PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus DCUN1D1 BTBD9 21145461 biogrid exp G G G GP G P G P GP GP G G P G G P P GP G SKA1 BTBD9 26496610 biogrid,intact exp P P P P P P P P P P P CBR3 BTBD9 26186194 biogrid exp P G P GP G G GP G GP GP G G GP P G GP G P GP P G CUL3 BTBD9 21145461 biogrid exp P G G G GP GP G G GP G G G GP GP G G GP GP G G GP G G GP GP GP G BTBD9 USP25 19615732 biogrid,intact exp P G G G GP GP G G GP G G G GP GP G G GP GP G G GP G G GP GP GP G VPS26B BTBD9 26186194 biogrid exp G G G G GP G G GP G G G GP GP G G GP GP G G GP G G G GP GP G COPS6 BTBD9 19615732,21145461 biogrid,intact exp P G G G GP GP G G GP G G G GP GP G G GP GP G G GP G G GP GP GP G UBXN1 BTBD9 26186194 biogrid exp P G G G G GP G G GP G G G GP GP G G GP GP G G G G G GP GP GP G TIRAP BTBD9 26186194 biogrid exp G G G G GP G G GP G G G G G G G GP GP G G GP G G G GP GP G BTBD9 SEPT3 26186194 biogrid exp G G G G GP G G G G G G GP P G G G G G G PDIA6 BTBD9 26186194 biogrid exp P G G G GP GP G G GP G G G GP GP G G GP GP G G GP G G GP GP GP G COPS5 BTBD9 21145461 biogrid exp P G G G GP GP G G GP G G G GP GP G G GP GP G G GP G G GP GP GP G NEDD8 BTBD9 21145461 biogrid exp P G G G GP GP G G GP G G G GP GP G G GP GP G G GP G G GP GP GP G BTBD9 EPN3 26186194 biogrid exp G P P G G GP G P G P GP G GP G P GP P BTBD9 BTBD9 ortho P G G G GP GP G G GP G G G GP GP G G GP GP G G GP G G GP GP GP G SMARCB1 BTBD9 ortho P G G G GP GP G G GP G G G GP GP G G GP GP G G GP G G GP GP GP G FBXO11 BTBD9 ortho G G G G GP G G G G G G GP G G G GP G G G G G G G G G G GALNT2 BTBD9 ortho P G G G GP GP G G GP G G G GP GP G G GP GP G G G G G GP GP GP G KBTBD11 BTBD9 23023127 pred P G G G GP GP G GP G G G GP GP G G GP P G G P G G GP P P G KLHL18 BTBD9 23023127 pred G G G GP GP G G GP G G G GP G G G GP GP G GP G G G GP GP G NEGR1 BTBD9 23023127 pred G G P GP G G G G GP G G G GP P G G GP G GP P BTBD6 BTBD9 23023127 pred G G G GP G G G GP G G G G GP G G G G G G G G G G G G G KLHL15 BTBD9 23023127 pred P G G G GP GP G G GP G G G GP GP G G GP GP G G GP G G GP GP GP G BTBD9 KLHL11 23023127 pred P P P P P P P P GP BTBD9 BTBD3 23023127 pred P G G G GP GP G G GP G G G GP GP G G GP GP G G GP G G GP GP GP G CNTN5 BTBD9 23023127 pred P G P P P P P P P P P P P BTBD9 UBQLN2 23023127 pred P G G G GP GP G G GP G G G GP GP G G GP GP G G GP G G GP GP GP G KLHL34 BTBD9 23023127 pred P P GP G P P P G GP P P G G P P P BTBD9 BTBD2 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G CNTN4 BTBD9 23023127 pred P G GP G G G G G G GP G G G P G G G BCL6 BTBD9 23023127 pred G G G GP G G G G G G G G GP G G G G G G G G G GP G G G KLHL26 BTBD9 23023127 pred P G P GP G GP G G P GP G G GP GP G G GP G G GP GP G BTBD9 KLHL3 23023127 pred G G G G GP G G GP G G G GP G G G GP GP G G GP G G G GP GP G ENC1 BTBD9 23023127 pred P G G G G GP G G GP G G G GP GP G G GP GP G G GP G G GP GP GP G BTBD9 KLHL1 23023127 pred G G G P P P P BTBD9 FAF1 23023127 pred P G G G GP GP G G GP G G G GP GP G G GP GP G G GP G G GP GP GP G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q96Q07 anti tag coimmunoprecipitation 19615732 physical association C 14 Q96Q07 Q7CG91 two hybrid pooling approach 20711500 physical association X 2 Q96Q07 anti tag coimmunoprecipitation 19615732 physical association C 55

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B BTBD9 USP25 MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_120784|UniProt_100690 prey|prey bait|bait CUL3 BTBD9 MI:0004(affinity chromatography technology) 21145461 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_201989 bait prey DCUN1D1 BTBD9 MI:0004(affinity chromatography technology) 21145461 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_205908 bait prey COPS6 BTBD9 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19615732,21145461 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(intact) BIOGRID_205752|BIOGRID_120783|UniProt_100633 bait|bait|bait prey|prey|prey COPS5 BTBD9 MI:0004(affinity chromatography technology) 21145461 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_205063 bait prey NEDD8 BTBD9 MI:0004(affinity chromatography technology) 21145461 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_206746 bait prey UBC BTBD9 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 21139048,21906983,22505724 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid) BIOGRID_171249|BIOGRID_223426|BIOGRID_180424 bait|bait|bait prey|prey|prey

PPI - HINT Gene A Gene B PMID Method Quality TIRAP BTBD9 26186194 0004 HT UBXN1 BTBD9 26186194,26389662 0004,0004 HT,LC CUL3 BTBD9 21145461 0004 HT PDIA6 BTBD9 26186194 0004 HT NEDD8 BTBD9 21145461 0004 HT VPS26B BTBD9 26186194 0004 HT COPS6 BTBD9 19615732,21145461,19615732 0004,0004,0007 HT COPS5 BTBD9 21145461 0004 HT SKA1 BTBD9 26496610,26496610 0007,0004 HT DCUN1D1 BTBD9 21145461 0004 HT BTBD9 EPN3 26186194 0004 HT BTBD9 SEPT3 26186194 0004 HT BTBD9 USP25 19615732,19615732 0004,0007 HT BTBD9 HEL-S-25 26186194 0004 HT TIRAP BTBD9 26186194 0004 HT UBXN1 BTBD9 26186194 0004 HT CUL3 BTBD9 21145461 0004 HT PDIA6 BTBD9 26186194 0004 HT NEDD8 BTBD9 21145461 0004 HT VPS26B BTBD9 26186194 0004 HT COPS6 BTBD9 19615732,21145461,19615732 0004,0004,0007 HT COPS5 BTBD9 21145461 0004 HT SKA1 BTBD9 26496610,26496610 0007,0004 HT DCUN1D1 BTBD9 21145461 0004 HT BTBD9 EPN3 26186194 0004 HT BTBD9 SEPT3 26186194 0004 HT BTBD9 USP25 19615732,19615732 0004,0007 HT BTBD9 HEL-S-25 26186194 0004 HT UBXN1 BTBD9 26389662 0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q96Q07 P58753 BTBD9 TIRAP 0.126 26186194 Q9H201 Q96Q07 EPN3 BTBD9 0.126 26186194 Q96Q07 O75828 BTBD9 CBR3 0.126 26186194 Q96Q07 Q7CG91 BTBD9 Q7CG91 0.126 20711500 Q96Q07 O94888 BTBD9 UBXN7 0.126 26389662 Q9UHP3 Q96Q07 USP25 BTBD9 0.236 19615732 Q96Q07 Q96BD8 BTBD9 SKA1 0.236 26496610 Q96Q07 Q04323 BTBD9 UBXN1 0.236 26389662,26186194 Q96Q07 Q7L5N1 BTBD9 COPS6 0.332 19615732,21145461 Q96Q07 Q92905 BTBD9 COPS5 0.126 21145461 Q96Q07 Q96GG9 BTBD9 DCUN1D1 0.126 21145461 Q9UH03 Q96Q07 SEPT3 BTBD9 0.126 26186194 Q9UNN5 Q96Q07 FAF1 BTBD9 0.126 26389662 Q96Q07 Q13618 BTBD9 CUL3 0.126 21145461 Q96Q07 Q15084 BTBD9 PDIA6 0.126 26186194 Q96Q07 Q15843 BTBD9 NEDD8 0.126 21145461 Q96Q07 Q4G0F5 BTBD9 VPS26B 0.126 26186194

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 HPGDS BTBD9 MI:0362 inference MI:0461 interaction database CBR3 BTBD9 MI:0045 experimental interaction detection MI:0461 interaction database UBXN7 BTBD9 MI:0045 experimental interaction detection MI:0461 interaction database UBC BTBD9 MI:0045 experimental interaction detection MI:0461 interaction database TIRAP BTBD9 MI:0045 experimental interaction detection MI:0461 interaction database UBXN1 BTBD9 MI:0045 experimental interaction detection MI:0461 interaction database GALNT2 BTBD9 MI:0362 inference MI:0461 interaction database SMARCB1 BTBD9 MI:0362 inference MI:0461 interaction database CUL3 BTBD9 MI:0045 experimental interaction detection MI:0461 interaction database PDIA6 BTBD9 MI:0045 experimental interaction detection MI:0461 interaction database NEDD8 BTBD9 MI:0045 experimental interaction detection MI:0461 interaction database VPS26B BTBD9 MI:0045 experimental interaction detection MI:0461 interaction database COPS6 BTBD9 MI:0045 experimental interaction detection MI:0461 interaction database FBXO11 BTBD9 MI:0362 inference MI:0461 interaction database GALNT16 BTBD9 MI:0362 inference MI:0461 interaction database COPS5 BTBD9 MI:0045 experimental interaction detection MI:0461 interaction database SKA1 BTBD9 MI:0045 experimental interaction detection MI:0461 interaction database DCUN1D1 BTBD9 MI:0045 experimental interaction detection MI:0461 interaction database BTBD9 EPN3 MI:0045 experimental interaction detection MI:0461 interaction database BTBD9 SEPT3 MI:0045 experimental interaction detection MI:0461 interaction database BTBD9 USP25 MI:0045 experimental interaction detection MI:0461 interaction database BTBD9 FAF1 MI:0045 experimental interaction detection MI:0461 interaction database BTBD9 RAD54L2 MI:0362 inference MI:0461 interaction database