PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus GTF2I TOPORS 17803295 biogrid exp G G G G G G G G G G G G G G G G G G G HNRNPM TOPORS 17803295 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G RANGAP1 TOPORS 17803295 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G UPF3A TOPORS 17803295 biogrid exp GP GP G G GP GP G G GP G GP GP GP GP G GP GP G GP G GP GP G GP GP GP GP GP G SETX TOPORS 24244371 intact exp G G G G GP GP G GP GP G GP G GP G G GP GP G G G G G G GP GP G GP GP G SATB1 TOPORS 18408014,20351170 biogrid,intact exp G GP G G G GP G G G G GP GP G GP G G GP G G G G GP G GP G G G GP G TOPORS SPIN1 26186194 biogrid exp GP G G G GP GP G GP GP G GP GP GP G G GP GP GP GP G GP GP GP GP GP GP GP GP G MTDH TOPORS 24529480 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G RBBP4 TOPORS 17803295 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G DDB2 TOPORS 17803295 biogrid exp GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP G GP GP G GP GP G S100A9 TOPORS 17803295 biogrid exp GP G G GP G G G G GP GP G G G G G GP G G G GP G G NIFK TOPORS 26186194 biogrid exp GP G G G GP GP G G GP G GP G G GP G GP GP GP GP G GP G G GP GP GP GP GP G SNIP1 TOPORS 15231748 hprd,i2d,mint,intact exp GP GP G G GP GP G GP GP G GP GP GP G G GP GP G GP G GP G GP GP GP G GP GP G H2AFX TOPORS 22972498 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SPIN2B TOPORS 26186194 biogrid exp P P P P P P P P P P P P P P P P P P P P SF3B1 TOPORS 17803295 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G RBBP7 TOPORS 17803295 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G UBXN7 TOPORS 18775313 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G HNRNPL TOPORS 17803295 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G RAC1 TOPORS 20936779 i2d exp GP GP G G GP G G G GP G G G GP G G GP G G GP G GP GP G GP GP G GP GP G CASP8 TOPORS 17290218 hprd,biogrid,mint,intact exp GP GP G GP P GP GP GP GP GP GP G GP P GP P G GP GP GP P GP GP GP GP G PLK1 TOPORS 22972498,19473992,19821153 biogrid exp P P G G GP P G GP GP P P P GP GP GP GP GP G GP P GP GP GP P P GP UBE2L6 TOPORS 19690564 biogrid,intact exp GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G SIN3A TOPORS 17803295 biogrid exp GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G UBC TOPORS 15247280 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SAFB2 TOPORS 17803295 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G EEF1A1 TOPORS 17803295 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G TOPORS UBE2J1 19690564 biogrid,intact exp GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP GP G GP GP GP GP GP G HABP4 TOPORS 16455055 hprd,biogrid exp G GP G G G GP G G G G GP GP GP G G GP GP G GP G G G GP GP G GP GP G IKBKE TOPORS 20188669 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G NKX3-1 TOPORS 18077445 biogrid exp GP GP G G GP GP G GP GP G GP GP GP G G GP GP GP GP G GP GP GP GP GP G GP GP G TOPORS TOPORS 11842245 hprd exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G TRIM28 TOPORS 17803295 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SMARCC2 TOPORS 17803295 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SEPT6 TOPORS 21082023 i2d exp G GP G G GP GP G G GP G GP GP GP GP G GP GP G GP G GP GP G GP GP GP GP G UBE2W TOPORS 19690564 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G TP53 TOPORS 17803295,11842245,10415337,17290218,15247280,16122737, 25402006, 21836163 hprd,biogrid,i2d,mint,intact,bci exp, ortho, pred G G G G G G G G G G G G G G G GP G G G G GP G G G GP G G GP G SUMO2 TOPORS 16524884, 25402006, 23023127 biogrid exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G UBE2D1 TOPORS 19690564,15247280,18077445,19053840, 23023127, 21836163 biogrid,intact exp, pred GP G G G GP GP G G GP G GP GP GP GP G G GP GP GP G GP GP G GP G GP GP GP G DHX15 TOPORS 17803295, 25402006 biogrid exp, pred G GP G G G GP G G GP G GP G G G G G GP GP GP G GP G G G G G GP GP G TOPORS UBE2D4 19690564, 23023127 biogrid,intact exp, pred GP G G G GP GP G G GP G GP GP GP GP G G GP GP GP G GP GP G GP G GP GP GP G PARP1 TOPORS 17803295, 25402006 biogrid exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G UBE2D3 TOPORS 19690564,15247280, 23023127 biogrid,intact exp, pred GP G G G GP GP G G GP G GP GP GP GP G G GP GP GP G GP GP G GP G GP GP GP G UBE2I TOPORS 14516784,16122737, 25402006, 23023127 hprd,biogrid exp, pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G UBE2D2 TOPORS 19690564, 23023127 biogrid,intact exp, pred GP G G G GP GP G G GP G GP GP GP GP G G GP GP GP G GP GP G GP G GP GP GP G NONO TOPORS 17803295, 25402006 biogrid exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G HNRNPA1 TOPORS 17803295, 25402006 biogrid exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SFPQ TOPORS 17803295, 25402006, 21836163 biogrid exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SUMO1 TOPORS 11842245,16524884,14516784, 25402006, 23023127, 21836163 hprd,biogrid,bci exp, pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G UBE2E1 TOPORS 15247280, 23023127 biogrid exp, pred GP GP G G G GP G G GP G GP G G GP G GP GP GP G G GP G G GP GP G GP GP G TOP1 TOPORS 10352183,17976381,20805487, 25402006, 21836163 hprd,biogrid,bci exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SERBP1 TOPORS 16679534, 21836163 hprd,biogrid,bci exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G PML TOPORS 20188669, 25402006 biogrid exp, pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G UBE2N TOPORS 19690564, 25402006, 23023127 biogrid,intact exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G SDC1 TOPORS ortho GP GP G G GP G G G GP G GP G G GP G GP G G GP G GP G GP G GP G GP GP G PHC2 TOPORS 25402006 ortho, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G UBE2B TOPORS 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G DDX17 TOPORS 25402006 pred GP GP G G GP GP G GP G G GP G GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G TOPORS SAE1 25402006 pred GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G UBE2G2 TOPORS 23023127 pred GP GP G G GP GP G G GP G GP GP GP GP G GP GP G GP G GP GP G G GP GP GP GP G HNRNPA2B1 TOPORS 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G TP53BP2 TOPORS 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G TOPORS UBA2 25402006, 23023127, 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G G GP GP GP GP GP GP GP G RAD23B TOPORS 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G KAT2B TOPORS 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G PNN TOPORS 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G MARCH7 TOPORS 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP G GP GP G RFWD2 TOPORS 25402006 pred G G G G G GP G G GP G G G G G G G GP G G G GP G G G G G GP G G CIDEA TOPORS 23023127 pred G G G G G G G G CSNK1A1 TOPORS 25402006 pred G G G G G G G G G G G G G G G G G G GP G G G G G G G G G G JUN TOPORS 25402006 pred GP GP G G G GP G G GP G GP G GP G G GP GP G G G GP G GP G GP G GP G G FBXO11 TOPORS 25402006 pred G G G G G GP G G G G G GP GP G G GP GP G G G GP G G G GP G G G G TOPORS RNF6 25402006 pred G GP G G GP GP G G GP G GP G GP G G GP GP G G G GP G G G GP GP GP GP G UBE2E2 TOPORS 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G TOPORS MBD1 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G UBE2T TOPORS 23023127 pred G G G GP G GP P P P GP GP P GP P G GP P GP G EIF4E TOPORS 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G MITF TOPORS 25402006 pred G G G G GP G G GP G G GP G GP GP G G G G G G G G G G G G G G G TAF9 TOPORS 25402006 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G DTX3L TOPORS 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP G G GP G GP GP GP GP GP GP G MDM2 TOPORS 25402006, 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G ELK1 TOPORS 25402006 pred GP GP G G G GP G GP GP G GP G GP G G GP GP GP G G GP GP GP G GP GP GP GP G CUL2 TOPORS 23023127 pred GP GP G G G GP G G GP G GP GP GP GP G G GP GP GP G GP GP GP G G G GP GP G TXNL1 TOPORS 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G PIAS4 TOPORS 25402006, 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G TOPORS ING4 25402006 pred GP GP G G GP GP G GP G G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP G HIPK3 TOPORS 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G SENP2 TOPORS 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G PRKDC TOPORS 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G HNRNPK TOPORS 25402006 pred P P P P P P P P P P P P P P P P P P P P P P TBP TOPORS 25402006 pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP GP GP GP GP GP G MSH6 TOPORS 23023127 pred GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G CUL3 TOPORS 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SRSF1 TOPORS 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G TP73 TOPORS 25402006, 23023127 pred G G G G G UBE2S TOPORS 23023127 pred G G G G G G G G GP G G G GP G G G G G G G G G G G GP G JAK2 TOPORS 23023127 pred G GP G G GP GP G GP GP G GP P GP GP G P GP GP P P G GP G GP GP GP GP SMARCA5 TOPORS 25402006 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G NFKBIA TOPORS 25402006 pred G GP G G GP GP G GP GP G G G GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G HUWE1 TOPORS 25402006, 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G ATR TOPORS 25402006 pred G GP G G G GP G GP GP G GP GP GP G G G GP G GP G GP G G G G G G GP G BCL3 TOPORS 23023127 pred G G G GP G GP GP G G G GP G GP G G GP G G G GP G GP G G UACA TOPORS 23023127 pred G GP G G G GP G G GP G GP G G G G GP GP G GP G GP GP GP G GP G GP GP G MORC3 TOPORS 25402006, 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G TOPORS STUB1 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G PIAS1 TOPORS 25402006, 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G BIRC3 TOPORS 25402006 pred GP G GP G G GP P GP G GP G GP G GP P G GP GP GP GP GP MNAT1 TOPORS 25402006 pred GP GP G P GP G G GP G GP GP GP G GP GP G P G P GP GP G GP G GP P HDAC2 TOPORS 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G UBE2F TOPORS 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G TOPORS THUMPD1 25402006 pred GP GP G G GP GP G GP GP G GP G G GP G GP GP GP GP G GP GP GP G GP GP GP GP G TRIM13 TOPORS 23023127 pred GP GP G G G GP G G GP G G GP GP G G GP GP G G G G GP G GP GP G GP GP G TP53INP1 TOPORS 25402006 pred GP GP G G G GP G G GP G GP G GP G G G GP G GP G GP GP GP G G G GP G G APTX TOPORS 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G TOPORS TLK1 25402006 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G PTK2 TOPORS 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G RNF125 TOPORS 25402006 pred GP GP G G GP GP G G GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP GP GP P G RCHY1 TOPORS 25402006 pred G GP G G G GP G GP GP G GP G GP G G GP GP G GP G G G GP G GP G GP G G ZBTB16 TOPORS 23023127 pred G GP G G G GP G G GP G G G GP G G GP GP G GP G G GP GP G GP G G GP G HIPK1 TOPORS 25402006 pred G GP G G G GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP G GP GP GP GP G CHEK2 TOPORS 25402006 pred GP GP G G P G P GP P P P P GP P GP GP G P GP P P GP GP G USP7 TOPORS 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G HIF1A TOPORS 25402006 pred GP GP G G GP GP G G GP G GP G GP GP G GP GP G GP G GP G GP G GP GP GP GP G TOPORS PLAGL1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G TAF3 TOPORS 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G COPS5 TOPORS 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G IFI16 TOPORS 25402006, 23023127 pred G G G G GP GP G G GP G GP G G GP G G GP GP G G G G G G G GP G G G PSMD7 TOPORS 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G UBOX5 TOPORS 25402006 pred GP GP G G G GP G GP P G G G GP GP G P GP G G G G G GP P GP GP GP G G CDC34 TOPORS 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G TOPORS ZMIZ1 25402006 pred GP GP G G G G G G GP G GP G G G G G G G G G G G G G G G GP GP G TOPORS RNF7 23023127 pred GP GP G G GP GP G G GP G GP GP G GP G GP GP G GP G GP GP G G GP GP GP GP G LCK TOPORS 23023127 pred G G GP G G G G G G GP G G G G G GP G SMC6 TOPORS 21836163 pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP G GP G GP G GP GP GP G GP GP HNRNPR TOPORS 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G RNF25 TOPORS 25402006 pred P G P P P P P P P P P P P P P GP P P MED1 TOPORS 25402006 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G CUL4A TOPORS 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2A TOPORS 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G TOPORS WWOX 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G CUL1 TOPORS 23023127 pred GP G G G G GP G GP GP G GP GP GP G G GP GP GP GP G GP GP GP GP GP GP GP GP G PARK7 TOPORS 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SMC5 TOPORS 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G S100A7 TOPORS 23023127 pred GP G SYNE1 TOPORS 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SNRPA1 TOPORS 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G RB1CC1 TOPORS 25402006 pred G GP G G G GP G G GP G GP G GP G G GP GP GP GP G GP GP GP G GP G GP GP G PPP1CC TOPORS 25402006 pred GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP GP GP GP GP GP G UBE2R2 TOPORS 23023127 pred G G G G GP G G G G G G G G GP G G G G G G G G G G G GP GP G G SMAD2 TOPORS 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G RNF2 TOPORS 25402006 pred P P P P GP P P P P P P P P P P P NPM1 TOPORS 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G TOPORS SENP1 25402006, 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G MEF2A TOPORS 25402006 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP GP G GP G PLK3 TOPORS 25402006 pred GP GP P P G G P G P P GP GP G GP P GP GP G GP P GP G GP GP GP P G UBE3A TOPORS 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SNRNP200 TOPORS 25402006 pred GP G G G GP GP G G GP G GP G GP GP G GP GP G GP G GP GP GP G GP GP GP GP G SIAH1 TOPORS 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G NFYB TOPORS 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G NFKBIB TOPORS 23023127 pred GP P G GP GP G GP P G GP GP GP GP G GP GP P GP G GP GP GP GP GP GP GP GP G XIAP TOPORS 25402006 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP G GP G G GP GP G GP G GP GP G SMAD4 TOPORS 25402006 pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP GP GP G GP GP GP G GP GP GP GP G TDG TOPORS 25402006, 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SFN TOPORS 25402006, 23023127 pred GP G G G G G G G G G G G GP G G G G GP G G G GP G G G G G G G UBE2G1 TOPORS 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G RNF4 TOPORS 25402006 pred GP G G G G GP G GP GP G GP G G G G G GP GP G G GP GP GP GP G G GP GP G BRCA1 TOPORS 25402006, 23023127 pred P P G GP P P P P P P P GP P P P P P P P P P P GP SUMO3 TOPORS 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G NR3C1 TOPORS 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G ARNT TOPORS 23023127 pred GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G EP300 TOPORS 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G ELF4 TOPORS 21836163 pred GP GP G G G G GP GP GP GP G G GP GP P G GP GP P GP GP GP GP G DAPK1 TOPORS 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G RAD51 TOPORS 25402006 pred P P G GP P G P GP P GP P P GP GP GP GP GP P P P GP P GP GP SUZ12 TOPORS 25402006 pred G G G G GP G G G GP G GP G G GP G GP G G G G GP G G G GP G GP G G PRKCA TOPORS 23023127 pred G GP G G GP GP G GP GP G GP G G GP G GP GP G GP G GP G G GP GP G GP GP G PRPF8 TOPORS 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G UFL1 TOPORS 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP G GP G GP GP G RFWD3 TOPORS 25402006, 23023127 pred G G G G G G G G G G G G G G G G G G DHX9 TOPORS 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G GTF2H1 TOPORS 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G TOP2A TOPORS 25402006 pred P P G GP GP P GP GP G P P GP GP GP GP MAPKAPK5 TOPORS 25402006 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP GP GP GP GP GP RANBP2 TOPORS 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G TOPORS TRAF6 25402006 pred GP GP G G GP G G GP GP G GP GP GP G G GP G GP G G GP GP GP G GP GP GP GP G HIPK2 TOPORS 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G UBE2K TOPORS 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G BIRC2 TOPORS 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP G GP GP GP GP GP GP G TOPORS RNF11 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G TOPORS AMFR 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G BBC3 TOPORS 25402006 pred APEX1 TOPORS 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G BTBD1 TOPORS 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G G G GP GP GP GP GP GP GP GP G CHD3 TOPORS 25402006, 21836163 pred GP GP G G G GP G G GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G NFYA TOPORS 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G HNRNPC TOPORS 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G TOPORS PIAS3 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G LATS1 TOPORS 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G TAF8 TOPORS 23023127 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP P GP G GP G GP P G CSNK2A1 TOPORS 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G TP63 TOPORS 25402006 pred GP G G G G G G G G G G G G G G G G G G GP GP G G G G G HNRNPUL1 TOPORS 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G CREB1 TOPORS 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SUPT7L TOPORS 23023127 pred GP GP G G GP GP G GP GP G GP G GP G G GP GP G GP G GP GP GP GP GP GP GP GP G UBE2E3 TOPORS 23023127 pred GP GP G G G GP G G GP G GP G G GP G GP GP GP G G GP G G GP GP G GP GP G DDX21 TOPORS 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G MDM4 TOPORS 25402006, 23023127, 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G ING2 TOPORS 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP IRF1 TOPORS 25402006 pred GP GP G G GP GP G GP GP G GP G GP G G GP GP G GP G GP G GP GP GP G GP GP G H1FX TOPORS 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G RYBP TOPORS 25402006 pred GP G G G G G G G G G GP G GP G G GP G G GP G GP GP G GP GP G GP GP G DDX5 TOPORS 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SART1 TOPORS 25402006 pred GP GP G G G GP G G GP G GP G G G G P GP G GP G GP G G G P G P GP G ERCC6 TOPORS 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G GNL3 TOPORS 21836163 pred P GP P P P P P P P P G GP P P GP GP GP P P P P P P HNRNPDL TOPORS 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G RNF111 TOPORS 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G NCL TOPORS 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G CLK2 TOPORS 21836163 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP G GP G GP GP G UBE2C TOPORS 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G ELL TOPORS 25402006 pred GP G G G P P P P P P P P P G G G GP G G P P GP G NAP1L1 TOPORS 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G XPA TOPORS 23023127 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G CUL5 TOPORS 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G XPO1 TOPORS 25402006 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G TOPORS BCLAF1 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G PIAS2 TOPORS 25402006, 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G HNRNPU TOPORS 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G BTBD2 TOPORS 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G ABL1 TOPORS 25402006, 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G TOPORS RWDD3 25402006 pred G G G G GP GP G GP GP G GP G GP G G GP GP G G G G G GP GP GP G GP G G RNF103 TOPORS 23023127 pred G GP G G GP GP G G GP G GP G GP GP G GP GP GP GP G G GP G G GP G GP GP G PBK TOPORS 25402006 pred P G GP P P GP P P P P GP P P P P P GP P GP GP SP100 TOPORS 25402006 pred GP GP G GP P G GP GP GP GP GP GP G GP P GP P G GP GP GP GP GP GP GP P G FGD1 TOPORS 23023127 pred G GP G G G GP G G G G G G GP G G G GP G G G GP GP G G G G GP GP G TOPORS DAXX 25402006, 21836163, 21836163, 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G AR TOPORS 25402006 pred GP G G G G G G G G G G G G G G G G G G G G G G G GP G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q9NS56 - 11842245 - X 2 Q9NS56 - 11842245 - X 2 Q9NS56 - 11842245 - X 2 Q9NS56 Q14790-5 two hybrid 17290218 - X 2 Q9NS56 Q14790-5 in vivo 17290218 - X 2 Q9NS56 A0A024R3Z2 two hybrid 11842245 - X 2 Q9NS56 A0A024R3Z2 in vivo 11842245 - X 2 Q9NS56 Q14790-5 in vivo 17290218 - X 2 Q9NS56 Q14790-5 two hybrid 17290218 - X 2 Q9NS56 A0A024R3Z2 in vivo 11842245 - X 2 Q9NS56 A0A024R3Z2 two hybrid 11842245 - X 2 Q9NS56 Q9NS56 two hybrid 11842245 - X 2 Q9NS56 Q9NS56 in vitro 11842245 - X 2 P04637-8 Q9NS56 in vivo 10415337,17290218 - X 2 P04637-8 Q9NS56 in vitro 10415337,17290218 - X 2 P04637-8 Q9NS56 in vitro 10415337,17290218 - X 2 P04637-8 Q9NS56 in vivo 10415337,17290218 - X 2 Q9NS56 P11387 two hybrid 10352183 - X 2 Q9NS56 P11387 in vitro 10352183 - X 2 Q9NS56 P11387 in vivo 10352183 - X 2 Q9NS56 P63279 two hybrid 14516784 - X 2 Q9NS56 Q5VU21 in vivo 16679534 - X 2 Q9NS56 Q5VU21 two hybrid 16679534 - X 2 Q9NS56 Q5JVS0 two hybrid 16455055 - X 2 Q9NS56 Q5VU21 in vivo 16679534 - X 2 Q9NS56 Q5VU21 two hybrid 16679534 - X 2 Q9NS56 P11387 two hybrid 10352183 - X 2 Q9NS56 P11387 in vitro 10352183 - X 2 Q9NS56 P11387 in vivo 10352183 - X 2 Q9NS56 P63279 two hybrid 14516784 - X 2 Q9NS56 Q5JVS0 two hybrid 16455055 - X 2 B1AK66 Q9NS56 two hybrid 15231748 - X 2 B1AK66 Q9NS56 two hybrid 15231748 - X 2 Q9NS56 anti tag coimmunoprecipitation 18775313 association C 23 Q9NS56 K7PPA8 anti tag coimmunoprecipitation 17290218 physical association X 2 Q9NS56 Q14790 anti bait coimmunoprecipitation 17290218 physical association X 2 Q9NS56 P62837 two hybrid array 19690564 physical association X 2 Q9NS56 A0A024RA90 two hybrid array 19690564 physical association X 2 Q9NS56 Q96B02 two hybrid array 19690564 physical association X 2 P02340 Q9NS56 two hybrid 11842245 physical association X 2 O14933 Q9NS56 two hybrid array 19690564 physical association X 2 A0A024QZJ2 Q9NS56 two hybrid array 19690564 physical association X 2 Q9NS56 Q89268 pull down 11842245 physical association X 2 Q9NS56 A0A024R2H1 two hybrid 18408014 physical association X 2 Q9NS56 A0A024RDH2 two hybrid array 19690564 physical association X 2 Q9NS56 Q9Y385 two hybrid array 19690564 physical association X 2 Q9NS56 P61088 two hybrid array 19690564 physical association X 2 Q9NS56 Q8ZFU4 two hybrid pooling approach 20711500 physical association X 2 Q9NS56 Q7Z333 two hybrid 24244371 physical association X 2 Q9NS56 Q7Z333 two hybrid 24244371 physical association X 2 P03132 Q9NS56 two hybrid 11842245 physical association X 2 P03132 Q9NS56 two hybrid 11842245 physical association X 2 P03132 Q9NS56 two hybrid 11842245 physical association X 2 B1AK66 Q9NS56 two hybrid 15231748 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B PML TOPORS MI:0004(affinity chromatography technology) 20188669 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_208973 prey bait SFPQ TOPORS MI:0096(pull down) 17803295 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_137204 prey bait UBE2E1 TOPORS MI:0415(enzymatic study) 15247280 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_225888 prey bait SIN3A TOPORS MI:0096(pull down)|MI:0096(pull down) 17803295 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid) BIOGRID_137205|BIOGRID_137222 prey|prey bait|bait GTF2I TOPORS MI:0096(pull down) 17803295 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_137202 prey bait SAFB2 TOPORS MI:0096(pull down) 17803295 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_137207 prey bait HNRNPM TOPORS MI:0096(pull down) 17803295 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_137217 prey bait UBE2D2 TOPORS MI:0018(two hybrid)|MI:0397(two hybrid array) 19690564 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_123466|UniProt_102456 bait|bait prey|prey H2AFX TOPORS MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 22972498 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_217266|BIOGRID_217268|BIOGRID_217269|BIOGRID_217270 prey|bait|prey|prey bait|prey|bait|bait EEF1A1 TOPORS MI:0096(pull down) 17803295 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_137220 prey bait UBE2D1 TOPORS MI:0018(two hybrid)|MI:0415(enzymatic study)|MI:0096(pull down)|MI:0096(pull down)|MI:0397(two hybrid array)|MI:0096(pull down) 15247280,18077445,19053840,19690564 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(intact)|(biogrid) BIOGRID_123434|BIOGRID_225886|BIOGRID_116236|BIOGRID_116237|UniProt_102422|BIOGRID_221547 bait|prey|prey|prey|bait|prey prey|bait|bait|bait|prey|bait UBE2I TOPORS MI:0018(two hybrid)|MI:0018(two hybrid) 14516784 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|- (biogrid)|MI:0468(hprd) BIOGRID_78081|HPRD_15016 prey|- bait|- HNRNPA1 TOPORS MI:0096(pull down) 17803295 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_137218 prey bait CASP8 TOPORS MI:0493(in vivo)|MI:0428(imaging technique)|MI:0428(imaging technique)|MI:0428(imaging technique)|MI:0415(enzymatic study) 17290218 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) MI:0468(hprd)|MI:0471(mint)|(intact)|MI:0471(mint)|(biogrid) HPRD_31210|MINT_52744|UniProt_90003|MINT_85270|BIOGRID_215102 -|bait|bait|bait|bait -|prey|prey|prey|prey UBE2L6 TOPORS MI:0397(two hybrid array)|MI:0018(two hybrid) 19690564 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_102594|BIOGRID_123605 bait|bait prey|prey RBBP7 TOPORS MI:0096(pull down) 17803295 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_137209 prey bait DDB2 TOPORS MI:0096(pull down) 17803295 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_137208 prey bait SUMO1 TOPORS MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0493(in vivo) 11842245,14516784,16524884 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction)|- (biogrid)|(biogrid)|MI:0468(hprd) BIOGRID_87969|BIOGRID_289448|HPRD_10065 prey|bait|- bait|prey|- p53 TOPORS MI:0415(enzymatic study)|MI:0415(enzymatic study)|MI:0428(imaging technique)|MI:0415(enzymatic study)|MI:0096(pull down)|MI:0428(imaging technique)|MI:0493(in vivo)|MI:0428(imaging technique)|MI:0018(two hybrid) 10415337,11842245,15247280,17290218,17803295 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|-|MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid)|(intact)|(biogrid)|(biogrid)|MI:0471(mint)|MI:0468(hprd)|MI:0471(mint)|(biogrid) BIOGRID_215106|BIOGRID_130267|UniProt_90002|BIOGRID_215104|BIOGRID_137201|MINT_85271|HPRD_4574|MINT_52745|BIOGRID_113181 bait|prey|prey|prey|prey|prey|-|prey|prey prey|bait|bait|bait|bait|bait|-|bait|bait UBE2D3 TOPORS MI:0415(enzymatic study)|MI:0018(two hybrid)|MI:0397(two hybrid array) 15247280,19690564 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid)|(intact) BIOGRID_225887|BIOGRID_123499|UniProt_102488 prey|bait|bait bait|prey|prey UBE2N TOPORS MI:0397(two hybrid array)|MI:0018(two hybrid) 19690564 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_102616|BIOGRID_123627 bait|bait prey|prey SATB1 TOPORS MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0096(pull down) 18408014,20351170 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid)|(intact) BIOGRID_138651|BIOGRID_209350|UniProt_94769 bait|bait|bait prey|prey|prey SF3B1 TOPORS MI:0096(pull down) 17803295 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_137219 prey bait RANGAP1 TOPORS MI:0096(pull down) 17803295 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_137215 prey bait NRF1 TOPORS MI:0428(imaging technique) 24250222 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_296297 bait prey S100A9 TOPORS MI:0096(pull down) 17803295 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_137221 prey bait TRIM28 TOPORS MI:0096(pull down) 17803295 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_137210 prey bait SUMO2 TOPORS MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0018(two hybrid)|MI:0004(affinity chromatography technology) 16524884,19471022,21252943,21693764 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_183971|BIOGRID_182991|BIOGRID_289460|BIOGRID_165959 bait|bait|bait|bait prey|prey|prey|prey UBXN7 TOPORS MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology) 18775313 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0914(association)|MI:0914(association)|MI:0915(physical association) (intact)|(intact)|(biogrid) UniProt_97407|UniProt_183211|BIOGRID_148871 bait|bait|bait prey|prey|prey DHX15 TOPORS MI:0096(pull down) 17803295 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_137213 prey bait NKX3-1 TOPORS MI:0096(pull down)|MI:0096(pull down) 18077445 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction) (biogrid)|(biogrid) BIOGRID_148068|BIOGRID_148069 prey|prey bait|bait UBC TOPORS MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0415(enzymatic study) 21139048,21890473,21906983,21963094,21987572,22505724,23000965 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_179729|BIOGRID_175170|BIOGRID_170495|BIOGRID_264763|BIOGRID_223247|BIOGRID_268504|BIOGRID_163931 bait|bait|bait|bait|bait|bait|bait prey|prey|prey|prey|prey|prey|prey UPF3A TOPORS MI:0096(pull down) 17803295 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_137216 prey bait SNIP1 TOPORS MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 15231748 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|- MI:0471(mint)|(intact)|MI:0471(mint)|MI:0468(hprd) MINT_61506|UniProt_79173|MINT_32658|HPRD_2795 bait|bait|bait|- prey|prey|prey|- TOP1 TOPORS MI:0492(in vitro)|MI:0004(affinity chromatography technology)|MI:0415(enzymatic study)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 10352183,17976381,20805487 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association) MI:0468(hprd)|(biogrid)|(biogrid)|(biogrid)|(biogrid) HPRD_30651|BIOGRID_197798|BIOGRID_200246|BIOGRID_112213|BIOGRID_112212 -|prey|prey|prey|prey -|bait|bait|bait|bait HABP4 TOPORS MI:0018(two hybrid)|MI:0018(two hybrid) 16455055 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|- (biogrid)|MI:0468(hprd) BIOGRID_130820|HPRD_26331 bait|- prey|- MTDH TOPORS MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 24529480 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction) (biogrid)|(biogrid) BIOGRID_307770|BIOGRID_307769 bait|bait prey|prey HNRNPL TOPORS MI:0096(pull down) 17803295 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_137214 prey bait TOPORS UBE2D4 MI:0397(two hybrid array)|MI:0018(two hybrid) 19690564 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_102519|BIOGRID_123531 prey|prey bait|bait TOPORS UBE2J1 MI:0018(two hybrid)|MI:0397(two hybrid array) 19690564 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_123595|UniProt_102584 prey|prey bait|bait SERBP1 TOPORS MI:0018(two hybrid)|MI:0018(two hybrid) 16679534 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0407(direct interaction) MI:0468(hprd)|(biogrid) HPRD_27169|BIOGRID_210677 -|bait -|prey NONO TOPORS MI:0096(pull down) 17803295 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_137203 prey bait PLK1 TOPORS MI:0004(affinity chromatography technology)|MI:0415(enzymatic study)|MI:0004(affinity chromatography technology) 19473992,19821153,22972498 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid) BIOGRID_217267|BIOGRID_140525|BIOGRID_211987 prey|bait|bait bait|prey|prey SMARCC2 TOPORS MI:0096(pull down) 17803295 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_137212 prey bait RBBP4 TOPORS MI:0096(pull down) 17803295 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_137211 prey bait PARP1 TOPORS MI:0096(pull down) 17803295 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_137206 prey bait UBE2W TOPORS MI:0018(two hybrid)|MI:0397(two hybrid array) 19690564 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_123708|UniProt_102697 bait|bait prey|prey

PPI - HINT Gene A Gene B PMID Method Quality UBXN7 TOPORS 18775313,18775313,26389662 0007,0004,0004 LC TP53 TOPORS 17803295,17290218 0096,0007 LC UBE2D1 TOPORS 15247280,19053840,18077445,19053840 0096,0096,0096,0004 LC PLK1 TOPORS 19473992,22972498,19473992,19821153 0004,0004,0415,0004 LC Q53GA5 TOPORS 17803295,17290218 0096,0004 LC SPIN2B TOPORS 26186194 0004 HT NIFK TOPORS 26186194 0004 HT TOPORS SPIN1 26186194 0004 HT SPIN2B TOPORS 26186194 0004 HT NIFK TOPORS 26186194 0004 HT TOPORS SPIN1 26186194 0004 HT UBXN7 TOPORS 18775313,18775313,26389662 0007,0004,0004 LC TP53 TOPORS 17803295,17290218 0096,0007 LC UBE2D1 TOPORS 15247280,19053840,18077445,19053840 0096,0096,0096,0004 LC PLK1 TOPORS 19473992,22972498,19473992,19821153 0004,0004,0415,0004 LC Q53GA5 TOPORS 17803295,17290218 0096,0004 LC EPM2A TOPORS 26493215 0018 LC UBE2L6 TOPORS 19690564,19690564 0397,0018 HT TP53 TOPORS 15247280,11842245 0415,0018 LC UBC TOPORS 15247280 0415 LC TOP1 TOPORS 10352183,17976381,10352183,20805487 0004,0415,0018,0415 LC H2AFX TOPORS 22972498,22972498 0004,0415 LC UBE2D1 TOPORS 19690564,19690564 0397,0018 HT PLK1 TOPORS 19473992,19473992 0004,0415 LC UBE2D3 TOPORS 19690564,19690564 0397,0018 HT UBE2N TOPORS 19690564,19690564 0397,0018 HT SUMO2 TOPORS 16524884 0018 LC PSMC1 TOPORS 26872363,26872363 0004,0018 LC UBE2D2 TOPORS 19690564,19690564 0397,0018 HT SUMO1 TOPORS 16524884,11842245,14516784 0018,0018,0018 LC UBE2I TOPORS 14516784 0018 LC SATB1 TOPORS 20351170,18408014 0018,0018 LC CASP8 TOPORS 17290218,17290218,17290218 0004,0018,0006 LC Q53GA5 TOPORS 11842245,16122737,15247280 0018,0415,0415 LC HABP4 TOPORS 16455055 0018 LC Q5VU21 TOPORS 16679534 0018 LC SETX TOPORS 24244371 0018 LC MTDH TOPORS 24529480,24529480 0018,0096 LC SERBP1 TOPORS 16679534 0018 LC SNIP1 TOPORS 15231748 0018 HT UBE2W TOPORS 19690564,19690564 0397,0018 HT SIN3A TOPORS 17803295,17803295 0004,0415 LC NKX3-1 TOPORS 18077445,18077445 0415,0096 LC TOPORS TOPORS 11842245 0018 LC TOPORS UBE2D4 19690564,19690564 0397,0018 HT TOPORS UBE2J1 19690564,19690564 0397,0018 HT TOPORS HEL-S-71 19690564 0018 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9NS56 Q5JVS0 TOPORS HABP4 0.309 16455055 Q9NS56 P61956 TOPORS SUMO2 0.183 16524884 Q9NS56 P16104 TOPORS H2AFX 0.569 22972498 Q9NS56 Q8NC51 TOPORS SERBP1 0.309 16679534 Q9NS56 O43143 TOPORS DHX15 0.21 17803295 Q9NS56 O75533 TOPORS SF3B1 0.21 17803295 Q9NS56 P06702 TOPORS S100A9 0.21 17803295 Q9NS56 P09651 TOPORS HNRNPA1 0.21 17803295 Q9NS56 P09874 TOPORS PARP1 0.21 17803295 Q9NS56 P0CG48 TOPORS UBC 0.309 15247280 Q9NS56 P14866 TOPORS HNRNPL 0.21 17803295 Q9NS56 P23246 TOPORS SFPQ 0.21 17803295 Q9NS56 P29590 TOPORS PML 0.126 20188669 Q9NS56 P46060 TOPORS RANGAP1 0.21 17803295 Q9NS56 P51965 TOPORS UBE2E1 0.309 15247280 Q9NS56 P52272 TOPORS HNRNPM 0.21 17803295 Q9NS56 P53350 TOPORS PLK1 0.569 19821153,19473992,22972498 Q9NS56 P61077 TOPORS UBE2D3 0.507 19690564,15247280 Q9NS56 P61088 TOPORS UBE2N 0.376 19690564 Q9NS56 P68104 TOPORS EEF1A1 0.21 17803295 Q9NS56 P78347 TOPORS GTF2I 0.21 17803295 Q9NS56 Q09028 TOPORS RBBP4 0.21 17803295 Q9NS56 Q13263 TOPORS TRIM28 0.21 17803295 Q9NS56 Q14151 TOPORS SAFB2 0.21 17803295 Q9NS56 Q15233 TOPORS NONO 0.21 17803295 Q9NS56 Q16576 TOPORS RBBP7 0.21 17803295 Q9NS56 Q8TAD8 TOPORS SNIP1 0.183 15231748 Q9NS56 Q8TAQ2 TOPORS SMARCC2 0.21 17803295 Q9NS56 Q92466 TOPORS DDB2 0.21 17803295 Q9NS56 Q96B02 TOPORS UBE2W 0.376 19690564 Q9NS56 Q9H1J1 TOPORS UPF3A 0.21 17803295 Q9NS56 P02340 TOPORS TP53 0.309 10415337 Q9NS56 O95278 TOPORS EPM2A 0.309 26493215 Q9NS56 Q99801 TOPORS NKX3-1 0.523 18077445 Q9NS56 Q96ST3 TOPORS SIN3A 0.454 17803295 Q9NS56 P63279 TOPORS UBE2I 0.523 16122737,14516784 Q9NS56 P62191 TOPORS PSMC1 0.454 26872363 Q9Y2X8 Q9NS56 UBE2D4 TOPORS 0.286 19690564 Q9NS56 Q91VJ5 TOPORS PQBP1 0.236 26496610 Q9Y385 Q9NS56 UBE2J1 TOPORS 0.286 19690564 Q9NS56 P04637 TOPORS TP53 0.888 16122737,17290218,11842245,15247280,17803295 Q9NS56 Q14790 TOPORS CASP8 0.376 17290218 Q9NS56 P51668 TOPORS UBE2D1 0.837 19690564,15247280,19053840,18077445 Q9NS56 O14933 TOPORS UBE2L6 0.286 19690564 Q9NS56 Q86UE4 TOPORS MTDH 0.523 24529480 Q9NS56 O94888 TOPORS UBXN7 0.332 18775313,26389662 Q9NS56 Q01826 TOPORS SATB1 0.671 18408014,20351170 Q9NS56 P11387 TOPORS TOP1 0.74 17976381,10352183,20805487 Q9NS56 Q8ZFU4 TOPORS PYRC 0.126 20711500 Q9NS56 Q9BPZ2 TOPORS SPIN2B 0.126 26186194 Q9NS56 Q9BYG3 TOPORS NIFK 0.126 26186194 Q9NS56 P62837 TOPORS UBE2D2 0.286 19690564 Q9NS56 Q14164 TOPORS IKBKE 0.309 20188669 Q9NS56 P63165 TOPORS SUMO1 0.436 16524884,14516784

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 UBE2L6 TOPORS MI:0045 experimental interaction detection MI:0461 interaction database DHX15 TOPORS MI:0045 experimental interaction detection MI:0461 interaction database PQBP1 TOPORS MI:0362 inference MI:0461 interaction database SF3B1 TOPORS MI:0045 experimental interaction detection MI:0461 interaction database UBXN7 TOPORS MI:0045 experimental interaction detection MI:0461 interaction database EPM2A TOPORS MI:0045 experimental interaction detection MI:0461 interaction database TP53 TOPORS MI:0045 experimental interaction detection MI:0461 interaction database JUN TOPORS MI:0045 experimental interaction detection MI:0461 interaction database S100A9 TOPORS MI:0045 experimental interaction detection MI:0461 interaction database HNRNPA1 TOPORS MI:0045 experimental interaction detection MI:0461 interaction database PARP1 TOPORS MI:0045 experimental interaction detection MI:0461 interaction database UBC TOPORS MI:0045 experimental interaction detection MI:0461 interaction database TOP1 TOPORS MI:0045 experimental interaction detection MI:0461 interaction database HNRNPL TOPORS MI:0045 experimental interaction detection MI:0461 interaction database ATF2 TOPORS MI:0045 experimental interaction detection MI:0461 interaction database H2AFX TOPORS MI:0045 experimental interaction detection MI:0461 interaction database SDC1 TOPORS MI:0362 inference MI:0461 interaction database SFPQ TOPORS MI:0045 experimental interaction detection MI:0461 interaction database RANGAP1 TOPORS MI:0045 experimental interaction detection MI:0461 interaction database UBE2D1 TOPORS MI:0045 experimental interaction detection MI:0461 interaction database UBE2E1 TOPORS MI:0045 experimental interaction detection MI:0461 interaction database HNRNPM TOPORS MI:0045 experimental interaction detection MI:0461 interaction database PLK1 TOPORS MI:0045 experimental interaction detection MI:0461 interaction database SUMO3 TOPORS MI:0045 experimental interaction detection MI:0461 interaction database UBE2D3 TOPORS MI:0045 experimental interaction detection MI:0461 interaction database UBE2N TOPORS MI:0045 experimental interaction detection MI:0461 interaction database SUMO2 TOPORS MI:0045 experimental interaction detection MI:0461 interaction database PSMC1 TOPORS MI:0045 experimental interaction detection MI:0461 interaction database UBE2D2 TOPORS MI:0045 experimental interaction detection MI:0461 interaction database SUMO1 TOPORS MI:0045 experimental interaction detection MI:0461 interaction database UBE2I TOPORS MI:0045 experimental interaction detection MI:0461 interaction database EEF1A1 TOPORS MI:0045 experimental interaction detection MI:0461 interaction database GTF2I TOPORS MI:0045 experimental interaction detection MI:0461 interaction database SATB1 TOPORS MI:0045 experimental interaction detection MI:0461 interaction database RBBP4 TOPORS MI:0045 experimental interaction detection MI:0461 interaction database TRIM28 TOPORS MI:0045 experimental interaction detection MI:0461 interaction database SAFB2 TOPORS MI:0045 experimental interaction detection MI:0461 interaction database IKBKE TOPORS MI:0045 experimental interaction detection MI:0461 interaction database HES1 TOPORS MI:0362 inference MI:0461 interaction database CASP8 TOPORS MI:0045 experimental interaction detection MI:0461 interaction database NONO TOPORS MI:0045 experimental interaction detection MI:0461 interaction database RBBP7 TOPORS MI:0045 experimental interaction detection MI:0461 interaction database IFI16 TOPORS MI:0362 inference MI:0461 interaction database HABP4 TOPORS MI:0045 experimental interaction detection MI:0461 interaction database SETX TOPORS MI:0045 experimental interaction detection MI:0461 interaction database MTDH TOPORS MI:0045 experimental interaction detection MI:0461 interaction database PHC2 TOPORS MI:0362 inference MI:0461 interaction database SERBP1 TOPORS MI:0045 experimental interaction detection MI:0461 interaction database SNIP1 TOPORS MI:0045 experimental interaction detection MI:0461 interaction database SMARCC2 TOPORS MI:0045 experimental interaction detection MI:0461 interaction database DDB2 TOPORS MI:0045 experimental interaction detection MI:0461 interaction database UBE2W TOPORS MI:0045 experimental interaction detection MI:0461 interaction database SIN3A TOPORS MI:0045 experimental interaction detection MI:0461 interaction database NKX3-1 TOPORS MI:0045 experimental interaction detection MI:0461 interaction database SPIN2B TOPORS MI:0045 experimental interaction detection MI:0461 interaction database NIFK TOPORS MI:0045 experimental interaction detection MI:0461 interaction database UPF3A TOPORS MI:0045 experimental interaction detection MI:0461 interaction database TOPORS UBE2D4 MI:0045 experimental interaction detection MI:0461 interaction database TOPORS UBE2J1 MI:0045 experimental interaction detection MI:0461 interaction database TOPORS SPIN1 MI:0045 experimental interaction detection MI:0461 interaction database