PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus KLHL26 KLHL14 26186194 biogrid exp P P P P P P GP P P GP P P P P P P P P P P P KLHL14 FBXL17 26186194 biogrid exp P P G GP P P P GP P P GP P P P P P P P P P GP P P FLAD1 KLHL14 26186194 biogrid exp P P G GP P P P GP P P GP P P P P P P P P P GP P P KCTD21 KLHL14 26186194 biogrid exp P G P P NUDCD3 KLHL14 26186194 biogrid exp P P G GP P P P GP P P GP P P P P P P P P P GP P P HSP90AA1 KLHL14 22939624 biogrid exp P P G G P P G G P P G P ALG3 KLHL14 26186194 biogrid exp P P G G P P GP P GP P P P P P P P G P P HSP90AB1 KLHL14 22939624 intact exp P P G GP P P P GP P P GP P P P P P P P P P GP P P TOR1A KLHL14 19535332 biogrid exp, ortho P P G GP P P P GP P P GP P P P P P P P P GP P P TCEB2 KLHL14 23023127 pred G G G G G VHL KLHL14 23023127 pred G G GP P P G P P P G P SOCS2 KLHL14 23023127 pred P P G GP P P P GP P P GP P P P P P P P P P GP P P ZBTB48 KLHL14 23023127 pred P G GP P P P GP P GP P P P P P GP P SOCS5 KLHL14 23023127 pred P P G GP P P P GP P P GP P P P P P P P P P G P P BTBD6 KLHL14 23023127 pred G GP P G GP P P P G SOCS4 KLHL14 23023127 pred P P G GP P P GP P GP P P P P P P P GP P P KLHL22 KLHL14 23023127 pred P G G P P GP P G P P P P P P G P P KLHL11 KLHL14 23023127 pred P P P P P P P P P P P P P P P P P P BACH1 KLHL14 23023127 pred P P G GP P P GP P GP P P P P P P P P GP P P SOCS3 KLHL14 23023127 pred P P G GP P P P GP P P G P P P P P P P P G P P

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q9P2G3 O14656 affinity chromatography technology 19535332 physical association X 2 Q9P2G3 O14656 biochemical 19535332 colocalization X 2 Q9P2G3 P07900-2 affinity chromatography technology 22939624 physical association X 2 Q9P2G3 O14656 imaging technique 19535332 colocalization X 2 Q9P2G3 A0A024RD80 luminescence based mammalian interactome mapping 22939624 physical association X 2

PPI - HINT Gene A Gene B PMID Method Quality KCTD21 KLHL14 26186194 0004 HT KLHL26 KLHL14 26186194 0004 HT NUDCD3 KLHL14 26186194 0004 HT FLAD1 KLHL14 26186194 0004 HT ALG3 KLHL14 26186194 0004 HT KLHL14 FBXL17 26186194 0004 HT KCTD21 KLHL14 26186194 0004 HT KLHL26 KLHL14 26186194 0004 HT NUDCD3 KLHL14 26186194 0004 HT FLAD1 KLHL14 26186194 0004 HT ALG3 KLHL14 26186194 0004 HT KLHL14 FBXL17 26186194 0004 HT TOR1A KLHL14 19535332,19535332,19535332 0401,0004,0428 LC HSP90AB1 KLHL14 22939624 0729 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9P2G3 P07900 KLHL14 HSP90AA1 0.126 22939624 Q9P2G3 Q92685 KLHL14 ALG3 0.126 26186194 Q9P2G3 O14656 KLHL14 TOR1A 0.396 19535332 Q9P2G3 Q53HC5 KLHL14 KLHL26 0.126 26186194 Q9P2G3 P08238 KLHL14 HSP90AB1 0.126 22939624 Q9P2G3 Q4G0X4 KLHL14 KCTD21 0.126 26186194 Q9UF56 Q9P2G3 FBXL17 KLHL14 0.126 26186194 Q9P2G3 Q8IVD9 KLHL14 NUDCD3 0.126 26186194 Q9P2G3 Q8NFF5 KLHL14 FLAD1 0.126 26186194

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 TOR1A KLHL14 MI:0045 experimental interaction detection MI:0461 interaction database HSP90AA1 KLHL14 MI:0045 experimental interaction detection MI:0461 interaction database HSP90AB1 KLHL14 MI:0045 experimental interaction detection MI:0461 interaction database KCTD21 KLHL14 MI:0045 experimental interaction detection MI:0461 interaction database KLHL26 KLHL14 MI:0045 experimental interaction detection MI:0461 interaction database NUDCD3 KLHL14 MI:0045 experimental interaction detection MI:0461 interaction database FLAD1 KLHL14 MI:0045 experimental interaction detection MI:0461 interaction database ALG3 KLHL14 MI:0045 experimental interaction detection MI:0461 interaction database KLHL14 FBXL17 MI:0045 experimental interaction detection MI:0461 interaction database