PTM - CPLM Gene Name UniProt ID Type Position Code HGS; HRS O14964 Acetylation 207 K HGS; HRS O14964 Ubiquitination 86 K HGS; HRS O14964 Ubiquitination 93 K HGS; HRS O14964 Ubiquitination 126 K HGS; HRS O14964 Ubiquitination 136 K HGS; HRS O14964 Ubiquitination 202 K HGS; HRS O14964 Ubiquitination 207 K HGS; HRS O14964 Ubiquitination 251 K HGS; HRS O14964 Ubiquitination 473 K HGS; HRS O14964 Ubiquitination 513 K HGS; HRS O14964 Ubiquitination 551 K HGS; HRS O14964 Ubiquitination 192 K HGS; HRS O14964 Ubiquitination 521 K HGS; HRS O14964 Ubiquitination 337 K HGS; HRS O14964 Ubiquitination 520 K HGS; HRS O14964 Ubiquitination 56 K HGS; HRS O14964 Ubiquitination 283 K HGS; HRS O14964 Ubiquitination 146 K HGS; HRS O14964 Ubiquitination 196 K HGS; HRS O14964 Ubiquitination 222 K HGS; HRS O14964 Ubiquitination 226 K HGS; HRS O14964 Ubiquitination 291 K HGS; HRS O14964 Ubiquitination 277 K HGS; HRS O14964 Ubiquitination 541 K

PTM - dbPAF Gene Name UniProt ID Position Type Species HGS; HRS O14964 125 Y Homo sapiens(Human) HGS; HRS O14964 131 T Homo sapiens(Human) HGS; HRS O14964 132 Y Homo sapiens(Human) HGS; HRS O14964 198 S Homo sapiens(Human) HGS; HRS O14964 216 Y Homo sapiens(Human) HGS; HRS O14964 228 T Homo sapiens(Human) HGS; HRS O14964 230 T Homo sapiens(Human) HGS; HRS O14964 237 Y Homo sapiens(Human) HGS; HRS O14964 239 T Homo sapiens(Human) HGS; HRS O14964 240 S Homo sapiens(Human) HGS; HRS O14964 243 S Homo sapiens(Human) HGS; HRS O14964 246 S Homo sapiens(Human) HGS; HRS O14964 284 S Homo sapiens(Human) HGS; HRS O14964 286 Y Homo sapiens(Human) HGS; HRS O14964 287 T Homo sapiens(Human) HGS; HRS O14964 288 S Homo sapiens(Human) HGS; HRS O14964 289 Y Homo sapiens(Human) HGS; HRS O14964 305 S Homo sapiens(Human) HGS; HRS O14964 306 S Homo sapiens(Human) HGS; HRS O14964 308 Y Homo sapiens(Human) HGS; HRS O14964 309 S Homo sapiens(Human) HGS; HRS O14964 310 S Homo sapiens(Human) HGS; HRS O14964 329 Y Homo sapiens(Human) HGS; HRS O14964 334 Y Homo sapiens(Human) HGS; HRS O14964 345 S Homo sapiens(Human) HGS; HRS O14964 347 T Homo sapiens(Human) HGS; HRS O14964 355 T Homo sapiens(Human) HGS; HRS O14964 466 Y Homo sapiens(Human) HGS; HRS O14964 467 Y Homo sapiens(Human) HGS; HRS O14964 485 S Homo sapiens(Human) HGS; HRS O14964 524 Y Homo sapiens(Human) HGS; HRS O14964 567 Y Homo sapiens(Human) HGS; HRS O14964 594 S Homo sapiens(Human) HGS; HRS O14964 625 T Homo sapiens(Human) HGS; HRS O14964 78 T Homo sapiens(Human)

PTM - PhosphositePlus UniProt ID MOD_RSD Type SITE_+/-7_AA O14964 K207-ac Acetylation IPkFGIEkEVRVCEP O14964 K494-ac Acetylation LREEHREkLRRAAEE O14964 Y125-p Phosphorylation AFRNEPKykVVQDty O14964 T131-p Phosphorylation KykVVQDtyQIMkVE O14964 Y132-p Phosphorylation ykVVQDtyQIMkVEG O14964 Y216-p Phosphorylation VRVCEPCyEQLNRkA O14964 T228-p Phosphorylation RkAEGkAtSTTELPP O14964 Y237-p Phosphorylation TTELPPEyLtsPLsQ O14964 T239-p Phosphorylation ELPPEyLtsPLsQQs O14964 S240-p Phosphorylation LPPEyLtsPLsQQsQ O14964 S243-p Phosphorylation EyLtsPLsQQsQLPP O14964 S246-p Phosphorylation tsPLsQQsQLPPkRD O14964 S284-p Phosphorylation kERLRQKsTytsyPk O14964 Y286-p Phosphorylation RLRQKsTytsyPkAE O14964 T287-p Phosphorylation LRQKsTytsyPkAEP O14964 S288-p Phosphorylation RQKsTytsyPkAEPM O14964 Y289-p Phosphorylation QKsTytsyPkAEPMP O14964 S305-p Phosphorylation ASSAPPAssLysSPV O14964 S306-p Phosphorylation SSAPPAssLysSPVN O14964 Y308-p Phosphorylation APPAssLysSPVNSS O14964 S309-p Phosphorylation PPAssLysSPVNSSA O14964 Y329-p Phosphorylation IDPELARyLNRNyWE O14964 Y334-p Phosphorylation ARyLNRNyWEkKQEE O14964 S345-p Phosphorylation KQEEARKsPtPSAPV O14964 T347-p Phosphorylation EEARKsPtPSAPVPL O14964 T355-p Phosphorylation PSAPVPLtEPAAQPG O14964 Y466-p Phosphorylation QLDERRLyyEGLQDk O14964 Y467-p Phosphorylation LDERRLyyEGLQDkL O14964 S485-p Phosphorylation RDARGALsALREEHR O14964 Y524-p Phosphorylation MRQKkQEyLEVQRQL O14964 Y567-p Phosphorylation MPAFPLPyAQLQAMP O14964 K56-ub Ubiquitination IKKKVNDkNPHVALY O14964 K86-ub Ubiquitination VHDEVANkQTMEELk O14964 K93-ub Ubiquitination kQTMEELkDLLkRQV O14964 K97-ub Ubiquitination EELkDLLkRQVEVNV O14964 K126-ub Ubiquitination FRNEPKykVVQDtyQ O14964 K136-ub Ubiquitination QDtyQIMkVEGHVFP O14964 K146-ub Ubiquitination GHVFPEFkESDAMFA O14964 K192-ub Ubiquitination CGQIFCGkCSSkYST O14964 K196-ub Ubiquitination FCGkCSSkYSTIPkF O14964 K202-ub Ubiquitination SkYSTIPkFGIEkEV O14964 K207-ub Ubiquitination IPkFGIEkEVRVCEP O14964 K222-ub Ubiquitination CyEQLNRkAEGkAtS O14964 K226-ub Ubiquitination LNRkAEGkAtSTTEL O14964 K251-ub Ubiquitination QQsQLPPkRDETALQ O14964 K277-ub Ubiquitination SQSEAEEkERLRQKs O14964 K291-ub Ubiquitination sTytsyPkAEPMPSA O14964 K337-ub Ubiquitination LNRNyWEkKQEEARK O14964 K473-ub Ubiquitination yyEGLQDkLAQIRDA O14964 K513-ub Ubiquitination RQIQLAQkLEIMRQK O14964 K521-ub Ubiquitination LEIMRQKkQEyLEVQ O14964 K541-ub Ubiquitination QRLQEQEkERQMRLE O14964 K551-ub Ubiquitination QMRLEQQkQTVQMRA

PTM - dbPTM UniProt ID Position Code Type Resources References O14964 132 Y Phosphorylation Swiss-Prot 1010711 18083107 O14964 207 K Acetylation Swiss-Prot 1010711 19608861 O14964 216 Y Phosphorylation Swiss-Prot 1010711 15592455;18083107 O14964 240 S Phosphorylation Swiss-Prot 1010711 19413330 O14964 286 Y Phosphorylation Swiss-Prot 1010711 19534553 O14964 289 Y Phosphorylation Swiss-Prot 1010711 19534553 O14964 308 Y Phosphorylation Swiss-Prot 1010711 16212419;19534553 O14964 310 S Phosphorylation PhosphoELM.10011 18669648 O14964 132 Y Phosphorylation PhosphoELM.10011 18083107 O14964 216 Y Phosphorylation PhosphoELM.10011 18083107;15592455 O14964 308 Y Phosphorylation PhosphoELM.10011 16212419 O14964 334 Y Phosphorylation PhosphoELM.10011 12953068;11687594 O14964 329 Y Phosphorylation PhosphoELM.10011 12953068 O14964 126 K Ubiquitylation Phosphositeplus.1010730 21890473;21906983 O14964 136 K Ubiquitylation Phosphositeplus.1010730 21890473;21906983 O14964 146 K Ubiquitylation Phosphositeplus.1010730 21906983 O14964 192 K Ubiquitylation Phosphositeplus.1010730 21906983 O14964 196 K Ubiquitylation Phosphositeplus.1010730 21906983 O14964 202 K Ubiquitylation Phosphositeplus.1010730 21890473;21906983 O14964 207 K Ubiquitylation Phosphositeplus.1010730 21890473;21906983 O14964 222 K Ubiquitylation Phosphositeplus.1010730 21906983 O14964 226 K Ubiquitylation Phosphositeplus.1010730 21906983 O14964 251 K Ubiquitylation Phosphositeplus.1010730 21890473;21906983 O14964 277 K Ubiquitylation Phosphositeplus.1010730 21906983 O14964 291 K Ubiquitylation Phosphositeplus.1010730 21906983 O14964 337 K Ubiquitylation Phosphositeplus.1010730 21906983 O14964 473 K Ubiquitylation Phosphositeplus.1010730 21890473;21906983 O14964 513 K Ubiquitylation Phosphositeplus.1010730 21890473;21906983 O14964 521 K Ubiquitylation Phosphositeplus.1010730 21906983 O14964 541 K Ubiquitylation Phosphositeplus.1010730 21906983 O14964 551 K Ubiquitylation Phosphositeplus.1010730 21906983 O14964 56 K Ubiquitylation Phosphositeplus.1010730 21906983 O14964 86 K Ubiquitylation Phosphositeplus.1010730 21890473;21906983 O14964 93 K Ubiquitylation Phosphositeplus.1010730 21890473 O14964 97 K Ubiquitylation Phosphositeplus.1010730 20972266 O14964 207 K Acetylation Phosphositeplus.1010730 19608861 O14964 240 S Phosphorylation Phosphositeplus.1010730 16964243 O14964 243 S Phosphorylation Phosphositeplus.1010730 16964243 O14964 345 S Phosphorylation Phosphositeplus.1010730 20058876 O14964 131 T Phosphorylation Phosphositeplus.1010730 21049007 O14964 132 Y Phosphorylation Phosphositeplus.1010730 18083107;18180459;19658100;19901323;20090780;20736484;21049007 O14964 216 Y Phosphorylation Phosphositeplus.1010730 15592455;16497976;17360941;18083107;18180459;19605366;19658100;20007894;20090780;20562096;20736484;21049007;21253578;21394647;21403953;21447384 O14964 237 Y Phosphorylation Phosphositeplus.1010730 18180459;20736484 O14964 286 Y Phosphorylation Phosphositeplus.1010730 19534553;20007894;20736484 O14964 289 Y Phosphorylation Phosphositeplus.1010730 19534553 O14964 308 Y Phosphorylation Phosphositeplus.1010730 16212419;17016520;18083107;18180459;19534553;20090780 O14964 329 Y Phosphorylation Phosphositeplus.1010730 11687594;12953068;17016520;17101784;18083107;20090780;20736484 O14964 334 Y Phosphorylation Phosphositeplus.1010730 11687594;12953068;17016520;17101784;18083107;18180459;19901323;20090780;20736484;21049007 O14964 207 K Acetylation HPRD 9.0 19608861 O14964 198 S Phosphorylation HPRD 9.0 20068231 O14964 240 S Phosphorylation HPRD 9.0 19413330 O14964 310 S Phosphorylation HPRD 9.0 18669648,20068231 O14964 345 S Phosphorylation HPRD 9.0 20058876 O14964 594 S Phosphorylation HPRD 9.0 20068231 O14964 625 T Phosphorylation HPRD 9.0 20068231 O14964 132 Y Phosphorylation HPRD 9.0 18083107,19901323 O14964 216 Y Phosphorylation HPRD 9.0 15592455,16497976 O14964 308 Y Phosphorylation HPRD 9.0 16212419,17016520 O14964 334 Y Phosphorylation HPRD 9.0 11687594,17016520,19901323 O14964 567 Y Phosphorylation HPRD 9.0 20068231 O14964 329 Y Phosphorylation (EGFR) HPRD 9.0 12953068,17016520 O14964 240 S Phosphorylation SysPTM 1.1 16964243

PTM - HPRD Symbol Position Code Type References HGS 132 Y Phosphorylation 18083107,19901323 HGS 198 S Phosphorylation 20068231 HGS 207 K Acetylation 19608861 HGS 216 Y Phosphorylation 15592455,16497976 HGS 240 S Phosphorylation 19413330 HGS 308 Y Phosphorylation 16212419,17016520 HGS 310 S Phosphorylation 18669648,20068231 HGS 329 Y Phosphorylation 12953068,17016520 HGS 334 Y Phosphorylation 11687594,17016520,19901323 HGS 345 S Phosphorylation 20058876 HGS 567 Y Phosphorylation 20068231 HGS 594 S Phosphorylation 20068231 HGS 625 T Phosphorylation 20068231

PTM - Phospho.ELM UniProt Position Code PMIDs Kinase Source Type O14964 216 Y 18083107 HTP Phosphorylation O14964 216 Y 15592455 HTP Phosphorylation O14964 329 Y 12953068 EGFR LTP Phosphorylation O14964 132 Y 18083107 HTP Phosphorylation O14964 334 Y 12953068 LTP Phosphorylation O14964 334 Y 11687594 LTP Phosphorylation O14964 308 Y 16212419 HTP Phosphorylation O14964 310 S 18669648 HTP Phosphorylation

PTM - UniProt UniProt ID Position Type PMIDs O14964 207 N6-acetyllysine 19608861 O14964 216 Phosphotyrosine 15592455

PTM - PHOSIDA Symbol Accession Code Position Surrounding Sequence Type HGS IPI00006176 K 207 PKFGIEaKEVRVCE acetylation HGS IPI00006176 T 78 VKNCGQpTVHDEVA phosphorylation HGS IPI00006176 Y 289 KSTYTSpYPKAEPM phosphorylation

PTM - BioGRID Entrez Gene BioGRID ID Position Code Type PMIDs 9146 114593 - K Ubiquitination 17101784 9146 114593 - K Ubiquitination 16771824 9146 114593 - K Ubiquitination 16735510 9146 114593 - K Ubiquitination 14602072 9146 114593 - K Ubiquitination 20505072 9146 114593 - K Ubiquitination 20675381 9146 114593 - K Ubiquitination 21987572 9146 114593 - K Ubiquitination 20972266 9146 114593 - K Ubiquitination 21963094 9146 114593 - K Ubiquitination 21139048 9146 114593 - K Ubiquitination 21890473 9146 114593 - K Ubiquitination 21906983 9146 114593 - K Ubiquitination 12953068 9146 114593 - K Ubiquitination 17686993 9146 114593 - K Ubiquitination 20224683 9146 114593 - K Ubiquitination 15809337 9146 114593 - K Ubiquitination 22505724 9146 114593 - K Ubiquitination 23000965 9146 114593 - K Ubiquitination 23602387 9146 114593 - K Ubiquitination 24790097 9146 114593 - K Ubiquitination 24816145 9146 114593 - K Ubiquitination 25015289 9146 114593 - K Ubiquitination 25195858 9146 114593 - K Ubiquitination 25147182 9146 114593 - K Ubiquitination 16429130

PTM - mUbiSiDa Gene Name Species Ubiquitination Site Ubiquitination Sequence Evidence PMID HGS Homo sapiens (Human) 136; 207; 86; 251; 513; 202; 473; 93; 126 "136,DTYQIMKVEGHVF; 207,PKFGIEKEVRVCE; 86,HDEVANKQTMEEL; 251,QSQLPPKRDETAL; 513,QIQLAQKLEIMRQ; 202,KYSTIPKFGIEKE; 473,YEGLQDKLAQIRD; 93,QTMEELKDLLKRQ; 126,RNEPKYKVVQDTY" 136:21890473; 207:21890473; 86:21890473; 251:21890473; 513:21890473; 202:21890473; 473:21890473; 93:21890473; 126:21890473 HGS Homo sapiens (Human) 136; 207; 86; 251; 513; 202; 473; 93; 126 "136,DTYQIMKVEGHVF; 207,PKFGIEKEVRVCE; 86,HDEVANKQTMEEL; 251,QSQLPPKRDETAL; 513,QIQLAQKLEIMRQ; 202,KYSTIPKFGIEKE; 473,YEGLQDKLAQIRD; 93,QTMEELKDLLKRQ; 126,RNEPKYKVVQDTY" 136:21890473; 207:21890473; 86:21890473; 251:21890473; 513:21890473; 202:21890473; 473:21890473; 93:21890473; 126:21890473 HGS Homo sapiens (Human) 551; 136; 207; 513; 337; 277; 473; 202; 196; 521; 192; 226; 222; 86; 291; 251; 93; 541; 126; 146; 56 "551,MRLEQQKQTVQMR; 136,DTYQIMKVEGHVF; 207,PKFGIEKEVRVCE; 513,QIQLAQKLEIMRQ; 337,NRNYWEKKQEEAR; 277,QSEAEEKERLRQK; 473,YEGLQDKLAQIRD; 202,KYSTIPKFGIEKE; 196,CGKCSSKYSTIPK; 521,EIMRQKKQEYLEV; 192,GQIFCGKCSSKYS; 226,NRKAEGKATSTTE; 222,YEQLNRKAEGKAT; 86,HDEVANKQTMEEL; 291,TYTSYPKAEPMPS; 251,QSQLPPKRDETAL; 93,QTMEELKDLLKRQ; 541,RLQEQEKERQMRL; 126,RNEPKYKVVQDTY; 146,HVFPEFKESDAMF; 56,KKKVNDKNPHVAL" "551:21906983; 136:21890473,21906983; 207:21890473,21906983; 513:21890473,21906983; 337:21906983; 277:21906983; 473:21890473,21906983; 202:21890473,21906983; 196:21906983; 521:21906983; 192:21906983; 226:21906983; 222:21906983; 86:21890473,21906983; 291:21906983; 251:21890473,21906983; 93:21890473; 541:21906983; 126:21890473,21906983; 146:21906983; 56:21906983" HGS Homo sapiens (Human) 136; 207; 337; 277; 473; 202; 196; 192; 226; 222; 291; 86; 251; 93; 126; 146; 56 "136,DTYQIMKVEGHVF; 207,PKFGIEKEVRVCE; 337,NRNYWEKKQEEAR; 277,QSEAEEKERLRQK; 473,YEGLQDKLAQIRD; 202,KYSTIPKFGIEKE; 196,CGKCSSKYSTIPK; 192,GQIFCGKCSSKYS; 226,NRKAEGKATSTTE; 222,YEQLNRKAEGKAT; 291,TYTSYPKAEPMPS; 86,HDEVANKQTMEEL; 251,QSQLPPKRDETAL; 93,QTMEELKDLLKRQ; 126,RNEPKYKVVQDTY; 146,HVFPEFKESDAMF; 56,KKKVNDKNPHVAL" "136:21890473,21906983; 207:21890473,21906983; 337:21906983; 277:21906983; 473:21890473,21906983; 202:21890473,21906983; 196:21906983; 192:21906983; 226:21906983; 222:21906983; 291:21906983; 86:21890473,21906983; 251:21890473,21906983; 93:21890473; 126:21890473,21906983; 146:21906983; 56:21906983"