PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus CUL4B WDR5B 17041588 biogrid exp GP GP G G GP GP G G GP G GP GP G GP G GP GP G GP G G G GP GP GP GP GP GP G ESR1 WDR5B 16603732 intact exp GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G WDR5B ASH2L 16603732 intact exp GP GP G G GP GP G G GP G GP G G G G GP GP G GP G G G G G GP G GP GP G WDR5 WDR5B 17041588 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G KMT2D WDR5B 16603732 intact exp G GP G G GP GP G G GP G GP G G G G G GP G GP G G G G G G G G GP G WDR5B GRWD1 17041588 intact exp GP GP G G GP GP G G GP G GP G G GP G GP GP G G G G G GP GP GP G G GP G WDR5B ATP13A2 22645275 biogrid,intact exp GP P G G GP GP G GP G GP P G GP G GP GP GP G G G GP P GP GP GP P CUL4A WDR5B 17041588 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G DDB1 WDR5B 17041588, 23023127 intact exp, pred GP GP G G GP GP G G GP G GP GP G GP G GP GP G GP G G G GP GP GP GP GP GP G RBBP5 WDR5B 16603732, 25402006, 16082366 intact exp, pred GP GP G G GP GP G G GP G GP GP G GP G GP GP G GP G G G GP GP GP GP GP GP WDR5B PLAA 23023127 pred GP GP G G GP GP G G GP G GP G G GP G GP GP G GP G G G GP GP GP GP GP GP G PDC WDR5B 23023127 pred P P P P P P P P P P P P P ARL3 WDR5B 23023127 pred GP GP G G GP GP G G GP G GP GP G GP G GP GP G GP G G G GP GP GP GP GP GP G GNB5 WDR5B 23023127 pred GP GP G G GP GP G G GP G GP G G G G GP GP G GP G G G GP GP GP G GP GP G RAB15 WDR5B 23023127 pred GP GP G G GP GP G G GP G GP GP G GP G GP GP G GP G G G GP GP GP GP GP GP G WDR5B PLEKHA1 23023127 pred GP GP G G GP GP G G GP G GP GP G GP G GP GP G GP G G G GP GP GP GP GP GP G KIF1A WDR5B 23023127 pred P G G P GP G G P G P P GP GP GP G GP G G P P GP P GP P G POU4F1 WDR5B 25402006 pred G G G G G G G G G G G G G G G G G WDR5B LINC00312 25402006 pred WDR5B RAB6B 23023127 pred G GP G G GP GP G G GP G GP G G GP G GP GP G GP G G G GP GP GP GP GP GP G PAFAH1B2 WDR5B 23023127 pred GP GP G G GP GP G G GP G GP G G GP G GP GP G GP G G G GP G GP GP GP GP G WDR5B WDR31 23023127 pred GP GP G G G GP G G GP G GP GP G G G GP GP G GP G G G GP GP GP G GP GP G WDR5B PLEKHM2 23023127 pred GP GP G G GP GP G G GP G GP GP G GP G GP GP G GP G G G GP GP GP GP GP GP G NR2C2 WDR5B 25402006 pred G GP G G GP GP G G GP G GP GP G GP G GP GP G GP G G G G GP GP GP GP GP G WDR5B PPP2R2C 23023127 pred GP P G G GP GP G G GP G P P GP GP GP G G P P GP P P GP G WDR5B ARL6 23023127 pred G GP G P GP G G GP G GP GP G GP G GP GP G GP G G G GP GP GP GP GP GP RGS4 WDR5B 23023127 pred GP GP G P GP G G GP G P GP GP G GP GP G GP G G P G GP P GP P G RAB6A WDR5B 23023127 pred GP GP G G G GP G G GP G GP GP G GP G GP GP G GP G G G GP GP GP GP GP GP G WDR5B KAT5 25402006 pred GP GP G G GP GP G G GP G GP GP G GP G GP GP G GP G G G GP GP GP GP GP GP G GNAZ WDR5B 23023127 pred G GP G G GP GP G G GP G GP GP G G G GP GP G GP G G G G G GP G GP GP G POU4F2 WDR5B 25402006 pred G G G G G G G G G G G G PPP2R2B WDR5B 23023127 pred GP P G G G GP G G GP G GP G G G G GP GP G GP G G G GP GP GP G GP GP G WDR5B RAB26 23023127 pred P G G G GP G G G GP G GP G G G G GP G G G G G G GP GP GP GP GP G SMU1 WDR5B 23023127 pred G GP G G GP GP G G GP G GP GP G GP G GP GP G GP G G G GP G GP GP GP GP G GNB1 WDR5B 23023127 pred G GP G G G GP G G GP G GP GP G G G GP GP G GP G G G GP G GP G GP GP G WDR5B SEPT8 23023127 pred G P G P GP G GP G P P P GP GP P G G GP P GP P RAB33A WDR5B 23023127 pred P G G GP GP G G P G P G GP P GP G GP G G G P P P GP G SPTBN2 WDR5B 23023127 pred GP GP G GP G G GP GP P GP GP G G GP P P P GP BTF3 WDR5B 25402006 pred GP GP G G GP GP G G GP G GP GP G GP G GP GP G GP G G G GP GP GP GP GP GP G GNAS WDR5B 23023127 pred G G G G G G G G GP G G G G G G GP G G GP G G G G G GP G G G G WDR5B WDR17 23023127 pred G GP G P G P GP P G P GNAL WDR5B 23023127 pred GP P G P GP G G GP G P P GP G P GP P G G GP GP GP GP GP GP G RAB3A WDR5B 23023127 pred GP G G G GP G G G G G G G GP G GP G G G G G G G WDR5B PHB2 25402006 pred GP GP G G GP GP G G GP G GP GP G GP G GP GP G GP G G G GP GP GP GP GP GP G WDR5B DAW1 23023127 pred P P P P P P GP P P P GP GNAI3 WDR5B 23023127 pred G GP G G G GP G G GP G G G G G G GP GP G GP G G G G G GP G GP GP G MRAS WDR5B 23023127 pred GP GP G G GP GP G G GP G GP GP G GP G GP GP G P G G G GP GP GP GP GP GP G ARF3 WDR5B 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G WDR5B RASD2 23023127 pred P G GP G G GP G P P G P GP GP G G G GP GP P P G WDR5B BTRC 23023127 pred GP GP G G GP GP G G GP G GP GP G GP G GP GP G GP G G G GP GP GP G GP GP G GNAS WDR5B 23023127 pred PPP2R2D WDR5B 23023127 pred GP GP G P GP P GP P G GP GP G GP G P P GP GP GP P GNG2 WDR5B 23023127 pred G G G G G GP G G GP G GP G G GP G G GP G GP G G G GP G G GP GP GP G WDR5B RAB9B 23023127 pred P P G GP G G GP G P P G GP GP G GP G G GP GP GP GP GP G RBM39 WDR5B 25402006 pred GP GP G G GP GP G G GP G GP G G GP G GP GP G GP G G G GP G GP GP GP GP G GNAQ WDR5B 23023127 pred GP GP G G G GP G G GP G GP GP G GP G GP GP G GP G G G G G GP GP GP GP G WDR5B ESR2 25402006 pred GP GP G GP GP G G GP GP GP G GP G P GP G GP G G GP GP GP GP GP GP WDR5B ZNF106 23023127 pred GP GP G G GP GP G G GP G GP G G GP G GP GP G GP G G G GP GP GP GP GP GP G WDR5B WSB2 23023127 pred GP G G G G GP G G GP G GP G G G G GP GP G GP G G G G GP GP G GP GP G RFX4 WDR5B 25402006 pred G GP G GP G P GP GNAT2 WDR5B 23023127 pred P P P P P P P P P P P P P P P P RELA WDR5B 25402006 pred GP GP G G GP GP G G GP G GP GP G GP G GP GP G GP G G G GP GP GP GP GP GP G WDR5B DMXL1 23023127 pred GP GP G G GP GP G G GP G GP G G G G GP GP G GP G G G G GP GP G GP GP G WDR5B PAGR1 25402006 pred GP GP G G GP GP G G GP G GP GP G G GP GP G GP G G G GP GP GP GP GP GP G WDR5B DDX54 25402006 pred G GP G G G GP G G GP G GP G G G G G GP G GP G G G G GP G G GP GP G RGS9 WDR5B 23023127 pred G G G G G G G G GNAT3 WDR5B 23023127 pred G G PAFAH1B1 WDR5B 23023127 pred GP GP G G GP GP G G GP G GP GP G GP G GP GP G GP G G G GP GP GP GP GP GP G DNTTIP2 WDR5B 25402006 pred GP G G G G GP G G G G GP G G G G GP GP G GP G G G G GP GP G GP GP G WDR82 WDR5B 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G CDC40 WDR5B 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G WDR5B NKIRAS1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G WDR5B PLK2 23023127 pred GP GP G P GP G G GP G GP GP G GP G GP GP G GP G G G GP GP GP GP GP GP G GNA11 WDR5B 23023127 pred GP GP G G G GP G G GP G GP GP G GP G GP GP G GP G G G G G GP GP GP GP G WDR5B SEPT3 23023127 pred G G G G G GP G G G G G G GP G P G G G G G G G WDR5B PNRC2 25402006 pred GP GP G G GP GP G G GP G GP GP G GP G GP GP G GP G G G GP GP GP GP GP GP G ADRBK1 WDR5B 23023127 pred GP GP G G GP GP G G GP G GP GP G GP G GP GP G GP G G G GP GP GP GP GP GP G WDR5B NBEA 23023127 pred GP GP G GP G G GP G GP G G G GP GP G GP G G G G GP G GP GP G ATAD2 WDR5B 25402006 pred P P G GP P G P P G P P P G G P P P P GP WDR5B PRPF19 23023127 pred GP GP G G GP GP G G GP G GP GP G GP G GP GP G GP G G G GP GP GP GP GP GP G WDR5B WDR48 23023127 pred GP GP G G GP GP G G GP G GP GP G G G GP GP G GP G G G GP GP GP G GP GP G GNAT1 WDR5B 23023127 pred PRDM2 WDR5B 25402006 pred GP GP G G GP GP G G GP G GP GP G GP G GP GP G GP G G G GP GP GP G GP GP G TRIM25 WDR5B 25402006 pred G GP G G GP GP G G GP G GP G G GP G GP GP G GP G G G GP G GP GP GP GP G RGS8 WDR5B 23023127 pred G G G G RAB3B WDR5B 23023127 pred P G G GP G GP G GP G G G GP P GNAI1 WDR5B 23023127 pred GP GP G G GP GP G G GP G GP GP G GP G GP GP G GP G G G GP GP GP GP GP GP G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q86VZ2 Q9NQ11 two hybrid 22645275 direct interaction X 2 Q86VZ2 B2RBV7 affinity chromatography technology 17041588 physical association X 2 Q86VZ2 Q13620-3 affinity chromatography technology 17041588 physical association X 2 Q86VZ2 P61964 affinity chromatography technology 17041588 physical association X 2 Q86VZ2 anti bait coimmunoprecipitation 17041588 association C 14 Q86VZ2 Q9NQ11 ubiquitin reconstruction 22645275 physical association X 2 Q86VZ2 anti tag coimmunoprecipitation 17041588 association C 3 Q86VZ2 anti bait coimmunoprecipitation 16603732 association C 4 Q86VZ2 anti bait coimmunoprecipitation 16603732 association C 4 Q86VZ2 anti bait coimmunoprecipitation 16603732 association C 4 Q86VZ2 pull down 16603732 association C 5 Q86VZ2 pull down 16603732 association C 5

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B WDR5B ATP13A2 MI:0007(anti tag coimmunoprecipitation)|MI:0018(two hybrid) 22645275 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_124453|BIOGRID_220403 prey|prey bait|bait CUL4B WDR5B MI:0006(anti bait coimmunoprecipitation)|MI:0004(affinity chromatography technology) 17041588 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0914(association)|MI:0915(physical association) (intact)|(biogrid) UniProt_87648|BIOGRID_129021 bait|bait prey|prey NRF1 WDR5B MI:0428(imaging technique) 24250222 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_296728 bait prey CUL4A WDR5B MI:0006(anti bait coimmunoprecipitation)|MI:0004(affinity chromatography technology) 17041588 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0914(association)|MI:0915(physical association) (intact)|(biogrid) UniProt_87648|BIOGRID_129009 bait|bait prey|prey WDR5 WDR5B MI:0004(affinity chromatography technology) 17041588 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_129035 prey bait

PPI - HINT Gene A Gene B PMID Method Quality WDR5B ATP13A2 22645275,22645275 0112,0018 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q86VZ2 O14686 WDR5B KMT2D 0.21 16603732 Q86VZ2 P61964 WDR5B WDR5 0.126 17041588 Q86VZ2 Q16531 WDR5B DDB1 0.126 17041588 Q9BQ67 Q86VZ2 GRWD1 WDR5B 0.126 17041588 Q86VZ2 P03372 WDR5B ESR1 0.21 16603732 Q9NQ11 Q86VZ2 ATP13A2 WDR5B 0.286 22645275 Q86VZ2 Q13619 WDR5B CUL4A 0.236 17041588 Q9UBL3 Q86VZ2 ASH2L WDR5B 0.21 16603732 Q86VZ2 Q13620 WDR5B CUL4B 0.126 17041588 Q86VZ2 Q15291 WDR5B RBBP5 0.21 16603732

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 MEN1 WDR5B MI:0362 inference MI:0461 interaction database DNM1L WDR5B MI:0362 inference MI:0461 interaction database PES1 WDR5B MI:0362 inference MI:0461 interaction database KMT2D WDR5B MI:0045 experimental interaction detection MI:0461 interaction database SETD1A WDR5B MI:0362 inference MI:0461 interaction database KIAA0355 WDR5B MI:0362 inference MI:0461 interaction database PLSCR1 WDR5B MI:0362 inference MI:0461 interaction database KDM1A WDR5B MI:0362 inference MI:0461 interaction database RNF40 WDR5B MI:0362 inference MI:0461 interaction database E2F6 WDR5B MI:0362 inference MI:0461 interaction database TADA2A WDR5B MI:0362 inference MI:0461 interaction database TADA3 WDR5B MI:0362 inference MI:0461 interaction database PRKRA WDR5B MI:0362 inference MI:0461 interaction database TRMU WDR5B MI:0362 inference MI:0461 interaction database ESRRB WDR5B MI:0362 inference MI:0461 interaction database HSPA4L WDR5B MI:0362 inference MI:0461 interaction database MOCS2 WDR5B MI:0362 inference MI:0461 interaction database MT-ATP6 WDR5B MI:0362 inference MI:0461 interaction database ESR1 WDR5B MI:0045 experimental interaction detection MI:0461 interaction database GAPDH WDR5B MI:0362 inference MI:0461 interaction database RPLP0 WDR5B MI:0362 inference MI:0461 interaction database HSP90AA1 WDR5B MI:0362 inference MI:0461 interaction database HSP90AB1 WDR5B MI:0362 inference MI:0461 interaction database ACAA1 WDR5B MI:0362 inference MI:0461 interaction database UBC WDR5B MI:0362 inference MI:0461 interaction database HSPA1A WDR5B MI:0362 inference MI:0461 interaction database HSPA1B WDR5B MI:0362 inference MI:0461 interaction database HSPD1 WDR5B MI:0362 inference MI:0461 interaction database HSPA8 WDR5B MI:0362 inference MI:0461 interaction database HSPA6 WDR5B MI:0362 inference MI:0461 interaction database POU3F3 WDR5B MI:0362 inference MI:0461 interaction database POU3F2 WDR5B MI:0362 inference MI:0461 interaction database POLR2A WDR5B MI:0362 inference MI:0461 interaction database HSPA1L WDR5B MI:0362 inference MI:0461 interaction database HSPA4 WDR5B MI:0362 inference MI:0461 interaction database MTOR WDR5B MI:0362 inference MI:0461 interaction database POU3F4 WDR5B MI:0362 inference MI:0461 interaction database CTCF WDR5B MI:0362 inference MI:0461 interaction database CEBPA WDR5B MI:0362 inference MI:0461 interaction database CPT1A WDR5B MI:0362 inference MI:0461 interaction database NR0B1 WDR5B MI:0362 inference MI:0461 interaction database YARS WDR5B MI:0362 inference MI:0461 interaction database HSPA2 WDR5B MI:0362 inference MI:0461 interaction database RAD23B WDR5B MI:0362 inference MI:0461 interaction database VCP WDR5B MI:0362 inference MI:0461 interaction database UBE2G2 WDR5B MI:0362 inference MI:0461 interaction database RPL37A WDR5B MI:0362 inference MI:0461 interaction database WDR5 WDR5B MI:0045 experimental interaction detection MI:0461 interaction database CNBP WDR5B MI:0362 inference MI:0461 interaction database HIST1H3A WDR5B MI:0362 inference MI:0461 interaction database H3F3A WDR5B MI:0362 inference MI:0461 interaction database GTF2B WDR5B MI:0362 inference MI:0461 interaction database RUNX1 WDR5B MI:0362 inference MI:0461 interaction database DR1 WDR5B MI:0362 inference MI:0461 interaction database POU5F1 WDR5B MI:0362 inference MI:0461 interaction database POU3F1 WDR5B MI:0362 inference MI:0461 interaction database KMT2A WDR5B MI:0362 inference MI:0461 interaction database POU5F1B WDR5B MI:0362 inference MI:0461 interaction database RING1 WDR5B MI:0362 inference MI:0461 interaction database TFCP2 WDR5B MI:0362 inference MI:0461 interaction database CHAF1A WDR5B MI:0362 inference MI:0461 interaction database PSMD2 WDR5B MI:0362 inference MI:0461 interaction database HDAC1 WDR5B MI:0362 inference MI:0461 interaction database CUL4A WDR5B MI:0045 experimental interaction detection MI:0461 interaction database CUL4B WDR5B MI:0045 experimental interaction detection MI:0461 interaction database PSME4 WDR5B MI:0362 inference MI:0461 interaction database SETDB1 WDR5B MI:0362 inference MI:0461 interaction database RBBP5 WDR5B MI:0045 experimental interaction detection MI:0461 interaction database TAF1A WDR5B MI:0362 inference MI:0461 interaction database DDB1 WDR5B MI:0045 experimental interaction detection MI:0461 interaction database NFE2 WDR5B MI:0362 inference MI:0461 interaction database HIST3H3 WDR5B MI:0362 inference MI:0461 interaction database SGO1 WDR5B MI:0362 inference MI:0461 interaction database RNF20 WDR5B MI:0362 inference MI:0461 interaction database H3F3C WDR5B MI:0362 inference MI:0461 interaction database ANKRD11 WDR5B MI:0362 inference MI:0461 interaction database WDR82 WDR5B MI:0362 inference MI:0461 interaction database PAXIP1 WDR5B MI:0362 inference MI:0461 interaction database HIST2H3A WDR5B MI:0362 inference MI:0461 interaction database KANSL1 WDR5B MI:0362 inference MI:0461 interaction database WDR5B MCAT MI:0362 inference MI:0461 interaction database WDR5B MGA MI:0362 inference MI:0461 interaction database WDR5B SUPV3L1 MI:0362 inference MI:0461 interaction database WDR5B ZZZ3 MI:0362 inference MI:0461 interaction database WDR5B RPTOR MI:0362 inference MI:0461 interaction database WDR5B DYNC2H1 MI:0362 inference MI:0461 interaction database WDR5B KDM2B MI:0362 inference MI:0461 interaction database WDR5B MAFA MI:0362 inference MI:0461 interaction database WDR5B DYNC2LI1 MI:0362 inference MI:0461 interaction database WDR5B ZCCHC13 MI:0362 inference MI:0461 interaction database WDR5B CKAP2 MI:0362 inference MI:0461 interaction database WDR5B GATAD2B MI:0362 inference MI:0461 interaction database WDR5B HSPH1 MI:0362 inference MI:0461 interaction database WDR5B KAT2A MI:0362 inference MI:0461 interaction database WDR5B KAT2B MI:0362 inference MI:0461 interaction database WDR5B RAD50 MI:0362 inference MI:0461 interaction database WDR5B FBXW7 MI:0362 inference MI:0461 interaction database WDR5B L3MBTL2 MI:0362 inference MI:0461 interaction database WDR5B SGF29 MI:0362 inference MI:0461 interaction database WDR5B MCRS1 MI:0362 inference MI:0461 interaction database WDR5B RNF2 MI:0362 inference MI:0461 interaction database WDR5B GRWD1 MI:0045 experimental interaction detection MI:0461 interaction database WDR5B PHF20 MI:0362 inference MI:0461 interaction database WDR5B SALL3 MI:0362 inference MI:0461 interaction database WDR5B DPY30 MI:0362 inference MI:0461 interaction database WDR5B ACTR6 MI:0362 inference MI:0461 interaction database WDR5B KAT8 MI:0362 inference MI:0461 interaction database WDR5B CSRP2BP MI:0362 inference MI:0461 interaction database WDR5B EPB41L5 MI:0362 inference MI:0461 interaction database WDR5B ATP13A2 MI:0045 experimental interaction detection MI:0461 interaction database WDR5B POLE3 MI:0362 inference MI:0461 interaction database WDR5B MBIP MI:0362 inference MI:0461 interaction database WDR5B SALL1 MI:0362 inference MI:0461 interaction database WDR5B OLA1 MI:0362 inference MI:0461 interaction database WDR5B TFCP2L1 MI:0362 inference MI:0461 interaction database WDR5B UBP1 MI:0362 inference MI:0461 interaction database WDR5B CXXC1 MI:0362 inference MI:0461 interaction database WDR5B RERE MI:0362 inference MI:0461 interaction database WDR5B ONECUT1 MI:0045 experimental interaction detection MI:0461 interaction database WDR5B ASH2L MI:0045 experimental interaction detection MI:0461 interaction database WDR5B SEC63 MI:0362 inference MI:0461 interaction database WDR5B SALL4 MI:0362 inference MI:0461 interaction database WDR5B ELF5 MI:0362 inference MI:0461 interaction database WDR5B INO80 MI:0362 inference MI:0461 interaction database WDR5B YEATS2 MI:0362 inference MI:0461 interaction database WDR5B SETD1B MI:0362 inference MI:0461 interaction database WDR5B KDM2A MI:0362 inference MI:0461 interaction database WDR5B HCFC2 MI:0362 inference MI:0461 interaction database WDR5B MRPS18B MI:0362 inference MI:0461 interaction database