PTM - CPLM Gene Name UniProt ID Type Position Code RACK1; GNB2L1; HLC7; PIG21 P63244 Acetylation 130 K RACK1; GNB2L1; HLC7; PIG21 P63244 Sumoylation 271 K RACK1; GNB2L1; HLC7; PIG21 P63244 Ubiquitination 130 K RACK1; GNB2L1; HLC7; PIG21 P63244 Ubiquitination 172 K RACK1; GNB2L1; HLC7; PIG21 P63244 Ubiquitination 175 K RACK1; GNB2L1; HLC7; PIG21 P63244 Ubiquitination 185 K RACK1; GNB2L1; HLC7; PIG21 P63244 Ubiquitination 257 K RACK1; GNB2L1; HLC7; PIG21 P63244 Ubiquitination 271 K RACK1; GNB2L1; HLC7; PIG21 P63244 Ubiquitination 12 K RACK1; GNB2L1; HLC7; PIG21 P63244 Ubiquitination 38 K RACK1; GNB2L1; HLC7; PIG21 P63244 Ubiquitination 44 K RACK1; GNB2L1; HLC7; PIG21 P63244 Ubiquitination 106 K RACK1; GNB2L1; HLC7; PIG21 P63244 Ubiquitination 139 K RACK1; GNB2L1; HLC7; PIG21 P63244 Ubiquitination 183 K RACK1; GNB2L1; HLC7; PIG21 P63244 Ubiquitination 225 K RACK1; GNB2L1; HLC7; PIG21 P63244 Ubiquitination 264 K RACK1; GNB2L1; HLC7; PIG21 P63244 Ubiquitination 212 K

PTM - dbPAF Gene Name UniProt ID Position Type Species RACK1; GNB2L1; HLC7; PIG21 P63244 10 T Homo sapiens(Human) RACK1; GNB2L1; HLC7; PIG21 P63244 110 S Homo sapiens(Human) RACK1; GNB2L1; HLC7; PIG21 P63244 128 T Homo sapiens(Human) RACK1; GNB2L1; HLC7; PIG21 P63244 134 T Homo sapiens(Human) RACK1; GNB2L1; HLC7; PIG21 P63244 146 S Homo sapiens(Human) RACK1; GNB2L1; HLC7; PIG21 P63244 157 S Homo sapiens(Human) RACK1; GNB2L1; HLC7; PIG21 P63244 160 S Homo sapiens(Human) RACK1; GNB2L1; HLC7; PIG21 P63244 161 S Homo sapiens(Human) RACK1; GNB2L1; HLC7; PIG21 P63244 167 S Homo sapiens(Human) RACK1; GNB2L1; HLC7; PIG21 P63244 194 Y Homo sapiens(Human) RACK1; GNB2L1; HLC7; PIG21 P63244 2 T Homo sapiens(Human) RACK1; GNB2L1; HLC7; PIG21 P63244 228 Y Homo sapiens(Human) RACK1; GNB2L1; HLC7; PIG21 P63244 24 T Homo sapiens(Human) RACK1; GNB2L1; HLC7; PIG21 P63244 242 S Homo sapiens(Human) RACK1; GNB2L1; HLC7; PIG21 P63244 246 Y Homo sapiens(Human) RACK1; GNB2L1; HLC7; PIG21 P63244 255 S Homo sapiens(Human) RACK1; GNB2L1; HLC7; PIG21 P63244 276 S Homo sapiens(Human) RACK1; GNB2L1; HLC7; PIG21 P63244 277 T Homo sapiens(Human) RACK1; GNB2L1; HLC7; PIG21 P63244 278 S Homo sapiens(Human) RACK1; GNB2L1; HLC7; PIG21 P63244 279 S Homo sapiens(Human) RACK1; GNB2L1; HLC7; PIG21 P63244 302 Y Homo sapiens(Human) RACK1; GNB2L1; HLC7; PIG21 P63244 313 T Homo sapiens(Human) RACK1; GNB2L1; HLC7; PIG21 P63244 316 T Homo sapiens(Human) RACK1; GNB2L1; HLC7; PIG21 P63244 39 T Homo sapiens(Human) RACK1; GNB2L1; HLC7; PIG21 P63244 46 T Homo sapiens(Human) RACK1; GNB2L1; HLC7; PIG21 P63244 50 T Homo sapiens(Human) RACK1; GNB2L1; HLC7; PIG21 P63244 52 Y Homo sapiens(Human) RACK1; GNB2L1; HLC7; PIG21 P63244 6 T Homo sapiens(Human) RACK1; GNB2L1; HLC7; PIG21 P63244 93 T Homo sapiens(Human) RACK1; GNB2L1; HLC7; PIG21 P63244 94 T Homo sapiens(Human) RACK1; GNB2L1; HLC7; PIG21 P63244 96 T Homo sapiens(Human) RACK1; GNB2L1; HLC7; PIG21 P63244 97 T Homo sapiens(Human)

PTM - PhosSNP Gene Name dbSNP ID Gene Mutation AA Mutation Mutation Position Code Peptide Score Modification Type RACK1; GNB2L1; HLC7; PIG21 rs11540199 ACG->GCG T->A 194 Y NHIGHTGYLNTVTVS 194 Phosphorylation: Tyk2 TypeIII-

PTM - PhosphositePlus UniProt ID MOD_RSD Type SITE_+/-7_AA P63244 K130-ac Acetylation GSRDKtIkLWNtLGV P63244 K172-ac Acetylation IVsCGWDkLVkVWNL P63244 K183-ac Acetylation VWNLANCkLkTNHIG P63244 R8-m1 Methylation MtEQMtLrGtLkGHN P63244 K12-m1 Methylation MtLrGtLkGHNGWVT P63244 R47-m1 Methylation IIMWkLtrDEtNyGI P63244 K172-m1 Methylation IVsCGWDkLVkVWNL P63244 R245-m1 Methylation ALCFSPNryWLCAAT P63244 K271-m2 Methylation kIIVDELkQEVIsTS P63244 K280-m1 Methylation EVIsTSSkAEPPQCT P63244 R317-m1 Methylation WQVtIGtr_______ P63244 T2-p Phosphorylation ______MtEQMtLrG P63244 T6-p Phosphorylation __MtEQMtLrGtLkG P63244 T10-p Phosphorylation EQMtLrGtLkGHNGW P63244 T24-p Phosphorylation WVTQIATtPQFPDMI P63244 T39-p Phosphorylation LSASRDktIIMWkLt P63244 T46-p Phosphorylation tIIMWkLtrDEtNyG P63244 T50-p Phosphorylation WkLtrDEtNyGIPQR P63244 Y52-p Phosphorylation LtrDEtNyGIPQRAL P63244 S63-p Phosphorylation QRALRGHsHFVSDVV P63244 T93-p Phosphorylation TLRLWDLttGtTTRR P63244 T94-p Phosphorylation LRLWDLttGtTTRRF P63244 T96-p Phosphorylation LWDLttGtTTRRFVG P63244 S110-p Phosphorylation GHTkDVLsVAFSSDN P63244 T128-p Phosphorylation VSGSRDKtIkLWNtL P63244 T134-p Phosphorylation KtIkLWNtLGVCkYT P63244 S146-p Phosphorylation kYTVQDEsHSEWVSC P63244 S157-p Phosphorylation WVSCVRFsPNSsNPI P63244 S161-p Phosphorylation VRFsPNSsNPIIVsC P63244 S167-p Phosphorylation SsNPIIVsCGWDkLV P63244 Y194-p Phosphorylation NHIGHTGyLNTVTVS P63244 Y228-p Phosphorylation LNEGkHLyTLDGGDI P63244 Y246-p Phosphorylation LCFSPNryWLCAATG P63244 S255-p Phosphorylation LCAATGPsIkIWDLE P63244 S276-p Phosphorylation ELkQEVIsTSSkAEP P63244 Y302-p Phosphorylation GQTLFAGyTDNLVRV P63244 T313-p Phosphorylation LVRVWQVtIGtr___ P63244 T316-p Phosphorylation VWQVtIGtr______ P63244 K130-sm Sumoylation GSRDKtIkLWNtLGV P63244 K271-sm Sumoylation kIIVDELkQEVIsTS P63244 K12-ub Ubiquitination MtLrGtLkGHNGWVT P63244 K38-ub Ubiquitination ILSASRDktIIMWkL P63244 K44-ub Ubiquitination DktIIMWkLtrDEtN P63244 K106-ub Ubiquitination RRFVGHTkDVLsVAF P63244 K130-ub Ubiquitination GSRDKtIkLWNtLGV P63244 K139-ub Ubiquitination WNtLGVCkYTVQDEs P63244 K172-ub Ubiquitination IVsCGWDkLVkVWNL P63244 K175-ub Ubiquitination CGWDkLVkVWNLANC P63244 K183-ub Ubiquitination VWNLANCkLkTNHIG P63244 K185-ub Ubiquitination NLANCkLkTNHIGHT P63244 K212-ub Ubiquitination SLCASGGkDGQAMLW P63244 K225-ub Ubiquitination LWDLNEGkHLyTLDG P63244 K257-ub Ubiquitination AATGPsIkIWDLEGk P63244 K264-ub Ubiquitination kIWDLEGkIIVDELk P63244 K271-ub Ubiquitination kIIVDELkQEVIsTS P63244 K280-ub Ubiquitination EVIsTSSkAEPPQCT

PTM - dbPTM UniProt ID Position Code Type Resources References P63244 130 K Acetylation Swiss-Prot 1010711 19608861 P63244 228 Y Phosphorylation Swiss-Prot 1010711 15592455 P63244 2 T Acetylation Swiss-Prot 1010711 - P63244 228 Y Phosphorylation PhosphoELM.10011 12400005 P63244 246 Y Phosphorylation PhosphoELM.10011 12400005 P63244 194 Y Phosphorylation PhosphoELM.10011 15240704 P63244 106 K Ubiquitylation Phosphositeplus.1010730 21890473;21906983 P63244 12 K Ubiquitylation Phosphositeplus.1010730 21890473;21906983 P63244 130 K Ubiquitylation Phosphositeplus.1010730 20639865;21890473;21906983 P63244 139 K Ubiquitylation Phosphositeplus.1010730 21890473;21906983 P63244 172 K Ubiquitylation Phosphositeplus.1010730 20639865;21890473 P63244 175 K Ubiquitylation Phosphositeplus.1010730 20639865;21890473;21906983 P63244 183 K Ubiquitylation Phosphositeplus.1010730 21890473;21906983 P63244 185 K Ubiquitylation Phosphositeplus.1010730 20639865 P63244 257 K Ubiquitylation Phosphositeplus.1010730 20639865;21890473;21906983 P63244 264 K Ubiquitylation Phosphositeplus.1010730 21906983 P63244 271 K Ubiquitylation Phosphositeplus.1010730 20639865;21890473;21906983 P63244 38 K Ubiquitylation Phosphositeplus.1010730 21890473;21906983 P63244 44 K Ubiquitylation Phosphositeplus.1010730 21890473 P63244 130 K Acetylation Phosphositeplus.1010730 19608861 P63244 146 S Phosphorylation Phosphositeplus.1010730 17965024 P63244 2 T Phosphorylation Phosphositeplus.1010730 20058876;20363803 P63244 313 T Phosphorylation Phosphositeplus.1010730 20068231 P63244 316 T Phosphorylation Phosphositeplus.1010730 20068231 P63244 6 T Phosphorylation Phosphositeplus.1010730 20068231 P63244 194 Y Phosphorylation Phosphositeplus.1010730 15240704 P63244 228 Y Phosphorylation Phosphositeplus.1010730 12400005;15592455;21685945;22174419 P63244 246 Y Phosphorylation Phosphositeplus.1010730 12400005;16849317;17574549;20090780;21685945;22174419;22523568 P63244 302 Y Phosphorylation Phosphositeplus.1010730 18567578 P63244 52 Y Phosphorylation Phosphositeplus.1010730 19423701 P63244 130 K Acetylation HPRD 9.0 19608861 P63244 2 T Acetylation HPRD 9.0 19413330 P63244 2 T Phosphorylation HPRD 9.0 20058876 P63244 6 T Phosphorylation HPRD 9.0 20068231 P63244 313 T Phosphorylation HPRD 9.0 20068231 P63244 316 T Phosphorylation HPRD 9.0 18767875,20068231 P63244 228 Y Phosphorylation HPRD 9.0 15592455 P63244 249 C S-Nitrosylation HPRD 9.0 18335467 P63244 138 C S-nitrosylation dbSNO 1.0 19483679 P63244 168 C S-nitrosylation dbSNO 1.0 19483679 P63244 182 C S-nitrosylation dbSNO 1.0 19483679 P63244 249 C S-nitrosylation dbSNO 1.0 18335467;19366988;19483679 P63244 249 C S-nitrosylation SysPTM 1.1 18335467

PTM - HPRD Symbol Position Code Type References GNB2L1 130 K Acetylation 19608861 GNB2L1 2 T Acetylation 19413330 GNB2L1 2 T Phosphorylation 20058876 GNB2L1 228 Y Phosphorylation 15592455 GNB2L1 249 C S-Nitrosylation 18335467 GNB2L1 313 T Phosphorylation 20068231 GNB2L1 316 T Phosphorylation 18767875,20068231 GNB2L1 6 T Phosphorylation 20068231

PTM - Phospho.ELM UniProt Position Code PMIDs Kinase Source Type P63244 194 Y 15240704 Tyk2 LTP Phosphorylation P63244 246 Y 12400005 SRC LTP Phosphorylation P63244 228 Y 12400005 SRC LTP Phosphorylation

PTM - UniProt UniProt ID Position Type PMIDs P63244 1 N-acetylmethionine 22814378 P63244 6 Phosphothreonine 23186163 P63244 10 Phosphothreonine 23186163 P63244 52 Phosphotyrosine; by ABL1 19423701 P63244 96 Phosphothreonine 23186163 P63244 130 N6-acetyllysine 19608861 P63244 228 Phosphotyrosine 11279199 P63244 276 Phosphoserine 23186163

PTM - BioGRID Entrez Gene BioGRID ID Position Code Type PMIDs 10399 115671 - K Ubiquitination 16196087 10399 115671 - K Ubiquitination 20639865 10399 115671 - K Ubiquitination 18781797 10399 115671 - K Ubiquitination 21987572 10399 115671 - K Ubiquitination 21139048 10399 115671 - K Ubiquitination 21890473 10399 115671 - K Ubiquitination 21906983 10399 115671 - K Sumoylation 16236267 10399 115671 - K Ubiquitination 22053931 10399 115671 - K Ubiquitination 22505724 10399 115671 - K FAT10ylation 22797925 10399 115671 - K Sumoylation 23077236 10399 115671 - K Ubiquitination 21963094 10399 115671 - K Ubiquitination 23000965 10399 115671 - K Sumoylation 25027693 10399 115671 - K Ubiquitination 25015289 10399 115671 - K Ubiquitination 25147182 10399 115671 - K Sumoylation 25391492 10399 115671 - K Neddylation 18247557

PTM - mUbiSiDa Gene Name Species Ubiquitination Site Ubiquitination Sequence Evidence PMID GNB2L1 Homo sapiens (Human) 38; 12; 44 "38,LSASRDKTIIMWK; 12,TLRGTLKGHNGWV; 44,KTIIMWKLTRDET" 38:21890473; 12:21890473; 44:21890473 GNB2L1 Homo sapiens (Human) 154; 101; 143; 110; 9; 77; 146; 15 "154,WNLANCKLKTNHI; 101,SRDKTIKLWNTLG; 143,VSCGWDKLVKVWN; 110,NTLGVCKYTVQDE; 9,LSASRDKTIIMWK; 77,RFVGHTKDVLSVA; 146,GWDKLVKVWNLAN; 15,KTIIMWKLTRDET" 154:21890473; 101:21890473; 143:21890473; 110:21890473; 9:21890473; 77:21890473; 146:21890473; 15:21890473 GNB2L1 Homo sapiens (Human) 38; 130; 12 "38,LSASRDKTIIMWK; 130,SRDKTIKLWNTLG; 12,TLRGTLKGHNGWV" 38:21906983; 130:21906983; 12:21906983 GNB2L1 Homo sapiens (Human) 139; 257; 38; 175; 172; 264; 130; 12; 106; 183; 271; 44 "139,NTLGVCKYTVQDE; 257,ATGPSIKIWDLEG; 38,LSASRDKTIIMWK; 175,GWDKLVKVWNLAN; 172,VSCGWDKLVKVWN; 264,IWDLEGKIIVDEL; 130,SRDKTIKLWNTLG; 12,TLRGTLKGHNGWV; 106,RFVGHTKDVLSVA; 183,WNLANCKLKTNHI; 271,IIVDELKQEVIST; 44,KTIIMWKLTRDET" "139:21890473,21906983; 257:21890473,21906983; 38:21890473,21906983; 175:21890473,21906983; 172:21890473,22053931; 264:21906983; 130:21890473,21906983; 12:21890473,21906983; 106:21139048,21890473,21906983,22053931; 183:21890473,21906983; 271:21139048,21890473,21906983; 44:21139048,21890473,22053931"