PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus TRIM69 TRIM44 25416956 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G G GP G G G GP GP G GP G GP GP GP G SKIL TRIM69 15231748 hprd exp GP GP G G GP GP G G GP G GP GP GP G G G GP G G G GP GP G GP G G GP GP G BAG3 TRIM69 23824909 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G G GP GP G G GP GP G GP G GP GP GP G LARP1B TRIM69 25416956 biogrid,intact exp G G G G GP G G GP GP G GP G GP GP G G G G G G GP G G GP G GP GP GP G FKBP1B TRIM69 25416956 biogrid,intact exp G GP G G G GP G G GP G GP GP G G G G GP GP G G GP GP G G GP GP G SF1 TRIM69 25416956 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G G GP GP G G GP GP G GP G GP GP GP G KRT17 TRIM69 25416956 biogrid,intact exp P P P APP TRIM69 21832049 biogrid exp G GP G G GP GP G G GP G G G G G G G GP G G G GP GP G G G G G GP G ASNS TRIM69 25416956 innatedb,biogrid,intact exp GP G G G GP GP G GP GP G G G GP G G GP G G G P G G G G G GP GP G PPP1R18 TRIM69 25416956 biogrid,intact exp G G G G GP GP G G GP G G G GP GP G G GP G G G G G G G G GP G G G NEK8 TRIM69 25416956 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G G GP GP G G GP GP G GP G GP GP GP G TLR3 TRIM69 21911421 biogrid exp GP GP P G P GP GP GP GP G G P GP G GP GP G G G GP GP G TRIM69 TLR9 21911421 biogrid exp GP G G G GP GP GP GP G GP P GP GP G GP GP G P P G GP G GP GP GP G ATP5G1 TRIM69 25416956,21516116 innatedb,biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G RECK TRIM69 25416956,21516116 biogrid,mint,intact exp GP G G G GP GP G GP GP G GP GP GP G G G GP GP G G GP G G G G G G GP G MAGEA4 TRIM69 25416956,16189514,21516116 hprd,biogrid,mint,intact exp P P GP SF3A3 TRIM69 25416956,21516116 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G G GP GP G G GP GP G GP G GP GP GP G TRIM69 SYNE4 25416956 biogrid,intact exp P GP P GP G GP GP G GP GP GP P G G GP P G G GP GP G GP G P GP P G TRIM69 RTDR1 25416956 biogrid,intact exp P P P P P P P P P P P P P P G P P GP TRIM69 HAUS1 25416956 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G G GP G G G GP GP G GP G GP GP GP G TLR4 TRIM69 21911421 biogrid exp G GP G G GP GP G G G G G GP G GP G G G G G GP G IYD TRIM69 25416956 biogrid,intact exp P GP GP TRIM69 ZNF483 25416956 biogrid,intact exp P G P GP P P G P P P P GP GP P P P DVL1 TRIM69 25416956 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G G GP GP G G GP GP G GP G GP GP GP G TRIM69 TRIM69 25416956 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G G GP GP G G GP GP G GP G GP GP GP G TRIM69 FAM110A 25416956 biogrid,intact exp G GP G G GP GP G GP GP G GP G GP GP G G GP G G G GP G P G GP G GP G PML TRIM69 12837286, 25402006 hprd,biogrid exp, pred GP GP G G GP GP G GP GP G GP G GP GP G G GP GP G G GP GP G G G GP GP GP G UBE2D2 TRIM69 23023127 pred GP G G G GP GP G G GP G GP GP GP GP G G GP GP G G GP GP G GP G GP GP GP G TRIM75P TRIM69 23023127 pred BTN3A3 TRIM69 23023127 pred GP GP G GP P G GP GP G GP GP GP GP G G GP GP G P GP P G GP GP P G TRIM69 BARD1 23023127 pred P G GP P P GP P P P GP G G P G P GP GP GP GP GP G HDAC1 TRIM69 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G G GP GP G G GP GP G G G GP GP GP G UBE2D3 TRIM69 23023127 pred GP G G G GP GP G G GP G GP GP GP GP G G GP GP G G GP GP G GP G GP GP GP G TOP3A TRIM69 25402006 pred GP G G G GP GP G G GP G GP G GP GP G G GP GP G G GP GP G GP G GP GP GP G HHEX TRIM69 25402006 pred G G G G GP G G G GP G GP G G GP G G G G G G G G G GP G GP GP G RFPL4A TRIM69 23023127 pred P P P P P P P P P P P P P P P P P P

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q86WT6 O95980 two hybrid 21516116 physical association X 2 Q86WT6 F5GWP8 two hybrid prey pooling approach 25416956 physical association X 2 Q86WT6 P05496 two hybrid prey pooling approach 25416956 physical association X 2 Q86WT6 P08243 two hybrid prey pooling approach 25416956 physical association X 2 Q86WT6 Q659C4 two hybrid prey pooling approach 25416956 physical association X 2 Q86WT6 Q6P088 two hybrid prey pooling approach 25416956 physical association X 2 Q86WT6 Q6PHW0 two hybrid prey pooling approach 25416956 physical association X 2 Q86WT6 Q86TH3 two hybrid prey pooling approach 25416956 physical association X 2 Q86WT6 Q8N205 two hybrid prey pooling approach 25416956 physical association X 2 Q86WT6 Q9BQ89 two hybrid prey pooling approach 25416956 physical association X 2 Q86WT6 F5GWP8 two hybrid array 25416956 physical association X 2 Q86WT6 P05496 two hybrid array 25416956 physical association X 2 Q86WT6 P08243 two hybrid array 25416956 physical association X 2 Q86WT6 Q659C4 two hybrid array 25416956 physical association X 2 Q86WT6 Q6P088 two hybrid array 25416956 physical association X 2 Q86WT6 Q6PHW0 two hybrid array 25416956 physical association X 2 Q86WT6 Q86TH3 two hybrid array 25416956 physical association X 2 Q86WT6 Q8N205 two hybrid array 25416956 physical association X 2 Q86WT6 Q9BQ89 two hybrid array 25416956 physical association X 2 Q86WT6 F5GWP8 validated two hybrid 25416956 physical association X 2 Q86WT6 Q659C4 validated two hybrid 25416956 physical association X 2 Q86WT6 Q6P088 validated two hybrid 25416956 physical association X 2 Q86WT6 Q6PHW0 validated two hybrid 25416956 physical association X 2 Q86WT6 Q86TH3 validated two hybrid 25416956 physical association X 2 Q86WT6 P05496 validated two hybrid 25416956 physical association X 2 Q86WT6 P08243 validated two hybrid 25416956 physical association X 2 Q86WT6 Q9BQ89 validated two hybrid 25416956 physical association X 2 Q86WT6 Q8N205 validated two hybrid 25416956 physical association X 2 Q86WT6 tandem affinity purification 20360068 physical association C 41 Q1RN33 Q86WT6 two hybrid prey pooling approach 25416956 physical association X 2 Q1RN33 Q86WT6 two hybrid array 25416956 physical association X 2 Q1RN33 Q86WT6 validated two hybrid 25416956 physical association X 2 A0A024RCJ8 Q86WT6 two hybrid prey pooling approach 25416956 physical association X 2 A0A024RCJ8 Q86WT6 two hybrid array 25416956 physical association X 2 A0A024RCJ8 Q86WT6 validated two hybrid 25416956 physical association X 2 Q86WT6 A0A024RC12 two hybrid pooling approach 16189514 physical association X 2 Q86WT6 A0A024RC12 two hybrid 21516116 physical association X 2 Q86WT6 Q86WT6 two hybrid array 25416956 physical association X 2 Q86WT6 Q12874 two hybrid prey pooling approach 25416956 physical association X 2 Q86WT6 A0A024R572 two hybrid prey pooling approach 25416956 physical association X 2 Q86WT6 P68106 two hybrid prey pooling approach 25416956 physical association X 2 Q86WT6 Q6P9E2 two hybrid prey pooling approach 25416956 physical association X 2 Q86WT6 Q86SG6 two hybrid prey pooling approach 25416956 physical association X 2 Q86WT6 Q96DX7 two hybrid prey pooling approach 25416956 physical association X 2 Q86WT6 Q96CS2 two hybrid prey pooling approach 25416956 physical association X 2 Q86WT6 Q9UHP6 two hybrid prey pooling approach 25416956 physical association X 2 Q86WT6 Q12874 two hybrid array 25416956 physical association X 2 Q86WT6 A0A024R572 two hybrid array 25416956 physical association X 2 Q86WT6 P68106 two hybrid array 25416956 physical association X 2 Q86WT6 Q6P9E2 two hybrid array 25416956 physical association X 2 Q86WT6 Q86SG6 two hybrid array 25416956 physical association X 2 Q86WT6 Q96DX7 two hybrid array 25416956 physical association X 2 Q86WT6 Q96CS2 two hybrid array 25416956 physical association X 2 Q86WT6 Q9UHP6 two hybrid array 25416956 physical association X 2 Q86WT6 Q6P9E2 validated two hybrid 25416956 physical association X 2 Q86WT6 Q86SG6 validated two hybrid 25416956 physical association X 2 Q86WT6 P68106 validated two hybrid 25416956 physical association X 2 Q86WT6 Q12874 validated two hybrid 25416956 physical association X 2 Q86WT6 A0A024R572 validated two hybrid 25416956 physical association X 2 Q86WT6 Q96DX7 validated two hybrid 25416956 physical association X 2 Q86WT6 Q9UHP6 validated two hybrid 25416956 physical association X 2 Q86WT6 Q96CS2 validated two hybrid 25416956 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B TRIM69 TLR9 MI:0004(affinity chromatography technology) 21911421 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_147011 prey bait TLR4 TRIM69 MI:0004(affinity chromatography technology) 21911421 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_147002 bait prey APP TRIM69 MI:0096(pull down) 21832049 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_229091 prey bait RECK TRIM69 MI:0018(two hybrid) 21516116 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_114173 bait prey BAG3 TRIM69 MI:0004(affinity chromatography technology) 23824909 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_283140 bait prey TLR3 TRIM69 MI:0004(affinity chromatography technology) 21911421 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_147017 bait prey SKIL TRIM69 MI:0018(two hybrid) 15231748 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_38409 - - MAGEA4 TRIM69 MI:0096(pull down)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 16189514,21516116 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|-|MI:0407(direct interaction) (intact)|MI:0471(mint)|MI:0471(mint)|(intact)|MI:0468(hprd)|(biogrid) UniProt_153203|MINT_38904|MINT_68147|UniProt_114927|HPRD_21164|BIOGRID_80361 unspecified role|bait|bait|prey|-|bait unspecified role|prey|prey|bait|-|prey PML TRIM69 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0493(in vivo) 12837286 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|- (biogrid)|(biogrid)|MI:0468(hprd) BIOGRID_88841|BIOGRID_88840|HPRD_13113 prey|bait|- bait|prey|-

PPI - HINT Gene A Gene B PMID Method Quality DVL1 TRIM69 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT RECK TRIM69 25416956,25416956,25416956,21516116,25416956 1112,0397,0018,0018,1356 HT ATP5G1 TRIM69 25416956,25416956,25416956,21516116,25416956 1112,0397,0018,0018,1356 HT ASNS TRIM69 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT SKIL TRIM69 15231748 0018 HT MAGEA4 TRIM69 16189514,21516116,25416956,25416956,25416956,16189514,25416956 0398,0018,1112,0397,0018,0018,1356 HT FKBP1B TRIM69 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT KRT17 TRIM69 25416956,25416956,25416956 1112,0397,1356 HT SF3A3 TRIM69 25416956,25416956,25416956,21516116,25416956 1112,0397,0018,0018,1356 HT Q14666 TRIM69 25416956 0018 HT SF1 TRIM69 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT LARP1B TRIM69 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT PPP1R18 TRIM69 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT IYD TRIM69 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT NEK8 TRIM69 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT TRIM69 TRIM69 25416956,25416956,24722452 0397,0018,0114 HT,LC TRIM69 SYNE4 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT TRIM69 ZNF483 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT TRIM69 HAUS1 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT TRIM69 TRIM44 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT TRIM69 FAM110A 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT TRIM69 RSPH14 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q86WT6 O14640 TRIM69 DVL1 0.183 25416956 Q86WT6 Q1RN33 TRIM69 MAGEA4 {ECO:0000313|EMBL:AAY27261.1} 0.332 25416956 Q86WT6 Q04695 TRIM69 KRT17 0.183 25416956 Q86WT6 O15455 TRIM69 TLR3 0.21 21911421 Q9NR96 Q86WT6 TLR9 TRIM69 0.21 21911421 Q86WT6 Q86SG6 TRIM69 NEK8 0.583 25416956,unassigned1304 Q86WT6 O95980 TRIM69 RECK 0.454 21516116,25416956 Q86WT6 P05067 TRIM69 APP 0.183 21832049 Q86WT6 P32502 TRIM69 GCD7 0.332 27107014 Q86WT6 P51668 TRIM69 UBE2D1 0.309 23131556 Q86WT6 P51965 TRIM69 UBE2E1 0.309 23131556 Q86WT6 P61077 TRIM69 UBE2D3 0.309 23131556 Q86WT6 P61088 TRIM69 UBE2N 0.309 23131556 Q86WT6 P62256 TRIM69 UBE2H 0.309 23131556 Q86WT6 Q659C4 TRIM69 LARP1B 0.454 25416956 Q86WT6 Q86TH3 TRIM69 DVL1 {ECO:0000313|EMBL:AAH50454.1} 0.332 25416956 Q8N205 Q86WT6 SYNE4 TRIM69 0.454 25416956 Q8TF39 Q86WT6 ZNF483 TRIM69 0.183 25416956 Q86WT6 Q6P088 TRIM69 Q6P088 0.332 25416956 Q86WT6 O95817 TRIM69 BAG3 0.126 23824909 Q86WT6 P08243 TRIM69 ASNS 0.583 25416956,unassigned1304 Q96CS2 Q86WT6 HAUS1 TRIM69 0.583 25416956,unassigned1304 Q96DX7 Q86WT6 TRIM44 TRIM69 0.454 25416956 Q86WT6 P68106 TRIM69 FKBP1B 0.583 25416956,unassigned1304 Q86WT6 Q2WGJ6 TRIM69 KLHL38 0.236 unassigned1304 Q86WT6 Q6NYC8 TRIM69 PPP1R18 0.454 25416956 Q86WT6 Q6P9E2 TRIM69 RECK {ECO:0000313|EMBL:AAH60806.1} 0.49 25416956,unassigned1304 Q86WT6 Q80X56 TRIM69 TRIM69 0.236 20360068 Q86WT6 Q16134 TRIM69 ETFDH 0.236 unassigned1304 Q86WT6 O14964 TRIM69 HGS 0.236 unassigned1304 Q86WT6 Q12874 TRIM69 SF3A3 0.554 25416956,21516116 Q86WT6 P55040 TRIM69 GEM 0.236 unassigned1304 Q86WT6 Q3B820 TRIM69 FAM161A 0.236 unassigned1304 Q86WT6 Q6NUQ1 TRIM69 RINT1 0.236 unassigned1304 Q86WT6 Q6PIF2 TRIM69 SYCE2 0.236 unassigned1304 Q8NFW5 Q86WT6 DMBX1 TRIM69 0.236 unassigned1304 Q86YD7 Q86WT6 FAM90A1 TRIM69 0.236 unassigned1304 Q9BXY8 Q86WT6 BEX2 TRIM69 0.236 unassigned1304 Q96LM5 Q86WT6 C4ORF45 TRIM69 0.236 unassigned1304 Q96HA8 Q86WT6 WDYHV1 TRIM69 0.236 unassigned1304 Q9BRQ8 Q86WT6 AIFM2 TRIM69 0.236 unassigned1304 Q96S90 Q86WT6 LYSMD1 TRIM69 0.236 unassigned1304 Q9UJV3 Q86WT6 MID2 TRIM69 0.236 unassigned1304 Q86WT6 Q6PHW0 TRIM69 IYD 0.636 25416956,25910212 Q86WT6 P38340 TRIM69 TAE1 0.332 27107014 Q9UHP6 Q86WT6 RTDR1 TRIM69 0.583 25416956,unassigned1304 Q86WT6 P43358 TRIM69 MAGEA4 0.702 25416956,16189514,unassigned1304,21516116 Q86WT6 P05496 TRIM69 ATP5G1 0.659 25416956,21516116,unassigned1304 Q86WT6 Q86WT6 TRIM69 TRIM69 0.523 25416956,unassigned1304 Q86WT6 P29590 TRIM69 PML 0.376 12837286 Q9BQ89 Q86WT6 FAM110A TRIM69 0.583 25416956,unassigned1304 Q86WT6 P32464 TRIM69 HYM1 0.332 27107014 Q86WT6 F5GWP8 TRIM69 KRT17 {ECO:0000313|ENSEMBL:ENSP00000441751} 0.332 25416956 Q86WT6 Q15637 TRIM69 SF1 0.454 25416956 Q86WT6 O00206 TRIM69 TLR4 0.21 21911421