PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus TGFBR1 DCAF12 15761153 hprd,i2d exp G G G G GP GP G G GP G G G GP G G GP GP G G G G G G G GP G GP G G DCAF12 NKD2 19888210 i2d exp G G G P GP G G GP G G G G GP G GP GP G GP G GP GP GP G GP G G DCAF12 AXIN2 19888210 i2d exp G G G G GP GP G G GP G G G GP GP G GP GP GP GP G G G GP GP GP GP GP G G DCAF12 COPS6 21145461 biogrid exp G G G G GP GP G G GP G G G GP GP G GP GP GP GP G G G GP G GP GP GP G G ELAVL1 DCAF12 19322201 biogrid exp G G G G GP GP G G GP G G G GP GP G GP GP GP GP G G G GP GP GP G GP G G DCAF12 NKD1 19888210 i2d exp G G G G G G G G G P G DVL2 DCAF12 19888210 i2d exp G G G G GP GP G G GP G G G GP GP G GP GP GP GP G G G GP GP GP GP GP G G BMPR1B DCAF12 15761153 hprd,i2d exp, ortho G G G GP GP G G GP G G GP G GP GP GP GP G G P GP GP GP GP G G DCAF12 DDA1 19295130, 25402006 biogrid exp, pred G G G G GP GP G G GP G G G GP G GP GP GP P G G G GP GP GP GP GP G G DCAF12 COPS5 21145461, 25402006 biogrid exp, pred G G G G GP GP G G GP G G G GP GP G GP GP GP GP G G G GP GP GP GP GP G G CUL4A DCAF12 21145461,16964240, 25402006 innatedb,biogrid exp, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G DDB1 DCAF12 19966799,16949367,16964240, 25402006 biogrid,dip exp, pred G G G G GP GP G G GP G G G GP GP G GP GP GP GP G G G GP GP GP GP GP G G CCT4 DCAF12 ortho G G G G G GP G G GP G G G G GP G G GP GP G G G G G G G G GP G G CCT8 DCAF12 ortho G G G G GP GP G G GP G G G GP GP G GP GP GP GP G G G GP GP GP GP GP G G CCT3 DCAF12 ortho G G G G GP GP G G GP G G G GP GP G GP GP GP GP G G G GP GP GP GP GP G G ERCC8 DCAF12 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G DCAF12 COPS7B 25402006 pred G G G G GP GP G G GP G G G GP GP G GP GP GP GP G G G GP GP GP GP GP G G UBXN1 DCAF12 25402006 pred G G G G G GP G G GP G G G GP GP G GP GP GP GP G G G G GP GP GP GP G G CUL4B DCAF12 25402006 pred G G G G GP GP G G GP G G G G GP G GP GP G GP G G G GP GP GP GP GP G G DCAF12 DCAF16 25402006 pred G G G G G GP G G GP G G G G G G G GP G G G G G GP G G G GP G G DCAF12 RFWD3 23023127 pred G G G G G G G G G G G G G G G G G G DCAF17 DCAF12 25402006 pred G GP G G G G G GP G G G G G GP G DCAF12 RFWD2 25402006 pred G G G G G GP G G GP G G G G G G G GP G G G G G G G G G GP G G DCAF12 DCAF5 25402006 pred G G G G GP GP G G GP G G G GP GP G GP GP GP GP G G G GP G GP GP GP G G DCAF12 DDIT4 25402006 pred G G G G GP GP G G GP G G G GP GP G GP GP GP GP G G G GP GP GP GP GP G G MAP3K1 DCAF12 25402006 pred G G G G GP GP G G GP G G G GP GP G GP GP GP GP G G G GP GP GP GP GP G G CDKN1A DCAF12 25402006 pred G G G G GP G G G GP G G G GP G G GP G G G G G G G G GP G G G G DCAF12 CDT1 25402006 pred G GP P G GP P P GP P GP GP G P P GP P GP G DCAF12 AMBRA1 25402006 pred G G G G GP GP G G GP G G G GP G G GP GP G P G G G GP GP GP G GP G G DCAF12 DTL 25402006 pred G GP P G P P G P GP P P G G G G DCAF7 DCAF12 25402006 pred G G G G GP GP G G GP G G G GP GP G GP GP GP GP G G G GP GP GP GP GP G G DCAF12 DDB2 25402006 pred G G G G GP GP G G GP G G G GP GP G GP GP GP GP G G G GP GP G GP G G DCAF12 WDTC1 25402006 pred G G G G GP GP G G GP G G G GP GP G GP GP GP GP G G G GP GP GP G GP G G DCAF12 DCAF4 25402006 pred G G G G G GP G G GP G G G GP GP G GP GP GP GP G G G GP G GP G GP G G TLE2 DCAF12 25402006 pred G G G G G GP G G GP G G G GP GP G GP GP G GP G G G G GP GP G GP G G DCAF12 TRPC4AP 25402006 pred G G G G GP GP G G GP G G G GP G G GP GP GP GP G G G GP G GP GP GP G G DCAF10 DCAF12 25402006 pred G G G G G GP G G G G G G GP G G G GP G G G G G G GP G G GP G G DCAF6 DCAF12 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G DCAF12 PHIP 25402006 pred G G G G G GP G G GP G G G GP GP G GP GP GP GP G G G GP GP GP G GP G G DCAF12 DCAF11 25402006 pred G G G G GP GP G G GP G G G GP GP G GP GP GP GP G G G GP GP GP GP GP G G DCAF12 TRAF7 23023127 pred G G G G G GP G G GP G G G GP G G GP GP G G G G G GP GP GP G GP G G DCAF12 DCAF8 25402006, 23023127 pred G G G G GP GP G G GP G G G GP GP G GP GP GP GP G G G GP GP GP GP GP G G DCAF12 VPRBP 25402006 pred G G G G GP GP G G GP G G G GP GP G GP GP GP GP G G G GP G GP GP GP G G DCAF12 DET1 25402006 pred G G G G GP GP G G G G G G GP GP G GP GP G GP G G G G GP GP G GP G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q16531 Q5T6F0 affinity chromatography technology 16949367 physical association X 2 Q16531 Q5T6F0 affinity chromatography technology 16964240 physical association X 2 Q16531 Q5T6F0 affinity chromatography technology 16949367 physical association X 2 A0A024R7W9 Q5T6F0 affinity chromatography technology 21145461 physical association X 2 Q3U1J4 Q5T6F0 affinity chromatography technology 20360068 physical association X 2 Q5T6F0 B2RBV7 affinity chromatography technology 21145461 physical association X 2 Q5T6F0 B2RBV7 affinity chromatography technology 16964240 physical association X 2 Q7L5N1 Q5T6F0 affinity chromatography technology 21145461 physical association X 2 P0CG48 Q5T6F0 affinity chromatography technology 21139048 physical association X 2 P0CG48 Q5T6F0 affinity chromatography technology 21906983 physical association X 2 Q5T6F0 Q9BW61 affinity chromatography technology 19295130 physical association X 2 Q5T6F0 x-ray crystallography 19966799 direct interaction X 2 O00238 Q5T6F0 in vivo 15761153 - X 2 O00238 Q5T6F0 in vivo 15761153 - X 2 P36897-3 Q5T6F0 in vivo 15761153 - X 2 P36897-3 Q5T6F0 in vivo 15761153 - X 2 Q5T6F0 tandem affinity purification 20360068 physical association C 32 Q5NFY6 Q5T6F0 two hybrid pooling approach 20711500 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B UBC DCAF12 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 21139048,21906983 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_181022|BIOGRID_171874 bait|bait prey|prey DCAF12 COPS6 MI:0004(affinity chromatography technology) 21145461 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_205714 prey bait CUL4A DCAF12 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 16964240,21145461 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_202931|BIOGRID_122527 bait|bait prey|prey DCAF12 DDA1 MI:0004(affinity chromatography technology) 19295130 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_221650 prey bait TGFBR1 DCAF12 MI:0493(in vivo) 15761153 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_18076 - - NRF1 DCAF12 MI:0428(imaging technique) 24250222 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_295281 bait prey DCAF12 COPS5 MI:0004(affinity chromatography technology) 21145461 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_205652 prey bait DDB1 DCAF12 MI:0114(x-ray crystallography)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 16949367,16964240,19966799 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) MI:0465(dip)|(biogrid)|(biogrid)|(biogrid) DIP_55184|BIOGRID_122854|BIOGRID_122500|BIOGRID_122882 -|bait|bait|prey -|prey|prey|bait BMPR1B DCAF12 MI:0493(in vivo) 15761153 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_17436 - - ELAVL1 DCAF12 MI:0096(pull down) 19322201 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_187419 bait prey

PPI - HINT Gene A Gene B PMID Method Quality CUL4A DCAF12 16964240,21145461 0004,0004 LC,HT DDB1 DCAF12 16949367,16964240,16949367 0004,0004,0096 LC DCAF12 COPS6 21145461 0004 HT DCAF12 COPS5 21145461 0004 HT CUL4A DCAF12 21145461 0004 HT DCAF12 COPS6 21145461 0004 HT DCAF12 COPS5 21145461 0004 HT CUL4A DCAF12 16964240 0004 LC DDB1 DCAF12 16949367,16964240,16949367 0004,0004,0096 LC BMPR1B DCAF12 15761153 0019 HT TGFBR1 DCAF12 15761153 0019 HT DDB1 DCAF12 19966799 0114 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q5T6F0 Q5NFY6 DCAF12 Q5NFY6 0.126 20711500 Q5T6F0 Q16531 DCAF12 DDB1 0.539 16964240,19966799,16949367 Q7L5N1 Q5T6F0 COPS6 DCAF12 0.126 21145461 Q5T6F0 Q13619 DCAF12 CUL4A 0.236 16964240,21145461 Q5T6F0 Q3U1J4 DCAF12 DDB1 0.416 26496610,20360068 Q92905 Q5T6F0 COPS5 DCAF12 0.126 21145461 Q9BW61 Q5T6F0 DDA1 DCAF12 0.126 19295130 Q5T6F0 Q15717 DCAF12 ELAVL1 0.126 19322201

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 BMPR1B DCAF12 MI:0045 experimental interaction detection MI:0461 interaction database UBC DCAF12 MI:0045 experimental interaction detection MI:0461 interaction database TGFBR1 DCAF12 MI:0045 experimental interaction detection MI:0461 interaction database CCT3 DCAF12 MI:0362 inference MI:0461 interaction database CCT8 DCAF12 MI:0362 inference MI:0461 interaction database CCT4 DCAF12 MI:0362 inference MI:0461 interaction database CUL4A DCAF12 MI:0045 experimental interaction detection MI:0461 interaction database ELAVL1 DCAF12 MI:0045 experimental interaction detection MI:0461 interaction database DDB1 DCAF12 MI:0045 experimental interaction detection MI:0461 interaction database DCAF12 COPS6 MI:0045 experimental interaction detection MI:0461 interaction database DCAF12 COPS5 MI:0045 experimental interaction detection MI:0461 interaction database DCAF12 DDA1 MI:0045 experimental interaction detection MI:0461 interaction database