PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus PCNA FAN1 20603015 biogrid exp G GP G G G G G G GP G G G G GP G GP G G G G G G G G GP GP G G G C1orf52 FAN1 26496610 biogrid,intact exp G GP G G G GP G GP GP G G G G GP G GP GP G G G G G G G GP GP G G G FANCI FAN1 20603015 biogrid exp G P G G GP GP GP G G G GP G GP GP G G G G G GP GP G G G AKR7A2 FAN1 26496610 biogrid,intact exp G GP G G G GP G GP GP G G G G GP G GP GP G G G G G G G GP GP G G G ANXA8 FAN1 26496610 intact exp MLH1 FAN1 20603015,26496610,20603073,17148452 biogrid,intact exp G GP G G G GP G GP GP G G G G GP G GP GP G G G G G G G GP GP G G G BLM FAN1 25135477 innatedb,biogrid exp G GP G G G GP G GP GP G G G G GP G GP GP G G G G G G G GP GP G G G FANCD2 FAN1 20603015,25135477,20603016,20603073 innatedb,biogrid exp G G P P GP G G GP P G G GP G G G WDR75 FAN1 26496610 biogrid,intact exp G GP G G G GP G GP GP G G G G GP G GP GP G G G G G G G GP GP G G G PMS1 FAN1 20603015,26496610,20603073 biogrid,intact exp G GP G G G GP G G GP G G G G GP G GP GP G G G G G G G GP GP G G G YWHAE FAN1 20603015 biogrid exp G GP G G G GP G GP GP G G G G GP G GP GP G G G G G G G GP GP G G G ANKLE2 FAN1 26496610 biogrid,intact exp G G G G G GP G G G G G G G G G G GP G G G G G G G G G G G G SDPR FAN1 26496610 biogrid,intact exp G G G G GP G G GP G G G G G G G GP G G G G G G G G G G G HEXA FAN1 26496610 biogrid,intact exp G GP G G G GP G GP GP G G G G G G GP GP G G G G G G G GP G G G G FSCN1 FAN1 20603015 intact exp G G G GP G G GP G G G GP G GP G G G G GP G G G KPNB1 FAN1 20603015 biogrid exp G GP G G G GP G GP GP G G G G GP G GP GP G G G G G G G GP GP G G G ANXA7 FAN1 26496610 biogrid exp G GP G G G GP G GP GP G G G G GP G G GP G G G G G G G G GP G G G TRAP1 FAN1 26496610 biogrid,intact exp G GP G G G GP G GP GP G G G G G G GP GP G G G G G G G GP GP G G G YWHAZ FAN1 20603015 biogrid exp G GP G G G GP G GP GP G G G G GP G GP GP G G G G G G G GP GP G G G RFC4 FAN1 20603015 biogrid exp G GP G G G GP G G GP G G G G GP G GP GP G G G G G G G GP GP G G G PIK3C2B FAN1 26496610 biogrid,intact exp G G G G G G G G GP G G G G G G GP G G G G G G G G GP G G G G MIER1 FAN1 26496610 biogrid,intact exp G GP G G G GP G GP GP G G G G GP G GP GP G G G G G G G GP GP G G G CD99L2 FAN1 26496610 biogrid,intact exp G GP G G G GP G GP GP G G G G GP G GP GP G G G G G G G GP GP G G G PMS2 FAN1 20603015,26496610,20603073,17148452 biogrid,intact exp P P P P P P P P P PLEKHA8 FAN1 26496610 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PRPF4B FAN1 26496610 biogrid,intact exp G GP G G G GP G G GP G G G G GP G GP GP G G G G G G G GP GP G G G FAN1 FAN1 20603015 biogrid exp G GP G G G GP G GP GP G G G G GP G GP GP G G G G G G G GP GP G G G PSMD11 FAN1 26496610 biogrid,intact exp G GP G G G GP G GP GP G G G G G G G GP G G G G G G G G G G G G HIST1H3A, HIST1H3B, HIST1H3C, HIST1H3D, HIST1H3E, HIST1H3F, HIST1H3G, HIST1H3H, HIST1H3I, HIST1H3J FAN1 26496610 intact exp GP G G P GP P P P P G G G P GP SUPT5H FAN1 26496610 biogrid,intact exp G GP G G G GP G GP GP G G G G GP G GP GP G G G G G G G GP GP G G G RFC3 FAN1 20603015 biogrid exp G GP G G G GP G GP GP G G G G GP G GP GP G G G G G G G GP GP G G G H3F3C FAN1 26496610 biogrid exp P P P P P P P P P FANCG FAN1 20603015 biogrid exp G GP G G G GP G GP GP G G G G GP G GP GP G G G G G G G GP GP G G G MLH3 FAN1 20603073 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G AP2A2 FAN1 26496610 biogrid,intact exp G GP G G G GP G GP GP G G G G GP G GP GP G G G G G G G GP GP G G G UBC FAN1 20603015,20935496 biogrid exp G GP G G G GP G GP GP G G G G GP G GP GP G G G G G G G GP GP G G G NCOA5 FAN1 26496610 biogrid,intact exp G GP G G G GP G GP GP G G G G GP G GP GP G G G G G G G GP GP G G G PPP2R1A FAN1 26496610 biogrid,intact exp G GP G G G GP G GP GP G G G G GP G GP GP G G G G G G G GP GP G G G SUMO1 FAN1 ortho G GP G G G GP G GP GP G G G G GP G GP GP G G G G G G G GP GP G G G EXOC6B FAN1 21836163 pred G GP G GP G GP GP G G G G G G GP GP G G G G G G G GP GP G G G RAD52 FAN1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q9Y2M0 affinity chromatography technology 17148452 physical association X 2 Q9Y2M0 affinity chromatography technology 20603073 physical association X 2 Q9Y2M0 affinity chromatography technology 20603073 physical association X 2 Q9Y2M0 affinity chromatography technology 20603073 physical association X 2 Q9Y2M0 affinity chromatography technology 20603015 physical association X 2 P0CG48 Q9Y2M0 affinity chromatography technology 20935496 physical association X 2 P0CG48 Q9Y2M0 affinity chromatography technology 20935496 physical association X 2 P0CG48 Q9Y2M0 affinity chromatography technology 20603015 physical association X 2 Q9Y2M0 Q9BXW9-3 affinity chromatography technology 25135477 physical association X 2 Q9Y2M0 Q9BXW9-3 imaging technique 20603073 colocalization X 2 Q9Y2M0 Q9BXW9-3 imaging technique 20603016 colocalization X 2 Q9Y2M0 Q9BXW9-3 affinity chromatography technology 20603016 physical association X 2 Q9Y2M0 Q9BXW9-3 affinity chromatography technology 20603015 physical association X 2 Q9Y2M0 Q9NVI1 affinity chromatography technology 20603015 physical association X 2 Q9Y2M0 P35249 affinity chromatography technology 20603015 physical association X 2 Q9Y2M0 P62258 affinity chromatography technology 20603015 physical association X 2 Q9Y2M0 Q9BXW9-3 affinity chromatography technology 20603015 physical association X 2 Q9Y2M0 Q9NVI1 affinity chromatography technology 20603015 physical association X 2 Q9Y2M0 Q9BXW9-3 biochemical 20603015 colocalization X 2 Q9Y2M0 Q9NVI1 biochemical 20603015 colocalization X 2 Q9Y2M0 Q9BXW9-3 imaging technique 20603015 colocalization X 2 Q9Y2M0 P61956-2 affinity chromatography technology 21693764 physical association X 2 P12004 Q9Y2M0 affinity chromatography technology 20603015 physical association X 2 P54132 Q9Y2M0 affinity chromatography technology 25135477 physical association X 2 D0PNI1 Q9Y2M0 affinity chromatography technology 20603015 physical association X 2 A0A024RDQ8 Q9Y2M0 affinity chromatography technology 20603015 physical association X 2 Q14974 Q9Y2M0 affinity chromatography technology 20603015 physical association X 2 Q9Y2M0 P40692 affinity chromatography technology 17148452 physical association X 2 Q9Y2M0 P40692 affinity chromatography technology 20603073 physical association X 2 Q9Y2M0 Q2M1Z1 affinity chromatography technology 20603073 physical association X 2 Q9Y2M0 I6L9H5 affinity chromatography technology 20603073 physical association X 2 Q9Y2M0 Q9Y2M0 affinity chromatography technology 20603073 physical association X 2 Q9Y2M0 P40692 affinity chromatography technology 20603073 physical association X 2 Q9Y2M0 Q2M1Z1 affinity chromatography technology 20603073 physical association X 2 Q9Y2M0 Q2M1Z1 affinity chromatography technology 20603073 physical association X 2 Q9Y2M0 P40692 affinity chromatography technology 20603073 physical association X 2 Q9Y2M0 Q9Y2M0 affinity chromatography technology 20603015 physical association X 2 Q9Y2M0 I6L9H5 affinity chromatography technology 20603015 physical association X 2 Q9Y2M0 P40692 affinity chromatography technology 20603015 physical association X 2 Q9Y2M0 O15287 affinity chromatography technology 20603015 physical association X 2 Q9Y2M0 P40692 affinity chromatography technology 20603015 physical association X 2 Q9Y2M0 P40692 biochemical 20603015 colocalization X 2 Q9Y2M0 pull down 20603015 association C 15 Q9Y2M0 pull down 20603015 association C 12

PPI - HINT Gene A Gene B PMID Method Quality B4DT77 FAN1 26496610 0007 HT PSMD11 FAN1 26496610,26496610 0007,0004 HT SUPT5H FAN1 26496610,26496610 0007,0004 HT PIK3C2B FAN1 26496610,26496610 0007,0004 HT AKR7A2 FAN1 26496610 0007 HT AP2A2 FAN1 26496610,26496610 0007,0004 HT SDPR FAN1 26496610,26496610 0007,0004 HT HEXA FAN1 26496610,26496610 0007,0004 HT UBC FAN1 20603015,20935496,20935496 0004,0004,0096 LC ANXA7 FAN1 26496610 0004 HT PPP2R1A FAN1 26496610,26496610 0007,0004 HT MLH1 FAN1 26496610,20603015,20603073,17148452,20603015 0007,0004,0004,0004,0401 HT,LC PMS1 FAN1 26496610,20603015,20603073,26496610 0007,0004,0004,0004 HT,LC PMS2 FAN1 26496610,20603015,20603073,17148452,26496610 0007,0004,0004,0004,0004 HT,LC HIST1H3A|HIST1H3B|HIST1H3C|HIST1H3D|HIST1H3E|HIST1H3F|HIST1H3G|HIST1H3H|HIST1H3I|HIST1H3J FAN1 26496610 0007 HT TRAP1 FAN1 26496610 0007 HT PRPF4B FAN1 26496610,26496610 0007,0004 HT Q53FS6 FAN1 26496610 0004 HT Q59EG3 FAN1 20603015,20603073,17148452,26496610,20603015 0004,0004,0004,0004,0401 LC,HT H3F3C FAN1 26496610 0004 HT ANKLE2 FAN1 26496610,26496610 0007,0004 HT WDR75 FAN1 26496610,26496610 0007,0004 HT MIER1 FAN1 26496610,26496610 0007,0004 HT C1ORF52 FAN1 26496610,26496610 0007,0004 HT CD99L2 FAN1 26496610,26496610 0007,0004 HT PLEKHA8 FAN1 26496610,26496610 0007,0004 HT FANCD2 FAN1 20603015,20603016,20603015,20603016,20603073,20603015,25135477 0428,0004,0004,0428,0428,0401,0004 LC NCOA5 FAN1 26496610,26496610 0007,0004 HT FAN1 FAN1 20603015,20603073 0004,0004 LC FAN1 HEL-S-166MP 26496610 0004 HT B4DT77 FAN1 26496610 0007 HT PSMD11 FAN1 26496610,26496610 0007,0004 HT SUPT5H FAN1 26496610,26496610 0007,0004 HT PIK3C2B FAN1 26496610,26496610 0007,0004 HT AKR7A2 FAN1 26496610 0007 HT AP2A2 FAN1 26496610,26496610 0007,0004 HT SDPR FAN1 26496610,26496610 0007,0004 HT HEXA FAN1 26496610,26496610 0007,0004 HT ANXA7 FAN1 26496610 0004 HT PPP2R1A FAN1 26496610,26496610 0007,0004 HT MLH1 FAN1 26496610 0007 HT PMS1 FAN1 26496610,26496610 0007,0004 HT PMS2 FAN1 26496610,26496610 0007,0004 HT HIST1H3A|HIST1H3B|HIST1H3C|HIST1H3D|HIST1H3E|HIST1H3F|HIST1H3G|HIST1H3H|HIST1H3I|HIST1H3J FAN1 26496610 0007 HT TRAP1 FAN1 26496610 0007 HT PRPF4B FAN1 26496610,26496610 0007,0004 HT Q53FS6 FAN1 26496610 0004 HT Q59EG3 FAN1 26496610 0004 HT H3F3C FAN1 26496610 0004 HT ANKLE2 FAN1 26496610,26496610 0007,0004 HT WDR75 FAN1 26496610,26496610 0007,0004 HT MIER1 FAN1 26496610,26496610 0007,0004 HT C1ORF52 FAN1 26496610,26496610 0007,0004 HT CD99L2 FAN1 26496610,26496610 0007,0004 HT PLEKHA8 FAN1 26496610,26496610 0007,0004 HT NCOA5 FAN1 26496610,26496610 0007,0004 HT FAN1 HEL-S-166MP 26496610 0004 HT UBC FAN1 20603015,20935496,20935496 0004,0004,0096 LC MLH1 FAN1 20603015,20603073,17148452,20603015 0004,0004,0004,0401 LC PMS1 FAN1 20603015,20603073 0004,0004 LC PMS2 FAN1 20603015,20603073,17148452 0004,0004,0004 LC Q59EG3 FAN1 20603015,20603073,17148452,20603015 0004,0004,0004,0401 LC FANCD2 FAN1 20603015,20603016,20603015,20603016,20603073,20603015,25135477 0428,0004,0004,0428,0428,0401,0004 LC FAN1 FAN1 20603015,20603073 0004,0004 LC MLH1 FAN1 20603015,20603015 0004,0401 LC Q59EG3 FAN1 20603015,20603015 0004,0401 LC FANCD2 FAN1 20603015,20603015,20603015 0428,0004,0401 LC FANCI FAN1 20603015,20603015 0004,0401 LC FAN1 FAN1 25500724,25430771 0114,0114 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9Y2M0 Q6NXT2 FAN1 H3F3C 0.126 26496610 Q9Y2M0 Q12931 FAN1 TRAP1 0.126 26496610 Q9Y2M0 P68431 FAN1 HIST1H3J 0.126 26496610 Q9Y2M0 P62258 FAN1 YWHAE 0.21 20603015 Q9Y2M0 P40938 FAN1 RFC3 0.21 20603015 Q9Y2M0 P63104 FAN1 YWHAZ 0.21 20603015 Q9Y2M0 O43488 FAN1 AKR7A2 0.126 26496610 Q9Y2M0 P12004 FAN1 PCNA 0.21 20603015 Q9Y2M0 O00750 FAN1 PIK3C2B 0.126 26496610 Q9Y2M0 F5GWN5 FAN1 PIK3C2B {ECO:0000313|ENSEMBL:ENSP00000400561} 0.126 26496610 Q9Y2M0 B4DT77 FAN1 B4DT77 0.126 26496610 Q9Y2M0 Q14974 FAN1 KPNB1 0.21 20603015 Q9Y2M0 Q9Y2M0 FAN1 FAN1 0.236 20603015 Q9Y2M0 P20073 FAN1 ANXA7 0.126 26496610 Q9Y2M0 O15287 FAN1 FANCG 0.21 20603015 Q9Y2M0 C9J9C1 FAN1 PPP2R1A {ECO:0000313|ENSEMBL:ENSP00000391905} 0.126 26496610 Q9Y2M0 P35249 FAN1 RFC4 0.21 20603015 Q9Y2M0 P30153 FAN1 PPP2R1A 0.126 26496610 Q9Y2M0 P0CG48 FAN1 UBC 0.623 20935496,20603015 Q9Y2M0 O00231 FAN1 PSMD11 0.236 26496610 Q9Y2M0 O00267 FAN1 SUPT5H 0.236 26496610 Q9Y2M0 O94973 FAN1 AP2A2 0.236 26496610 Q9Y2M0 O95810 FAN1 SDPR 0.236 26496610 Q9Y2M0 P06865 FAN1 HEXA 0.236 26496610 Q9Y2M0 Q13523 FAN1 PRPF4B 0.236 26496610 Q9Y2M0 Q86XL3 FAN1 ANKLE2 0.236 26496610 Q9Y2M0 Q8IWA0 FAN1 WDR75 0.236 26496610 Q9Y2M0 Q8N108 FAN1 MIER1 0.236 26496610 Q9Y2M0 Q8N6N3 FAN1 C1ORF52 0.236 26496610 Q9Y2M0 Q8TCZ2 FAN1 CD99L2 0.236 26496610 Q9Y2M0 Q96JA3 FAN1 PLEKHA8 0.236 26496610 Q9Y2M0 Q9HCD5 FAN1 NCOA5 0.236 26496610 Q9Y2M0 Q9NVI1 FAN1 FANCI 0.309 20603015 Q9Y2M0 P40692 FAN1 MLH1 0.671 20603015,26496610,17148452,20603073 Q9Y2M0 P54278 FAN1 PMS2 0.712 20603015,26496610,17148452,20603073 Q9Y2M0 Q9BXW9 FAN1 FANCD2 0.712 20603016,20603015,25135477,20603073 Q9Y2M0 P54277 FAN1 PMS1 0.523 20603015,26496610,20603073 Q9Y2M0 Q9UHC1 FAN1 MLH3 0.376 20603073 Q9Y2M0 Q16658 FAN1 FSCN1 0.21 20603015 Q9Y2M0 P54132 FAN1 BLM 0.21 25135477