PTM - CPLM Gene Name UniProt ID Type Position Code USP7; HAUSP Q93009 Acetylation 595 K USP7; HAUSP Q93009 Acetylation 869 K USP7; HAUSP Q93009 Acetylation 1084 K USP7; HAUSP Q93009 Acetylation 1096 K USP7; HAUSP Q93009 Ubiquitination 98 K USP7; HAUSP Q93009 Ubiquitination 148 K USP7; HAUSP Q93009 Ubiquitination 355 K USP7; HAUSP Q93009 Ubiquitination 420 K USP7; HAUSP Q93009 Ubiquitination 479 K USP7; HAUSP Q93009 Ubiquitination 824 K USP7; HAUSP Q93009 Ubiquitination 841 K USP7; HAUSP Q93009 Ubiquitination 869 K USP7; HAUSP Q93009 Ubiquitination 882 K USP7; HAUSP Q93009 Ubiquitination 1033 K USP7; HAUSP Q93009 Ubiquitination 1096 K USP7; HAUSP Q93009 Ubiquitination 476 K USP7; HAUSP Q93009 Ubiquitination 240 K USP7; HAUSP Q93009 Ubiquitination 335 K USP7; HAUSP Q93009 Ubiquitination 595 K USP7; HAUSP Q93009 Ubiquitination 934 K USP7; HAUSP Q93009 Ubiquitination 254 K USP7; HAUSP Q93009 Ubiquitination 490 K USP7; HAUSP Q93009 Ubiquitination 926 K USP7; HAUSP Q93009 Ubiquitination 914 K USP7; HAUSP Q93009 Ubiquitination 523 K USP7; HAUSP Q93009 Ubiquitination 681 K USP7; HAUSP Q93009 Ubiquitination 1039 K USP7; HAUSP Q93009 Ubiquitination 927 K USP7; HAUSP Q93009 Ubiquitination 875 K USP7; HAUSP Q93009 Ubiquitination 312 K USP7; HAUSP Q93009 Ubiquitination 695 K USP7; HAUSP Q93009 Ubiquitination 712 K USP7; HAUSP Q93009 Ubiquitination 272 K USP7; HAUSP Q93009 Ubiquitination 439 K USP7; HAUSP Q93009 Ubiquitination 770 K USP7; HAUSP Q93009 Ubiquitination 755 K

PTM - dbPAF Gene Name UniProt ID Position Type Species USP7; HAUSP Q93009 1050 Y Homo sapiens(Human) USP7; HAUSP Q93009 1056 Y Homo sapiens(Human) USP7; HAUSP Q93009 1091 Y Homo sapiens(Human) USP7; HAUSP Q93009 1092 T Homo sapiens(Human) USP7; HAUSP Q93009 1093 Y Homo sapiens(Human) USP7; HAUSP Q93009 143 Y Homo sapiens(Human) USP7; HAUSP Q93009 155 S Homo sapiens(Human) USP7; HAUSP Q93009 18 S Homo sapiens(Human) USP7; HAUSP Q93009 331 Y Homo sapiens(Human) USP7; HAUSP Q93009 379 Y Homo sapiens(Human) USP7; HAUSP Q93009 49 S Homo sapiens(Human) USP7; HAUSP Q93009 54 T Homo sapiens(Human) USP7; HAUSP Q93009 730 T Homo sapiens(Human) USP7; HAUSP Q93009 735 Y Homo sapiens(Human) USP7; HAUSP Q93009 743 T Homo sapiens(Human) USP7; HAUSP Q93009 752 S Homo sapiens(Human) USP7; HAUSP Q93009 791 Y Homo sapiens(Human) USP7; HAUSP Q93009 845 Y Homo sapiens(Human) USP7; HAUSP Q93009 963 S Homo sapiens(Human)

PTM - PhosphositePlus UniProt ID MOD_RSD Type SITE_+/-7_AA Q93009 K272-ac Acetylation YELQHSDkPVGTKKL Q93009 K595-ac Acetylation KVKYTVFkVLKNSSL Q93009 K841-ac Acetylation PMLLQFFkSQGyRDG Q93009 K869-ac Acetylation RDLLQFFkPRQPKkL Q93009 K914-ac Acetylation EITLYPDkHGCVRDL Q93009 K934-ac Acetylation KAVELGEkASGKLRL Q93009 K1084-ac Acetylation LGLDHFNkAPKRSRy Q93009 K1096-ac Acetylation SRytyLEkAIKIHN_ Q93009 R424-m1 Methylation QNIkINDrFEFPEQL Q93009 K841-m1 Methylation PMLLQFFkSQGyRDG Q93009 R891-m1 Methylation KITDFENrRSFKCIW Q93009 S18-p Phosphorylation KAGEQQLsEPEDMEM Q93009 S49-p Phosphorylation INGNVALsDGHNtAE Q93009 T54-p Phosphorylation ALsDGHNtAEEDMED Q93009 S155-p Phosphorylation kSFSRRIsHLFFHKE Q93009 Y331-p Phosphorylation FRGKMVSyIQCkEVD Q93009 Y379-p Phosphorylation QLDGDNKyDAGEHGL Q93009 T730-p Phosphorylation RAGFIQDtSLILyEE Q93009 Y735-p Phosphorylation QDtSLILyEEVKPNL Q93009 T743-p Phosphorylation EEVKPNLtERIQDYD Q93009 S752-p Phosphorylation RIQDYDVsLDKALDE Q93009 Y791-p Phosphorylation KEYFRDLyHRVDVIF Q93009 Y845-p Phosphorylation QFFkSQGyRDGPGNP Q93009 S963-p Phosphorylation DELLECLsPATSRTF Q93009 Y1050-p Phosphorylation VMMGRHQyINEDEyE Q93009 Y1056-p Phosphorylation QyINEDEyEVNLKDF Q93009 Y1091-p Phosphorylation kAPKRSRytyLEkAI Q93009 T1092-p Phosphorylation APKRSRytyLEkAIK Q93009 Y1093-p Phosphorylation PKRSRytyLEkAIKI Q93009 K98-ub Ubiquitination FVRNLPWkIMVMPRF Q93009 K148-ub Ubiquitination INYRDDEkSFSRRIs Q93009 K254-ub Ubiquitination TEGDDSSkSVPLALQ Q93009 K322-ub Ubiquitination CVEGTIPkLFRGKMV Q93009 K335-ub Ubiquitination MVSyIQCkEVDYRSD Q93009 K355-ub Ubiquitination YDIQLSIkGkKNIFE Q93009 K357-ub Ubiquitination IQLSIkGkKNIFESF Q93009 K420-ub Ubiquitination PQTDQNIkINDrFEF Q93009 K439-ub Ubiquitination PLDEFLQkTDPKDPA Q93009 K479-ub Ubiquitination KGDGKWCkFDDDVVS Q93009 K824-ub Ubiquitination MNYFQVAkTVAQRLN Q93009 K841-ub Ubiquitination PMLLQFFkSQGyRDG Q93009 K869-ub Ubiquitination RDLLQFFkPRQPKkL Q93009 K875-ub Ubiquitination FkPRQPKkLYYQQLk Q93009 K882-ub Ubiquitination kLYYQQLkMKITDFE Q93009 K934-ub Ubiquitination KAVELGEkASGKLRL Q93009 K1033-ub Ubiquitination SLLDIQEkEFEKFKF Q93009 K1096-ub Ubiquitination SRytyLEkAIKIHN_

PTM - dbPTM UniProt ID Position Code Type Resources References Q93009 18 S Phosphorylation Swiss-Prot 1010711 15302935;17651432;18669648;19413330;19690332 Q93009 49 S Phosphorylation Swiss-Prot 1010711 19690332 Q93009 54 T Phosphorylation Swiss-Prot 1010711 19690332 Q93009 595 K Acetylation Swiss-Prot 1010711 19608861 Q93009 869 K Ubiquitylation Swiss-Prot 1010711 17651432 Q93009 869 K Acetylation Swiss-Prot 1010711 19608861 Q93009 963 S Phosphorylation Swiss-Prot 1010711 17651432;18669648 Q93009 1084 K Acetylation Swiss-Prot 1010711 19608861 Q93009 1096 K Acetylation Swiss-Prot 1010711 19608861 Q93009 18 S Phosphorylation PhosphoELM.10011 18669648;15302935 Q93009 963 S Phosphorylation PhosphoELM.10011 18669648 Q93009 1033 K Ubiquitylation Phosphositeplus.1010730 21890473 Q93009 1096 K Ubiquitylation Phosphositeplus.1010730 21890473;21906983 Q93009 148 K Ubiquitylation Phosphositeplus.1010730 21890473 Q93009 254 K Ubiquitylation Phosphositeplus.1010730 21906983 Q93009 355 K Ubiquitylation Phosphositeplus.1010730 21906983 Q93009 420 K Ubiquitylation Phosphositeplus.1010730 21890473;21906983 Q93009 439 K Ubiquitylation Phosphositeplus.1010730 21906983 Q93009 479 K Ubiquitylation Phosphositeplus.1010730 21890473 Q93009 824 K Ubiquitylation Phosphositeplus.1010730 21890473;21906983 Q93009 841 K Ubiquitylation Phosphositeplus.1010730 21890473 Q93009 869 K Ubiquitylation Phosphositeplus.1010730 17651432;21890473;21906983 Q93009 875 K Ubiquitylation Phosphositeplus.1010730 21906983 Q93009 882 K Ubiquitylation Phosphositeplus.1010730 21890473 Q93009 934 K Ubiquitylation Phosphositeplus.1010730 21906983 Q93009 98 K Ubiquitylation Phosphositeplus.1010730 21890473 Q93009 1084 K Acetylation Phosphositeplus.1010730 19608861 Q93009 1096 K Acetylation Phosphositeplus.1010730 19608861 Q93009 595 K Acetylation Phosphositeplus.1010730 19608861 Q93009 869 K Acetylation Phosphositeplus.1010730 19608861 Q93009 18 S Phosphorylation Phosphositeplus.1010730 15302935;17651432;18669648;18707149;19362540;19415658;19664995;19690332;20044836;20058876;20068231;20166139;20230923;20363803;20562096;21406692;22115753;22361354 Q93009 49 S Phosphorylation Phosphositeplus.1010730 19690332 Q93009 963 S Phosphorylation Phosphositeplus.1010730 17651432;18669648 Q93009 54 T Phosphorylation Phosphositeplus.1010730 19690332 Q93009 595 K Acetylation HPRD 9.0 19608861 Q93009 869 K Acetylation HPRD 9.0 19608861 Q93009 1084 K Acetylation HPRD 9.0 19608861 Q93009 1096 K Acetylation HPRD 9.0 19608861 Q93009 18 S Phosphorylation HPRD 9.0 15302935,18669648,19413330,19664995,19651622,18707149,18452278,19415658,20230923,20166139,20068231,20058876 Q93009 963 S Phosphorylation HPRD 9.0 18669648 Q93009 18 S Phosphorylation SysPTM 1.1 18669648;18707149 Q93009 963 S Phosphorylation SysPTM 1.1 18669648

PTM - HPRD Symbol Position Code Type References USP7 1084 K Acetylation 19608861 USP7 1096 K Acetylation 19608861 USP7 18 S Phosphorylation 15302935,18669648,19413330,19664995,19651622,18707149,18452278,19415658,20230923,20166139,20068231,20058876 USP7 595 K Acetylation 19608861 USP7 869 K Acetylation 19608861 USP7 963 S Phosphorylation 18669648

PTM - Phospho.ELM UniProt Position Code PMIDs Kinase Source Type Q93009 18 S 18669648 HTP Phosphorylation Q93009 18 S 15302935 HTP Phosphorylation Q93009 963 S 18669648 HTP Phosphorylation

PTM - UniProt UniProt ID Position Type PMIDs Q93009 18 Phosphoserine 18669648;20068231;21406692;23186163;24275569;17651432 Q93009 869 N6-acetyllysine; alternate 19608861 Q93009 963 Phosphoserine 18669648;17651432 Q93009 1084 N6-acetyllysine 19608861 Q93009 1096 N6-acetyllysine 19608861

PTM - PHOSIDA Symbol Accession Code Position Surrounding Sequence Type USP7 IPI00003965 K 1084 GLDHFNaKAPKRSR acetylation USP7 IPI00003965 K 1096 RYTYLEaKAIKIHN acetylation USP7 IPI00003965 K 595 VKYTVFaKVLKNSS acetylation USP7 IPI00003965 K 869 DLLQFFaKPRQPKK acetylation USP7 IPI00003965 S 18 AGEQQLpSEPEDME phosphorylation

PTM - BioGRID Entrez Gene BioGRID ID Position Code Type PMIDs 7874 113622 - K Ubiquitination 22118674 7874 113622 - K Ubiquitination 21963094 7874 113622 - K Ubiquitination 21139048 7874 113622 - K Ubiquitination 21890473 7874 113622 - K Ubiquitination 21906983 7874 113622 - K Sumoylation 19471022 7874 113622 - K Sumoylation 21252943 7874 113622 - K Ubiquitination 22505724 7874 113622 - K FAT10ylation 22797925 7874 113622 - K Ubiquitination 23000965 7874 113622 - K Sumoylation 24654937 7874 113622 - K Ubiquitination 24816145 7874 113622 - K Sumoylation 25027693 7874 113622 - K Ubiquitination 25015289 7874 113622 - K Ubiquitination 25147182

PTM - mUbiSiDa Gene Name Species Ubiquitination Site Ubiquitination Sequence Evidence PMID USP7 Homo sapiens (Human) 463; 1017; 866; 1080; 339; 853; 82; 808; 825; 132; 404 "463,GDGKWCKFDDDVV; 1017,LLDIQEKEFEKFK; 866,LYYQQLKMKITDF; 1080,RYTYLEKAIKIHN; 339,DIQLSIKGKKNIF; 853,DLLQFFKPRQPKK; 82,VRNLPWKIMVMPR; 808,NYFQVAKTVAQRL; 825,MLLQFFKSQGYRD; 132,NYRDDEKSFSRRI; 404,QTDQNIKINDRFE" 1017:21890473; 339:21890473; 1096:21906983; 853:21890473; 825:21890473; 132:21890473; 824:21906983; 404:21890473; 439:21906983; 254:21906983; 463:21890473; 866:21890473; 1080:21890473; 869:21906983; 355:21906983; 82:21890473; 934:21906983; 875:21906983; 808:21890473; 420:21906983 USP7 Homo sapiens (Human) 297; 40; 421; 362; 90 "297,DIQLSIKGKKNIF; 40,VRNLPWKIMVMPR; 421,GDGKWCKFDDDVV; 362,QTDQNIKINDRFE; 90,NYRDDEKSFSRRI" 297:21890473; 40:21890473; 421:21890473; 362:21890473; 90:21890473 USP7 Homo sapiens (Human) 463; 1017; 866; 1080; 339; 853; 82; 808; 825; 132; 404 "463,GDGKWCKFDDDVV; 1017,LLDIQEKEFEKFK; 866,LYYQQLKMKITDF; 1080,RYTYLEKAIKIHN; 339,DIQLSIKGKKNIF; 853,DLLQFFKPRQPKK; 82,VRNLPWKIMVMPR; 808,NYFQVAKTVAQRL; 825,MLLQFFKSQGYRD; 132,NYRDDEKSFSRRI; 404,QTDQNIKINDRFE" 463:21890473; 1017:21890473; 866:21890473; 1080:21890473; 339:21890473; 853:21890473; 82:21890473; 808:21890473; 825:21890473; 132:21890473; 404:21890473 USP7 Homo sapiens (Human) 463; 1017; 866; 1080; 339; 853; 82; 808; 825; 132; 404 "463,GDGKWCKFDDDVV; 1017,LLDIQEKEFEKFK; 866,LYYQQLKMKITDF; 1080,RYTYLEKAIKIHN; 339,DIQLSIKGKKNIF; 853,DLLQFFKPRQPKK; 82,VRNLPWKIMVMPR; 808,NYFQVAKTVAQRL; 825,MLLQFFKSQGYRD; 132,NYRDDEKSFSRRI; 404,QTDQNIKINDRFE" 463:21890473; 1017:21890473; 866:21890473; 1080:21890473; 339:21890473; 853:21890473; 82:21890473; 808:21890473; 825:21890473; 132:21890473; 404:21890473 USP7 Homo sapiens (Human) 1017; 238; 339; 853; 825; 132; 404; 463; 866; 1080; 82; 808; 423 "1017,LLDIQEKEFEKFK; 238,EGDDSSKSVPLAL; 339,DIQLSIKGKKNIF; 853,DLLQFFKPRQPKK; 825,MLLQFFKSQGYRD; 132,NYRDDEKSFSRRI; 404,QTDQNIKINDRFE; 463,GDGKWCKFDDDVV; 866,LYYQQLKMKITDF; 1080,RYTYLEKAIKIHN; 82,VRNLPWKIMVMPR; 808,NYFQVAKTVAQRL; 423,LDEFLQKTDPKDP" "1017:21890473; 238:21906983; 339:21906983,21890473; 853:21890473; 825:21890473; 132:21890473; 404:21906983,21890473; 463:21890473; 866:21890473; 1080:21890473; 82:21890473; 808:21890473; 423:21906983" USP7 Homo sapiens (Human) 463; 1017; 866; 1080; 339; 853; 82; 808; 825; 132; 404 "463,GDGKWCKFDDDVV; 1017,LLDIQEKEFEKFK; 866,LYYQQLKMKITDF; 1080,RYTYLEKAIKIHN; 339,DIQLSIKGKKNIF; 853,DLLQFFKPRQPKK; 82,VRNLPWKIMVMPR; 808,NYFQVAKTVAQRL; 825,MLLQFFKSQGYRD; 132,NYRDDEKSFSRRI; 404,QTDQNIKINDRFE" 463:21890473; 1017:21890473; 866:21890473; 1080:21890473; 339:21890473; 853:21890473; 82:21890473; 808:21890473; 825:21890473; 132:21890473; 404:21890473