PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus TRIM59 VTI1B 25416956 biogrid,intact exp P G G G GP P GP G P P GP GP GP GP G GP P GP P P GP GP GP GP G TRIM59 ZDHHC22 25416956 biogrid,intact exp G G G G TRIM59 ESR2 15941852 hprd exp P G G GP P GP P P GP GP P GP GP GP P P P P GP GP GP GP TRIM59 NRM 25416956 biogrid,intact exp G G G G G G G G G G G G G G G G G G TRIM59 ECSIT 22588174 biogrid exp P G G G GP P GP G P P GP GP GP GP GP GP P GP P P GP GP GP GP G ESR1 TRIM59 15941852 hprd exp G G G G G G G G G G G G G G G G G G TP53 TRIM59 25046164 biogrid exp G G G G G G G G GP G G G P G GP G G GP G TRIM59 UBE2D4 23023127 pred G G G GP GP G P P GP GP G GP GP GP P GP P G GP GP GP G UBE2D1 TRIM59 23023127 pred G G G GP GP G P P GP GP G GP GP GP P GP P G GP GP GP G TRIM59 UBE2F 23023127 pred P G G G GP P GP G P P GP GP GP GP G GP P GP P P GP GP GP GP G UBE2D3 TRIM59 23023127 pred G G G GP GP G P P GP GP G GP GP GP P GP P G GP GP GP G NASP TRIM59 23023127 pred P G G G GP P GP G P P G GP GP GP GP GP P GP P P GP G GP GP G TRIM59 ASPM 25402006 pred P G G P P GP P P P P P P P P P P P P P P P GP UBE2D2 TRIM59 23023127 pred G G G GP GP G P P GP GP G GP GP GP P GP P G GP GP GP G UBE2E1 TRIM59 23023127 pred P G G G GP GP G P G GP GP GP GP G P G P GP G GP GP G UBE2B TRIM59 23023127 pred G G G G G G G G G G G G G G G G G G TRIM59 RNF125 23023127 pred P G G G GP GP G P GP GP GP GP GP GP P GP P P GP GP GP P G UBE2K TRIM59 23023127 pred P G G G GP P GP G P P GP GP GP GP GP GP P GP P P GP GP GP GP G LDB3 TRIM59 23023127 pred P G G P G G P G G G G G P G P G G GP G UBE2N TRIM59 23023127 pred P G G G GP P GP G P P GP GP GP GP G GP P GP P P GP GP GP GP G UBE2NL TRIM59 23023127 pred G G G G G G G G G G G G G G G G G G TRIM59 UBE2E2 23023127 pred P G G G GP P GP G P P GP GP GP GP GP GP P GP P P GP GP GP GP G TRIM59 STUB1 23023127 pred P G G G GP P GP G P P GP GP GP GP GP GP P GP P P GP GP GP GP G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P0CG48 Q8IWR1 affinity chromatography technology 21139048 physical association X 2 P0CG48 Q8IWR1 affinity chromatography technology 21906983 physical association X 2 Q8IWR1 Q8IXM6 two hybrid 25416956 direct interaction X 2 Q8IWR1 Q8N966 two hybrid 25416956 direct interaction X 2 Q8IWR1 Q9BQ95-2 affinity chromatography technology 22588174 physical association X 2 Q8IWR1 Q9BQ95-2 affinity chromatography technology 22588174 physical association X 2 Q8IWR1 Q9BQ95-2 two hybrid 22588174 direct interaction X 2 Q8IWR1 P04637-7 affinity chromatography technology 25046164 physical association X 2 Q8IWR1 Q9UEU0 two hybrid 25416956 direct interaction X 2 Q8IWR1 G4XH65 two hybrid 15941852 - X 2 Q8IWR1 G4XH65 in vivo 15941852 - X 2 Q8IWR1 G4XH65 in vitro 15941852 - X 2 Q8IWR1 F1D8N3 in vitro 15941852 - X 2 Q8IWR1 F1D8N3 in vivo 15941852 - X 2 Q8IWR1 F1D8N3 two hybrid 15941852 - X 2 Q8IWR1 G4XH65 in vitro 15941852 - X 2 Q8IWR1 G4XH65 in vivo 15941852 - X 2 Q8IWR1 G4XH65 two hybrid 15941852 - X 2 Q8IWR1 F1D8N3 in vivo 15941852 - X 2 Q8IWR1 F1D8N3 in vitro 15941852 - X 2 Q8IWR1 F1D8N3 two hybrid 15941852 - X 2 Q8IWR1 Q8N966 two hybrid prey pooling approach 25416956 physical association X 2 Q8IWR1 Q8IXM6 two hybrid prey pooling approach 25416956 physical association X 2 Q8IWR1 Q8N966 two hybrid array 25416956 physical association X 2 Q8IWR1 Q8IXM6 two hybrid array 25416956 physical association X 2 Q8IWR1 Q8IXM6 validated two hybrid 25416956 physical association X 2 Q8IWR1 Q8N966 validated two hybrid 25416956 physical association X 2 Q8IWR1 Q9UEU0 two hybrid prey pooling approach 25416956 physical association X 2 Q8IWR1 Q9UEU0 two hybrid array 25416956 physical association X 2 Q8IWR1 Q9UEU0 validated two hybrid 25416956 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B UBC TRIM59 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 21139048,21906983 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_179950|BIOGRID_170726 bait|bait prey|prey NRF1 TRIM59 MI:0428(imaging technique) 24250222 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_296455 bait prey TRIM59 ECSIT MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 22588174 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid) BIOGRID_200771|BIOGRID_200767|BIOGRID_200766 bait|prey|bait prey|bait|prey TRIM59 ESR2 MI:0493(in vivo) 15941852 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_25515 - - ESR1 TRIM59 MI:0493(in vivo) 15941852 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_24557 - -

PPI - HINT Gene A Gene B PMID Method Quality ESR1 TRIM59 15941852 0018 LC TRIM59 NRM 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT TRIM59 ZDHHC22 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT TRIM59 ESR2 15941852 0018 LC TRIM59 ECSIT 22588174,22588174 0004,0018 LC TRIM59 VTI1B 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q8IWR1 P04637 TRIM59 TP53 0.376 25046164 Q8N966 Q8IWR1 ZDHHC22 TRIM59 0.583 25416956,unassigned1304 Q8IWR1 Q7L0Q8 TRIM59 RHOU 0.183 26598620 Q8N2K1 Q8IWR1 UBE2J2 TRIM59 0.236 unassigned1304 Q9UEU0 Q8IWR1 VTI1B TRIM59 0.583 25416956,unassigned1304 Q96IW7 Q8IWR1 SEC22A TRIM59 0.236 unassigned1304 Q8IWR1 Q14232 TRIM59 EIF2B1 0.236 unassigned1304 Q8IWR1 H3BTW2 TRIM59 NECAB2 {ECO:0000313|ENSEMBL:ENSP00000457354} 0.236 unassigned1304 Q8IWR1 O14493 TRIM59 CLDN4 0.236 unassigned1304 Q8IWR1 Q5SQN1 TRIM59 SNAP47 0.236 unassigned1304 Q8IWR1 Q8IVQ6 TRIM59 ZDHHC21 0.236 unassigned1304 Q9H2G9 Q8IWR1 BLZF1 TRIM59 0.236 unassigned1304 Q9Y342 Q8IWR1 PLLP TRIM59 0.236 unassigned1304 Q8IXM6 Q8IWR1 NRM TRIM59 0.583 25416956,unassigned1304 Q9BQ95 Q8IWR1 ECSIT TRIM59 0.569 22588174

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 TP53 TRIM59 MI:0045 experimental interaction detection MI:0461 interaction database UBC TRIM59 MI:0045 experimental interaction detection MI:0461 interaction database RHOU TRIM59 MI:0045 experimental interaction detection MI:0461 interaction database TRIM59 NRM MI:0045 experimental interaction detection MI:0461 interaction database TRIM59 ZDHHC22 MI:0045 experimental interaction detection MI:0461 interaction database TRIM59 ECSIT MI:0045 experimental interaction detection MI:0461 interaction database TRIM59 VTI1B MI:0045 experimental interaction detection MI:0461 interaction database