PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus UBA1 TRIM52 25260751 intact exp GP GP G G G GP G GP GP G GP G GP G G GP GP GP G G GP GP GP GP GP G GP GP G NEDD4 TRIM52 19953087 biogrid exp GP GP G G P G GP GP GP G GP G G GP GP GP G G GP GP GP GP GP G GP P G TRIM52 RNF114 22493164 biogrid,intact exp GP GP G G G GP G GP GP G GP G GP G G GP GP GP G G GP GP GP GP GP G GP GP G UBE2V1 TRIM52 25260751 intact exp TRIM41 TRIM52 22493164 biogrid,intact exp GP GP G G G GP G G GP G GP G GP G G GP GP G G G GP GP GP GP GP G GP GP G TRIM52 RNF126 22493164 biogrid,intact exp GP G G G G GP G G GP G GP G GP G G GP GP GP G GP GP G G GP G GP GP G APP TRIM52 21832049 innatedb,biogrid exp G GP G G G GP G G GP G G G G G G GP GP G G G GP GP G G GP G G GP G UBE2N TRIM52 25260751 intact exp GP GP G G G GP G GP GP G GP G GP G G GP GP G G G GP GP GP GP GP G GP GP G TRIM52 TRIM31 23023127 pred P P G G P GP P P P P P GP P P P GP P GP P TRIM52 TRIM31 23023127 pred P P G G P GP P P P P P GP P P P GP P GP P TRIM52 TRIM54 23023127 pred P P GP P P P G P GP GP P P TRIM50 TRIM52 23023127 pred P P P P GP P P P P G P P P P GP GP TRIM38 TRIM52 23023127 pred GP GP G G P G GP GP GP G GP G G GP GP GP G GP GP GP GP GP G GP P G TRIM22 TRIM52 23023127 pred GP GP G G G GP G GP GP G GP G GP G G GP GP GP G G GP GP GP GP GP G GP GP G MID1 TRIM52 23023127 pred G G G GP G GP GP G GP G G G G GP GP G G G GP G G GP GP G GP GP G TRIM73 TRIM52 23023127 pred GP G G G G GP G GP GP G GP G G G G GP GP G G P GP GP P GP G GP G G TRIM26 TRIM52 23023127 pred GP GP G G G GP G GP GP G GP G GP G G GP GP GP G G GP GP GP GP GP G GP GP G TRIM71 TRIM52 23023127 pred P P P P P P P P P P P P P P P P TRIM74 TRIM52 23023127 pred TRIM75P TRIM52 23023127 pred TRIM52 TRIM36 23023127 pred G GP G P GP G P GP GP P G GP P GP TRIM21 TRIM52 23023127 pred GP GP G G G GP G GP GP G GP G GP G G GP GP GP G G GP GP GP GP GP G GP GP G TRIM63 TRIM52 23023127 pred G G G G TRIM52 TRIM5 23023127 pred GP GP G G P G GP GP GP G GP G G GP P GP G G GP GP GP P GP G GP P G TRIM52 TRIM10 23023127 pred G G G G G G G G G G G G G G GP G GP G G G G G GP GP GP GP G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q96A61 Q8WV44-2 two hybrid 22493164 direct interaction X 2 Q96A61 P0CG48 affinity chromatography technology 20596523 physical association X 2 A0A024R206 Q96A61 two hybrid 22493164 direct interaction X 2 Q96A61 P05067-7 pull down 21832049 direct interaction X 2 Q96A61 Q9Y508 two hybrid 22493164 direct interaction X 2 Q96A61 P46934-4 enzymatic study 19953087 direct interaction X 2 Q96A61 P46934-4 pull down 19953087 direct interaction X 2 Q5NF74 Q96A61 two hybrid pooling approach 20711500 physical association X 2 Q96A61 Q9BV68 two hybrid array 22493164 physical association X 2 Q96A61 ubiquitinase assay 25260751 ubiquitination reaction C 4 Q96A61 Q8WV44 two hybrid array 22493164 physical association X 2 Q96A61 Q9Y508 two hybrid array 22493164 physical association X 2 Q5NHN8 Q96A61 two hybrid pooling approach 20711500 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B APP TRIM52 MI:0096(pull down) 21832049 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_228010 prey bait TRIM52 RNF126 MI:0415(enzymatic study)|MI:0397(two hybrid array) 22493164 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_284026|UniProt_122567 prey|bait bait|prey NEDD4 TRIM52 MI:0415(enzymatic study)|MI:0415(enzymatic study) 19953087 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction) (biogrid)|(biogrid) BIOGRID_148257|BIOGRID_164696 bait|bait prey|prey TRIM52 TRIM41 MI:0415(enzymatic study)|MI:0397(two hybrid array) 22493164 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_283976|UniProt_122448 prey|prey bait|bait TRIM52 RNF114 MI:0415(enzymatic study)|MI:0397(two hybrid array) 22493164 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_283981|UniProt_122570 prey|bait bait|prey UBC TRIM52 MI:0004(affinity chromatography technology) 20596523 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_146120 prey bait

PPI - HINT Gene A Gene B PMID Method Quality UBA1 TRIM52 25260751 0997 LC NEDD4 TRIM52 19953087,19953087 0415,0096 HT UBE2N TRIM52 25260751 0997 LC UBE2V1 TRIM52 25260751 0997 LC TRIM41 TRIM52 22493164,22493164 0018,0397 HT TRIM52 RNF126 22493164,22493164 0018,0397 HT TRIM52 RNF114 22493164,22493164 0018,0397 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q96A61 Q5NF74 TRIM52 TKTA 0.126 20711500 Q9Y508 Q96A61 RNF114 TRIM52 0.286 22493164 Q96A61 Q8WV44 TRIM52 TRIM41 0.286 22493164 Q96A61 P46934 TRIM52 NEDD4 0.332 19953087 Q96A61 P05067 TRIM52 APP 0.183 21832049 Q96A61 P22314 TRIM52 UBA1 0.033 25260751 Q96A61 P61088 TRIM52 UBE2N 0.033 25260751 Q96A61 Q13404 TRIM52 UBE2V1 0.033 25260751 Q96A61 Q5NHN8 TRIM52 GCVPA 0.126 20711500 Q9BV68 Q96A61 RNF126 TRIM52 0.286 22493164

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 APP TRIM52 MI:0045 experimental interaction detection MI:0461 interaction database UBC TRIM52 MI:0045 experimental interaction detection MI:0461 interaction database UBA1 TRIM52 MI:0045 experimental interaction detection MI:0461 interaction database NEDD4 TRIM52 MI:0045 experimental interaction detection MI:0461 interaction database UBE2N TRIM52 MI:0045 experimental interaction detection MI:0461 interaction database UBE2V1 TRIM52 MI:0045 experimental interaction detection MI:0461 interaction database TRIM41 TRIM52 MI:0045 experimental interaction detection MI:0461 interaction database TRIM52 RNF126 MI:0045 experimental interaction detection MI:0461 interaction database TRIM52 RNF114 MI:0045 experimental interaction detection MI:0461 interaction database