PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus OTUD6A CBLC 23105109 biogrid exp P P P P P P P P P P P P P P P P OTUD6A RNF2 23105109 biogrid exp P P P P P P P P P P P P P P P P OTUD6A TRIM5 23105109 biogrid exp P P P P P P P P P P P P P P P P P P P P P DARS OTUD6A 26344197 biogrid exp P P P P P P P P P P P P P P P P P P P OTUD6A TRIM39 23105109 biogrid exp P P P P P P P P P P P P OTUD6A RBCK1 23105109 biogrid exp P P P P P P P P P P P P P P P P P P P P P OTUD6A TRIM46 23105109 biogrid exp P P P P P P P P P P P P P P P P P UBC OTUD6A 23827681 biogrid exp P P P P P P P P P P P P P P P P P P P P P

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q7L8S5 Q99496 two hybrid 23105109 direct interaction X 2 Q7L8S5 Q9ULV8 two hybrid 23105109 direct interaction X 2 Q7L8S5 A0A024RCP5 two hybrid 23105109 direct interaction X 2 Q7L8S5 Q9C035 two hybrid 23105109 direct interaction X 2 P0CG48 Q7L8S5 enzymatic study 23827681 direct interaction X 2 Q7Z4K8 Q7L8S5 two hybrid 23105109 direct interaction X 2 Q7L8S5 two hybrid 23105109 direct interaction X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B OTUD6A TRIM39 MI:0018(two hybrid) 23105109 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_248252 bait prey OTUD6A RNF2 MI:0018(two hybrid) 23105109 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_248249 bait prey OTUD6A RBCK1 MI:0018(two hybrid) 23105109 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_248250 bait prey OTUD6A TRIM5 MI:0018(two hybrid) 23105109 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_248254 bait prey OTUD6A CBLC MI:0018(two hybrid) 23105109 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_248251 bait prey OTUD6A TRIM46 MI:0018(two hybrid) 23105109 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_248253 bait prey

PPI - HINT Gene A Gene B PMID Method Quality DARS OTUD6A 26344197 0401 HT DARS OTUD6A 26344197 0401 HT UBC OTUD6A 23827681 0415 LC DARS OTUD6A 26344197 0401 LC OTUD6A TRIM46 23105109 0018 LC OTUD6A RNF2 23105109 0018 LC OTUD6A RBCK1 23105109 0018 LC OTUD6A TRIM5 23105109 0018 LC OTUD6A TRIM39 23105109 0018 LC OTUD6A CBLC 23105109 0018 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q7L8S5 P0CG48 OTUD6A UBC 0.309 23827681 Q7Z4K8 Q7L8S5 TRIM46 OTUD6A 0.183 23105109 Q99496 Q7L8S5 RNF2 OTUD6A 0.183 23105109 Q9BYM8 Q7L8S5 RBCK1 OTUD6A 0.183 23105109 Q9C035 Q7L8S5 TRIM5 OTUD6A 0.183 23105109 Q9HCM9 Q7L8S5 TRIM39 OTUD6A 0.183 23105109 Q9ULV8 Q7L8S5 CBLC OTUD6A 0.183 23105109 Q96HA1 Q7L8S5 POM121 OTUD6A 0.236 unassigned1304 Q96FJ2 Q7L8S5 DYNLL2 OTUD6A 0.236 unassigned1304 Q7L8S5 Q04743 OTUD6A EMX2 0.236 unassigned1304 Q7L8S5 P37198 OTUD6A NUP62 0.236 unassigned1304 Q7L8S5 P63167 OTUD6A DYNLL1 0.236 unassigned1304 Q8N1B4 Q7L8S5 VPS52 OTUD6A 0.236 unassigned1304 Q7L8S5 Q04837 OTUD6A SSBP1 0.236 unassigned1304 Q7L8S5 Q14195 OTUD6A DPYSL3 0.236 unassigned1304 Q9C029 Q7L8S5 TRIM7 OTUD6A 0.236 unassigned1304 Q9NR12 Q7L8S5 PDLIM7 OTUD6A 0.236 unassigned1304 Q7L8S5 P14868 OTUD6A DARS 0.081 26344197

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 XPO1 OTUD6A MI:0362 inference MI:0461 interaction database ULK1 OTUD6A MI:0362 inference MI:0461 interaction database HSPA4L OTUD6A MI:0362 inference MI:0461 interaction database UBC OTUD6A MI:0045 experimental interaction detection MI:0461 interaction database HSPA1B OTUD6A MI:0362 inference MI:0461 interaction database HSPA8 OTUD6A MI:0362 inference MI:0461 interaction database HSPA6 OTUD6A MI:0362 inference MI:0461 interaction database PRKACA OTUD6A MI:0362 inference MI:0461 interaction database RCC1 OTUD6A MI:0362 inference MI:0461 interaction database PRKACG OTUD6A MI:0362 inference MI:0461 interaction database PRKACB OTUD6A MI:0362 inference MI:0461 interaction database HSPA1L OTUD6A MI:0362 inference MI:0461 interaction database HSPA4 OTUD6A MI:0362 inference MI:0461 interaction database CSNK1D OTUD6A MI:0362 inference MI:0461 interaction database PRKX OTUD6A MI:0362 inference MI:0461 interaction database HSPA2 OTUD6A MI:0362 inference MI:0461 interaction database CNBP OTUD6A MI:0362 inference MI:0461 interaction database OTUD6A TRIM46 MI:0045 experimental interaction detection MI:0461 interaction database OTUD6A ULK2 MI:0362 inference MI:0461 interaction database OTUD6A ZCCHC13 MI:0362 inference MI:0461 interaction database OTUD6A HSPH1 MI:0362 inference MI:0461 interaction database OTUD6A KAT5 MI:0362 inference MI:0461 interaction database OTUD6A AURKB MI:0362 inference MI:0461 interaction database OTUD6A RNF2 MI:0045 experimental interaction detection MI:0461 interaction database OTUD6A RBCK1 MI:0045 experimental interaction detection MI:0461 interaction database OTUD6A TRIM5 MI:0045 experimental interaction detection MI:0461 interaction database OTUD6A TRIM39 MI:0045 experimental interaction detection MI:0461 interaction database OTUD6A GLTSCR2 MI:0362 inference MI:0461 interaction database OTUD6A CBLC MI:0045 experimental interaction detection MI:0461 interaction database OTUD6A AURKC MI:0362 inference MI:0461 interaction database