DNA & RNA Element - UTRdb Gene Name Type ASPicDB UTRaspic Refseq ID Genome ISG15 3'UTR 15f5ab1d8a BA053911 NM_005101 chr1:939722-939783:+ ISG15 3'UTR 15fbb29e96 BA053912 NM_005101 chr1:939722-939787:+ ISG15 3'UTR 3f02924315 BA053913 NM_005101 chr1:939722-939787:+ ISG15 3'UTR b856b323a6 BA053914 NM_005101 chr1:939722-939783:+ ISG15 5'UTR 15f5ab1d8a CA083398 NM_005101 chr1:938710-938816:+ ISG15 5'UTR 15fbb29e96 CA083399 NM_005101 chr1:926381-939247:+ ISG15 5'UTR 3f02924315 CA083400 NM_005101 chr1:926388-939247:+ ISG15 5'UTR b856b323a6 CA083401 NM_005101 chr1:938740-938816:+

DNA & RNA Element - circBase circRNA ID Chrom Start End Strand hsa_circ_0009211 chr1 949363 949919 +

DNA & RNA Element - CircNet Circ ID GITPosition Express Symbol Entrez Category Strand Refered Name hsa-circ-ISG15-antisense.1 NM_005101Tchr1:949569-949699 expressed ISG15 9636 protein-coding - not_available hsa-circ-ISG15-antisense.2 NM_005101Tchr1:949662-949734 expressed ISG15 9636 protein-coding - not_available hsa-circ-ISG15-antisense.3 NM_005101Tchr1:948897-949601 expressed ISG15 9636 protein-coding - not_available hsa-circ-ISG15-overlap.1 NM_005101Tchr1:949489-949690 expressed ISG15 9636 protein-coding + not_available hsa-circ-ISG15.1 NM_005101Tchr1:949363-949919 expressed ISG15 9636 protein-coding + hsa_circ_0009211

DNA & RNA Element - miRTarBase Target Gene (Entrez ID) miRTarBase ID miRNA Species (miRNA) Target Gene Species (Target Gene) Experiments Support Type References (PMID) MIRT021235 hsa-miR-146a-5p Homo sapiens ISG15 9636 Homo sapiens Microarray Functional MTI (Weak) 18057241 MIRT023954 hsa-miR-1-3p Homo sapiens ISG15 9636 Homo sapiens Microarray Functional MTI (Weak) 18668037

DNA & RNA Element - microRNA Mirbase Acc miRNA Name Gene ID Gene Symbol miRNA Alignment Alignment Gene Alignment miRNA Start miRNA End Gene Start Gene End Genome Coordinates Conservation Align Score Seed Cat Energy mirSVR Score MIMAT0003282 hsa-miR-614 9636 ISG15 ggugGACCGUUCUUGUCCG-CAAg | || || || |||| ||| agggCCGGAAAUAA-AGGCUGUUg 2 20 30 52 [hg19:1:949888-949910:+] 0.4568 121 0 -16.97 -1.0819 MIMAT0005825 hsa-miR-1180 9636 ISG15 ugugugggugcgCUCGGCCUUu |:||||||| gagcaggaucaaGGGCCGGAAa 2 11 19 40 [hg19:1:949877-949898:+] 0.4656 146 7 -23.48 -0.2710 MIMAT0000430 hsa-miR-138 9636 ISG15 gccggacuaaguguuGUGGUCGa ||||||| --------gggccucCACCAGCa 2 9 1 15 [hg19:1:949859-949873:+] 0.4656 140 7 -18.64 -0.2197

DNA & RNA Element - TRANSFAC Accession AS Description Species Entrez Pubmed Binding Info G000325 MO000022672 ISG15 Homo sapiens 9636 2460869 0 0 R35238; HS$ISG15_10; Binding factors: IRF-1 // 0 0 R26723; HS$ISG15_09; Binding factors: IRF-1 , IRF-9:STAT2 , ISGF-3 , STAT1 , STAT2

DNA & RNA Element - miRWalk Gene Name miRNAname Entrez ID Pathways ISG15 hsa-miR-1 9636 hsa04622_RIG I like receptor signaling pathway ISG15 hsa-miR-146a-5p 9636 hsa04622_RIG I like receptor signaling pathway

DNA & RNA Element - TargetScan Gene Name UTR Region Start UTR Region End AIR Total Normalized 3P-seq-tags & Pseudocounts Strand hg19_chromosome Genome Start Genome End ISG15; G1P2; UCRP 1 58 100 380.525 + chr1 949858 949916 ISG15; G1P2; UCRP 59 62 1.317 380.525 + chr1 949916 949920

DNA & RNA Element - RepTar Gene Name miRNA Begin End Profile ISG15 hsa-miR-1180 beg:19 end:41 pic:3' TGTGTGGGTGCGCTCGGCCTTT 5'& .|| . || |.|||||||| &5' GCAGGATCAA--GGGCCGGAAA 3' ISG15 hsa-miR-1268 beg:1 end:20 pic:3' GGGGGTGGTGGTGCGGGC 5'& ||.|||||| ||. ||| &5' CCTCCACCAGCAT--CCG 3' ISG15 hsa-miR-1301 beg:41 end:56 pic:3' CTTCAGTGAGGGTCCGTCGACGTT 5'& |||| |.||.|| &5' ------------AGGCTGTTGTAA 3' ISG15 hsa-miR-1322 beg:8 end:30 pic:3' GTCGTAG--TCGTCGTAGTAG 5'& ||||||| ||||| |||| &5' CAGCATCCGAGCAGGATCA-- 3' ISG15 hsa-miR-132 beg:33 end:53 pic:3' GCTGGTACCGACA--TCTGACAAT 5'& || ||.|||||. &5' -------GGAAATAAAGGCTGTTG 3' ISG15 hsa-miR-212 beg:29 end:53 pic:3' CCGGCACTGACC-TCTGACAAT 5'& ||||| || ||.|||||. &5' GGCCG-GAAATAAAGGCTGTTG 3' ISG15 hsa-miR-3140 beg:30 end:49 pic:3' TGATGGACTTAAGGGTTTTCGA 5'& .|| ||| .|||.||| &5' ---GCCGGAAA---TAAAGGCT 3'

DNA & RNA Element - miRcode Gene Name Type microRNA Seed Position Seed Type Total Cons% Tr Region ISG15 High_conserved miR-138/138ab chr1:949873 8-mer 13 3pUTR ISG15 High_conserved miR-193/193b/193a-3p chr1:948912 7-mer-A1 9 5pUTR ISG15 High_conserved miR-214/761/3619-5p chr1:949580 7-mer-m8 33 CDS ISG15 High_conserved miR-31 chr1:949544 7-mer-A1 13 CDS ISG15 High_conserved miR-338/338-3p chr1:949392 7-mer-m8 38 CDS ISG15 High_conserved miR-10abc/10a-5p chr1:949534 7-mer-m8 11 CDS ISG15 Medium_conserved miR-504/4725-5p chr1:949535 7-mer-m8 7 CDS ISG15 Medium_conserved miR-615-3p chr1:948814 7-mer-m8 2 5pUTR ISG15 Medium_conserved miR-339b/339-5p/3586-5p chr1:949533 7-mer-m8 11 CDS ISG15 Medium_conserved miR-370 chr1:949884 7-mer-A1 7 3pUTR ISG15 Medium_conserved miR-125a-3p/1554 chr1:949682 7-mer-A1 11 CDS ISG15 Medium_conserved miR-433 chr1:949812 7-mer-A1 29 CDS ISG15 Medium_conserved miR-486-5p/3107 chr1:948917 8-mer 11 5pUTR

DNA & RNA Element - RAID2 Gene Name RAID ID Interactor 1 Category 1 ID 1 Interactor 2 Category 2 ID 2 Methods Score ISG15 RAID00492767 hcmv-miR-US29-3p miRNA MIMAT0028168 ISG15 mRNA 9636 RT-PCR 0.7311 ISG15 RAID00989464 hcmv-miR-US5-2-3p miRNA MIMAT0001580 ISG15 mRNA 9636 RT-PCR 0.7311 ISG15 RAID01101078 hcmv-miR-US25-2-3p miRNA MIMAT0001583 ISG15 mRNA 9636 RT-PCR 0.7311 ISG15 RAID01106725 hcmv-miR-US5-1 miRNA MIMAT0001579 ISG15 mRNA 9636 RT-PCR 0.7311 ISG15 RAID02202047 hsa-miR-1-3p miRNA MIMAT0000416 ISG15 mRNA 9636 Microarray 0.5483 ISG15 RAID02997740 hsa-miR-138-5p miRNA MIMAT0000430 ISG15 mRNA 9636 Prediction 0.1828 ISG15 RAID03114070 hsa-miR-146a-5p miRNA MIMAT0000449 ISG15 mRNA 9636 Microarray 0.5483 ISG15 RAID03345562 hcmv-miR-UL36-3p miRNA MIMAT0004754 ISG15 mRNA 9636 RT-PCR 0.7311 ISG15 RAID04714266 FENDRR lncRNA 400550 ISG15 protein 9636 Microarray//RNA-seq 0.6606