PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus CTNNB1 RNF220 25266658 biogrid exp G GP G G GP GP G G GP G GP GP GP G G G GP G GP G GP GP GP G G G GP G G UBE2D3 RNF220 20170641 biogrid exp G G G G GP GP G G GP G GP GP GP G G G GP G GP G GP GP G GP G G GP G G RNF220 UBE2W 19549727 intact exp G GP G G GP GP G G GP G GP GP GP G G G GP G GP G GP GP GP GP G G GP G G GSK3B RNF220 25266658 biogrid exp G G G G G GP G G GP G G G G G G G GP G G G GP G G G G G G G G RNF220 GOPC 25416956 biogrid,intact exp G GP G G GP GP G G GP G GP GP GP G G G GP G GP G GP GP GP GP G G GP G G RNF220 ZC4H2 26186194 biogrid exp, ortho G G G G G GP G GP G G G G G G GP G P G G GP G G GP G SIN3B RNF220 20170641, 25402006 biogrid exp, ortho, pred G GP G G G GP G G GP G GP G GP G G G GP G GP G GP GP G G G G GP G G UBE2E1 RNF220 19549727, 25402006, 23023127 intact exp, ortho, pred G GP G G G GP G G GP G GP G G G G G GP G G G GP G G GP G G GP G G RNF220 UBE2E3 19549727, 25402006 intact exp, ortho, pred G GP G G G GP G G GP G GP G G G G G GP G G G GP G G GP G G GP G G RNF220 UBE2E2 19549727, 23023127 intact exp, ortho, pred G GP G G GP GP G G GP G GP GP GP G G G GP G GP G GP GP GP GP G G GP G G RNF220 USP7 25266658,19615732,16713569, 25402006 hprd,biogrid,mint,intact exp, pred G GP G G GP GP G G GP G GP GP GP G G G GP G GP G GP GP GP GP G G GP G G RNF220 AP2M1 ortho G GP G G G GP G G GP G GP GP GP G G G GP G GP G GP G G G G G GP G G RNF220 TMEM214 ortho G G G G G GP G G G G GP G G G G G GP G GP G G G GP G G G GP G G EXOC5 RNF220 ortho G GP G G GP GP G G GP G GP G GP G G G GP G GP G GP G GP GP G G GP G G RNF220 PACSIN2 ortho G GP G G GP GP G G GP G GP GP GP G G G GP G GP G GP GP GP G G G GP G G CSNK2B RNF220 ortho G GP G G GP GP G G GP G GP GP GP G G G GP G GP G GP GP GP GP G G GP G G CSNK2A1 RNF220 ortho G GP G G GP GP G G GP G GP GP GP G G G GP G GP G GP GP GP GP G G GP G G RNF220 HIBCH ortho G GP G G GP GP G G GP G GP GP GP G G G GP G GP G GP GP GP GP G G GP G G UBE2K RNF220 23023127 pred G GP G G GP GP G G GP G GP GP GP G G G GP G GP G GP GP GP GP G G GP G G RNF220 RNF14 23023127 pred G GP G G GP GP G G GP G GP GP GP G G G GP G GP G GP GP GP GP G G GP G G RNF220 WDR82 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G RNF220 FBXL15 21836163 pred G G G G G G G G G G G G G G G G G G G G G G CUL3 RNF220 23023127 pred G GP G G GP GP G G GP G GP GP GP G G G GP G GP G GP GP GP GP G G GP G G RNF220 UBE2R2 23023127 pred G G G G GP G G G G G G G G G G G G G G G G G G G G G GP G G RAE1 RNF220 25402006 pred G GP G G GP GP G G GP G GP G GP G G G GP G GP G GP G G GP G G GP G G RNF220 TRAF6 25402006, 23023127 pred G GP G G GP G G G GP G GP GP GP G G G G G G G GP GP GP G G G GP G G UBOX5 RNF220 23023127 pred G GP G G G GP G G P G G G GP G G GP G G G G G GP P G G GP G G RNF220 CAND1 23023127 pred G GP G G G G G G GP G GP GP G G G G G G G G G G GP GP G G G G G GMPS RNF220 25402006 pred G G G G GP GP G G G G G G G G G G GP G G G G G G G G G G G G RNF220 RNF115 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G TRIM37 RNF220 23023127 pred G GP G G G GP G G GP G GP G GP G G G GP G GP G GP GP GP G G G GP G G RNF144A RNF220 23023127 pred G GP G G GP GP G G GP G GP P GP G G G GP G GP G P G GP GP G G GP G RELB RNF220 25402006 pred G GP G G GP G GP G GP GP GP G G G GP G G G G G G G G G GP G G UBE2N RNF220 23023127 pred G GP G G GP GP G G GP G GP GP GP G G G GP G GP G GP GP GP GP G G GP G G RNF220 RNF182 23023127 pred P G G GP GP P G P GP GP G G GP P G TRIM21 RNF220 23023127 pred G GP G G GP GP G G GP G GP GP GP G G G GP G GP G GP GP GP GP G G GP G G TRIM13 RNF220 23023127 pred G GP G G G GP G G GP G G GP GP G G G GP G G G G GP G GP G G GP G G RNF220 PRPF19 23023127 pred G GP G G GP GP G G GP G GP GP GP G G G GP G GP G GP GP GP GP G G GP G G IKZF1 RNF220 25402006 pred G G G G GP G G G G G G G G G G G G G G G G G G G G G G G PRKCG RNF220 23023127 pred G G G G G GP G G G G G G G GP G G G G G G G G RAG1 RNF220 23023127 pred ZBTB16 RNF220 25402006 pred G GP G G G GP G G GP G G G GP G G G GP G GP G G GP GP G G G G G G RNF220 DAXX 25402006 pred G GP G G GP GP G G GP G GP GP GP G G G GP G GP G GP GP GP GP G G GP G G TTC3 RNF220 23023127 pred P P RNF220 RNF7 23023127 pred G GP G G GP GP G G GP G GP GP G G G G GP G GP G GP GP G G G G GP G G RING1 RNF220 23023127 pred G GP G G GP GP G G GP G GP GP GP G G G GP G GP G GP GP GP GP G G GP G G RNF220 USP44 23023127 pred P P P P P P P P GP G P P P P P G MDM4 RNF220 25402006 pred G GP G G GP GP G G GP G GP GP GP G G G GP G GP G GP GP GP GP G G GP G G RNF220 HUWE1 23023127 pred G GP G G GP GP G G GP G GP GP GP G G G GP G GP G GP GP GP GP G G GP G G RNF103 RNF220 23023127 pred G GP G G GP GP G G GP G GP G GP G G G GP G GP G G GP G G G G GP G G RNF220 RBBP6 23023127 pred G G G G G GP G G GP G GP GP GP G G G GP G G G GP G GP G G G GP G G RNF8 RNF220 23023127 pred G GP G G G GP G G GP G GP G G G G G GP G GP G G G GP G G G GP G G RNF220 RLIM 23023127 pred G GP G G GP GP G G GP G GP GP GP G G G GP G GP G GP GP GP GP G G GP G G PARK2 RNF220 23023127 pred GP G P GP G G GP G GP P P G GP G P G P GP GP G P G G UBE2L3 RNF220 23023127 pred G G G G G GP G G GP G GP G G G G G GP G GP G G G GP GP G G GP G G TRIM32 RNF220 23023127 pred G GP G G G GP G G GP G GP GP G G G G GP G GP G GP GP GP GP G G GP G G TP53 RNF220 25402006 pred G G G G G G G G G G G G G G G G G G G G GP G G G G G G G G MGRN1 RNF220 23023127 pred G GP G G GP GP G G GP G GP GP GP G G G GP G GP G GP GP GP GP G G GP G G RNF220 RNF208 23023127 pred G GP G G G GP G G G GP GP P G GP GP G GP G GP P G G RNF220 RNF133 23023127 pred P P P P P P G BRCA1 RNF220 23023127 pred P G GP P P P P P G P P P P P P P G BMI1 RNF220 23023127 pred P P P P P P P P P P P P P P MDM2 RNF220 25402006 pred G GP G G GP GP G G GP G GP GP GP G G G GP G GP G GP GP GP GP G G GP G G HDAC1 RNF220 25402006 pred G GP G G GP GP G G GP G GP GP GP G G G GP G GP G GP GP GP G G G GP G G RNF220 RNF125 23023127 pred G GP G G GP GP G G GP G GP G GP G G G GP G GP G GP GP GP GP G G GP G RNF220 RNF11 23023127 pred G GP G G GP GP G G GP G GP GP GP G G G GP G GP G GP GP GP GP G G GP G G RNF220 HDAC2 25402006 pred G GP G G GP GP G G GP G GP GP GP G G G GP G GP G GP GP GP GP G G GP G G UBE2A RNF220 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G RNF220 RNF2 23023127 pred P P P GP P P P P P P P P RNF13 RNF220 23023127 pred G GP G G GP GP G G GP G GP GP GP G G G GP G GP G GP GP GP GP G G GP G G TRAF2 RNF220 23023127 pred P P P P P P P P P P P P P G GP USP11 RNF220 25402006 pred G GP G G G GP G G GP G GP G G G G G GP G G G G G G G G G G G G RNF220 TBCB 25402006 pred G G G G GP GP G G GP G GP GP G G G G GP G GP G GP GP G G G G GP G G RNF220 DZIP3 23023127 pred G GP G G GP GP G G GP G GP G GP G G G GP G GP G P GP GP GP G G GP G G RNF220 RNF31 23023127 pred P G G GP GP P G GP GP GP G GP GP G GP P P GP G G P G RNF220 RNF41 23023127 pred G GP G G G GP G G GP G GP P G G G GP P G P G P GP G G GP RNF220 STUB1 23023127 pred G GP G G GP GP G G GP G GP GP GP G G G GP G GP G GP GP GP GP G G GP G G RNF220 TRIM17 23023127 pred P P P P P P P P P P P P G RNF220 LRSAM1 23023127 pred GP G P GP G GP G GP GP P G GP G GP G P GP P P G P G RNF220 UHRF2 23023127 pred G GP G G GP GP G G GP G GP GP GP G G G GP G GP G GP GP GP GP G G GP G G UBE2D1 RNF220 23023127 pred G G G G GP GP G G GP G GP GP GP G G G GP G GP G GP GP G GP G G GP G G USP5 RNF220 23023127 pred G GP G G GP GP G G GP G GP GP GP G G G GP G GP G GP GP G GP G G GP G G RNF220 MYLIP 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G RNF220 RCHY1 23023127 pred G GP G G G GP G G GP G GP G GP G G G GP G GP G G G GP G G G GP G G CUL1 RNF220 23023127 pred G G G G G GP G G GP G GP GP GP G G G GP G GP G GP GP GP GP G G GP G G RNF220 MAD1L1 25402006 pred G P G P GP G P P GP GP G G G GP P G P GP P GP G G P G UBE2B RNF220 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G RNF220 MIB1 23023127 pred G GP G G GP GP G G GP G GP GP G G G G GP G GP G GP GP GP G G G GP G G RNF220 UBQLN1 23023127 pred G GP G G GP GP G G GP G GP GP GP G G G GP G GP G GP GP GP GP G G GP G G UBE2M RNF220 23023127 pred G GP G G GP GP G G GP G GP G GP G G G GP G GP G GP G GP GP G G GP G G UBE4A RNF220 23023127 pred G GP G G G GP G G GP G GP GP GP G G G GP G GP G GP GP GP GP G G GP G G RNF220 SUDS3 25402006 pred G GP G G GP GP G G GP G GP GP GP G G G GP G GP G GP GP GP GP G G GP G G RNF4 RNF220 23023127 pred G G G G G GP G G GP G GP G G G G G GP G G G GP GP GP GP G G GP G G S100A5 RNF220 23023127 pred G LDB3 RNF220 23023127 pred G GP G G G G G G GP G G G G G G G GP G G GP G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q5VTB9 Q93009 two hybrid 16713569 direct interaction X 2 Q5VTB9 Q93009 affinity chromatography technology 25266658 physical association X 2 Q5VTB9 Q93009 affinity chromatography technology 25266658 physical association X 2 Q5VTB9 Q93009 affinity chromatography technology 19615732 physical association X 2 Q5VTB9 O75182 affinity chromatography technology 20170641 physical association X 2 Q5VTB9 O75182 pull down 20170641 direct interaction X 2 Q5VTB9 O75182 enzymatic study 20170641 direct interaction X 2 Q5VTB9 P0CG48 affinity chromatography technology 22505724 physical association X 2 Q5VTB9 P61077-3 pull down 20170641 direct interaction X 2 Q5VTB9 P0CG48 affinity chromatography technology 21963094 physical association X 2 Q5VTB9 P0CG48 affinity chromatography technology 23000965 physical association X 2 Q5VTB9 A0A024R2Q3 affinity chromatography technology 25266658 physical association X 2 Q5VTB9 A0A024R2Q3 affinity chromatography technology 25266658 physical association X 2 Q5VTB9 affinity chromatography technology 25266658 physical association X 2 Q5VTB9 Q9HD26-3 two hybrid 25416956 direct interaction X 2 Q5VTB9 P0CG48 affinity chromatography technology 21139048 physical association X 2 Q5VTB9 P0CG48 affinity chromatography technology 21890473 physical association X 2 Q5VTB9 P0CG48 affinity chromatography technology 21906983 physical association X 2 Q5VTB9 Q93009 two hybrid 16713569 - X 2 Q5VTB9 Q93009 two hybrid 16713569 - X 2 Q5VTB9 Q93009 two hybrid 16713569 physical association X 2 Q5VTB9 A0A024R2Q2 two hybrid 19549727 physical association X 2 Q5VTB9 Q969T4 two hybrid 19549727 physical association X 2 Q5VTB9 Q96B02 two hybrid 19549727 physical association X 2 Q5VTB9 A0A024R2K3 two hybrid 19549727 physical association X 2 Q5VTB9 Q7CH24 two hybrid pooling approach 20711500 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B RNF220 UBE2W MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_100918 prey bait RNF220 UBE2E2 MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_100840 prey bait RNF220 UBE2E3 MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_100891 prey bait SIN3B RNF220 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 20170641 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid) BIOGRID_122474|BIOGRID_122476|BIOGRID_122475 bait|prey|prey prey|bait|bait UBE2E1 RNF220 MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_100830 bait prey UBE2D3 RNF220 MI:0004(affinity chromatography technology) 20170641 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_225702 prey bait UBC RNF220 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 21139048,21890473,21906983,21963094,22505724,23000965 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_264313|BIOGRID_267978|BIOGRID_224512|BIOGRID_181309|BIOGRID_172217|BIOGRID_173298 bait|bait|bait|bait|bait|bait prey|prey|prey|prey|prey|prey RNF220 USP7 MI:0397(two hybrid array)|MI:0004(affinity chromatography technology)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0096(pull down)|MI:0096(pull down) 16713569,19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|-|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid)|MI:0468(hprd)|(biogrid)|MI:0471(mint)|MI:0471(mint) UniProt_86503|BIOGRID_120519|HPRD_27990|BIOGRID_215924|MINT_83041|MINT_50753 prey|prey|-|prey|prey|prey bait|bait|-|bait|bait|bait

PPI - HINT Gene A Gene B PMID Method Quality RNF220 USP7 19615732,25266658 0004,0004 HT,LC RNF220 ZC4H2 26186194 0004 HT RNF220 USP7 19615732 0004 HT RNF220 ZC4H2 26186194 0004 HT RNF220 USP7 25266658 0004 LC SIN3B RNF220 20170641,20170641,20170641 0004,0415,0096 LC UBE2E1 RNF220 19549727 0018 HT RNF220 USP7 16713569 0018 HT RNF220 UBE2E3 19549727 0018 HT RNF220 UBE2W 19549727 0018 HT RNF220 UBE2E2 19549727 0018 HT RNF220 GOPC 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q5VTB9 P49841 RNF220 GSK3B 0.21 25266658 Q5VTB9 P61077 RNF220 UBE2D3 0.309 20170641 Q7CH24 Q5VTB9 CUTF RNF220 0.126 20711500 Q969T4 Q5VTB9 UBE2E3 RNF220 0.183 19549727 Q9HD26 Q5VTB9 GOPC RNF220 0.183 25416956 Q8R5L1 Q5VTB9 Q8R5L1 RNF220 0.126 26496610 Q9NQZ6 Q5VTB9 ZC4H2 RNF220 0.126 26186194 Q5VTB9 O75182 RNF220 SIN3B 0.623 20170641 Q93009 Q5VTB9 USP7 RNF220 0.702 16713569,25266658,19615732 Q5VTB9 P35222 RNF220 CTNNB1 0.376 25266658 Q96B02 Q5VTB9 UBE2W RNF220 0.332 19549727 Q96LR5 Q5VTB9 UBE2E2 RNF220 0.332 19549727 Q5VTB9 P51965 RNF220 UBE2E1 0.332 19549727

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 EXOC5 RNF220 MI:0362 inference MI:0461 interaction database SIN3B RNF220 MI:0045 experimental interaction detection MI:0461 interaction database UBB RNF220 MI:0362 inference MI:0461 interaction database UBC RNF220 MI:0045 experimental interaction detection MI:0461 interaction database TAF1 RNF220 MI:0045 experimental interaction detection MI:0461 interaction database UBA1 RNF220 MI:0362 inference MI:0461 interaction database CTNNB1 RNF220 MI:0045 experimental interaction detection MI:0461 interaction database PCYT1A RNF220 MI:0362 inference MI:0461 interaction database GSK3B RNF220 MI:0045 experimental interaction detection MI:0461 interaction database ST13 RNF220 MI:0362 inference MI:0461 interaction database UBE2E1 RNF220 MI:0045 experimental interaction detection MI:0461 interaction database UBE2D3 RNF220 MI:0045 experimental interaction detection MI:0461 interaction database UBE2D2 RNF220 MI:0362 inference MI:0461 interaction database CSNK2B RNF220 MI:0362 inference MI:0461 interaction database CSNK2A1 RNF220 MI:0362 inference MI:0461 interaction database C1QBP RNF220 MI:0362 inference MI:0461 interaction database RNF220 TMEM214 MI:0362 inference MI:0461 interaction database RNF220 HIBCH MI:0362 inference MI:0461 interaction database RNF220 CSNK2A3 MI:0362 inference MI:0461 interaction database RNF220 USP7 MI:0045 experimental interaction detection MI:0461 interaction database RNF220 UBE2E3 MI:0045 experimental interaction detection MI:0461 interaction database RNF220 UBE2W MI:0045 experimental interaction detection MI:0461 interaction database RNF220 AP2M1 MI:0362 inference MI:0461 interaction database RNF220 UBE2E2 MI:0045 experimental interaction detection MI:0461 interaction database RNF220 GOPC MI:0045 experimental interaction detection MI:0461 interaction database RNF220 ZC4H2 MI:0045 experimental interaction detection MI:0461 interaction database RNF220 ACOT9 MI:0362 inference MI:0461 interaction database RNF220 PCYT1B MI:0362 inference MI:0461 interaction database