PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus DCUN1D1 KLHL9 21145461 biogrid exp G G G G G P P G P P P G G GP G G GP P GP GP P GP G COPS5 KLHL9 19615732,21145461 biogrid,intact exp GP G G G G G G GP GP G GP GP G G G GP G G GP G G GP GP GP GP G GP GP G UBE2D1 KLHL9 17543862 biogrid exp GP G G G G G G G GP G GP GP G G G G G G GP G G GP G GP G G GP GP G NEDD8 KLHL9 21145461 biogrid exp GP G G G G G G GP GP G GP GP G G G GP G G GP G G GP GP GP GP G GP GP G KLHL22 KLHL9 19995937 biogrid exp G G G G G G G GP GP G GP G G G G GP G G GP G G G GP GP GP G GP GP G AURKB KLHL9 19995937,17543862 biogrid exp G G G GP P GP G P GP GP P KLHL9 USP25 19615732 biogrid,intact exp GP G G G G G G GP GP G GP GP G G G GP G G GP G G GP GP GP GP G GP GP G SMAD3 KLHL9 15527767 mint exp GP G G G G G G G G G G G G G G G G G GP G G G G G G G G G G CUL3 KLHL9 19295130,19995937,17543862,21145461 innatedb,biogrid exp GP G G G G G G GP GP G GP GP G G G GP G G GP G G GP GP GP GP G GP GP G PLK1 KLHL9 23455478 biogrid exp P G G G G GP GP P P G GP G G GP G G P GP GP GP P GP CUL4A KLHL9 21145461 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G CEP170 KLHL9 26638075 biogrid,intact exp GP G G G G G G GP GP G GP GP G G G GP G G GP G G GP GP GP GP G GP GP G KLHL29 KLHL9 24778252 biogrid exp GP G G G G GP GP G GP GP G G G GP G G GP G G GP GP G GP G GP GP G NUDCD3 KLHL9 25036637 biogrid,intact exp GP G G G G G G GP GP G GP GP G G G GP G G GP G G GP GP GP GP G GP GP G COPS6 KLHL9 19615732,21145461 biogrid,intact exp GP G G G G G G GP GP G GP G G G G GP G G GP G G GP GP G GP G GP GP G KLHL9 KLHL13 19995937,17543862,19615732, 23023127 biogrid,intact exp, pred GP G G G G GP GP G GP GP G G GP G G GP G GP GP GP GP GP GP G KLHL9 KLHL21 19995937, 23023127 biogrid exp, pred GP G G G G GP GP G GP GP G G G GP G G GP G G G GP GP G GP GP G VHL KLHL9 23023127 pred G G G G G G G G G G GP GP G G G G G G P G G GP GP G G G G GP G ROCK2 KLHL9 23023127 pred GP G G G G G G GP GP G G G G G G GP G G GP G G GP GP GP GP G GP GP G

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B UBE2D1 KLHL9 MI:0004(affinity chromatography technology) 17543862 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_225872 prey bait COPS6 KLHL9 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19615732,21145461 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(intact) BIOGRID_205741|BIOGRID_120568|UniProt_100633 bait|bait|bait prey|prey|prey PLK1 KLHL9 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 23455478 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_258142|BIOGRID_258145 bait|prey prey|bait SMAD3 KLHL9 MI:0096(pull down)|MI:0096(pull down) 15527767 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|MI:0471(mint) MINT_58813|MINT_55966 bait|bait prey|prey AURKB KLHL9 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 17543862,19995937 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_200519|BIOGRID_148441|BIOGRID_200523|BIOGRID_148438|BIOGRID_148436|BIOGRID_200520 prey|prey|prey|prey|bait|prey bait|bait|bait|bait|prey|bait KLHL9 KLHL13 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 17543862,19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(intact) BIOGRID_200515|BIOGRID_200522|BIOGRID_120570|UniProt_100711 prey|bait|prey|prey bait|prey|bait|bait NEDD8 KLHL9 MI:0004(affinity chromatography technology) 21145461 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_206827 bait prey COPS5 KLHL9 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19615732,21145461 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(intact) BIOGRID_120567|BIOGRID_205321|UniProt_100632 bait|bait|bait prey|prey|prey KLHL9 KLHL21 MI:0004(affinity chromatography technology) 19995937 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_148429 prey bait KLHL9 USP25 MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_120569|UniProt_100690 prey|prey bait|bait CUL4A KLHL9 MI:0004(affinity chromatography technology) 21145461 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_202996 bait prey CUL3 KLHL9 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 17543862,19295130,19995937,21145461 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_221823|BIOGRID_148431|BIOGRID_201957|BIOGRID_200509|BIOGRID_221280|BIOGRID_200521 prey|bait|bait|bait|bait|prey bait|prey|prey|prey|prey|bait DCUN1D1 KLHL9 MI:0004(affinity chromatography technology) 21145461 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_205996 bait prey UBC KLHL9 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 21139048,21890473,21906983,21963094 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_168752|BIOGRID_178108|BIOGRID_265435|BIOGRID_176387 bait|bait|bait|bait prey|prey|prey|prey

PPI - HINT Gene A Gene B PMID Method Quality CUL3 KLHL9 21145461,19295130,17543862,19995937 0004,0004,0004,0004 HT,LC CUL4A KLHL9 21145461 0004 HT NEDD8 KLHL9 21145461 0004 HT CEP170 KLHL9 26638075,26638075 1314,1313 HT COPS6 KLHL9 19615732,21145461,19615732 0004,0004,0007 HT COPS5 KLHL9 19615732,21145461,19615732 0004,0004,0007 HT AURKB KLHL9 17543862,19995937,17543862,17543862,19995937,19995937 0096,0004,0415,0004,0096,0415 LC DCUN1D1 KLHL9 21145461 0004 HT KLHL9 KLHL13 19615732,19615732,17543862,19995937 0004,0007,0004,0004 HT,LC KLHL9 USP25 19615732,19615732 0004,0007 HT CUL3 KLHL9 21145461 0004 HT CUL4A KLHL9 21145461 0004 HT NEDD8 KLHL9 21145461 0004 HT CEP170 KLHL9 26638075,26638075 1314,1313 HT COPS6 KLHL9 19615732,21145461,19615732 0004,0004,0007 HT COPS5 KLHL9 19615732,21145461,19615732 0004,0004,0007 HT DCUN1D1 KLHL9 21145461 0004 HT KLHL9 KLHL13 19615732,19615732 0004,0007 HT KLHL9 USP25 19615732,19615732 0004,0007 HT CUL3 KLHL9 19295130,17543862,19995937 0004,0004,0004 LC AURKB KLHL9 17543862,19995937,17543862,17543862,19995937,19995937 0096,0004,0415,0004,0096,0415 LC KLHL9 KLHL13 17543862,19995937 0004,0004 LC AURKB KLHL9 17543862,19995937,17543862,17543862,19995937,19995937 0096,0004,0415,0004,0096,0415 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9P2J3 Q13618 KLHL9 CUL3 0.671 17543862,21145461,19295130,19995937 Q9UHP3 Q9P2J3 USP25 KLHL9 0.236 19615732 Q9P2J3 Q5SW79 KLHL9 CEP170 0.236 26638075 Q9P2J3 Q8IVD9 KLHL9 NUDCD3 0.236 25036637 Q9P2J3 Q7L5N1 KLHL9 COPS6 0.332 19615732,21145461 Q9P2J3 Q92905 KLHL9 COPS5 0.332 19615732,21145461 Q9P2J3 Q96CT2 KLHL9 KLHL29 0.126 24778252 Q9P2J3 Q96GD4 KLHL9 AURKB 0.858 17543862,19995937 Q9P2J3 Q96GG9 KLHL9 DCUN1D1 0.126 21145461 Q9P2N7 Q9P2J3 KLHL13 KLHL9 0.523 17543862,19615732 Q9P2J3 P51668 KLHL9 UBE2D1 0.309 17543862 Q9P2J3 P53350 KLHL9 PLK1 0.376 23455478 Q9UJP4 Q9P2J3 KLHL21 KLHL9 0.21 19995937 Q9P2J3 Q13619 KLHL9 CUL4A 0.126 21145461 Q9P2J3 Q15843 KLHL9 NEDD8 0.126 21145461

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 UBC KLHL9 MI:0045 experimental interaction detection MI:0461 interaction database UBE2D1 KLHL9 MI:0045 experimental interaction detection MI:0461 interaction database PLK1 KLHL9 MI:0045 experimental interaction detection MI:0461 interaction database RBX1 KLHL9 MI:0362 inference MI:1106 pathways database CUL3 KLHL9 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database CUL4A KLHL9 MI:0045 experimental interaction detection MI:0461 interaction database NEDD8 KLHL9 MI:0045 experimental interaction detection MI:0461 interaction database KLHL22 KLHL9 MI:0045 experimental interaction detection MI:0461 interaction database CEP170 KLHL9 MI:0045 experimental interaction detection MI:0461 interaction database COPS6 KLHL9 MI:0045 experimental interaction detection MI:0461 interaction database NUDCD3 KLHL9 MI:0045 experimental interaction detection MI:0461 interaction database COPS5 KLHL9 MI:0045 experimental interaction detection MI:0461 interaction database KLHL29 KLHL9 MI:0045 experimental interaction detection MI:0461 interaction database AURKB KLHL9 MI:0045 experimental interaction detection MI:0461 interaction database DCUN1D1 KLHL9 MI:0045 experimental interaction detection MI:0461 interaction database TRPM7 KLHL9 MI:0362 inference MI:0461 interaction database KLHL9 KLHL13 MI:0045 experimental interaction detection MI:0461 interaction database KLHL9 USP25 MI:0045 experimental interaction detection MI:0461 interaction database KLHL9 KLHL21 MI:0045 experimental interaction detection MI:0461 interaction database