PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus ZRANB2 FBXL7 24035498 biogrid exp G G G G G G G G GP G GP G G G G GP G G G G G G GP G GP G GP G G APP FBXL7 21832049 biogrid exp G G G G G G G G GP G G G G G G GP G G G G G G G G GP G G G G FBXL7 NUDC 25036637 intact exp G G G G G G G G GP G GP G G G G GP G G G G G G GP G GP G GP G G AHCYL1 FBXL7 24035498 biogrid exp G G G G G G G G GP G GP G G G G G G G G G G G GP G G G GP G G WDR48 FBXL7 24035498 biogrid exp G G G G G G G G GP G GP G G G G GP G G G G G G GP G GP G GP G G FBXL7 SUGT1 25036637 intact exp G G G G G G G G GP G GP G G G G GP G G G G G G G G GP G GP G G NUDCD2 FBXL7 25036637 intact exp G G G G G G G G GP G GP G G G G GP G G G G G G GP G GP G GP G G SKP1 FBXL7 15070733,17704768, 25402006, 23023127, 16082366 biogrid,intact,bci exp, ortho, pred G G G G G G G G GP G GP G G G G GP G G G G G G GP G GP G GP G G CDK20 FBXL7 ortho G G G G G G G G P G GP G G G G GP G G G G G G GP G GP G GP G G AURKA FBXL7 ortho G G G G G G G G G G G G G G NTN1 FBXL7 ortho G G G G G G GP G P G G G G GP G G G G G G GP G GP GP G G CUL2 FBXL7 16082366 pred G G G G G G G G GP G GP G G G G G G G G G G G GP G G G GP G G SQSTM1 FBXL7 23023127 pred G G G G G G G G GP G GP G G G G GP G G G G G G GP G GP G GP G G WWP2 FBXL7 21836163 pred G G G G G G G G GP G GP G G G G GP G G G G G G GP G GP G GP G G GSTM5 FBXL7 25402006 pred G G G G G G G G GP G GP G G G G GP G G G G G G GP G GP G GP G G MXRA8 FBXL7 25402006 pred G G G G G G G G GP G GP G G G G GP G G G G G G GP G GP G GP G G CUL1 FBXL7 16082366 pred G G G G G G G G GP G GP G G G G GP G G G G G G GP G GP G GP G G RNF144B FBXL7 21836163 pred G G G G G G G G GP G GP G G G G GP G G G G G G G G GP G G G G VSTM4 FBXL7 25402006 pred G G G GP G GP G G G GP G G P P P G JAM3 FBXL7 25402006 pred G G G G G G G G GP G GP G G G G G G G G G G G G G G G GP G G UBE4A FBXL7 21836163 pred G G G G G G G G GP G GP G G G G GP G G G G G G GP G GP G GP G G WWP1 FBXL7 21836163 pred G G G G G G G G GP G GP G G G G GP G G G G G G GP G GP G GP G G FBXL7 FBXW11 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G HTRA1 FBXL7 25402006 pred G G G G G G G G GP G GP G G G G GP G G G G G G GP G GP G GP G G SMURF2 FBXL7 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q9UJT9 A0A024R0A8 affinity chromatography technology 24035498 physical association X 2 Q8TAF3 Q9UJT9 affinity chromatography technology 24035498 physical association X 2 P63208 Q9UJT9 affinity chromatography technology 15070733 physical association X 2 P63208 Q9UJT9 affinity chromatography technology 17704768 physical association X 2 Q9UJT9 P05067-7 pull down 21832049 direct interaction X 2 Q9UJT9 O95218-2 affinity chromatography technology 24035498 physical association X 2 Q9UJT9 Q9Y266 luminescence based mammalian interactome mapping 25036637 physical association X 2 P63208 Q9UJT9 anti tag coimmunoprecipitation 15070733 physical association X 2 Q8WVJ2 Q9UJT9 luminescence based mammalian interactome mapping 25036637 physical association X 2 Q8D166 Q9UJT9 two hybrid pooling approach 20711500 physical association X 2

PPI - HINT Gene A Gene B PMID Method Quality SKP1 FBXL7 17704768,15070733,15070733,25654763,15070733 0004,0019,0007,0004,0004 LC SKP1 FBXL7 17704768,15070733,15070733,25654763,15070733 0004,0019,0007,0004,0004 LC B4DYC6 FBXL7 25036637 0729 HT BIRC5 FBXL7 25778398,25778398,25778398 0096,0004,0415 LC SKP1 FBXL7 15070733,15070733,15070733 0019,0007,0004 LC NUDCD2 FBXL7 25036637 0729 HT FBXL18 FBXL7 25654763,25654763,25654763 0004,0415,0096 LC FBXL7 NUDC 25036637 0729 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9Y266 Q9UJT9 NUDC FBXL7 0.126 25036637 Q9UJT9 A0A0C3SFZ9 FBXL7 A0A0C3SFZ9 0.236 unassigned1304 Q9UJT9 Q92609 FBXL7 TBC1D5 0.236 unassigned1304 Q9UJT9 O15392 FBXL7 BIRC5 0.623 25778398 Q9UJT9 P63208 FBXL7 SKP1 0.61 15070733,17704768,25654763 Q9UJT9 Q8WVJ2 FBXL7 NUDCD2 0.126 25036637 Q9UJT9 B4DYC6 FBXL7 B4DYC6 0.126 25036637 Q9UJT9 O43865 FBXL7 AHCYL1 0.21 24035498 Q9UJT9 O95218 FBXL7 ZRANB2 0.21 24035498 Q9UJT9 P05067 FBXL7 APP 0.183 21832049 Q9UJT9 Q13616 FBXL7 CUL1 0.21 25654763 Q9UJT9 Q8D166 FBXL7 GGT 0.126 20711500 Q9UJT9 Q8TAF3 FBXL7 WDR48 0.21 24035498

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 NTN3 FBXL7 MI:0362 inference MI:0461 interaction database AURKA FBXL7 MI:0362 inference MI:0461 interaction database BIRC5 FBXL7 MI:0045 experimental interaction detection MI:0461 interaction database SIAH2 FBXL7 MI:0362 inference MI:1106 pathways database AHCYL1 FBXL7 MI:0045 experimental interaction detection MI:0461 interaction database FBXO21 FBXL7 MI:0362 inference MI:1106 pathways database ZRANB2 FBXL7 MI:0045 experimental interaction detection MI:0461 interaction database NTN1 FBXL7 MI:0362 inference MI:0461 interaction database APP FBXL7 MI:0045 experimental interaction detection MI:0461 interaction database UBB FBXL7 MI:0362 inference MI:1106 pathways database UBC FBXL7 MI:0362 inference MI:1106 pathways database TRIM21 FBXL7 MI:0362 inference MI:1106 pathways database CCNF FBXL7 MI:0362 inference MI:1106 pathways database HNF4A FBXL7 MI:0045 experimental interaction detection MI:0461 interaction database MTNR1B FBXL7 MI:0362 inference MI:0461 interaction database UBE2A FBXL7 MI:0362 inference MI:1106 pathways database FBXW4 FBXL7 MI:0362 inference MI:1106 pathways database RBX1 FBXL7 MI:0362 inference MI:1106 pathways database RPS27A FBXL7 MI:0362 inference MI:1106 pathways database UBA52 FBXL7 MI:0362 inference MI:1106 pathways database SKP1 FBXL7 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database SKP2 FBXL7 MI:0362 inference MI:1106 pathways database CUL1 FBXL7 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database TRIP12 FBXL7 MI:0362 inference MI:1106 pathways database LONRF1 FBXL7 MI:0362 inference MI:1106 pathways database HECTD2 FBXL7 MI:0362 inference MI:1106 pathways database FBXO31 FBXL7 MI:0362 inference MI:1106 pathways database FBXW9 FBXL7 MI:0362 inference MI:1106 pathways database FBXW10 FBXL7 MI:0362 inference MI:1106 pathways database RNF213 FBXL7 MI:0362 inference MI:1106 pathways database FBXL22 FBXL7 MI:0362 inference MI:1106 pathways database FBXL19 FBXL7 MI:0362 inference MI:1106 pathways database FBXW12 FBXL7 MI:0362 inference MI:1106 pathways database RNF19B FBXL7 MI:0362 inference MI:1106 pathways database RNF144B FBXL7 MI:0362 inference MI:1106 pathways database RBBP6 FBXL7 MI:0362 inference MI:1106 pathways database HUWE1 FBXL7 MI:0362 inference MI:1106 pathways database TRIM69 FBXL7 MI:0362 inference MI:1106 pathways database SIAH1 FBXL7 MI:0362 inference MI:1106 pathways database HERC6 FBXL7 MI:0362 inference MI:1106 pathways database UBR2 FBXL7 MI:0362 inference MI:1106 pathways database CDK20 FBXL7 MI:0362 inference MI:0461 interaction database FBXL14 FBXL7 MI:0362 inference MI:1106 pathways database FBXW8 FBXL7 MI:0362 inference MI:1106 pathways database FBXL16 FBXL7 MI:0362 inference MI:1106 pathways database FBXO15 FBXL7 MI:0362 inference MI:1106 pathways database ZNRF1 FBXL7 MI:0362 inference MI:1106 pathways database FBXL13 FBXL7 MI:0362 inference MI:1106 pathways database FBXO22 FBXL7 MI:0362 inference MI:1106 pathways database ZNRF2 FBXL7 MI:0362 inference MI:1106 pathways database FBXO27 FBXL7 MI:0362 inference MI:1106 pathways database WDR48 FBXL7 MI:0045 experimental interaction detection MI:0461 interaction database FBXO30 FBXL7 MI:0362 inference MI:1106 pathways database RNF217 FBXL7 MI:0362 inference MI:1106 pathways database DTX3L FBXL7 MI:0362 inference MI:1106 pathways database FBXO41 FBXL7 MI:0362 inference MI:1106 pathways database NUDCD2 FBXL7 MI:0045 experimental interaction detection MI:0461 interaction database LMO7 FBXL7 MI:0362 inference MI:1106 pathways database MYLIP FBXL7 MI:0362 inference MI:1106 pathways database FBXW7 FBXL7 MI:0362 inference MI:1106 pathways database FBXO32 FBXL7 MI:0362 inference MI:1106 pathways database FBXW5 FBXL7 MI:0362 inference MI:1106 pathways database MIB2 FBXL7 MI:0362 inference MI:1106 pathways database SPSB1 FBXL7 MI:0362 inference MI:1106 pathways database FBXL8 FBXL7 MI:0362 inference MI:1106 pathways database FBXO17 FBXL7 MI:0362 inference MI:1106 pathways database FBXL20 FBXL7 MI:0362 inference MI:1106 pathways database FBXL18 FBXL7 MI:0362 inference MI:1106 pathways database NEDD4L FBXL7 MI:0362 inference MI:1106 pathways database RBCK1 FBXL7 MI:0362 inference MI:1106 pathways database FBXL15 FBXL7 MI:0362 inference MI:1106 pathways database FBXO44 FBXL7 MI:0362 inference MI:1106 pathways database UNKL FBXL7 MI:0362 inference MI:1106 pathways database SMURF2 FBXL7 MI:0362 inference MI:1106 pathways database TRIM36 FBXL7 MI:0362 inference MI:1106 pathways database FBXO6 FBXL7 MI:0362 inference MI:1106 pathways database RNF19A FBXL7 MI:0362 inference MI:1106 pathways database RLIM FBXL7 MI:0362 inference MI:1106 pathways database FBXL12 FBXL7 MI:0362 inference MI:1106 pathways database FBXO40 FBXL7 MI:0362 inference MI:1106 pathways database HERC5 FBXL7 MI:0362 inference MI:1106 pathways database FBXL7 FBXO2 MI:0362 inference MI:1106 pathways database FBXL7 FBXO10 MI:0362 inference MI:1106 pathways database FBXL7 FBXO9 MI:0362 inference MI:1106 pathways database FBXL7 FBXL5 MI:0362 inference MI:1106 pathways database FBXL7 FBXL4 MI:0362 inference MI:1106 pathways database FBXL7 FBXW11 MI:0362 inference MI:1106 pathways database FBXL7 FBXO4 MI:0362 inference MI:1106 pathways database FBXL7 FBXL21 MI:0362 inference MI:1106 pathways database FBXL7 FBXL3 MI:0362 inference MI:1106 pathways database FBXL7 FBXW2 MI:0362 inference MI:1106 pathways database FBXL7 NUDC MI:0045 experimental interaction detection MI:0461 interaction database FBXL7 BTRC MI:0362 inference MI:1106 pathways database FBXL7 FBXO7 MI:0362 inference MI:1106 pathways database FBXL7 RNF115 MI:0362 inference MI:1106 pathways database FBXL7 RNF114 MI:0362 inference MI:1106 pathways database FBXL7 WSB1 MI:0362 inference MI:1106 pathways database