PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus ANXA1 KLHL23 21900206 biogrid,mint,intact exp G G G G G P P G G G G P GP G G G KLHL23 USP22 19615732 biogrid,intact exp G G G G G P P G G G GP P GP G G G HSP90AB1 KLHL23 22939624 intact exp G G G G G P P G G G GP P GP G G G ACOT8 KLHL23 26186194 biogrid exp G G G G G P P G G G GP P GP G G G BNIP3L KLHL23 21900206 biogrid,mint,intact exp G G G G G P P G G G GP P GP G G G CDKN1A KLHL23 21900206 biogrid,mint,intact exp G G G G G P G G G G P G G G G NUDCD3 KLHL23 25036637 biogrid,intact exp G G G G G P P G G G GP P GP G G G ANXA7 KLHL23 21900206 biogrid,mint,intact exp G G G G G P P G G G GP P GP G G G HSP90AA1 KLHL23 22939624 biogrid exp G G G G G G G G G P G G G G KLHL23 AMDHD1 26186194 biogrid exp P P G GP P P KLHL23 COPS5 21145461 biogrid exp G G G G G P P G G G GP P GP G G G CUL3 KLHL23 21145461 innatedb,biogrid exp G G G G G P P G G G GP P GP G G G TK1 KLHL23 21900206 biogrid,mint,intact exp G G P G G G P G G KLHL23 DCUN1D1 21145461 biogrid exp G G G P P G G GP P GP G G ZBTB8B KLHL23 23023127 pred G G G P P G P P P ZBTB8B KLHL23 23023127 pred G G G P P G P P P KLHL36 KLHL23 23023127 pred G G G G G P P G G G GP P GP G G G KBTBD6 KLHL23 23023127 pred G G G G G P P G G G G G G G G KLHL23 BTBD6 23023127 pred G G G G G G G G G G G G G TCEB2 KLHL23 23023127 pred G G G G G G G G G G G G G SOCS3 KLHL23 23023127 pred G G G G G P P G G G GP P G G G G KLHL23 KCTD5 23023127 pred G G G G G G G G G G G G G BACH1 KLHL23 23023127 pred G G G G G P P G G G GP P GP G G G KLHL23 GAN 23023127 pred P P P P P KLHL23 ZBTB18 23023127 pred G G G G G G G G G G G G G KLHL23 ZBTB12 23023127 pred G P P P P P KLHL23 NACC1 23023127 pred G G G G G P P G G G GP P GP G G G ZBTB5 KLHL23 23023127 pred G G G G G P P G G G GP P GP G G G KLHL23 KLHL11 23023127 pred P P P KLHL23 KLHL13 23023127 pred G G G G G P G G G GP GP G G G KLHL23 KLHL25 23023127 pred G G G G P P G G G GP P GP G G G KLHL23 SOCS4 23023127 pred G G G G G P P G G G G P GP G G G ZBTB6 KLHL23 23023127 pred P P P KLHL24 KLHL23 23023127 pred G G G G G G G G GP G G G G KLHL23 KLHL20 23023127 pred G G G G G P P G G G GP P GP G G G ZBTB17 KLHL23 23023127 pred G G G G G P P G G G GP P GP G G G CXorf22 KLHL23 25402006 pred G G G G G G G G G G G G KLHL23 KLHL28 23023127 pred G G G G G P G G G GP P G G G G KLHL23 PHOSPHO1 21836163 pred P P BTBD17 KLHL23 23023127 pred P P KLHL23 ZBTB26 23023127 pred G G G G G P P G G G GP P GP G G G ZBTB43 KLHL23 23023127 pred G G G G G P G G G GP G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q8NBE8 A0A024R475 affinity chromatography technology 21145461 physical association X 2 Q8NBE8 Q96GG9 affinity chromatography technology 21145461 physical association X 2 Q8NBE8 Q8IVD9 affinity chromatography technology 25036637 physical association X 2 Q8NBE8 Q8IVD9 affinity chromatography technology 25036637 physical association X 2 Q8NBE8 P20073-2 two hybrid 21900206 direct interaction X 2 A0A024RCX5 Q8NBE8 two hybrid 21900206 direct interaction X 2 Q8NBE8 P07900-2 affinity chromatography technology 22939624 physical association X 2 Q8NBE8 P04183 two hybrid 21900206 direct interaction X 2 Q8NBE8 P04083 two hybrid 21900206 direct interaction X 2 O60238 Q8NBE8 two hybrid 21900206 direct interaction X 2 Q9UPT9 Q8NBE8 affinity chromatography technology 19615732 physical association X 2 A0A024R7W9 Q8NBE8 affinity chromatography technology 21145461 physical association X 2 P0CG48 Q8NBE8 affinity chromatography technology 22505724 physical association X 2 P0CG48 Q8NBE8 affinity chromatography technology 21890473 physical association X 2 P0CG48 Q8NBE8 affinity chromatography technology 21906983 physical association X 2 Q8NBE8 anti tag coimmunoprecipitation 25036637 association C 13 Q8NBE8 Q8IVD9 luminescence based mammalian interactome mapping 25036637 physical association X 2 A0A024RCX5 Q8NBE8 two hybrid 21900206 physical association X 2 Q8NBE8 anti tag coimmunoprecipitation 19615732 physical association C 29 Q8NBE8 P20073 two hybrid 21900206 physical association X 2 Q8NBE8 P04083 two hybrid 21900206 physical association X 2 Q8NBE8 P04183 two hybrid 21900206 physical association X 2 Q8NBE8 A0A024RD80 luminescence based mammalian interactome mapping 22939624 physical association X 2 O60238 Q8NBE8 two hybrid 21900206 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B CUL3 KLHL23 MI:0004(affinity chromatography technology) 21145461 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_201915 bait prey TK1 KLHL23 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 21900206 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) (intact)|(biogrid)|(intact) UniProt_157529|BIOGRID_157258|UniProt_178127 bait|bait|bait prey|prey|prey HSP90AB1 KLHL23 MI:0729(luminescence based mammalian interactome mapping) 22939624 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_125036 prey bait ANXA7 KLHL23 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 21900206 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact)|(intact) BIOGRID_158419|UniProt_178529|UniProt_157931 bait|bait|bait prey|prey|prey KLHL23 USP22 MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_120824|UniProt_100668 prey|prey bait|bait HSP90AA1 KLHL23 MI:0004(affinity chromatography technology) 22939624 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_255434 bait prey ANXA1 KLHL23 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 21900206 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) (intact)|(biogrid)|(intact) UniProt_178469|BIOGRID_157431|UniProt_157871 bait|bait|bait prey|prey|prey UBC KLHL23 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 21890473,21906983,22505724 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_263346|BIOGRID_223217|BIOGRID_223536|BIOGRID_267351 bait|bait|bait|bait prey|prey|prey|prey KLHL23 DCUN1D1 MI:0004(affinity chromatography technology) 21145461 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_205993 prey bait BNIP3L KLHL23 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 21900206 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) (intact)|(biogrid)|(intact) UniProt_178631|BIOGRID_156229|UniProt_158033 bait|bait|bait prey|prey|prey CDKN1A KLHL23 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 21900206 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact)|(intact) BIOGRID_157671|UniProt_158239|UniProt_178837 bait|bait|bait prey|prey|prey KLHL23 COPS5 MI:0004(affinity chromatography technology) 21145461 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_205314 prey bait

PPI - HINT Gene A Gene B PMID Method Quality ACOT8 KLHL23 26186194 0004 HT CUL3 KLHL23 21145461 0004 HT KLHL23 COPS5 21145461 0004 HT KLHL23 DCUN1D1 21145461 0004 HT KLHL23 AMDHD1 26186194 0004 HT KLHL23 USP22 19615732,19615732 0004,0007 HT ACOT8 KLHL23 26186194 0004 HT CUL3 KLHL23 21145461 0004 HT KLHL23 COPS5 21145461 0004 HT KLHL23 DCUN1D1 21145461 0004 HT KLHL23 AMDHD1 26186194 0004 HT KLHL23 USP22 19615732,19615732 0004,0007 HT BNIP3L KLHL23 21900206 0018 HT ANXA1 KLHL23 21900206 0018 HT TK1 KLHL23 21900206 0018 HT HSP90AB1 KLHL23 22939624 0729 HT ANXA7 KLHL23 21900206 0018 HT CDKN1A KLHL23 21900206 0018 HT NUDCD3 KLHL23 25036637,25036637,25036637 0007,0004,0729 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q8NBE8 O14734 KLHL23 ACOT8 0.126 26186194 Q8NBE8 O60238 KLHL23 BNIP3L 0.332 21900206 Q8NBE8 P04183 KLHL23 TK1 0.332 21900206 Q8NBE8 P08238 KLHL23 HSP90AB1 0.126 22939624 Q8NBE8 P20073 KLHL23 ANXA7 0.183 21900206 Q8NBE8 P38936 KLHL23 CDKN1A 0.183 21900206 Q8NBE8 P07900 KLHL23 HSP90AA1 0.126 22939624 Q9UPT9 Q8NBE8 USP22 KLHL23 0.236 19615732 Q8NBE8 P04083 KLHL23 ANXA1 0.332 21900206 Q8NBE8 Q8IVD9 KLHL23 NUDCD3 0.332 25036637 Q92905 Q8NBE8 COPS5 KLHL23 0.126 21145461 Q96GG9 Q8NBE8 DCUN1D1 KLHL23 0.126 21145461 Q96NU7 Q8NBE8 AMDHD1 KLHL23 0.126 26186194 Q8NBE8 Q13618 KLHL23 CUL3 0.126 21145461

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 ACOT8 KLHL23 MI:0045 experimental interaction detection MI:0461 interaction database BNIP3L KLHL23 MI:0045 experimental interaction detection MI:0461 interaction database ANXA1 KLHL23 MI:0045 experimental interaction detection MI:0461 interaction database TK1 KLHL23 MI:0045 experimental interaction detection MI:0461 interaction database HSP90AA1 KLHL23 MI:0045 experimental interaction detection MI:0461 interaction database HSP90AB1 KLHL23 MI:0045 experimental interaction detection MI:0461 interaction database UBC KLHL23 MI:0045 experimental interaction detection MI:0461 interaction database ANXA7 KLHL23 MI:0045 experimental interaction detection MI:0461 interaction database CDKN1A KLHL23 MI:0045 experimental interaction detection MI:0461 interaction database CUL3 KLHL23 MI:0045 experimental interaction detection MI:0461 interaction database NUDCD3 KLHL23 MI:0045 experimental interaction detection MI:0461 interaction database KLHL23 COPS5 MI:0045 experimental interaction detection MI:0461 interaction database KLHL23 DCUN1D1 MI:0045 experimental interaction detection MI:0461 interaction database KLHL23 AMDHD1 MI:0045 experimental interaction detection MI:0461 interaction database KLHL23 USP22 MI:0045 experimental interaction detection MI:0461 interaction database