PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus THRA ZBTB3 20211142 biogrid exp GP P G GP P P GP G GP GP GP G GP P GP P GP P GP GP GP G GP P G PPARG ZBTB3 20211142 biogrid exp GP P P P GP P G GP P G GP P P P GP P SMAD3 ZBTB3 20211142 biogrid exp GP P G G P G G G G GP G G P G P GP G G G G G G FOXM1 ZBTB3 20211142 biogrid exp P P G GP P P P P P P GP P P P P P P P P P P PKNOX1 ZBTB3 20211142 biogrid exp GP G G G G G G G G G GP G G G G G G GATA4 ZBTB3 20211142 biogrid exp P P P P P P P GP P GP P GP P GP P P P GP GP P SSX3 ZBTB3 20211142 biogrid exp P P P P P P P P P P P P P P P P IRF6 ZBTB3 20211142 biogrid exp G G G G G G G G G G G G G G G G G G EIF5B ZBTB3 20211142 biogrid exp GP P G GP P P GP G GP GP GP G GP P GP P GP P GP GP GP G GP P G ZBTB3 LEF1 20211142 biogrid exp G G GP P GP G GP GP G G P G G G G G G G ZBTB3 IKBKG 20211142 biogrid exp G G G G G G G G G G G G G G G G G G ZBTB3 ZMYM2 20211142 biogrid exp GP P G GP P P GP G GP G GP G GP P GP P GP P GP GP GP G GP P G ELAVL1 ZBTB3 19322201 biogrid exp GP P G GP P P GP G GP GP GP G GP P GP P GP P GP GP GP G GP P G ZBTB3 JADE2 20211142 biogrid exp G P G G P GP G G G G G GP P GP GP P G GP GP G G G ANKRD2 ZBTB3 20211142 biogrid exp P GP GP G ZBTB3 ZNF556 20211142 biogrid exp G ZBTB3 GTF2A1L 20211142 biogrid exp SKIL ZBTB3 15231748 hprd,biogrid,i2d,mint,intact exp GP P G GP P GP G GP GP G G GP P G GP P GP GP GP G GP P G PROX1 ZBTB3 20211142 biogrid exp G G G G G G G G G G G G G G G G G G SUPT5H ZBTB3 20211142 biogrid exp GP P G GP P P GP G GP GP GP G GP P GP P GP P GP GP GP G GP P G BAG3 ZBTB3 23824909 biogrid exp GP P G GP P P GP G GP GP GP G GP P GP P GP P GP GP GP G GP P G BIN1 ZBTB3 20211142 biogrid exp GP P G GP P P GP G GP GP GP G GP P GP P GP P GP GP GP G GP P G NR3C1 ZBTB3 20211142 biogrid exp GP P G GP P P GP G GP GP GP G GP P GP P GP P GP GP GP G GP P G OTX2 ZBTB3 ortho P P G P P P P P P P P P P ZBTB3 UBP1 ortho G G G G G G G G G G G G G G G G G G SIRT2 ZBTB3 ortho G P G G P P G G GP G G G GP P G G G GP GP G G P G MLLT10 ZBTB3 ortho G G G P G G G G G G G P G G G G G G GP P G ZBTB3 POLR3E ortho P P P P P P P P P P P P P P P P P P P KLHL32 ZBTB3 23023127 pred P P P G P P P P P KLHL24 ZBTB3 23023127 pred G G G P G G G G G G GP P G P G G G GP G G G ZBTB17 ZBTB3 23023127 pred GP P G G P P GP G GP GP GP G GP P GP P GP P GP GP GP G GP P G KBTBD3 ZBTB3 23023127 pred G P G G P G G G G G G GP G G G G BTBD6 ZBTB3 23023127 pred G G GP GP G G G GP G GP G G G GP GP G G G ZBTB44 ZBTB3 23023127 pred GP P G GP P P GP G GP GP GP G GP P GP P GP P GP GP GP G GP P G

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B SMAD3 ZBTB3 MI:0018(two hybrid) 20211142 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_128538 bait prey SUPT5H ZBTB3 MI:0018(two hybrid) 20211142 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_128688 bait prey GATA4 ZBTB3 MI:0018(two hybrid) 20211142 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_128404 bait prey NR3C1 ZBTB3 MI:0018(two hybrid) 20211142 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_128414 bait prey SKIL ZBTB3 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 15231748 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|- MI:0471(mint)|(intact)|MI:0471(mint)|(biogrid)|MI:0468(hprd) MINT_60586|UniProt_78682|MINT_31802|BIOGRID_258981|HPRD_38420 bait|bait|bait|bait|- prey|prey|prey|prey|- ZBTB3 ANKRD2 MI:0018(two hybrid) 20211142 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_128900 prey bait PKNOX1 ZBTB3 MI:0018(two hybrid) 20211142 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_128617 bait prey FOXM1 ZBTB3 MI:0018(two hybrid) 20211142 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_128390 bait prey ZBTB3 ZNF556 MI:0018(two hybrid) 20211142 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_128934 bait prey PROX1 ZBTB3 MI:0018(two hybrid) 20211142 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_128645 bait prey ELAVL1 ZBTB3 MI:0096(pull down) 19322201 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_187519 bait prey IRF6 ZBTB3 MI:0018(two hybrid) 20211142 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_128528 bait prey EIF5B ZBTB3 MI:0018(two hybrid) 20211142 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_128820 bait prey ZBTB3 IKBKG MI:0018(two hybrid) 20211142 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_128796 prey bait ZBTB3 PHF15 MI:0018(two hybrid) 20211142 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_128874 prey bait ZBTB3 GTF2A1L MI:0018(two hybrid) 20211142 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_128860 prey bait ZBTB3 LEF1 MI:0018(two hybrid) 20211142 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_128913 prey bait PPARG ZBTB3 MI:0018(two hybrid) 20211142 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_128641 bait prey BIN1 ZBTB3 MI:0018(two hybrid) 20211142 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_128285 bait prey THRA ZBTB3 MI:0018(two hybrid) 20211142 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_128716 bait prey ZBTB3 ZMYM2 MI:0018(two hybrid) 20211142 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_128747 prey bait BAG3 ZBTB3 MI:0004(affinity chromatography technology) 23824909 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_283160 bait prey SSX3 ZBTB3 MI:0018(two hybrid) 20211142 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_128835 bait prey

PPI - HINT Gene A Gene B PMID Method Quality SUPT5H ZBTB3 20211142 0018 HT BIN1 ZBTB3 20211142 0018 HT IRF6 ZBTB3 20211142 0018 HT EIF5B ZBTB3 20211142 0018 HT NR3C1 ZBTB3 20211142 0018 HT THRA ZBTB3 20211142 0018 HT SKIL ZBTB3 15231748 0018 HT PPARG ZBTB3 20211142 0018 HT GATA4 ZBTB3 20211142 0018 HT PKNOX1 ZBTB3 20211142 0018 HT SMAD3 ZBTB3 20211142 0018 HT FOXM1 ZBTB3 20211142 0018 HT PROX1 ZBTB3 20211142 0018 HT SSX3 ZBTB3 20211142 0018 HT ANKRD2 ZBTB3 20211142 0018 HT ZBTB3 ZNF556 20211142 0018 HT ZBTB3 JADE2 20211142 0018 HT ZBTB3 Q9P0T0 20211142 0018 HT ZBTB3 ZMYM2 20211142 0018 HT ZBTB3 LEF1 20211142 0018 HT ZBTB3 GTF2A1L 20211142 0018 HT ZBTB3 IKBKG 20211142 0018 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9H5J0 O14896 ZBTB3 IRF6 0.183 20211142 Q9H5J0 Q9GZV1 ZBTB3 ANKRD2 0.183 20211142 Q9NQC1 Q9H5J0 JADE2 ZBTB3 0.183 20211142 Q9H5J0 O60841 ZBTB3 EIF5B 0.183 20211142 Q9HAH1 Q9H5J0 ZNF556 ZBTB3 0.183 20211142 Q9H5J0 P12757 ZBTB3 SKIL 0.332 15231748 Q9Y6K9 Q9H5J0 IKBKG ZBTB3 0.183 20211142 Q9H5J0 P10827 ZBTB3 THRA 0.183 20211142 Q9H5J0 P04150 ZBTB3 NR3C1 0.183 20211142 Q9H5J0 O95817 ZBTB3 BAG3 0.126 23824909 Q9H5J0 Q9BXS5 ZBTB3 AP1M1 0.236 unassigned1304 Q9H5J0 Q8NB12 ZBTB3 SMYD1 0.236 unassigned1304 Q9H5J0 P37231 ZBTB3 PPARG 0.183 20211142 Q9H5J0 Q92786 ZBTB3 PROX1 0.183 20211142 Q9H5J0 Q99909 ZBTB3 SSX3 0.183 20211142 Q9UBW7 Q9H5J0 ZMYM2 ZBTB3 0.183 20211142 Q9UJU2 Q9H5J0 LEF1 ZBTB3 0.183 20211142 Q9UNN4 Q9H5J0 GTF2A1L ZBTB3 0.183 20211142 Q9H5J0 P43694 ZBTB3 GATA4 0.183 20211142 Q9H5J0 P84022 ZBTB3 SMAD3 0.183 20211142 Q9H5J0 Q15717 ZBTB3 ELAVL1 0.126 19322201 Q9H5J0 O00267 ZBTB3 SUPT5H 0.183 20211142 Q9H5J0 O00499 ZBTB3 BIN1 0.183 20211142 Q9H5J0 Q08050 ZBTB3 FOXM1 0.183 20211142 Q9H5J0 P55347 ZBTB3 PKNOX1 0.183 20211142

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 SUPT5H ZBTB3 MI:0045 experimental interaction detection MI:0461 interaction database BIN1 ZBTB3 MI:0045 experimental interaction detection MI:0461 interaction database IRF6 ZBTB3 MI:0045 experimental interaction detection MI:0461 interaction database EIF5B ZBTB3 MI:0045 experimental interaction detection MI:0461 interaction database BAG3 ZBTB3 MI:0045 experimental interaction detection MI:0461 interaction database NR3C1 ZBTB3 MI:0045 experimental interaction detection MI:0461 interaction database THRA ZBTB3 MI:0045 experimental interaction detection MI:0461 interaction database SKIL ZBTB3 MI:0045 experimental interaction detection MI:0461 interaction database OTX2 ZBTB3 MI:0362 inference MI:0461 interaction database PPARG ZBTB3 MI:0045 experimental interaction detection MI:0461 interaction database GATA4 ZBTB3 MI:0045 experimental interaction detection MI:0461 interaction database MLLT10 ZBTB3 MI:0362 inference MI:0461 interaction database PKNOX1 ZBTB3 MI:0045 experimental interaction detection MI:0461 interaction database SMAD3 ZBTB3 MI:0045 experimental interaction detection MI:0461 interaction database FOXM1 ZBTB3 MI:0045 experimental interaction detection MI:0461 interaction database TFCP2 ZBTB3 MI:0362 inference MI:0461 interaction database ELAVL1 ZBTB3 MI:0045 experimental interaction detection MI:0461 interaction database SIRT2 ZBTB3 MI:0362 inference MI:0461 interaction database PROX1 ZBTB3 MI:0045 experimental interaction detection MI:0461 interaction database SSX3 ZBTB3 MI:0045 experimental interaction detection MI:0461 interaction database ANKRD2 ZBTB3 MI:0045 experimental interaction detection MI:0461 interaction database ZBTB3 ZNF556 MI:0045 experimental interaction detection MI:0461 interaction database ZBTB3 JADE2 MI:0045 experimental interaction detection MI:0461 interaction database ZBTB3 POLR3E MI:0362 inference MI:0461 interaction database ZBTB3 TFCP2L1 MI:0362 inference MI:0461 interaction database ZBTB3 UBP1 MI:0362 inference MI:0461 interaction database ZBTB3 ZMYM2 MI:0045 experimental interaction detection MI:0461 interaction database ZBTB3 LEF1 MI:0045 experimental interaction detection MI:0461 interaction database ZBTB3 GTF2A1L MI:0045 experimental interaction detection MI:0461 interaction database ZBTB3 IKBKG MI:0045 experimental interaction detection MI:0461 interaction database