PTM - CPLM Gene Name UniProt ID Type Position Code PIK3R4; VPS15 Q99570 Ubiquitination 1293 K PIK3R4; VPS15 Q99570 Ubiquitination 89 K PIK3R4; VPS15 Q99570 Ubiquitination 772 K PIK3R4; VPS15 Q99570 Ubiquitination 941 K PIK3R4; VPS15 Q99570 Ubiquitination 918 K PIK3R4; VPS15 Q99570 Ubiquitination 773 K PIK3R4; VPS15 Q99570 Ubiquitination 951 K PIK3R4; VPS15 Q99570 Ubiquitination 801 K PIK3R4; VPS15 Q99570 Ubiquitination 816 K PIK3R4; VPS15 Q99570 Ubiquitination 97 K PIK3R4; VPS15 Q99570 Ubiquitination 888 K PIK3R4; VPS15 Q99570 Ubiquitination 1307 K PIK3R4; VPS15 Q99570 Ubiquitination 713 K PIK3R4; VPS15 Q99570 Ubiquitination 850 K PIK3R4; VPS15 Q99570 Ubiquitination 309 K PIK3R4; VPS15 Q99570 Ubiquitination 786 K PIK3R4; VPS15 Q99570 Ubiquitination 791 K PIK3R4; VPS15 Q99570 Ubiquitination 280 K PIK3R4; VPS15 Q99570 Ubiquitination 1309 K PIK3R4; VPS15 Q99570 Ubiquitination 1081 K PIK3R4; VPS15 Q99570 Ubiquitination 443 K PIK3R4; VPS15 Q99570 Ubiquitination 68 K PIK3R4; VPS15 Q99570 Ubiquitination 75 K PIK3R4; VPS15 Q99570 Ubiquitination 449 K PIK3R4; VPS15 Q99570 Ubiquitination 736 K PIK3R4; VPS15 Q99570 Ubiquitination 553 K

PTM - dbPAF Gene Name UniProt ID Position Type Species PIK3R4; VPS15 Q99570 1038 Y Homo sapiens(Human) PIK3R4; VPS15 Q99570 1074 S Homo sapiens(Human) PIK3R4; VPS15 Q99570 1079 S Homo sapiens(Human) PIK3R4; VPS15 Q99570 115 S Homo sapiens(Human) PIK3R4; VPS15 Q99570 116 T Homo sapiens(Human) PIK3R4; VPS15 Q99570 1272 Y Homo sapiens(Human) PIK3R4; VPS15 Q99570 1282 S Homo sapiens(Human) PIK3R4; VPS15 Q99570 1283 T Homo sapiens(Human) PIK3R4; VPS15 Q99570 1287 S Homo sapiens(Human) PIK3R4; VPS15 Q99570 1289 S Homo sapiens(Human) PIK3R4; VPS15 Q99570 1290 Y Homo sapiens(Human) PIK3R4; VPS15 Q99570 1291 Y Homo sapiens(Human) PIK3R4; VPS15 Q99570 1316 T Homo sapiens(Human) PIK3R4; VPS15 Q99570 543 T Homo sapiens(Human) PIK3R4; VPS15 Q99570 546 S Homo sapiens(Human) PIK3R4; VPS15 Q99570 61 T Homo sapiens(Human) PIK3R4; VPS15 Q99570 673 Y Homo sapiens(Human) PIK3R4; VPS15 Q99570 680 T Homo sapiens(Human) PIK3R4; VPS15 Q99570 698 Y Homo sapiens(Human) PIK3R4; VPS15 Q99570 740 S Homo sapiens(Human) PIK3R4; VPS15 Q99570 808 S Homo sapiens(Human) PIK3R4; VPS15 Q99570 813 S Homo sapiens(Human) PIK3R4; VPS15 Q99570 814 S Homo sapiens(Human) PIK3R4; VPS15 Q99570 853 S Homo sapiens(Human) PIK3R4; VPS15 Q99570 861 S Homo sapiens(Human) PIK3R4; VPS15 Q99570 865 S Homo sapiens(Human) PIK3R4; VPS15 Q99570 892 S Homo sapiens(Human) PIK3R4; VPS15 Q99570 894 S Homo sapiens(Human) PIK3R4; VPS15 Q99570 895 S Homo sapiens(Human) PIK3R4; VPS15 Q99570 925 S Homo sapiens(Human) PIK3R4; VPS15 Q99570 926 S Homo sapiens(Human) PIK3R4; VPS15 Q99570 927 T Homo sapiens(Human) PIK3R4; VPS15 Q99570 931 S Homo sapiens(Human) PIK3R4; VPS15 Q99570 942 T Homo sapiens(Human)

PTM - PhosphositePlus UniProt ID MOD_RSD Type SITE_+/-7_AA Q99570 K951-ac Acetylation LQQLIQQkREQCNAE Q99570 T61-p Phosphorylation VFAIQDPtLPLTSYk Q99570 S115-p Phosphorylation DNLYDRIstRPFLNN Q99570 T116-p Phosphorylation NLYDRIstRPFLNNI Q99570 S169-p Phosphorylation VLLTDFAsFKPTYLP Q99570 T220-p Phosphorylation EYMRDPStPLVDLNS Q99570 S338-p Phosphorylation FAKETFLsADERILV Q99570 Y673-p Phosphorylation HPNLWIRyGAVGFIt Q99570 T680-p Phosphorylation yGAVGFItVVARQIS Q99570 S740-p Phosphorylation LRSkDITsLFRHLHM Q99570 T780-p Phosphorylation kLLSQGMtEEEEDKL Q99570 S808-p Phosphorylation KANIVDQsHLHDssQ Q99570 S813-p Phosphorylation DQsHLHDssQKGVID Q99570 S814-p Phosphorylation QsHLHDssQKGVIDL Q99570 S853-p Phosphorylation RKHVkQDsNVNEEWK Q99570 S861-p Phosphorylation NVNEEWKsMFGsLDP Q99570 S865-p Phosphorylation EWKsMFGsLDPPNMP Q99570 S892-p Phosphorylation QTGkPPRsEsSAGIC Q99570 S894-p Phosphorylation GkPPRsEsSAGICVP Q99570 S925-p Phosphorylation kPVIPVLsStILPST Q99570 T927-p Phosphorylation VIPVLsStILPSTYQ Q99570 T942-p Phosphorylation IRITTCKtELQQLIQ Q99570 S1074-p Phosphorylation QLLGIEAsKLPKsPK Q99570 S1079-p Phosphorylation EAsKLPKsPKIHPLQ Q99570 Y1272-p Phosphorylation IRFWDLAyPERSYVV Q99570 T1283-p Phosphorylation SYVVAGStSSPSVsy Q99570 S1289-p Phosphorylation StSSPSVsyyRkIIE Q99570 Y1290-p Phosphorylation tSSPSVsyyRkIIEG Q99570 Y1291-p Phosphorylation SSPSVsyyRkIIEGT Q99570 T1316-p Phosphorylation KVGPSDDtPRRGPES Q99570 K68-ub Ubiquitination tLPLTSYkQELEELk Q99570 K75-ub Ubiquitination kQELEELkIRLNSAQ Q99570 K89-ub Ubiquitination QNCLPFQkASEKASE Q99570 K97-ub Ubiquitination ASEKASEkAAMLFRQ Q99570 K280-ub Ubiquitination FPEQVLNkIEDHSIR Q99570 K309-ub Ubiquitination LEAEDYLkQQRGNAF Q99570 K449-ub Ubiquitination TKVLALVkEVPRNDI Q99570 K553-ub Ubiquitination SDPENIVkQTLMENG Q99570 K736-ub Ubiquitination FDYALRSkDITsLFR Q99570 K773-ub Ubiquitination AIAQLLKkLLSQGMt Q99570 K791-ub Ubiquitination EDKLLALkDFMMKSN Q99570 K850-ub Ubiquitination KRARKHVkQDsNVNE Q99570 K888-ub Ubiquitination QEVIQTGkPPRsEsS Q99570 K918-ub Ubiquitination VTTVQNKkPVIPVLs Q99570 K951-ub Ubiquitination LQQLIQQkREQCNAE Q99570 K1293-ub Ubiquitination PSVsyyRkIIEGTEV Q99570 K1307-ub Ubiquitination VVQEIQNkQKVGPSD

PTM - dbPTM UniProt ID Position Code Type Resources References Q99570 2 G Myristoylation Swiss-Prot 1010711 8999962 Q99570 808 S Phosphorylation Swiss-Prot 1010711 19369195 Q99570 813 S Phosphorylation Swiss-Prot 1010711 19369195 Q99570 814 S Phosphorylation Swiss-Prot 1010711 19369195 Q99570 853 S Phosphorylation Swiss-Prot 1010711 18691976;19369195 Q99570 861 S Phosphorylation Swiss-Prot 1010711 19369195 Q99570 865 S Phosphorylation Swiss-Prot 1010711 18691976;19369195 Q99570 892 S Phosphorylation Swiss-Prot 1010711 19369195 Q99570 925 S Phosphorylation Swiss-Prot 1010711 19369195 Q99570 1079 S Phosphorylation Swiss-Prot 1010711 19369195 Q99570 1316 T Phosphorylation Swiss-Prot 1010711 18691976 Q99570 925 S Phosphorylation PhosphoELM.10011 18669648 Q99570 1290 Y Phosphorylation PhosphoELM.10011 18669648 Q99570 1293 K Ubiquitylation Phosphositeplus.1010730 21890473 Q99570 1307 K Ubiquitylation Phosphositeplus.1010730 21906983 Q99570 280 K Ubiquitylation Phosphositeplus.1010730 21906983 Q99570 309 K Ubiquitylation Phosphositeplus.1010730 21906983 Q99570 449 K Ubiquitylation Phosphositeplus.1010730 21906983 Q99570 553 K Ubiquitylation Phosphositeplus.1010730 21906983 Q99570 68 K Ubiquitylation Phosphositeplus.1010730 21906983 Q99570 773 K Ubiquitylation Phosphositeplus.1010730 21906983 Q99570 791 K Ubiquitylation Phosphositeplus.1010730 21906983 Q99570 850 K Ubiquitylation Phosphositeplus.1010730 21906983 Q99570 888 K Ubiquitylation Phosphositeplus.1010730 21906983 Q99570 951 K Ubiquitylation Phosphositeplus.1010730 21906983 Q99570 97 K Ubiquitylation Phosphositeplus.1010730 21906983 Q99570 808 S Phosphorylation Phosphositeplus.1010730 19369195 Q99570 813 S Phosphorylation Phosphositeplus.1010730 19369195 Q99570 814 S Phosphorylation Phosphositeplus.1010730 19369195 Q99570 853 S Phosphorylation Phosphositeplus.1010730 18691976;19369195 Q99570 865 S Phosphorylation Phosphositeplus.1010730 18691976;19369195 Q99570 925 S Phosphorylation Phosphositeplus.1010730 19369195 Q99570 1283 T Phosphorylation Phosphositeplus.1010730 18669648 Q99570 1316 T Phosphorylation Phosphositeplus.1010730 18691976 Q99570 61 T Phosphorylation Phosphositeplus.1010730 21406692 Q99570 927 T Phosphorylation Phosphositeplus.1010730 18669648 Q99570 673 Y Phosphorylation Phosphositeplus.1010730 19664994 Q99570 813 S Phosphorylation HPRD 9.0 18691976,20068231 Q99570 814 S Phosphorylation HPRD 9.0 20068231 Q99570 853 S Phosphorylation HPRD 9.0 18691976 Q99570 865 S Phosphorylation HPRD 9.0 18691976 Q99570 894 S Phosphorylation HPRD 9.0 20068231 Q99570 926 S Phosphorylation HPRD 9.0 18669648 Q99570 931 S Phosphorylation HPRD 9.0 20068231 Q99570 1282 S Phosphorylation HPRD 9.0 18669648 Q99570 1287 S Phosphorylation HPRD 9.0 18669648 Q99570 1289 S Phosphorylation HPRD 9.0 18669648 Q99570 927 T Phosphorylation HPRD 9.0 18669648 Q99570 1283 T Phosphorylation HPRD 9.0 18669648 Q99570 1316 T Phosphorylation HPRD 9.0 18691976 Q99570 673 Y Phosphorylation HPRD 9.0 19664994 Q99570 1038 Y Phosphorylation HPRD 9.0 20068231 Q99570 1290 Y Phosphorylation HPRD 9.0 18669648 Q99570 1291 Y Phosphorylation HPRD 9.0 18669648 Q99570 853 S Phosphorylation SysPTM 1.1 18691976 Q99570 865 S Phosphorylation SysPTM 1.1 18691976 Q99570 1316 T Phosphorylation SysPTM 1.1 18691976

PTM - HPRD Symbol Position Code Type References PIK3R4 1038 Y Phosphorylation 20068231 PIK3R4 1282 S Phosphorylation 18669648 PIK3R4 1283 T Phosphorylation 18669648 PIK3R4 1287 S Phosphorylation 18669648 PIK3R4 1289 S Phosphorylation 18669648 PIK3R4 1290 Y Phosphorylation 18669648 PIK3R4 1291 Y Phosphorylation 18669648 PIK3R4 1316 T Phosphorylation 18691976 PIK3R4 673 Y Phosphorylation 19664994 PIK3R4 813 S Phosphorylation 18691976,20068231 PIK3R4 814 S Phosphorylation 20068231 PIK3R4 853 S Phosphorylation 18691976 PIK3R4 865 S Phosphorylation 18691976 PIK3R4 894 S Phosphorylation 20068231 PIK3R4 926 S Phosphorylation 18669648 PIK3R4 927 T Phosphorylation 18669648 PIK3R4 931 S Phosphorylation 20068231

PTM - Phospho.ELM UniProt Position Code PMIDs Kinase Source Type Q99570 925 S 18669648 HTP Phosphorylation Q99570 1290 Y 18669648 HTP Phosphorylation

PTM - UniProt UniProt ID Position Type PMIDs Q99570 808 Phosphoserine 19369195 Q99570 813 Phosphoserine 23186163 Q99570 853 Phosphoserine 19369195 Q99570 865 Phosphoserine 19369195 Q99570 1316 Phosphothreonine 18691976

PTM - PHOSIDA Symbol Accession Code Position Surrounding Sequence Type PIK3R4 IPI00024006 S 545 KVVTLLpSDPENIV phosphorylation PIK3R4 IPI00024006 S 812 QSHLHDpSSQKGVI phosphorylation PIK3R4 IPI00024006 S 813 SHLHDSpSQKGVID phosphorylation PIK3R4 IPI00024006 S 852 KHVKQDpSNVNEEW phosphorylation PIK3R4 IPI00024006 S 864 WKSMFGpSLDPPNM phosphorylation PIK3R4 IPI00024006 S 925 VIPVLSpSTILPST phosphorylation PIK3R4 IPI00024006 T 1315 VGPSDDpTPRRGPE phosphorylation PIK3R4 IPI00024006 T 542 VQQKVVpTLLSDPE phosphorylation PIK3R4 IPI00024006 Y 1037 TRSILTpYSRIGGR phosphorylation

PTM - BioGRID Entrez Gene BioGRID ID Position Code Type PMIDs 30849 119059 - K Ubiquitination 21139048 30849 119059 - K Ubiquitination 21890473 30849 119059 - K Ubiquitination 21906983 30849 119059 - K Ubiquitination 22505724 30849 119059 - K Ubiquitination 21963094 30849 119059 - K Ubiquitination 24816145

PTM - mUbiSiDa Gene Name Species Ubiquitination Site Ubiquitination Sequence Evidence PMID PIK3R4 Homo sapiens (Human) 1293 "1293,SVSYYRKIIEGTE" 1293:21890473 PIK3R4 Homo sapiens (Human) 1293 "1293,SVSYYRKIIEGTE" 1293:21890473 PIK3R4 Homo sapiens (Human) 791; 68; 1307; 850; 773; 309; 1293; 97; 888; 951; 280; 449; 553 "791,DKLLALKDFMMKS; 68,LPLTSYKQELEEL; 1307,VQEIQNKQKVGPS; 850,RARKHVKQDSNVN; 773,IAQLLKKLLSQGM; 309,EAEDYLKQQRGNA; 1293,SVSYYRKIIEGTE; 97,SEKASEKAAMLFR; 888,EVIQTGKPPRSES; 951,QQLIQQKREQCNA; 280,PEQVLNKIEDHSI; 449,KVLALVKEVPRND; 553,DPENIVKQTLMEN" 791:21906983; 68:21906983; 1307:21906983; 850:21906983; 773:21906983; 309:21906983; 1293:21890473; 97:21906983; 888:21906983; 951:21906983; 280:21906983; 449:21906983; 553:21906983