PTM - dbPAF Gene Name UniProt ID Position Type Species MAP3K3; MAPKKK3; MEKK3 Q99759 129 S Homo sapiens(Human) MAP3K3; MAPKKK3; MEKK3 Q99759 130 S Homo sapiens(Human) MAP3K3; MAPKKK3; MEKK3 Q99759 131 S Homo sapiens(Human) MAP3K3; MAPKKK3; MEKK3 Q99759 145 S Homo sapiens(Human) MAP3K3; MAPKKK3; MEKK3 Q99759 147 S Homo sapiens(Human) MAP3K3; MAPKKK3; MEKK3 Q99759 155 Y Homo sapiens(Human) MAP3K3; MAPKKK3; MEKK3 Q99759 162 S Homo sapiens(Human) MAP3K3; MAPKKK3; MEKK3 Q99759 166 S Homo sapiens(Human) MAP3K3; MAPKKK3; MEKK3 Q99759 168 S Homo sapiens(Human) MAP3K3; MAPKKK3; MEKK3 Q99759 169 S Homo sapiens(Human) MAP3K3; MAPKKK3; MEKK3 Q99759 175 S Homo sapiens(Human) MAP3K3; MAPKKK3; MEKK3 Q99759 176 S Homo sapiens(Human) MAP3K3; MAPKKK3; MEKK3 Q99759 194 S Homo sapiens(Human) MAP3K3; MAPKKK3; MEKK3 Q99759 197 S Homo sapiens(Human) MAP3K3; MAPKKK3; MEKK3 Q99759 234 S Homo sapiens(Human) MAP3K3; MAPKKK3; MEKK3 Q99759 237 S Homo sapiens(Human) MAP3K3; MAPKKK3; MEKK3 Q99759 250 S Homo sapiens(Human) MAP3K3; MAPKKK3; MEKK3 Q99759 274 T Homo sapiens(Human) MAP3K3; MAPKKK3; MEKK3 Q99759 275 Y Homo sapiens(Human) MAP3K3; MAPKKK3; MEKK3 Q99759 288 Y Homo sapiens(Human) MAP3K3; MAPKKK3; MEKK3 Q99759 289 S Homo sapiens(Human) MAP3K3; MAPKKK3; MEKK3 Q99759 294 T Homo sapiens(Human) MAP3K3; MAPKKK3; MEKK3 Q99759 311 S Homo sapiens(Human) MAP3K3; MAPKKK3; MEKK3 Q99759 312 S Homo sapiens(Human) MAP3K3; MAPKKK3; MEKK3 Q99759 314 S Homo sapiens(Human) MAP3K3; MAPKKK3; MEKK3 Q99759 316 S Homo sapiens(Human) MAP3K3; MAPKKK3; MEKK3 Q99759 317 T Homo sapiens(Human) MAP3K3; MAPKKK3; MEKK3 Q99759 337 S Homo sapiens(Human) MAP3K3; MAPKKK3; MEKK3 Q99759 340 S Homo sapiens(Human) MAP3K3; MAPKKK3; MEKK3 Q99759 345 S Homo sapiens(Human) MAP3K3; MAPKKK3; MEKK3 Q99759 353 T Homo sapiens(Human) MAP3K3; MAPKKK3; MEKK3 Q99759 355 S Homo sapiens(Human) MAP3K3; MAPKKK3; MEKK3 Q99759 357 S Homo sapiens(Human) MAP3K3; MAPKKK3; MEKK3 Q99759 384 T Homo sapiens(Human) MAP3K3; MAPKKK3; MEKK3 Q99759 427 Y Homo sapiens(Human) MAP3K3; MAPKKK3; MEKK3 Q99759 428 Y Homo sapiens(Human) MAP3K3; MAPKKK3; MEKK3 Q99759 445 Y Homo sapiens(Human) MAP3K3; MAPKKK3; MEKK3 Q99759 464 S Homo sapiens(Human) MAP3K3; MAPKKK3; MEKK3 Q99759 511 S Homo sapiens(Human) MAP3K3; MAPKKK3; MEKK3 Q99759 516 T Homo sapiens(Human) MAP3K3; MAPKKK3; MEKK3 Q99759 520 S Homo sapiens(Human) MAP3K3; MAPKKK3; MEKK3 Q99759 526 S Homo sapiens(Human) MAP3K3; MAPKKK3; MEKK3 Q99759 528 T Homo sapiens(Human) MAP3K3; MAPKKK3; MEKK3 Q99759 530 T Homo sapiens(Human)

PTM - PhosphositePlus UniProt ID MOD_RSD Type SITE_+/-7_AA Q99759 S130-p Phosphorylation QDRNHNSssPHSGVS Q99759 S131-p Phosphorylation DRNHNSssPHSGVSR Q99759 S145-p Phosphorylation RQVRIKAsQsAGDIN Q99759 S147-p Phosphorylation VRIKAsQsAGDINTI Q99759 Y155-p Phosphorylation AGDINTIyQPPEPRs Q99759 S162-p Phosphorylation yQPPEPRsRHLsVss Q99759 S166-p Phosphorylation EPRsRHLsVssQNPG Q99759 S168-p Phosphorylation RsRHLsVssQNPGRs Q99759 S169-p Phosphorylation sRHLsVssQNPGRss Q99759 S175-p Phosphorylation ssQNPGRssPPPGYV Q99759 S176-p Phosphorylation sQNPGRssPPPGYVP Q99759 S194-p Phosphorylation QHIARQGsYTSINSE Q99759 S234-p Phosphorylation SCQSLDRsADsPSFR Q99759 S237-p Phosphorylation SLDRsADsPSFRKSR Q99759 S250-p Phosphorylation SRMSRAQsFPDNRQE Q99759 T263-p Phosphorylation QEYSDREtQLyDKGV Q99759 Y266-p Phosphorylation SDREtQLyDKGVKGG Q99759 T274-p Phosphorylation DKGVKGGtyPRRYHV Q99759 Y275-p Phosphorylation KGVKGGtyPRRYHVS Q99759 Y288-p Phosphorylation VSVHHKDysDGRRtF Q99759 S289-p Phosphorylation SVHHKDysDGRRtFP Q99759 T294-p Phosphorylation DysDGRRtFPRIRRH Q99759 S312-p Phosphorylation LFTLVPSsRsLstNG Q99759 S314-p Phosphorylation TLVPSsRsLstNGEN Q99759 S316-p Phosphorylation VPSsRsLstNGENMG Q99759 T317-p Phosphorylation PSsRsLstNGENMGL Q99759 S337-p Phosphorylation DPRGRLRsADsENAL Q99759 S340-p Phosphorylation GRLRsADsENALsVQ Q99759 S345-p Phosphorylation ADsENALsVQERNVP Q99759 S355-p Phosphorylation ERNVPTKsPsAPINW Q99759 S357-p Phosphorylation NVPTKsPsAPINWRR Q99759 S464-p Phosphorylation AYGALTEsVTRKYTR Q99759 T516-p Phosphorylation GASKRLQtICMsGTG Q99759 S520-p Phosphorylation RLQtICMsGTGMRsV Q99759 S526-p Phosphorylation MsGTGMRsVtGtPYW Q99759 T528-p Phosphorylation GTGMRsVtGtPYWMS Q99759 T530-p Phosphorylation GMRsVtGtPYWMSPE

PTM - dbPTM UniProt ID Position Code Type Resources References Q99759 129 S Phosphorylation Swiss-Prot 1010711 19369195 Q99759 130 S Phosphorylation Swiss-Prot 1010711 19369195 Q99759 131 S Phosphorylation Swiss-Prot 1010711 18691976 Q99759 145 S Phosphorylation Swiss-Prot 1010711 19369195 Q99759 147 S Phosphorylation Swiss-Prot 1010711 19369195 Q99759 166 S Phosphorylation Swiss-Prot 1010711 12761204;18220336;18691976;19369195 Q99759 168 S Phosphorylation Swiss-Prot 1010711 19369195 Q99759 175 S Phosphorylation Swiss-Prot 1010711 19369195 Q99759 176 S Phosphorylation Swiss-Prot 1010711 19369195 Q99759 234 S Phosphorylation Swiss-Prot 1010711 18691976 Q99759 237 S Phosphorylation Swiss-Prot 1010711 18691976;19369195 Q99759 250 S Phosphorylation Swiss-Prot 1010711 18691976;19369195 Q99759 288 Y Phosphorylation Swiss-Prot 1010711 17924679 Q99759 289 S Phosphorylation Swiss-Prot 1010711 17924679 Q99759 294 T Phosphorylation Swiss-Prot 1010711 17924679 Q99759 311 S Phosphorylation Swiss-Prot 1010711 19369195 Q99759 314 S Phosphorylation Swiss-Prot 1010711 19369195 Q99759 316 S Phosphorylation Swiss-Prot 1010711 19369195 Q99759 317 T Phosphorylation Swiss-Prot 1010711 19369195 Q99759 337 S Phosphorylation Swiss-Prot 1010711 12761204;18691976;19369195;19690332 Q99759 340 S Phosphorylation Swiss-Prot 1010711 18691976;19369195;19413330;19690332 Q99759 353 T Phosphorylation Swiss-Prot 1010711 19369195 Q99759 355 S Phosphorylation Swiss-Prot 1010711 18691976;19369195 Q99759 464 S Phosphorylation Swiss-Prot 1010711 19369195 Q99759 526 S Phosphorylation Swiss-Prot 1010711 19369195 Q99759 166 S Phosphorylation PhosphoELM.10011 18220336;12392720;12761204 Q99759 337 S Phosphorylation PhosphoELM.10011 12392720;12761204 Q99759 130 S Phosphorylation Phosphositeplus.1010730 19369195 Q99759 131 S Phosphorylation Phosphositeplus.1010730 18691976 Q99759 145 S Phosphorylation Phosphositeplus.1010730 19369195 Q99759 147 S Phosphorylation Phosphositeplus.1010730 19369195 Q99759 166 S Phosphorylation Phosphositeplus.1010730 18220336;18691976;19276368;19369195;20363803;22115753 Q99759 175 S Phosphorylation Phosphositeplus.1010730 20058876 Q99759 176 S Phosphorylation Phosphositeplus.1010730 19369195;20058876 Q99759 234 S Phosphorylation Phosphositeplus.1010730 18691976 Q99759 237 S Phosphorylation Phosphositeplus.1010730 18691976;19369195 Q99759 250 S Phosphorylation Phosphositeplus.1010730 18691976;19369195;20363803;22115753 Q99759 316 S Phosphorylation Phosphositeplus.1010730 19369195;19690332 Q99759 337 S Phosphorylation Phosphositeplus.1010730 18691976;19369195;19690332;20363803 Q99759 340 S Phosphorylation Phosphositeplus.1010730 18691976;19369195;19690332;20363803;21659604;22115753 Q99759 355 S Phosphorylation Phosphositeplus.1010730 18691976;19369195;20363803 Q99759 357 S Phosphorylation Phosphositeplus.1010730 20363803 Q99759 464 S Phosphorylation Phosphositeplus.1010730 19369195 Q99759 520 S Phosphorylation Phosphositeplus.1010730 20068038;20448038 Q99759 526 S Phosphorylation Phosphositeplus.1010730 19369195;20068038 Q99759 317 T Phosphorylation Phosphositeplus.1010730 19369195 Q99759 516 T Phosphorylation Phosphositeplus.1010730 20068038;20448038 Q99759 427 Y Phosphorylation Phosphositeplus.1010730 18083107 Q99759 428 Y Phosphorylation Phosphositeplus.1010730 18083107 Q99759 445 Y Phosphorylation Phosphositeplus.1010730 18083107 Q99759 130 S Phosphorylation HPRD 9.0 18691976 Q99759 131 S Phosphorylation HPRD 9.0 18691976 Q99759 145 S Phosphorylation HPRD 9.0 18691976 Q99759 162 S Phosphorylation HPRD 9.0 18691976 Q99759 168 S Phosphorylation HPRD 9.0 18691976 Q99759 175 S Phosphorylation HPRD 9.0 18691976,20058876 Q99759 176 S Phosphorylation HPRD 9.0 18691976 Q99759 176 S Phosphorylation HPRD 9.0 20058876 Q99759 234 S Phosphorylation HPRD 9.0 18691976 Q99759 237 S Phosphorylation HPRD 9.0 18691976 Q99759 250 S Phosphorylation HPRD 9.0 18691976 Q99759 289 S Phosphorylation HPRD 9.0 17924679 Q99759 314 S Phosphorylation HPRD 9.0 18691976 Q99759 340 S Phosphorylation HPRD 9.0 19413330,18691976 Q99759 345 S Phosphorylation HPRD 9.0 18691976 Q99759 355 S Phosphorylation HPRD 9.0 18691976 Q99759 294 T Phosphorylation HPRD 9.0 17924679 Q99759 353 T Phosphorylation HPRD 9.0 18691976 Q99759 384 T Phosphorylation HPRD 9.0 18691976 Q99759 288 Y Phosphorylation HPRD 9.0 17924679 Q99759 526 S Phosphorylation (MAP3K3) HPRD 9.0 16407301 Q99759 166 S Phosphorylation (PRKACA) HPRD 9.0 12392720,18691976,19651622 Q99759 197 S Phosphorylation (PRKACA) HPRD 9.0 12392720,18691976,19651622 Q99759 337 S Phosphorylation (PRKACA) HPRD 9.0 12392720,18691976 Q99759 162 S Phosphorylation SysPTM 1.1 18691976 Q99759 197 S Phosphorylation SysPTM 1.1 18691976 Q99759 355 S Phosphorylation SysPTM 1.1 18691976 Q99759 234 S Phosphorylation SysPTM 1.1 18691976 Q99759 237 S Phosphorylation SysPTM 1.1 18691976 Q99759 250 S Phosphorylation SysPTM 1.1 18691976 Q99759 337 S Phosphorylation SysPTM 1.1 18691976 Q99759 340 S Phosphorylation SysPTM 1.1 18691976

PTM - HPRD Symbol Position Code Type References MAP3K3 130 S Phosphorylation 18691976 MAP3K3 131 S Phosphorylation 18691976 MAP3K3 145 S Phosphorylation 18691976 MAP3K3 161 S Phosphorylation 18691976 MAP3K3 162 S Phosphorylation 18691976 MAP3K3 166 S Phosphorylation 12392720,18691976,19651622 MAP3K3 168 S Phosphorylation 18691976 MAP3K3 175 S Phosphorylation 18691976,20058876 MAP3K3 176 S Phosphorylation 18691976 MAP3K3 176 S Phosphorylation 20058876 MAP3K3 197 S Phosphorylation 12392720,18691976,19651622 MAP3K3 199 S Phosphorylation 18691976 MAP3K3 206 S Phosphorylation 18691976,20058876 MAP3K3 207 S Phosphorylation 20058876 MAP3K3 234 S Phosphorylation 18691976 MAP3K3 237 S Phosphorylation 18691976 MAP3K3 250 S Phosphorylation 18691976 MAP3K3 265 S Phosphorylation 18691976 MAP3K3 268 S Phosphorylation 18691976 MAP3K3 281 S Phosphorylation 18691976 MAP3K3 288 Y Phosphorylation 17924679 MAP3K3 289 S Phosphorylation 17924679 MAP3K3 294 T Phosphorylation 17924679 MAP3K3 314 S Phosphorylation 18691976 MAP3K3 319 Y Phosphorylation 17924679 MAP3K3 320 S Phosphorylation 17924679 MAP3K3 325 T Phosphorylation 17924679 MAP3K3 337 S Phosphorylation 12392720,18691976 MAP3K3 340 S Phosphorylation 19413330,18691976 MAP3K3 345 S Phosphorylation 18691976 MAP3K3 353 T Phosphorylation 18691976 MAP3K3 355 S Phosphorylation 18691976 MAP3K3 368 S Phosphorylation 12392720,18691976 MAP3K3 371 S Phosphorylation 19413330,18691976 MAP3K3 384 T Phosphorylation 18691976 MAP3K3 386 S Phosphorylation 18691976 MAP3K3 526 S Phosphorylation 16407301 MAP3K3 557 S Phosphorylation 16407301

PTM - Phospho.ELM UniProt Position Code PMIDs Kinase Source Type Q99759 337 S 12392720 LTP Phosphorylation Q99759 337 S 12761204 SGK_group LTP Phosphorylation Q99759 166 S 18220336 HTP Phosphorylation Q99759 166 S 12392720 LTP Phosphorylation Q99759 166 S 12761204 SGK_group LTP Phosphorylation

PTM - UniProt UniProt ID Position Type PMIDs Q99759 166 Phosphoserine; by SGK1 23186163;12761204 Q99759 250 Phosphoserine 18691976;19369195;23186163 Q99759 312 Phosphoserine 23186163 Q99759 337 Phosphoserine; by SGK1 18691976;19369195;19690332;23186163;12761204 Q99759 340 Phosphoserine 18691976;19369195;19690332;23186163

PTM - PHOSIDA Symbol Accession Code Position Surrounding Sequence Type MAP3K3 IPI00017801 S 130 DRNHNSpSSPHSGV phosphorylation MAP3K3 IPI00017801 S 131 RNHNSSpSPHSGVS phosphorylation MAP3K3 IPI00017801 S 145 QVRIKApSQSAGDI phosphorylation MAP3K3 IPI00017801 S 147 RIKASQpSAGDINT phosphorylation MAP3K3 IPI00017801 S 166 PRSRHLpSVSSQNP phosphorylation MAP3K3 IPI00017801 S 176 QNPGRSpSPPPGYV phosphorylation MAP3K3 IPI00017801 S 234 CQSLDRpSADSPSF phosphorylation MAP3K3 IPI00017801 S 237 LDRSADpSPSFRKS phosphorylation MAP3K3 IPI00017801 S 250 RMSRAQpSFPDNRQ phosphorylation MAP3K3 IPI00017801 S 316 PSSRSLpSTNGENM phosphorylation MAP3K3 IPI00017801 S 337 PRGRLRpSADSENA phosphorylation MAP3K3 IPI00017801 S 340 RLRSADpSENALSV phosphorylation MAP3K3 IPI00017801 S 355 RNVPTKpSPSAPIN phosphorylation MAP3K3 IPI00017801 S 464 YGALTEpSVTRKYT phosphorylation MAP3K3 IPI00017801 S 526 SGTGMRpSVTGTPY phosphorylation MAP3K3 IPI00017801 T 317 SSRSLSpTNGENMG phosphorylation

PTM - BioGRID Entrez Gene BioGRID ID Position Code Type PMIDs 4215 110379 - K Ubiquitination 19560753 4215 110379 - K Ubiquitination 19843958