0006,0007,0018 LC RBFOX2 PJA1 26186194 0004 HT DNAJB2 PJA1 26186194 0004 HT TALDO1 PJA1 26186194 0004 HT BCAT1 PJA1 26186194 0004 HT MORC1 PJA1 26186194 0004 HT Q8IZZ5 PJA1 26186194 0004 HT PNKD PJA1 26186194 0004 HT PJA1 FAF2 26186194 0004 HT PJA1 AP2M1 26186194 0004 HT PJA1 RNF126 26186194 0004 HT PJA1 SFXN3 26186194 0004 HT PJA1 USP36 26186194 0004 HT UBC PJA1 20972266,12036302,16247473 0004,0096,0004 LC PJA1 MAGED1 11959851,20864041,20864041,20864041,11959851,11959851,20864041,20864041,11959851 0096,0004,0096,0416,0004,0415,0006,0007,0018 LC B7Z8L6 PJA1 21513699 0415 LC EED PJA1 21513699 0415 LC STAMBP PJA1 22626734 0415 HT GSR PJA1 16169070,16169070 0018,0398 HT HNRNPL PJA1 16169070,16169070 0018,0398 HT UCHL3 PJA1 22626734 0415 HT ATP5C1 PJA1 16169070,16169070 0018,0398 HT USP8 PJA1 22626734 0415 HT USP5 PJA1 22626734 0415 HT ATXN3 PJA1 22626734 0415 HT ESPL1 PJA1 22626734 0415 HT KIF22 PJA1 16169070,16169070 0018,0398 HT SUZ12 PJA1 21513699 0415 LC JOSD1 PJA1 22626734 0415 HT EZH2 PJA1 21513699 0415 LC UBE2U PJA1 19690564,19690564 0397,0018 HT USP51 PJA1 22626734 0415 HT ZNF440 PJA1 16169070,16169070 0018,0398 HT PJA1 PJA1 21513699,12036302 0415,0415 LC PJA1 Q8TAS0 16169070 0018 HT PJA1 STAM 22626734 0415 HT PJA1 USP7 22626734 0415 HT PJA1 OTUB2 22626734 0415 HT PJA1 OTUB1 22626734 0415 HT PJA1 USP28 22626734 0415 HT PJA1 ASCC2 16169070,16169070 0018,0398 HT PJA1 ATXN3L 22626734 0415 HT PJA1 RIBC2 16169070,16169070 0018,0398 HT PJA1 USP20 22626734 0415 HT PJA1 UCHL5 22626734 0415 HT PJA1 MAGED1 11959851,20864041,20864041,20864041,11959851,11959851,20864041,20864041,11959851 0096,0004,0096,0416,0004,0415,0006,0007,0018 LC PJA1 HEL-75 16169070 0018 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q8NG27 Q53QD7 PJA1 DNAJB2 {ECO:0000312|HGNC:HGNC:5228} 0.126 Q8NG27 O43251 PJA1 RBFOX2 0.126 26186194 Q8NG27 Q8IYI8 PJA1 ZNF440 0.126 16169070 Q8NG27 Q8N490 PJA1 PNKD 0.126 26186194 Q8NG27 O75530 PJA1 EED 0.309 21513699 Q8NG27 O95630 PJA1 STAMBP 0.183 22626734 Q8NG27 P00390 PJA1 GSR 0.286 16169070 Q8NG27 P15374 PJA1 UCHL3 0.183 22626734 Q8NG27 P40818 PJA1 USP8 0.183 22626734 Q8NG27 P45974 PJA1 USP5 0.183 22626734 Q8NG27 P54252 PJA1 ATXN3 0.183 22626734 Q8NG27 P61077 PJA1 UBE2D3 0.183 22626734 Q8NG27 P62837 PJA1 UBE2D2 0.569 12036302 Q8NG27 P68036 PJA1 UBE2L3 0.309 21513699 Q8NG27 Q14674 PJA1 ESPL1 0.183 22626734 Q8NG27 Q15022 PJA1 SUZ12 0.309 21513699 Q8NG27 Q15040 PJA1 JOSD1 0.183 22626734 Q8NG27 Q5VVX9 PJA1 UBE2U 0.376 19690564 Q8NG27 Q70EK9 PJA1 USP51 0.183 22626734 Q92783 Q8NG27 STAM PJA1 0.183 22626734 Q93009 Q8NG27 USP7 PJA1 0.183 22626734 Q96DC9 Q8NG27 OTUB2 PJA1 0.183 22626734 Q96FW1 Q8NG27 OTUB1 PJA1 0.183 22626734 Q96RU2 Q8NG27 USP28 PJA1 0.183 22626734 Q9H1I8 Q8NG27 ASCC2 PJA1 0.286 16169070 Q9H3M9 Q8NG27 ATXN3L PJA1 0.183 22626734 Q9H4K1 Q8NG27 RIBC2 PJA1 0.286 16169070 Q9Y2K6 Q8NG27 USP20 PJA1 0.183 22626734 Q9Y5K5 Q8NG27 UCHL5 PJA1 0.183 22626734 Q8NG27 P25686 PJA1 DNAJB2 0.126 26186194 Q8NG27 P0CG48 PJA1 UBC 0.126 16196087 Q8NG27 Q6P5F9 PJA1 XPO1 0.126 26673895 Q8NG27 Q86VD1 PJA1 MORC1 0.126 26186194 Q8NG27 P00748 PJA1 F12 0.126 26186194 Q9Y5V3 Q8NG27 MAGED1 PJA1 0.891 unassigned1304,11959851,20864041 Q8NG27 Q8NG27 PJA1 PJA1 0.554 12036302,21513699 Q96MG7 Q8NG27 NDNL2 PJA1 0.454 20864041 Q8NG27 P84022 PJA1 SMAD3 0.236 18729074 Q93008 Q8NG27 USP9X PJA1 0.21 22544753 Q8NG27 P37837 PJA1 TALDO1 0.126 26186194 Q96CS3 Q8NG27 FAF2 PJA1 0.126 26186194 Q96CW1 Q8NG27 AP2M1 PJA1 0.126 26186194 Q99J34 Q8NG27 IRAK1 PJA1 0.126 21903422 Q9BV68 Q8NG27 RNF126 PJA1 0.126 26186194 Q9BWM7 Q8NG27 SFXN3 PJA1 0.126 26186194 Q8NG27 P36542 PJA1 ATP5C1 0.286 16169070 Q9P275 Q8NG27 USP36 PJA1 0.126 26186194 Q8NG27 Q14807 PJA1 KIF22 0.286 16169070 Q8NG27 P14866 PJA1 HNRNPL 0.126 16169070 Q8NG27 Q01082 PJA1 SPTBN1 0.623 16247473 Q8NG27 P51617 PJA1 IRAK1 0.126 21903422 Q8NG27 Q15910 PJA1 EZH2 0.454 23688634,21513699 Q8NG27 P54687 PJA1 BCAT1 0.126 26186194

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 XPO1 PJA1 MI:0045 experimental interaction detection MI:0461 interaction database RBFOX2 PJA1 MI:0045 experimental interaction detection MI:0461 interaction database EED PJA1 MI:0045 experimental interaction detection MI:0461 interaction database STAMBP PJA1 MI:0045 experimental interaction detection MI:0461 interaction database GSR PJA1 MI:0045 experimental interaction detection MI:0461 interaction database F12 PJA1 MI:0045 experimental interaction detection MI:0461 interaction database UBC PJA1 MI:0045 experimental interaction detection MI:0461 interaction database HNRNPL PJA1 MI:0045 experimental interaction detection MI:0461 interaction database UCHL3 PJA1 MI:0045 experimental interaction detection MI:0461 interaction database DNAJB2 PJA1 MI:0045 experimental interaction detection MI:0461 interaction database MSX1 PJA1 MI:0362 inference MI:0461 interaction database MSX2 PJA1 MI:0362 inference MI:0461 interaction database ATP5C1 PJA1 MI:0045 experimental interaction detection MI:0461 interaction database TALDO1 PJA1 MI:0045 experimental interaction detection MI:0461 interaction database USP8 PJA1 MI:0045 experimental interaction detection MI:0461 interaction database USP5 PJA1 MI:0045 experimental interaction detection MI:0461 interaction database IRAK1 PJA1 MI:0045 experimental interaction detection MI:0461 interaction database ATXN3 PJA1 MI:0045 experimental interaction detection MI:0461 interaction database BCAT1 PJA1 MI:0045 experimental interaction detection MI:0461 interaction database SUMO3 PJA1 MI:0045 experimental interaction detection MI:0461 interaction database UBE2D3 PJA1 MI:0045 experimental interaction detection MI:0461 interaction database UBE2D2 PJA1 MI:0045 experimental interaction detection MI:0461 interaction database UBE2L3 PJA1 MI:0045 experimental interaction detection MI:0461 interaction database SMAD3 PJA1 MI:0045 experimental interaction detection MI:0461 interaction database SPTBN1 PJA1 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database ESPL1 PJA1 MI:0045 experimental interaction detection MI:0461 interaction database KIF22 PJA1 MI:0045 experimental interaction detection MI:0461 interaction database SUZ12 PJA1 MI:0045 experimental interaction detection MI:0461 interaction database JOSD1 PJA1 MI:0045 experimental interaction detection MI:0461 interaction database EZH2 PJA1 MI:0045 experimental interaction detection MI:0461 interaction database KIAA0753 PJA1 MI:0045 experimental interaction detection MI:0461 interaction database UBE2U PJA1 MI:0045 experimental interaction detection MI:0461 interaction database USP51 PJA1 MI:0045 experimental interaction detection MI:0461 interaction database MORC1 PJA1 MI:0045 experimental interaction detection MI:0461 interaction database ZNF440 PJA1 MI:0045 experimental interaction detection MI:0461 interaction database PNKD PJA1 MI:0045 experimental interaction detection MI:0461 interaction database PJA1 NSMCE1 MI:0362 inference MI:0461 interaction database PJA1 STAM MI:0045 experimental interaction detection MI:0461 interaction database PJA1 USP9X MI:0045 experimental interaction detection MI:0461 interaction database PJA1 USP7 MI:0045 experimental interaction detection MI:0461 interaction database PJA1 FAF2 MI:0045 experimental interaction detection MI:0461 interaction database PJA1 AP2M1 MI:0045 experimental interaction detection MI:0461 interaction database PJA1 OTUB2 MI:0045 experimental interaction detection MI:0461 interaction database PJA1 OTUB1 MI:0045 experimental interaction detection MI:0461 interaction database PJA1 NSMCE3 MI:0045 experimental interaction detection MI:0461 interaction database PJA1 USP28 MI:0045 experimental interaction detection MI:0461 interaction database PJA1 NDN MI:0362 inference MI:0461 interaction database PJA1 RNF126 MI:0045 experimental interaction detection MI:0461 interaction database PJA1 SFXN3 MI:0045 experimental interaction detection MI:0461 interaction database PJA1 ASCC2 MI:0045 experimental interaction detection MI:0461 interaction database PJA1 ATXN3L MI:0045 experimental interaction detection MI:0461 interaction database PJA1 RIBC2 MI:0045 experimental interaction detection MI:0461 interaction database PJA1 USP36 MI:0045 experimental interaction detection MI:0461 interaction database PJA1 USP20 MI:0045 experimental interaction detection MI:0461 interaction database PJA1 UCHL5 MI:0045 experimental interaction detection MI:0461 interaction database PJA1 MAGED1 MI:0045 experimental interaction detection MI:0461 interaction database