PTM - CPLM Gene Name UniProt ID Type Position Code SLX4; BTBD12; KIAA1784; KIAA1987 Q8IY92 Methylation 404 K SLX4; BTBD12; KIAA1784; KIAA1987 Q8IY92 Methylation 405 K SLX4; BTBD12; KIAA1784; KIAA1987 Q8IY92 Ubiquitination 341 K SLX4; BTBD12; KIAA1784; KIAA1987 Q8IY92 Ubiquitination 863 K SLX4; BTBD12; KIAA1784; KIAA1987 Q8IY92 Ubiquitination 412 K SLX4; BTBD12; KIAA1784; KIAA1987 Q8IY92 Ubiquitination 1169 K SLX4; BTBD12; KIAA1784; KIAA1987 Q8IY92 Ubiquitination 1180 K SLX4; BTBD12; KIAA1784; KIAA1987 Q8IY92 Ubiquitination 291 K SLX4; BTBD12; KIAA1784; KIAA1987 Q8IY92 Ubiquitination 835 K SLX4; BTBD12; KIAA1784; KIAA1987 Q8IY92 Ubiquitination 1179 K SLX4; BTBD12; KIAA1784; KIAA1987 Q8IY92 Ubiquitination 1657 K

PTM - dbPAF Gene Name UniProt ID Position Type Species SLX4; BTBD12; KIAA1784; KIAA1987 Q8IY92 1028 S Homo sapiens(Human) SLX4; BTBD12; KIAA1784; KIAA1987 Q8IY92 1044 S Homo sapiens(Human) SLX4; BTBD12; KIAA1784; KIAA1987 Q8IY92 1065 T Homo sapiens(Human) SLX4; BTBD12; KIAA1784; KIAA1987 Q8IY92 1066 S Homo sapiens(Human) SLX4; BTBD12; KIAA1784; KIAA1987 Q8IY92 1070 S Homo sapiens(Human) SLX4; BTBD12; KIAA1784; KIAA1987 Q8IY92 1072 T Homo sapiens(Human) SLX4; BTBD12; KIAA1784; KIAA1987 Q8IY92 1075 S Homo sapiens(Human) SLX4; BTBD12; KIAA1784; KIAA1987 Q8IY92 1087 S Homo sapiens(Human) SLX4; BTBD12; KIAA1784; KIAA1987 Q8IY92 1092 S Homo sapiens(Human) SLX4; BTBD12; KIAA1784; KIAA1987 Q8IY92 1121 S Homo sapiens(Human) SLX4; BTBD12; KIAA1784; KIAA1987 Q8IY92 1123 S Homo sapiens(Human) SLX4; BTBD12; KIAA1784; KIAA1987 Q8IY92 1134 S Homo sapiens(Human) SLX4; BTBD12; KIAA1784; KIAA1987 Q8IY92 1138 S Homo sapiens(Human) SLX4; BTBD12; KIAA1784; KIAA1987 Q8IY92 1157 S Homo sapiens(Human) SLX4; BTBD12; KIAA1784; KIAA1987 Q8IY92 1170 S Homo sapiens(Human) SLX4; BTBD12; KIAA1784; KIAA1987 Q8IY92 1172 S Homo sapiens(Human) SLX4; BTBD12; KIAA1784; KIAA1987 Q8IY92 1173 S Homo sapiens(Human) SLX4; BTBD12; KIAA1784; KIAA1987 Q8IY92 1185 S Homo sapiens(Human) SLX4; BTBD12; KIAA1784; KIAA1987 Q8IY92 1204 S Homo sapiens(Human) SLX4; BTBD12; KIAA1784; KIAA1987 Q8IY92 1206 S Homo sapiens(Human) SLX4; BTBD12; KIAA1784; KIAA1987 Q8IY92 1260 T Homo sapiens(Human) SLX4; BTBD12; KIAA1784; KIAA1987 Q8IY92 1264 S Homo sapiens(Human) SLX4; BTBD12; KIAA1784; KIAA1987 Q8IY92 1271 S Homo sapiens(Human) SLX4; BTBD12; KIAA1784; KIAA1987 Q8IY92 1273 T Homo sapiens(Human) SLX4; BTBD12; KIAA1784; KIAA1987 Q8IY92 1288 T Homo sapiens(Human) SLX4; BTBD12; KIAA1784; KIAA1987 Q8IY92 1291 T Homo sapiens(Human) SLX4; BTBD12; KIAA1784; KIAA1987 Q8IY92 1309 S Homo sapiens(Human) SLX4; BTBD12; KIAA1784; KIAA1987 Q8IY92 1315 T Homo sapiens(Human) SLX4; BTBD12; KIAA1784; KIAA1987 Q8IY92 1320 T Homo sapiens(Human) SLX4; BTBD12; KIAA1784; KIAA1987 Q8IY92 1322 S Homo sapiens(Human) SLX4; BTBD12; KIAA1784; KIAA1987 Q8IY92 1323 S Homo sapiens(Human) SLX4; BTBD12; KIAA1784; KIAA1987 Q8IY92 1326 T Homo sapiens(Human) SLX4; BTBD12; KIAA1784; KIAA1987 Q8IY92 1329 S Homo sapiens(Human) SLX4; BTBD12; KIAA1784; KIAA1987 Q8IY92 1332 T Homo sapiens(Human) SLX4; BTBD12; KIAA1784; KIAA1987 Q8IY92 1333 S Homo sapiens(Human) SLX4; BTBD12; KIAA1784; KIAA1987 Q8IY92 1377 S Homo sapiens(Human) SLX4; BTBD12; KIAA1784; KIAA1987 Q8IY92 1382 S Homo sapiens(Human) SLX4; BTBD12; KIAA1784; KIAA1987 Q8IY92 1387 T Homo sapiens(Human) SLX4; BTBD12; KIAA1784; KIAA1987 Q8IY92 1398 S Homo sapiens(Human) SLX4; BTBD12; KIAA1784; KIAA1987 Q8IY92 1406 S Homo sapiens(Human) SLX4; BTBD12; KIAA1784; KIAA1987 Q8IY92 1446 T Homo sapiens(Human) SLX4; BTBD12; KIAA1784; KIAA1987 Q8IY92 1450 S Homo sapiens(Human) SLX4; BTBD12; KIAA1784; KIAA1987 Q8IY92 1452 S Homo sapiens(Human) SLX4; BTBD12; KIAA1784; KIAA1987 Q8IY92 1453 S Homo sapiens(Human) SLX4; BTBD12; KIAA1784; KIAA1987 Q8IY92 1455 S Homo sapiens(Human) SLX4; BTBD12; KIAA1784; KIAA1987 Q8IY92 1464 S Homo sapiens(Human) SLX4; BTBD12; KIAA1784; KIAA1987 Q8IY92 1469 S Homo sapiens(Human) SLX4; BTBD12; KIAA1784; KIAA1987 Q8IY92 1475 T Homo sapiens(Human) SLX4; BTBD12; KIAA1784; KIAA1987 Q8IY92 1476 T Homo sapiens(Human) SLX4; BTBD12; KIAA1784; KIAA1987 Q8IY92 1631 S Homo sapiens(Human) SLX4; BTBD12; KIAA1784; KIAA1987 Q8IY92 1674 S Homo sapiens(Human) SLX4; BTBD12; KIAA1784; KIAA1987 Q8IY92 1676 T Homo sapiens(Human) SLX4; BTBD12; KIAA1784; KIAA1987 Q8IY92 1679 S Homo sapiens(Human) SLX4; BTBD12; KIAA1784; KIAA1987 Q8IY92 1681 S Homo sapiens(Human) SLX4; BTBD12; KIAA1784; KIAA1987 Q8IY92 1683 T Homo sapiens(Human) SLX4; BTBD12; KIAA1784; KIAA1987 Q8IY92 169 S Homo sapiens(Human) SLX4; BTBD12; KIAA1784; KIAA1987 Q8IY92 1716 S Homo sapiens(Human) SLX4; BTBD12; KIAA1784; KIAA1987 Q8IY92 173 S Homo sapiens(Human) SLX4; BTBD12; KIAA1784; KIAA1987 Q8IY92 199 S Homo sapiens(Human) SLX4; BTBD12; KIAA1784; KIAA1987 Q8IY92 201 S Homo sapiens(Human) SLX4; BTBD12; KIAA1784; KIAA1987 Q8IY92 228 S Homo sapiens(Human) SLX4; BTBD12; KIAA1784; KIAA1987 Q8IY92 232 S Homo sapiens(Human) SLX4; BTBD12; KIAA1784; KIAA1987 Q8IY92 287 S Homo sapiens(Human) SLX4; BTBD12; KIAA1784; KIAA1987 Q8IY92 383 S Homo sapiens(Human) SLX4; BTBD12; KIAA1784; KIAA1987 Q8IY92 467 S Homo sapiens(Human) SLX4; BTBD12; KIAA1784; KIAA1987 Q8IY92 478 T Homo sapiens(Human) SLX4; BTBD12; KIAA1784; KIAA1987 Q8IY92 499 S Homo sapiens(Human) SLX4; BTBD12; KIAA1784; KIAA1987 Q8IY92 500 T Homo sapiens(Human) SLX4; BTBD12; KIAA1784; KIAA1987 Q8IY92 506 S Homo sapiens(Human) SLX4; BTBD12; KIAA1784; KIAA1987 Q8IY92 57 S Homo sapiens(Human) SLX4; BTBD12; KIAA1784; KIAA1987 Q8IY92 584 S Homo sapiens(Human) SLX4; BTBD12; KIAA1784; KIAA1987 Q8IY92 590 T Homo sapiens(Human) SLX4; BTBD12; KIAA1784; KIAA1987 Q8IY92 592 T Homo sapiens(Human) SLX4; BTBD12; KIAA1784; KIAA1987 Q8IY92 597 S Homo sapiens(Human) SLX4; BTBD12; KIAA1784; KIAA1987 Q8IY92 601 S Homo sapiens(Human) SLX4; BTBD12; KIAA1784; KIAA1987 Q8IY92 71 S Homo sapiens(Human) SLX4; BTBD12; KIAA1784; KIAA1987 Q8IY92 884 S Homo sapiens(Human) SLX4; BTBD12; KIAA1784; KIAA1987 Q8IY92 956 S Homo sapiens(Human) SLX4; BTBD12; KIAA1784; KIAA1987 Q8IY92 957 S Homo sapiens(Human) SLX4; BTBD12; KIAA1784; KIAA1987 Q8IY92 959 S Homo sapiens(Human) SLX4; BTBD12; KIAA1784; KIAA1987 Q8IY92 960 S Homo sapiens(Human)

PTM - PhosphositePlus UniProt ID MOD_RSD Type SITE_+/-7_AA Q8IY92 K404-m2 Methylation KRRGPTSkkEPRKRR Q8IY92 K405-m2 Methylation RRGPTSkkEPRKRRK Q8IY92 R1046-m1 Methylation PPQGGsPrGSHHTSG Q8IY92 R1062-m1 Methylation SLSTPRsrGGtsQVG Q8IY92 S57-p Phosphorylation DFKELCAsFFQRVKK Q8IY92 S71-p Phosphorylation KHGIKEVsGERKTQK Q8IY92 S169-p Phosphorylation TGNQQEPsPNLsREK Q8IY92 S173-p Phosphorylation QEPsPNLsREKTREN Q8IY92 S228-p Phosphorylation PERLRHAsEECsLEA Q8IY92 S232-p Phosphorylation RHAsEECsLEAAREE Q8IY92 Y255-p Phosphorylation EMMAGNVyGLGPPAP Q8IY92 S264-p Phosphorylation LGPPAPEsDAAVALT Q8IY92 S287-p Phosphorylation GASAHDDsLEEkGLF Q8IY92 S348-p Phosphorylation KPFLTLKsRTSHLKQ Q8IY92 S383-p Phosphorylation AQPEGSSsPPMFSFS Q8IY92 S448-p Phosphorylation LRLESAFsERIRPEA Q8IY92 S467-p Phosphorylation RKKKPPVsPPLLLVQ Q8IY92 T478-p Phosphorylation LLVQDSEtTGRQIED Q8IY92 S499-p Phosphorylation SEEVELSstPPLPAs Q8IY92 T500-p Phosphorylation EEVELSstPPLPAsR Q8IY92 S506-p Phosphorylation stPPLPAsRILKEGW Q8IY92 S584-p Phosphorylation SELSERRsPALHGtP Q8IY92 T590-p Phosphorylation RsPALHGtPTAGCGS Q8IY92 S601-p Phosphorylation GCGSRGPsPSASQRE Q8IY92 T832-p Phosphorylation DEEEEAEtLLkSKDH Q8IY92 S884-p Phosphorylation ADWLEGGsPVSGQLL Q8IY92 S956-p Phosphorylation PEEALGHsSCSSPSR Q8IY92 S1028-p Phosphorylation RLAPWQAsPPHPCRF Q8IY92 S1044-p Phosphorylation LGPPQGGsPrGSHHT Q8IY92 S1061-p Phosphorylation SSLSTPRsrGGtsQV Q8IY92 T1065-p Phosphorylation TPRsrGGtsQVGsPt Q8IY92 S1066-p Phosphorylation PRsrGGtsQVGsPtL Q8IY92 S1070-p Phosphorylation GGtsQVGsPtLLsPA Q8IY92 T1072-p Phosphorylation tsQVGsPtLLsPAVP Q8IY92 S1075-p Phosphorylation VGsPtLLsPAVPSKQ Q8IY92 S1087-p Phosphorylation SKQKRDRsILTLsKE Q8IY92 S1092-p Phosphorylation DRsILTLsKEPGHQK Q8IY92 S1123-p Phosphorylation MFPEKSPsIDLTQSN Q8IY92 S1134-p Phosphorylation TQSNPDHsSSRsQKS Q8IY92 S1138-p Phosphorylation PDHsSSRsQKSSSKL Q8IY92 S1157-p Phosphorylation EVILLLDsDEELELE Q8IY92 S1170-p Phosphorylation LEQTKMksISsDPLE Q8IY92 S1173-p Phosphorylation TKMksISsDPLEEkk Q8IY92 S1185-p Phosphorylation EkkALEIsPRSCELF Q8IY92 T1260-p Phosphorylation TSWLVPAtPLAsRSR Q8IY92 S1264-p Phosphorylation VPAtPLAsRSRDCSs Q8IY92 S1271-p Phosphorylation sRSRDCSsQtQISSL Q8IY92 T1273-p Phosphorylation SRDCSsQtQISSLRS Q8IY92 T1288-p Phosphorylation GLAVQAVtQHtPRAS Q8IY92 T1291-p Phosphorylation VQAVtQHtPRASVGN Q8IY92 S1309-p Phosphorylation NEVAQKFsVIRPQtP Q8IY92 T1315-p Phosphorylation FsVIRPQtPPPQtPs Q8IY92 T1320-p Phosphorylation PQtPPPQtPssCLtP Q8IY92 S1322-p Phosphorylation tPPPQtPssCLtPVs Q8IY92 S1323-p Phosphorylation PPPQtPssCLtPVsP Q8IY92 T1326-p Phosphorylation QtPssCLtPVsPGts Q8IY92 S1329-p Phosphorylation ssCLtPVsPGtsDGR Q8IY92 T1332-p Phosphorylation LtPVsPGtsDGRRQG Q8IY92 S1333-p Phosphorylation tPVsPGtsDGRRQGH Q8IY92 S1342-p Phosphorylation GRRQGHRsPSRPHPG Q8IY92 S1355-p Phosphorylation PGGHPHSsPLAPHPI Q8IY92 S1398-p Phosphorylation EVVEVGDsDDEQEVA Q8IY92 T1446-p Phosphorylation DHWNLERtGPLSTss Q8IY92 S1452-p Phosphorylation RtGPLSTssPsRRMN Q8IY92 S1453-p Phosphorylation tGPLSTssPsRRMNE Q8IY92 S1455-p Phosphorylation PLSTssPsRRMNEAA Q8IY92 S1464-p Phosphorylation RMNEAADsRDCRsPG Q8IY92 S1469-p Phosphorylation ADsRDCRsPGLLDTt Q8IY92 T1476-p Phosphorylation sPGLLDTtPIRGSCT Q8IY92 S1631-p Phosphorylation PHCQTLAsQTYKPSR Q8IY92 T1676-p Phosphorylation RKHHESItPPSRsPt Q8IY92 S1681-p Phosphorylation SItPPSRsPtKEAPP Q8IY92 T1683-p Phosphorylation tPPSRsPtKEAPPGL Q8IY92 S1716-p Phosphorylation GSDSSLSsQSSSSCE Q8IY92 K291-sm Sumoylation HDDsLEEkGLFFCQI Q8IY92 K359-sm Sumoylation HLKQCAVkMEVGPQL Q8IY92 K1180-sm Sumoylation sDPLEEkkALEIsPR Q8IY92 K1575-sm Sumoylation IMETPVLkKELDRFG Q8IY92 K835-ub Ubiquitination EEAEtLLkSKDHEED Q8IY92 K1169-ub Ubiquitination ELEQTKMksISsDPL Q8IY92 K1179-ub Ubiquitination SsDPLEEkkALEIsP Q8IY92 K1657-ub Ubiquitination GPGAHRPkGPAKTKG

PTM - dbPTM UniProt ID Position Code Type Resources References Q8IY92 287 S Phosphorylation Swiss-Prot 1010711 18669648 Q8IY92 1044 S Phosphorylation Swiss-Prot 1010711 18691976;19690332 Q8IY92 1452 S Phosphorylation Swiss-Prot 1010711 19369195 Q8IY92 1469 S Phosphorylation Swiss-Prot 1010711 18220336;18669648 Q8IY92 201 S Phosphorylation HPRD 9.0 18691976 Q8IY92 287 S Phosphorylation HPRD 9.0 18669648 Q8IY92 884 S Phosphorylation HPRD 9.0 18691976 Q8IY92 1044 S Phosphorylation HPRD 9.0 19664995,19664994,18691976,20068231 Q8IY92 1070 S Phosphorylation HPRD 9.0 20068231 Q8IY92 1075 S Phosphorylation HPRD 9.0 20068231 Q8IY92 1185 S Phosphorylation HPRD 9.0 20068231 Q8IY92 1452 S Phosphorylation HPRD 9.0 19664995 Q8IY92 1453 S Phosphorylation HPRD 9.0 19664995 Q8IY92 1469 S Phosphorylation HPRD 9.0 18669648,19664994,20068231 Q8IY92 1674 S Phosphorylation HPRD 9.0 20068231 Q8IY92 1679 S Phosphorylation HPRD 9.0 20068231 Q8IY92 1475 T Phosphorylation HPRD 9.0 20068231 Q8IY92 287 S Phosphorylation SysPTM 1.1 18669648 Q8IY92 1469 S Phosphorylation SysPTM 1.1 18669648 Q8IY92 1044 S Phosphorylation SysPTM 1.1 18691976

PTM - HPRD Symbol Position Code Type References BTBD12 1044 S Phosphorylation 19664995,19664994,18691976,20068231 BTBD12 1070 S Phosphorylation 20068231 BTBD12 1075 S Phosphorylation 20068231 BTBD12 1185 S Phosphorylation 20068231 BTBD12 1452 S Phosphorylation 19664995 BTBD12 1453 S Phosphorylation 19664995 BTBD12 1469 S Phosphorylation 18669648,19664994,20068231 BTBD12 1475 T Phosphorylation 20068231 BTBD12 1674 S Phosphorylation 20068231 BTBD12 1679 S Phosphorylation 20068231 BTBD12 201 S Phosphorylation 18691976 BTBD12 287 S Phosphorylation 18669648 BTBD12 361 S Phosphorylation 19664995,19664994,18691976,20068231 BTBD12 387 S Phosphorylation 20068231 BTBD12 392 S Phosphorylation 20068231 BTBD12 502 S Phosphorylation 20068231 BTBD12 769 S Phosphorylation 19664995 BTBD12 770 S Phosphorylation 19664995 BTBD12 786 S Phosphorylation 18669648,19664994,20068231 BTBD12 792 T Phosphorylation 20068231 BTBD12 884 S Phosphorylation 18691976 BTBD12 991 S Phosphorylation 20068231 BTBD12 996 S Phosphorylation 20068231

PTM - UniProt UniProt ID Position Type PMIDs Q8IY92 169 Phosphoserine 23186163 Q8IY92 287 Phosphoserine 18669648 Q8IY92 1028 Phosphoserine 23186163 Q8IY92 1044 Phosphoserine 20068231;23186163 Q8IY92 1070 Phosphoserine 23186163 Q8IY92 1185 Phosphoserine 23186163 Q8IY92 1469 Phosphoserine 18220336;18669648;23186163

PTM - BioGRID Entrez Gene BioGRID ID Position Code Type PMIDs 84464 124097 - K Sumoylation 21693764 84464 124097 - K Ubiquitination 21139048 84464 124097 - K Ubiquitination 21890473 84464 124097 - K Ubiquitination 21906983 84464 124097 - K Sumoylation 19471022

PTM - mUbiSiDa Gene Name Species Ubiquitination Site Ubiquitination Sequence Evidence PMID BTBD12 Homo sapiens (Human) 835; 1169; 341; 1657; 1179 "835,EAETLLKSKDHEE; 1169,LEQTKMKSISSDP; 341,ECPICGKPFLTLK; 1657,PGAHRPKGPAKTK; 1179,SDPLEEKKALEIS" 835:21906983; 1169:21906983; 341:21890473; 1657:21906983; 1179:21906983 BTBD12 Homo sapiens (Human) 867; 857; 29; 523; 1345 "867,SDPLEEKKALEIS; 857,LEQTKMKSISSDP; 29,ECPICGKPFLTLK; 523,EAETLLKSKDHEE; 1345,PGAHRPKGPAKTK" 867:21906983; 857:21906983; 29:21890473; 523:21906983; 1345:21906983