PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus GTF2E1 TRIM15 20211142 biogrid exp P P G GP GP G P GP GP GP P P G GP GP G GP G GP GP P GP GP GP P G UBE2U TRIM15 19549727 biogrid,intact exp P P P P P P P P P P P P P P P P P P P IRF5 TRIM15 20211142 biogrid exp G GP GP G G G G P G G GP G G G G G G G G P G SNW1 TRIM15 20211142 biogrid exp P P G GP GP G P GP GP GP P P G GP GP G GP G GP GP P GP GP GP P G MED7 TRIM15 20211142 biogrid exp G G G G G G G G G G G G G G G G G G G PXN TRIM15 25015296 biogrid exp P P G GP GP G GP GP G P P G GP GP G GP G GP GP P G GP G P G ACD TRIM15 21044950 biogrid,intact exp P P G G GP G P GP GP GP P P G GP GP G GP G P GP P GP GP GP P G TRIM15 EHMT1 20211142 biogrid exp G G G G G G G G G G G G G G G G G G G TRIM8 TRIM15 22493164 biogrid,intact exp P P G GP GP G P GP GP GP P P G GP GP G GP G GP GP P GP GP GP P G FAM161A TRIM15 25416956 biogrid,intact exp P P GP G P GP GP P P P GP G GP G GP P P P GP MYBL2 TRIM15 20211142 biogrid exp P P G GP P P P P P P P GP P GP G P P P P GP GP P FAM151B TRIM15 25416956 biogrid,intact exp P P P P P P P P P P P P P P P P P P TINF2 TRIM15 21044950 biogrid,intact exp G G G G G G G G G G G G G G G G G G G TRIM15 TAF9B 20211142 biogrid exp P P G GP G G GP GP G P P G GP G G GP G GP GP P GP GP GP P G TRIM15 TRIM15 20211142 biogrid exp P P G GP GP G P GP GP GP P P G GP GP G GP G GP GP P GP GP GP P G TRIM15 TRIM10 25402006 pred G G G G G G G GP G G G G G G GP GP GP P G CRYBB3 TRIM15 25402006 pred P P P P P P P P P P P P P P TRIM15 GFRA4 25402006 pred TRIM15 CCRN4L 25402006 pred P G G GP G GP G G P G GP GP G GP G G G G GP GP P G TRIM15 CDHR5 25402006 pred GP GP GP GP GP TRIM15 KLK13 25402006 pred G GP GP G GP GP G P G GP GP G GP G GP GP P G GP GP P G NTF4 TRIM15 23023127 pred P P P P P G P GP P DSCAML1 TRIM15 23023127 pred P P GP P GP P GP GP GP G P P GP P P G GLP1R TRIM15 25402006 pred G G G G G G G G G G G G G G G G G G G RFPL4A TRIM15 23023127 pred P P P P P P P P P P P P P P P P P P P P SFRP2 TRIM15 23023127 pred G G GP G G G G G GP G G G P GP G G G G ALPI TRIM15 25402006 pred P P GP P P GP BMPR1A TRIM15 23023127 pred P P P GP G P GP GP GP P P G GP GP G GP G GP GP P GP GP GP P G NTF3 TRIM15 23023127 pred P P P P P GP P GP P P G GP P G GP P GP P G GP GP P G TRIM15 A1CF 25402006 pred P G G GP G P GP GP GP G GP GP G GP G G G G GP GP G ACVR2B TRIM15 23023127 pred P P G GP GP G P GP GP G G GP GP G GP G GP G G GP GP P G SFTPC TRIM15 25402006 pred G G G G G G G P G G G G G G G G G G G G BMPR2 TRIM15 23023127 pred P G G GP G P GP GP GP P P G GP GP G GP G G GP GP GP GP P G GAST TRIM15 25402006 pred G G G G G G G P G G G G G G G G G GP G NOTCH4 TRIM15 23023127 pred G G G G G G G G G G G G G G G G G G G FOXC2 TRIM15 23023127 pred G G G G G G G G G G G G G G G G MAPK11 TRIM15 25402006 pred P P G GP GP G P GP GP GP P P G P GP G GP G GP GP P GP P GP P G DNASE1 TRIM15 25402006 pred G G P GP G GP P P G G GP GP TRIM15 ZNF835 25402006 pred P P P G P P P P P P P P P P P P NCR2 TRIM15 25402006 pred G G G G G GP G G G G G G G G G G G G G

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B ACD TRIM15 MI:0018(two hybrid) 21044950 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_198469 bait prey IRF5 TRIM15 MI:0018(two hybrid) 20211142 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_128526 bait prey SNW1 TRIM15 MI:0018(two hybrid) 20211142 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_128870 bait prey TRIM15 EHMT1 MI:0018(two hybrid) 20211142 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_128933 prey bait MYBL2 TRIM15 MI:0018(two hybrid) 20211142 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_128554 bait prey TRIM15 TAF9B MI:0018(two hybrid) 20211142 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_128915 prey bait GTF2E1 TRIM15 MI:0018(two hybrid) 20211142 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_128421 bait prey TRIM15 TRIM8 MI:0415(enzymatic study)|MI:0397(two hybrid array) 22493164 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_283973|UniProt_122446 bait|prey prey|bait TRIM15 TINF2 MI:0018(two hybrid) 21044950 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_198406 prey bait UBE2U TRIM15 MI:0018(two hybrid)|MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_124517|UniProt_101524 bait|bait prey|prey MED7 TRIM15 MI:0018(two hybrid) 20211142 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_128816 bait prey

PPI - HINT Gene A Gene B PMID Method Quality MED7 TRIM15 20211142 0018 HT NCK2 TRIM15 25450970,25450970 0004,0090 LC PRNP TRIM15 25450970 0090 LC PFN1 TRIM15 25450970 0090 LC MYBL2 TRIM15 20211142 0018 HT SRC TRIM15 25450970,25450970 0004,0090 LC GTF2E1 TRIM15 20211142 0018 HT SHC1 TRIM15 25450970 0090 LC AKT1 TRIM15 25450970,25450970 0004,0090 LC SYK TRIM15 25450970 0090 LC CRK TRIM15 25450970,25450970 0004,0090 LC VASP TRIM15 25450970,25450970 0004,0090 LC NEXN TRIM15 25450970 0090 LC ROCK1 TRIM15 25450970 0090 LC IRF5 TRIM15 20211142 0018 HT SNW1 TRIM15 20211142 0018 HT KEAP1 TRIM15 25450970 0090 LC PS1TP5BP1 TRIM15 25450970 0090 LC FAM161A TRIM15 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT Q53HG7 TRIM15 25450970,25450970 0004,0090 LC UBE2U TRIM15 19549727,19549727 0397,0018 HT DKFZP666O0110 TRIM15 25450970 0090 LC CRSP9 TRIM15 20211142 0018 HT FAM151B TRIM15 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT FERMT3 TRIM15 25450970 0090 LC FBLIM1 TRIM15 25450970,25450970 0004,0090 LC FERMT2 TRIM15 25450970 0090 LC ACD TRIM15 21044950,21044950 0809,0018 HT CORO1B TRIM15 25450970,25450970 0004,0090 LC TINF2 TRIM15 21044950,21044950 0809,0018 HT TRIM8 TRIM15 22493164,22493164 0018,0397 HT TRIM15 TRIM15 20211142,25450970,25450970 0018,0004,0090 HT,LC TRIM15 EHMT1 20211142 0018 HT TRIM15 Q9HA84 25450970 0090 LC TRIM15 TAF9B 20211142 0018 HT TRIM15 RABGEF1 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT TRIM15 HEL70 25450970 0090 LC TRIM15 HEL113 25450970 0090 LC TRIM15 HEL-S-15 25450970 0090 LC TRIM15 HEL114 25450970 0090 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9C019 O43513 TRIM15 MED7 0.183 20211142 Q9H9B1 Q9C019 EHMT1 TRIM15 0.183 20211142 Q9HBM6 Q9C019 TAF9B TRIM15 0.183 20211142 Q9C019 P10244 TRIM15 MYBL2 0.183 20211142 Q9UJ41 Q9C019 RABGEF1 TRIM15 0.454 25416956 Q9UJ41 Q9C019 RABGEF1 TRIM15 0.454 25416956 Q9C019 O43639 TRIM15 NCK2 0.454 25450970 Q9C019 P50552 TRIM15 VASP 0.454 25450970 Q9C019 P12931 TRIM15 SRC 0.454 25450970 Q9C019 P31749 TRIM15 AKT1 0.454 25450970 Q9C019 P46108 TRIM15 CRK 0.454 25450970 Q9C019 Q14247 TRIM15 CTTN 0.454 25450970 Q9C019 Q9BZR9 TRIM15 TRIM8 0.286 22493164 Q9C019 Q8WUP2 TRIM15 FBLIM1 0.454 25450970 Q9C019 Q9BR76 TRIM15 CORO1B 0.454 25450970 Q9C019 Q9C019 TRIM15 TRIM15 0.597 20211142,25450970 Q9C019 Q96AP0 TRIM15 ACD 0.183 21044950 Q9C019 P29083 TRIM15 GTF2E1 0.183 20211142 Q9C019 Q9BSI4 TRIM15 TINF2 0.183 21044950 Q9C019 F7VJQ1 TRIM15 F7VJQ1 0.309 25450970 Q9C019 P04156 TRIM15 PRNP 0.309 25450970 Q9C019 P07737 TRIM15 PFN1 0.309 25450970 Q9C019 P08670 TRIM15 VIM 0.309 25450970 Q9C019 P18206 TRIM15 VCL 0.309 25450970 Q9C019 P23528 TRIM15 CFL1 0.309 25450970 Q9C019 P26038 TRIM15 MSN 0.309 25450970 Q9C019 P29353 TRIM15 SHC1 0.309 25450970 Q9C019 P43405 TRIM15 SYK 0.309 25450970 Q9C019 P60709 TRIM15 ACTB 0.309 25450970 Q9C019 Q05397 TRIM15 PTK2 0.309 25450970 Q9C019 Q0ZGT2 TRIM15 NEXN 0.309 25450970 Q9C019 Q13464 TRIM15 ROCK1 0.309 25450970 Q9C019 Q13480 TRIM15 GAB1 0.309 25450970 Q9C019 Q14145 TRIM15 KEAP1 0.309 25450970 Q9C019 Q3B820 TRIM15 FAM161A 0.454 25416956 Q9C019 Q5VVX9 TRIM15 UBE2U 0.286 19549727 Q9C019 Q6UXP7 TRIM15 FAM151B 0.454 25416956 Q9C019 Q86UX7 TRIM15 FERMT3 0.309 25450970 Q9C019 Q96AC1 TRIM15 FERMT2 0.309 25450970 Q9C019 Q13568 TRIM15 IRF5 0.183 20211142 Q9C019 Q13573 TRIM15 SNW1 0.183 20211142 Q9C019 P49023 TRIM15 PXN 0.569 25015296