PTM - CPLM Gene Name UniProt ID Type Position Code COPB2 P35606 Acetylation 318 K COPB2 P35606 Acetylation 627 K COPB2 P35606 Ubiquitination 168 K COPB2 P35606 Ubiquitination 318 K COPB2 P35606 Ubiquitination 328 K COPB2 P35606 Ubiquitination 346 K COPB2 P35606 Ubiquitination 386 K COPB2 P35606 Ubiquitination 608 K COPB2 P35606 Ubiquitination 822 K COPB2 P35606 Ubiquitination 724 K COPB2 P35606 Ubiquitination 199 K COPB2 P35606 Ubiquitination 69 K COPB2 P35606 Ubiquitination 627 K COPB2 P35606 Ubiquitination 783 K COPB2 P35606 Ubiquitination 771 K

PTM - dbPAF Gene Name UniProt ID Position Type Species COPB2 P35606 101 Y Homo sapiens(Human) COPB2 P35606 116 T Homo sapiens(Human) COPB2 P35606 15 S Homo sapiens(Human) COPB2 P35606 174 S Homo sapiens(Human) COPB2 P35606 175 S Homo sapiens(Human) COPB2 P35606 176 S Homo sapiens(Human) COPB2 P35606 20 S Homo sapiens(Human) COPB2 P35606 26 T Homo sapiens(Human) COPB2 P35606 354 Y Homo sapiens(Human) COPB2 P35606 560 T Homo sapiens(Human) COPB2 P35606 612 T Homo sapiens(Human) COPB2 P35606 679 S Homo sapiens(Human) COPB2 P35606 731 S Homo sapiens(Human) COPB2 P35606 732 Y Homo sapiens(Human) COPB2 P35606 767 S Homo sapiens(Human) COPB2 P35606 778 S Homo sapiens(Human) COPB2 P35606 787 S Homo sapiens(Human) COPB2 P35606 794 Y Homo sapiens(Human) COPB2 P35606 828 T Homo sapiens(Human) COPB2 P35606 845 S Homo sapiens(Human) COPB2 P35606 848 T Homo sapiens(Human) COPB2 P35606 859 S Homo sapiens(Human) COPB2 P35606 86 Y Homo sapiens(Human) COPB2 P35606 861 T Homo sapiens(Human) COPB2 P35606 867 S Homo sapiens(Human) COPB2 P35606 869 T Homo sapiens(Human)

PTM - PhosphositePlus UniProt ID MOD_RSD Type SITE_+/-7_AA P35606 K318-ac Acetylation NGKIIWAkHSEVQQA P35606 K627-ac Acetylation RVAHFLEkQGFKQQA P35606 R165-m1 Methylation FASASLDrTIkVWQL P35606 R833-m1 Methylation LVtPNEErNVMEEGK P35606 S15-p Phosphorylation KRKLTARsDRVKsVD P35606 S20-p Phosphorylation ARsDRVKsVDLHPtE P35606 T26-p Phosphorylation KsVDLHPtEPWMLAS P35606 Y86-p Phosphorylation MQIRVFNyNTLERVH P35606 S99-p Phosphorylation VHMFEAHsDyIRCIA P35606 Y101-p Phosphorylation MFEAHsDyIRCIAVH P35606 T116-p Phosphorylation PTQPFILtSSDDMLI P35606 S176-p Phosphorylation VWQLGSSsPNFTLEG P35606 S350-p Phosphorylation LAVkDMGsCEIyPQT P35606 Y354-p Phosphorylation DMGsCEIyPQTIQHN P35606 S401-p Phosphorylation FAWAHDSsEyAIRES P35606 Y403-p Phosphorylation WAHDSsEyAIRESNS P35606 T560-p Phosphorylation TIAHLDRtMYLLGYI P35606 T612-p Phosphorylation MADkVLPtIPKEQRT P35606 S679-p Phosphorylation QLAELAIsKCQFGLA P35606 Y696-p Phosphorylation CLHHAQDyGGLLLLA P35606 S731-p Phosphorylation kNNVAFMsyFLQGKV P35606 Y732-p Phosphorylation NNVAFMsyFLQGKVD P35606 S767-p Phosphorylation TYLPSQVsRVVKLWR P35606 S787-p Phosphorylation VNQkAAEsLADPTEy P35606 Y794-p Phosphorylation sLADPTEyENLFPGL P35606 T828-p Phosphorylation AkQYPLVtPNEErNV P35606 S845-p Phosphorylation EGKDFQPsRStAQQE P35606 T848-p Phosphorylation DFQPsRStAQQELDG P35606 S859-p Phosphorylation ELDGKPAsPtPVIVA P35606 T861-p Phosphorylation DGKPAsPtPVIVAsH P35606 S867-p Phosphorylation PtPVIVAsHtANKEE P35606 T869-p Phosphorylation PVIVAsHtANKEEKS P35606 K168-ub Ubiquitination ASLDrTIkVWQLGSS P35606 K212-ub Ubiquitination GADDRLVkIWDYQNK P35606 K318-ub Ubiquitination NGKIIWAkHSEVQQA P35606 K328-ub Ubiquitination EVQQANLkAMGDAEI P35606 K346-ub Ubiquitination ERLPLAVkDMGsCEI P35606 K386-ub Ubiquitination TAMALRNkSFGSAQE P35606 K425-ub Ubiquitination FKEKKSFkPDFGAES P35606 K608-ub Ubiquitination RDFSMADkVLPtIPK P35606 K724-ub Ubiquitination EGAERDGkNNVAFMs P35606 K779-ub Ubiquitination LWRENLSkVNQkAAE P35606 K783-ub Ubiquitination NLSkVNQkAAEsLAD P35606 K822-ub Ubiquitination HADLWPAkQYPLVtP

PTM - dbPTM UniProt ID Position Code Type Resources References P35606 318 K Acetylation Swiss-Prot 1010711 19608861 P35606 354 Y Phosphorylation Swiss-Prot 1010711 18083107 P35606 627 K Acetylation Swiss-Prot 1010711 19608861 P35606 859 S Phosphorylation Swiss-Prot 1010711 17081983;17924679;18669648;18691976;19413330;19690332 P35606 861 T Phosphorylation Swiss-Prot 1010711 19413330 P35606 859 S Phosphorylation PhosphoELM.10011 18669648;17081983 P35606 861 T Phosphorylation PhosphoELM.10011 18669648 P35606 354 Y Phosphorylation PhosphoELM.10011 18083107 P35606 168 K Ubiquitylation Phosphositeplus.1010730 21890473 P35606 318 K Ubiquitylation Phosphositeplus.1010730 21890473 P35606 328 K Ubiquitylation Phosphositeplus.1010730 21890473 P35606 346 K Ubiquitylation Phosphositeplus.1010730 21890473 P35606 386 K Ubiquitylation Phosphositeplus.1010730 21890473 P35606 608 K Ubiquitylation Phosphositeplus.1010730 21890473;21906983 P35606 724 K Ubiquitylation Phosphositeplus.1010730 21906983 P35606 783 K Ubiquitylation Phosphositeplus.1010730 21906983 P35606 822 K Ubiquitylation Phosphositeplus.1010730 21906983 P35606 318 K Acetylation Phosphositeplus.1010730 19608861 P35606 627 K Acetylation Phosphositeplus.1010730 19608861 P35606 15 S Phosphorylation Phosphositeplus.1010730 20736484 P35606 20 S Phosphorylation Phosphositeplus.1010730 20736484 P35606 679 S Phosphorylation Phosphositeplus.1010730 21406692 P35606 787 S Phosphorylation Phosphositeplus.1010730 20068231 P35606 859 S Phosphorylation Phosphositeplus.1010730 18491316;18669648;18691976;19276368;19362540;19664995;19690332;20058876;20068231;20166139;20363803;20562096;20886841;21060948;21406692;21659604;22067460;22115753 P35606 867 S Phosphorylation Phosphositeplus.1010730 20166139 P35606 26 T Phosphorylation Phosphositeplus.1010730 20736484 P35606 848 T Phosphorylation Phosphositeplus.1010730 19276368 P35606 861 T Phosphorylation Phosphositeplus.1010730 18669648;19276368;19362540;19690332;20058876;20166139;20562096;21406692 P35606 354 Y Phosphorylation Phosphositeplus.1010730 18083107;19658100 P35606 794 Y Phosphorylation Phosphositeplus.1010730 20562096 P35606 318 K Acetylation HPRD 9.0 19608861 P35606 627 K Acetylation HPRD 9.0 19608861 P35606 787 S Phosphorylation HPRD 9.0 20068231 P35606 859 S Phosphorylation HPRD 9.0 17081983,18669648,19413330,18691976,17924679,18491316,19664995,19651622,18452278,20166139,20068231,20058876 P35606 867 S Phosphorylation HPRD 9.0 20166139 P35606 612 T Phosphorylation HPRD 9.0 20068231 P35606 861 T Phosphorylation HPRD 9.0 18669648,19413330,19651622,18452278,20166139,20068231,20058876 P35606 869 T Phosphorylation HPRD 9.0 19651622 P35606 354 Y Phosphorylation HPRD 9.0 18083107 P35606 859 S Phosphorylation SysPTM 1.1 17081983;18691976;18669648;18491316

PTM - HPRD Symbol Position Code Type References COPB2 318 K Acetylation 19608861 COPB2 354 Y Phosphorylation 18083107 COPB2 612 T Phosphorylation 20068231 COPB2 627 K Acetylation 19608861 COPB2 787 S Phosphorylation 20068231 COPB2 859 S Phosphorylation 17081983,18669648,19413330,18691976,17924679,18491316,19664995,19651622,18452278,20166139,20068231,20058876 COPB2 861 T Phosphorylation 18669648,19413330,19651622,18452278,20166139,20068231,20058876 COPB2 867 S Phosphorylation 20166139 COPB2 869 T Phosphorylation 19651622

PTM - Phospho.ELM UniProt Position Code PMIDs Kinase Source Type P35606 859 S 18669648 HTP Phosphorylation P35606 859 S 17081983 HTP Phosphorylation P35606 354 Y 18083107 HTP Phosphorylation P35606 861 T 18669648 HTP Phosphorylation

PTM - UniProt UniProt ID Position Type PMIDs P35606 627 N6-acetyllysine 19608861 P35606 859 Phosphoserine 18669648;19690332;20068231;21406692;23186163;24275569 P35606 861 Phosphothreonine 24275569

PTM - PHOSIDA Symbol Accession Code Position Surrounding Sequence Type COPB2 IPI00220219 K 317 GKIIWAaKHSEVQQ acetylation COPB2 IPI00220219 K 626 VAHFLEaKQGFKQQ acetylation COPB2 IPI00220219 S 858 LDGKPApSPTPVIV phosphorylation COPB2 IPI00220219 T 860 GKPASPpTPVIVAS phosphorylation

PTM - BioGRID Entrez Gene BioGRID ID Position Code Type PMIDs 9276 114693 - K Ubiquitination 16196087 9276 114693 - K Ubiquitination 18781797 9276 114693 - K Ubiquitination 21139048 9276 114693 - K Ubiquitination 21890473 9276 114693 - K Ubiquitination 21906983 9276 114693 - K Ubiquitination 22505724 9276 114693 - K Ubiquitination 21963094 9276 114693 - K Ubiquitination 23000965 9276 114693 - K Sumoylation 24654937 9276 114693 - K Ubiquitination 24816145 9276 114693 - K Sumoylation 25027693

PTM - mUbiSiDa Gene Name Species Ubiquitination Site Ubiquitination Sequence Evidence PMID COPB2 Homo sapiens (Human) 608; 168; 822; 386; 783; 724; 346; 328; 318 "608,DFSMADKVLPTIP; 168,SLDRTIKVWQLGS; 822,ADLWPAKQYPLVT; 386,AMALRNKSFGSAQ; 783,LSKVNQKAAESLA; 724,GAERDGKNNVAFM; 346,RLPLAVKDMGSCE; 328,VQQANLKAMGDAE; 318,GKIIWAKHSEVQQ" "608:21890473,21906983; 168:21890473; 822:21906983; 386:21890473; 783:21906983; 724:21906983; 346:21890473; 328:21890473; 318:21890473" COPB2 Homo sapiens (Human) 608; 168; 386; 346; 328; 318 "608,DFSMADKVLPTIP; 168,SLDRTIKVWQLGS; 386,AMALRNKSFGSAQ; 346,RLPLAVKDMGSCE; 328,VQQANLKAMGDAE; 318,GKIIWAKHSEVQQ" 608:21890473; 168:21890473; 386:21890473; 346:21890473; 328:21890473; 318:21890473 COPB2 Homo sapiens (Human) 168 "168,SLDRTIKVWQLGS" 168:21890473