PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus HSPA1A, HSPA1B FCHSD1 19041431 biogrid exp P P P P P P P P P P P P P P P P P P P P P P DNM2 FCHSD1 19041431 biogrid exp P P P P P P P GP P P P G P P P P GP P P SBK1 FCHSD1 19041431 biogrid exp G G G XRCC6 FCHSD1 19041431 biogrid exp P P P P P P P P P GP P P P P G P P P P P GP P P FCHSD1 MOV10 22658674 biogrid exp G G G FCHSD1 ASAP1 19041431, 23023127 biogrid exp, pred P P P P P P P P P GP P P P P G P P P P GP P P FCHSD1 ITSN2 22558309,19041431, 23023127 biogrid exp, pred P P P P G P P P G P P P G P P RPGRIP1L FCHSD1 ortho P P P P P P P P P P P P P G P P P P P P P FCHSD1 AHI1 23023127 pred P P P P P P P P GP P P P G P P P GP P P FCHSD1 NOSTRIN 25402006, 23023127 pred P P P P P P P P P GP P P P G P P P P P GP P P NCF1C FCHSD1 23023127 pred FCHSD1 PACSIN3 25402006, 23023127 pred P P P P P P P P G P P P P P P P P P P P GRB2 FCHSD1 23023127 pred P P P P P P P P GP P P P P G P P P P P GP P P DNMBP FCHSD1 23023127 pred P P P P P P G P P G P P P G P FCHSD1 SH3KBP1 23023127 pred P P GP P G P GP ITSN1 FCHSD1 23023127 pred P P P P P P P GP P P G P P P P G P P FCHSD1 SH3GLB1 23023127 pred P P P P P P P P P GP P P P P G P P P P P GP P P SLA FCHSD1 23023127 pred P P P P P P GP P P P G P P P P GP P P FCHSD1 SRMS 23023127 pred P P P P P P P P P P P P P P P P P P P P P P FCHSD1 EPS8L3 23023127 pred P P P P P P G P P P P G P P P MYO7B FCHSD1 23023127 pred P P P P P P G P P P P G P SRGAP3 FCHSD1 25402006, 23023127 pred P P P P P G P G P HERPUD1 FCHSD1 23023127 pred P P P P P P P P P GP P P P P G P P P P P GP P P CRK FCHSD1 23023127 pred P P P P P G P P G P P P P P G P RIMBP3C FCHSD1 23023127 pred P P P P PHF1 FCHSD1 23023127 pred P P P P P P P P P GP P P P P G P P P P P GP P P CLIP1 FCHSD1 23023127 pred P P P P P P P P P GP P P P P G P P P P P GP P P SH3PXD2A FCHSD1 23023127 pred P P P P P P P P P G P P P P G P P P P P G P P SORBS3 FCHSD1 23023127 pred P P P P P G P P P G P P P P P G P VAV1 FCHSD1 23023127 pred P P P P P P P P P GP P P P G P P P P GP P P FCHSD1 SKAP1 23023127 pred P P GP G GP FCHSD1 MIA2 23023127 pred P P P P P P P P P P P P P P P FCHSD1 DVL3 23023127 pred P P P P P P P P P GP P P P P G P P P P P GP P P FCHSD1 ARHGEF19 23023127 pred G FYN FCHSD1 23023127 pred P P P P P P GP P G GP FCHSD1 ABI1 23023127 pred P P P P P P P P P GP P P P P G P P P P P GP P P FCHSD1 SH3GL3 23023127 pred P G P P G G P P MATK FCHSD1 23023127 pred P P P P P P P P P GP P P P P P P P P P GP P P SRGAP2 FCHSD1 23023127 pred G G FCHO2 FCHSD1 21836163 pred P P P P P P P P G P P P G P P P P P GP P P LYN FCHSD1 23023127 pred P P P P P GP P P P G P P P P GP P SASH3 FCHSD1 23023127 pred P P P P GP P P G P P P GP P P NCK1 FCHSD1 23023127 pred P P P P P P P P P GP P P P P G P P P P GP P P ARHGEF6 FCHSD1 23023127 pred P P P P P P P GP P P P G P G P HCLS1 FCHSD1 23023127 pred P P P GP P G GP FCHSD1 PPP1R13B 23023127 pred P P P P P P P P P GP P P P P G P P P P P GP P P STAC2 FCHSD1 23023127 pred P P P P P P P GP P P P P G P P P P GP P P HCK FCHSD1 23023127 pred P P P P P P G P P P P G P P P P P GP P P SH3PXD2B FCHSD1 23023127 pred P P P P P P G P P P G P P P G P P FCHSD1 EPS8L1 23023127 pred P P P P P P P G P P P P ITK FCHSD1 23023127 pred G G G BAIAP2L2 FCHSD1 23023127 pred P P P P P P P P P P P P P P P P P P P P P LCK FCHSD1 23023127 pred P GP GP MLK4 FCHSD1 23023127 pred P P P P P P P P GP P P P G P P P P P P GRB14 FCHSD1 23023127 pred P P P P P P P P GP P P P P P P P P P P FCHSD1 FCHSD1 23023127 pred P P P P P P P P P GP P P P P G P P P P P GP P P VAV2 FCHSD1 23023127 pred P P P P P P P P G P P P P G P P P P GP P P GRAP2 FCHSD1 23023127 pred P P P P P P P P P P P P P P P MYO1E FCHSD1 23023127 pred P P P P P P P P P GP P P P G P P P G P P TMUB2 FCHSD1 23023127 pred P P P P P P P P P GP P P P P G P P P P P GP P P MAP3K9 FCHSD1 23023127 pred P P P P P P P P G P P P P G P P P P P GP P P SH3D21 FCHSD1 23023127 pred P P P P P P P P P GP P P P P G P P P P P P P P SOCS3 FCHSD1 23023127 pred P P P P P P P P P G P P P P G P P P P G P P GRB10 FCHSD1 23023127 pred P P P P P P P P P GP P P P P G P P P P P GP P P SH2D1A FCHSD1 23023127 pred G G FCHSD1 SH3BP4 23023127 pred P P P P P P P GP P P P G P P P P GP P P FCHSD1 SH3GLB2 23023127 pred P P P P GP P P G P GP P P FCHSD1 PPP1R13L 23023127 pred P P P P P P P P GP P P P P G P P P GP P P FCHSD1 SAMSN1 23023127 pred P P P P P P P P GP P P P P P P P GP P P FCHSD1 MYO15A 23023127 pred P P P P G P P P P G P P P P P FCHSD1 VAV3 23023127 pred P P P P P P P P P GP P P P G P P P P P GP P P AMPH FCHSD1 23023127 pred P P P P G G FCHSD1 SH3YL1 23023127 pred P P P P P P GP P P P G P P P P G P P FCHSD1 NSFL1C 23023127 pred P P P P P P P P P GP P P P P G P P P P GP P P NCF4 FCHSD1 23023127 pred P P GP GP NCF4 FCHSD1 23023127 pred P P GP GP PLCG2 FCHSD1 23023127 pred P P P P P P P GP P P P G P P P GP P P FCHSD1 UHRF2 23023127 pred P P P P P P P P P GP P P P P G P P P P P GP P P NCF2 FCHSD1 23023127 pred P P GP G GP BTK FCHSD1 23023127 pred P P GP GP FCHSD1 STAC3 23023127 pred G G FCHSD1 CASS4 23023127 pred P P P P P P P P P P P P P P P P P P P SHB FCHSD1 23023127 pred P P P P P P P P GP P P P P G P P P P P GP P P FCHSD1 STAM 23023127 pred P P P P P P P P P GP P P P P G P P P P G P P NEB FCHSD1 23023127 pred P P G P P CRKL FCHSD1 23023127 pred P P P P P GP P P P G P P P GP P PSTPIP1 FCHSD1 23023127 pred P P P GP GP ARID4B FCHSD1 23023127 pred P P P P P GP P P G P P G P P FCHSD1 ABI2 23023127 pred G G G FCHSD1 SLA2 23023127 pred G G G FCHSD1 SPATA13 23023127 pred P P P P P P P P G P P P P G P P P P G P P NCK2 FCHSD1 23023127 pred P P P P P P P P GP P P P P G P P P P P GP P P PRMT2 FCHSD1 23023127 pred P P P P P P GP P P P P G P P P P P G P P PLCG1 FCHSD1 23023127 pred P P P P P P P P P GP P P P P G P P P P P GP P P SOCS6 FCHSD1 23023127 pred P P P P P P P P P GP P P P P G P P P P P P P P SASH1 FCHSD1 23023127 pred P P P P P P P P P G P P G P P P P G P P ARHGEF16 FCHSD1 23023127 pred P P P P P P P P GP P P P P G P P P P GP P P FCHSD1 OTOR 23023127 pred P P P P P P P P P P P P P P P P P P FCHSD1 SNX18 23023127 pred P P P P P P P GP P P P G P P P P G P P SKI FCHSD1 23023127 pred P P P P P P P P G P P P P G P P P P P GP P P FCHSD1 BAHD1 23023127 pred P G G G FCHSD1 SP140L 23023127 pred P G G G P BZRAP1 FCHSD1 23023127 pred P P P P P P P P P GP P P P P G P P P P P GP P P FCHSD1 HERPUD2 23023127 pred P P P P P P P P P GP P P P P G P P P P P GP P P RIMBP3B FCHSD1 23023127 pred NPHP1 FCHSD1 23023127 pred P P P P P P P P P P P G P P P P P P FCHSD1 CD2AP 23023127 pred P P P P P P P P GP P P P G P P P P GP P P ABL2 FCHSD1 23023127 pred P P P P P P P P P GP P P P P G P P P P P GP P P MAPK8IP2 FCHSD1 23023127 pred P P P P P P P P GP P P P G P P P P P GP P P BCAR1 FCHSD1 23023127 pred P P P P P P P P P GP P P P P G P P P P P GP P P FCHSD1 ARHGAP26 23023127 pred P P P P P P P GP P P P P G P P P P G P P NCF1B FCHSD1 23023127 pred FCHSD1 UBASH3B 23023127 pred P P P P P P P P P P P P P P P P P P GP P P MIA3 FCHSD1 23023127 pred P P P P P P P P GP P P P P G P P P P GP P P NEDD9 FCHSD1 23023127 pred P P P P P P P P P GP P P P P G P P P P P GP P P TRIO FCHSD1 23023127 pred P P P P P P P GP P P P P G P P P P GP P P RIMBP2 FCHSD1 23023127 pred P P P P P P P P P G P P P G P P P P P P P P MYO1F FCHSD1 23023127 pred P GP G P GP WAS FCHSD1 25402006 pred P P P P P P GP P P G P P GP P P PIK3R2 FCHSD1 23023127 pred G G G SPTAN1 FCHSD1 23023127 pred P P P P P P P P P GP P P P P G P P P P P GP P P MIA FCHSD1 23023127 pred P P P P P P P P P P G P P G P P FCHSD1 PACSIN2 25402006 pred P P P P P P P P GP P P P G P P P P GP P P ABL1 FCHSD1 23023127 pred P P P P P P P P P GP P P P P G P P P P P GP P P FCHSD1 OSTF1 23023127 pred P P P P P P P P P GP P P P P G P P P P GP P P UBASH3A FCHSD1 23023127 pred P P G P P P G MAP3K11 FCHSD1 23023127 pred P P P P P P P P P GP P P P P G P P P P P GP P P FCHSD1 SORBS1 23023127 pred P P P P P P P P P G P P P P G P P P P P G P P FCHSD1 EPS8L2 23023127 pred P P P P P P P P G P P P G P P P P P P P P GRB7 FCHSD1 23023127 pred P P P P P P P P P GP P P P P G P P P P P P P P SRGAP1 FCHSD1 23023127 pred P P P P P G P P P G P G P TEC FCHSD1 23023127 pred P P P P P P P P P P P P P P P P P P P EFS FCHSD1 23023127 pred P P P P P P G P P P G P P P G FCHSD1 SH3GL2 23023127 pred P P P G FCHSD1 BAIAP2 23023127 pred P P P P P P P P P GP P P P P G P P P P P P P P FCHSD1 SGSM3 23023127 pred P P P P P P P P P GP P P P P G P P P P GP P P PHF19 FCHSD1 23023127 pred P P P P P P P P G P P P P G P P P P GP P P FCHSD1 STAC 23023127 pred P P P P P P P P P GP P P P P G P P P P P GP P P PIK3R1 FCHSD1 23023127 pred P P P P P P P P P GP P P P P G P P P P P GP P P STAM2 FCHSD1 23023127 pred P P P P P P P P P GP P P P P G P P P P P GP P P FCHSD1 KIF13B 23023127 pred P P P P P P P P P GP P P P P G P P P G P P UBC FCHSD1 23023127 pred FCHSD1 SH2B3 23023127 pred P P P P P P P P GP P P P P G P P P P P GP P P FNBP1L FCHSD1 25402006 pred G G G FCHSD1 GAS2L3 23023127 pred P P P P P G P P P P P P P P P P FCHSD1 SNX9 23023127 pred P P P P P P P P P GP P P P P G P P P P P GP P P FCHSD1 LSM10 23023127 pred P P P P P GP P P P G P P P P GP P P NCF1 FCHSD1 23023127 pred P P P P OBSCN FCHSD1 23023127 pred P P P P P P P P P GP P P P P G P P P P P GP P P FCHSD1 TMUB1 23023127 pred P P P P P P P P P GP P P P P G P P P P P G P P FCHSD1 BAIAP2L1 23023127 pred P P P P P P P P P P P P P P G P P P P P P P P FCHSD1 DBNL 23023127 pred P P P P P P P P GP P P P P G P P P P GP P P FCHSD1 SH3RF2 23023127 pred P P P P P P P P P P P P P P P P KALRN FCHSD1 23023127 pred P P P P P P P P P P P P P P P P P P GP P P FCHSD1 RUSC2 23023127 pred P P P P P P P P P GP P P P P G P P P P P GP P P FCHSD1 NOXO1 23023127 pred FCHSD1 PACSIN1 25402006, 23023127 pred P P P P G MAP3K10 FCHSD1 23023127 pred P P P P P P P P P P P P P P P P P P P P P ARHGEF37 FCHSD1 23023127 pred P P P P P P G P P P G P P P G P P FCHSD1 PEX13 23023127 pred P P P P P P P P P GP P P P P G P P P P P GP P P FCHSD2 FCHSD1 25402006, 23023127 pred P P P P P P P P P G P P P G P P P P P GP P ARHGEF7 FCHSD1 23023127 pred P P P P P P P P P GP P P P P G P P P P GP P P BIN1 FCHSD1 23023127 pred P P P P P P P P P GP P P P P G P P P P P GP P P SQSTM1 FCHSD1 23023127 pred P P P P P P P GP P P P G P P P P P GP P P ARHGAP4 FCHSD1 25402006, 23023127 pred P P GP GP RASA1 FCHSD1 23023127 pred P P P G P G P G P TRIP10 FCHSD1 25402006, 23023127 pred G G G CTTN FCHSD1 23023127 pred P P P P P P P P P GP P P P P G P P P P P GP P P FCHSD1 MYO15B 23023127 pred FCHSD1 NGEF 23023127 pred P P P P P P P P P GP P P P P P P P P P P P NEBL FCHSD1 23023127 pred P P P P P P P GP P P G P P P FRK FCHSD1 23023127 pred P P P P P P P P P P P P P P P P P P P FCHSD1 SH3GL1 23023127 pred P P P P P P P P P G P P P P G P P P P P G P P ARHGEF9 FCHSD1 23023127 pred P P P P P P P P G P P G P P P GP P SH3RF1 FCHSD1 23023127 pred G G G FCHSD1 MAPK8IP1 23023127 pred P P P P P P P P P P P P P G P P P P P P P P SORBS2 FCHSD1 23023127 pred P P P P P P P P GP P P P P G P P P P P G P P LASP1 FCHSD1 23023127 pred P P P P P P GP P P P P G P P P GP P FCHSD1 SH3RF3 23023127 pred P P P P P P P P P GP P P P P G P P P P P GP P P FCHSD1 STK31 23023127 pred P P P P P P P P P P P P NOXA1 FCHSD1 23023127 pred P P P P P P G P P P P G P P P P G P P FCHSD1 SFMBT1 23023127 pred P P P P P P P P P GP P P P P G P P P P P GP P P FCHSD1 ABI3 23023127 pred P P P P P P GP P P G P P GP FCHSD1 RUSC1 23023127 pred P P P P P P P P P GP P P P G P P P P P G P P FCHSD1 RIMBP3 23023127 pred FYB FCHSD1 23023127 pred P GP G GP FCHSD1 TDRD1 23023127 pred P P P P P P P P P P P P P P P P P P P P P P FCHSD1 SH2B1 23023127 pred G G G FCHSD1 CBX8 23023127 pred P P P P P P P P P P P P P P P P P P P P

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants A6H8W8 Q86WN1 affinity chromatography technology 19041431 physical association X 2 A6H8W8 Q86WN1 two hybrid 22558309 direct interaction X 2 Q86WN1 unspecified method 20467438 direct interaction X 2 Q52WX2 Q86WN1 affinity chromatography technology 19041431 physical association X 2 A0A024R1N4 Q86WN1 affinity chromatography technology 19041431 physical association X 2 P50570-5 Q86WN1 affinity chromatography technology 19041431 physical association X 2 Q86WN1 affinity chromatography technology 19041431 physical association X 2 A8K5I0 Q86WN1 affinity chromatography technology 19041431 physical association X 2 Q8D1R0 Q86WN1 two hybrid pooling approach 20711500 physical association X 2 P31016 Q86WN1 peptide array 20467438 direct interaction X 2 Q3KSV2 Q86WN1 two hybrid 17446270 physical association X 2 Q5NGE6 Q86WN1 two hybrid pooling approach 20711500 physical association X 2 Q81LC7 Q86WN1 two hybrid pooling approach 20711500 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B FCHSD1 ASAP1 MI:0004(affinity chromatography technology) 19041431 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_122223 bait prey SBK1 FCHSD1 MI:0004(affinity chromatography technology) 19041431 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_122227 prey bait FCHSD1 ITSN2 MI:0004(affinity chromatography technology)|MI:0018(two hybrid) 19041431,22558309 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid) BIOGRID_122226|BIOGRID_185903 bait|prey prey|bait DNM2 FCHSD1 MI:0004(affinity chromatography technology) 19041431 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_122224 prey bait XRCC6 FCHSD1 MI:0004(affinity chromatography technology) 19041431 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_122222 prey bait HSPA1A FCHSD1 MI:0004(affinity chromatography technology) 19041431 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_122225 prey bait

PPI - HINT Gene A Gene B PMID Method Quality FCHSD1 ITSN2 22558309 0018 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q8D1R0 Q86WN1 DEGQ FCHSD1 0.126 20711500 Q9HCE1 Q86WN1 MOV10 FCHSD1 0.126 22658674 Q9NZM3 Q86WN1 ITSN2 FCHSD1 0.286 22558309,19041431 Q86WN1 P0DMV8 FCHSD1 HSPA1A 0.126 19041431 Q86WN1 P0DMV9 FCHSD1 HSPA1B {ECO:0000312|HGNC:HGNC:5233} 0.126 19041431 Q86WN1 P12956 FCHSD1 XRCC6 0.126 19041431 Q86WN1 P31016 FCHSD1 DLG4 0.183 20467438 Q86WN1 P50570 FCHSD1 DNM2 0.126 19041431 Q86WN1 Q52WX2 FCHSD1 SBK1 0.126 19041431 Q86WN1 Q5NGE6 FCHSD1 PRLC 0.126 20711500 Q86WN1 Q81LC7 FCHSD1 HEMC 0.126 20711500 Q86WN1 Q86WN1 FCHSD1 FCHSD1 0.332 26702831 Q9ULH1 Q86WN1 ASAP1 FCHSD1 0.126 19041431 Q86WN1 Q3KSV2 FCHSD1 EBNA2 0.183 17446270

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 HSPA1A FCHSD1 MI:0045 experimental interaction detection MI:0461 interaction database HSPA1B FCHSD1 MI:0045 experimental interaction detection MI:0461 interaction database XRCC6 FCHSD1 MI:0045 experimental interaction detection MI:0461 interaction database DNM2 FCHSD1 MI:0045 experimental interaction detection MI:0461 interaction database DLG4 FCHSD1 MI:0362 inference MI:0461 interaction database SBK1 FCHSD1 MI:0045 experimental interaction detection MI:0461 interaction database RPGRIP1L FCHSD1 MI:0362 inference MI:0461 interaction database FCHSD1 MOV10 MI:0045 experimental interaction detection MI:0461 interaction database FCHSD1 ITSN2 MI:0045 experimental interaction detection MI:0461 interaction database FCHSD1 ASAP1 MI:0045 experimental interaction detection MI:0461 interaction database