PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus RBX1 DCUN1D3 19617556,25349211 biogrid exp G G G G G GP G GP G G G G GP G G G GP G GP G GP GP G G G G GP G ELAVL1 DCUN1D3 19322201 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP P GP GP G GP GP G DCUN1D3 UBE2F 23201271 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP P GP GP GP GP GP G CAND1 DCUN1D3 25349211 biogrid exp G GP G G G G G G GP G GP GP G G G GP G GP G G G G P GP GP G G GP G CUL4A DCUN1D3 23201271 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2M DCUN1D3 23201271,19617556 biogrid,dip exp GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP G P GP GP GP GP GP G DCUN1D3 CUL5 23201271 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP P GP GP GP GP GP G CUL4B DCUN1D3 23201271 biogrid exp, ortho GP GP G G GP GP G GP GP G GP GP G GP G GP GP G GP G GP GP P GP GP GP GP GP G CUL3 DCUN1D3 23201271,19617556,25349211 biogrid,dip exp, ortho GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP P GP GP GP GP GP G CUL2 DCUN1D3 23201271,19617556 biogrid,dip exp, ortho GP GP G G G GP G G GP G GP GP GP GP G G GP GP GP G GP GP P G G G GP GP G CUL1 DCUN1D3 23201271,19617556,25349211 biogrid,dip exp, ortho GP G G G G GP G GP GP G GP GP GP G G GP GP GP GP G GP GP P GP GP GP GP GP G FOXC1 DCUN1D3 23023127 pred GP GP G G G GP G G GP G GP G GP GP G P GP GP GP G GP GP P G GP P GP GP G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q86VP6 Q8IWE4 affinity chromatography technology 25349211 physical association X 2 A0A090N7U0 Q8IWE4 pull down 23201271 direct interaction X 2 A0A090N7U0 Q8IWE4 affinity chromatography technology 19617556 physical association X 2 A0A090N7U0 Q8IWE4 affinity chromatography technology 25349211 physical association X 2 A0A090N7U0 Q8IWE4 enzymatic study 23201271 direct interaction X 2 Q13617 Q8IWE4 pull down 23201271 direct interaction X 2 Q13617 Q8IWE4 affinity chromatography technology 19617556 physical association X 2 Q13617 Q8IWE4 enzymatic study 23201271 direct interaction X 2 Q8IWE4 A0A024R475 pull down 23201271 direct interaction X 2 Q8IWE4 B2RBV7 pull down 23201271 direct interaction X 2 Q8IWE4 Q13620-3 pull down 23201271 direct interaction X 2 Q8IWE4 Q93034 pull down 23201271 direct interaction X 2 Q8IWE4 A0A024R475 affinity chromatography technology 19617556 physical association X 2 Q8IWE4 A0A024R475 pull down 19617556 direct interaction X 2 Q8IWE4 P62877 pull down 19617556 direct interaction X 2 Q8IWE4 A0A024R475 imaging technique 19617556 colocalization X 2 Q8IWE4 A0A024R475 biochemical 19617556 colocalization X 2 Q8IWE4 A0A024R475 affinity chromatography technology 25349211 physical association X 2 Q8IWE4 P62877 affinity chromatography technology 25349211 physical association X 2 Q8IWE4 A0A024R475 enzymatic study 23201271 direct interaction X 2 Q8IWE4 B2RBV7 enzymatic study 23201271 direct interaction X 2 Q8IWE4 Q13620-3 enzymatic study 23201271 direct interaction X 2 Q8IWE4 Q93034 enzymatic study 23201271 direct interaction X 2 A0A024R4T4 Q8IWE4 pull down 23201271 direct interaction X 2 A0A024R4T4 Q8IWE4 pull down 19617556 direct interaction X 2 Q969M7 Q8IWE4 pull down 23201271 direct interaction X 2 Q969M7 Q8IWE4 x-ray crystallography 23201271 association X 2 A0A090N7U0 Q8IWE4 anti bait coimmunoprecipitation 19617556 physical association X 2 Q13617 Q8IWE4 anti bait coimmunoprecipitation 19617556 physical association X 2 Q8IWE4 pull down 19617556 - C 3 Q8IWE4 anti bait coimmunoprecipitation 19617556 - C 4 Q8IWE4 A0A024R475 pull down 19617556 physical association X 2 Q8IWE4 A0A024R475 anti bait coimmunoprecipitation 19617556 physical association X 2 Q8IWE4 A0A024R475 anti tag coimmunoprecipitation 19617556 physical association X 2 Q8IWE4 A0A024R475 pull down 19617556 physical association X 2 Q8IWE4 A0A024R475 anti tag coimmunoprecipitation 19617556 physical association X 2 A0A024R4T4 Q8IWE4 pull down 19617556 direct interaction X 2

PPI - HINT Gene A Gene B PMID Method Quality UBE2M DCUN1D3 26906416,23201271,19617556 0096,0096,0096 LC RBX1 DCUN1D3 25349211,26906416,19617556 0004,0004,0096 LC CUL1 DCUN1D3 25349211,23201271,19617556,19617556,23201271,26906416 0004,0096,0006,0004,0415,0004 LC CUL2 DCUN1D3 19617556,19617556,23201271,23201271,26906416 0006,0004,0415,0096,0004 LC CUL3 DCUN1D3 25349211,26906416,23201271,19617556,19617556,19617556,19617556,26906416,19617556,23201271,19617556,26906416 0004,0096,0096,0096,0007,0428,0006,0415,0004,0415,0401,0004 LC CUL4A DCUN1D3 23201271,23201271,26906416 0415,0096,0004 LC CUL4B DCUN1D3 23201271,23201271,26906416 0415,0096,0004 LC CAND1 DCUN1D3 25349211,26906416,26906416 0004,0096,0004 LC DCUN1D3 CUL5 23201271,23201271,26906416 0415,0096,0004 LC DCUN1D3 UBE2F 23201271,23201271 0114,0096 LC UBE2M DCUN1D3 26906416,23201271,19617556 0096,0096,0096 LC RBX1 DCUN1D3 25349211,26906416,19617556 0004,0004,0096 LC CUL1 DCUN1D3 25349211,23201271,19617556,19617556,23201271,26906416 0004,0096,0006,0004,0415,0004 LC CUL2 DCUN1D3 19617556,19617556,23201271,23201271,26906416 0006,0004,0415,0096,0004 LC CUL3 DCUN1D3 25349211,26906416,23201271,19617556,19617556,19617556,19617556,26906416,19617556,23201271,19617556,26906416 0004,0096,0096,0096,0007,0428,0006,0415,0004,0415,0401,0004 LC CUL4A DCUN1D3 23201271,23201271,26906416 0415,0096,0004 LC CUL4B DCUN1D3 23201271,23201271,26906416 0415,0096,0004 LC CAND1 DCUN1D3 25349211,26906416,26906416 0004,0096,0004 LC DCUN1D3 CUL5 23201271,23201271,26906416 0415,0096,0004 LC DCUN1D3 UBE2F 23201271,23201271 0114,0096 LC CUL1 DCUN1D3 23201271,23201271 0096,0415 LC CUL2 DCUN1D3 23201271,23201271 0415,0096 LC CUL3 DCUN1D3 26906416,23201271,19617556,19617556,19617556,19617556,26906416,19617556,23201271,19617556,26906416 0096,0096,0096,0007,0428,0006,0415,0004,0415,0401,0004 LC CUL4A DCUN1D3 23201271,23201271 0415,0096 LC CUL4B DCUN1D3 23201271,23201271 0415,0096 LC DCUN1D3 DCUN1D3 23201271 0114 LC DCUN1D3 CUL5 23201271,23201271 0415,0096 LC DCUN1D3 UBE2F 23201271,23201271 0114,0096 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q8IWE4 P61081 DCUN1D3 UBE2M 0.332 23201271,26906416 Q8IWE4 Q15370 DCUN1D3 TCEB2 0.126 26906416 Q9UBF6 Q8IWE4 RNF7 DCUN1D3 0.126 26906416 Q969M7 Q8IWE4 UBE2F DCUN1D3 0.332 23201271 Q93034 Q8IWE4 CUL5 DCUN1D3 0.416 26906416,23201271 Q8IWE4 Q86VP6 DCUN1D3 CAND1 0.436 26906416,25349211 Q8IWE4 Q13620 DCUN1D3 CUL4B 0.416 26906416,23201271 Q8IWE4 Q13619 DCUN1D3 CUL4A 0.416 26906416,23201271 Q8IWE4 Q13617 DCUN1D3 CUL2 0.539 26906416,19617556,23201271 Q8IWE4 Q13616 DCUN1D3 CUL1 0.539 26906416,23201271,25349211 Q8IWE4 Q13618 DCUN1D3 CUL3 0.787 26906416,19617556,23201271,25349211 Q8IWE4 P62877 DCUN1D3 RBX1 0.523 26906416,19617556,25349211 Q8IWE4 Q15717 DCUN1D3 ELAVL1 0.126 19322201

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 DNM2 DCUN1D3 MI:0362 inference MI:0461 interaction database UBE2M DCUN1D3 MI:0045 experimental interaction detection MI:0461 interaction database RBX1 DCUN1D3 MI:0045 experimental interaction detection MI:0461 interaction database RPL38 DCUN1D3 MI:0362 inference MI:0461 interaction database SKP1 DCUN1D3 MI:0362 inference MI:0461 interaction database DNM1 DCUN1D3 MI:0362 inference MI:0461 interaction database CUL1 DCUN1D3 MI:0045 experimental interaction detection MI:0461 interaction database CUL2 DCUN1D3 MI:0045 experimental interaction detection MI:0461 interaction database CUL3 DCUN1D3 MI:0045 experimental interaction detection MI:0461 interaction database CUL4A DCUN1D3 MI:0045 experimental interaction detection MI:0461 interaction database CUL4B DCUN1D3 MI:0045 experimental interaction detection MI:0461 interaction database TCEB2 DCUN1D3 MI:0045 experimental interaction detection MI:0461 interaction database ELAVL1 DCUN1D3 MI:0045 experimental interaction detection MI:0461 interaction database NEDD8 DCUN1D3 MI:0045 experimental interaction detection MI:0461 interaction database CAND1 DCUN1D3 MI:0045 experimental interaction detection MI:0461 interaction database DCUN1D3 CUL5 MI:0045 experimental interaction detection MI:0461 interaction database DCUN1D3 UBE2F MI:0045 experimental interaction detection MI:0461 interaction database DCUN1D3 NCLN MI:0362 inference MI:0461 interaction database DCUN1D3 DCUN1D1 MI:0362 inference MI:0461 interaction database DCUN1D3 ATP13A1 MI:0362 inference MI:0461 interaction database DCUN1D3 RNF7 MI:0045 experimental interaction detection MI:0461 interaction database DCUN1D3 DNM3 MI:0362 inference MI:0461 interaction database