PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus SH3D21 EGFR 20029029 i2d,intact exp P GP G P G G GP G GP GP G GP GP G G GP P G GP GP P GP G SH3D21 JUN 25609649 intact exp P GP G G G P G G GP G GP G P G GP GP G G GP GP G GP P G G SH3D21 GOLGB1 16169070 i2d exp P GP G G GP P G GP GP G GP GP P GP GP GP P GP G GP P GP GP GP P P GP G SH3D21 ARHGEF10L 16169070 i2d exp P GP G G GP P G GP GP G GP GP P GP GP GP P GP G GP P GP GP GP P P GP G SH3D21 MAPK3 ortho P GP G G GP P G GP GP G GP GP P GP GP GP P GP G GP P GP GP GP P P GP G SH3D21 ITSN1 23023127 pred GP G G G P G GP GP G GP GP P GP GP GP G G GP GP GP GP P GP G SH3D21 OBSCN 23023127 pred P P P P GP GP GP P P GP P P P P G P P GP GP GP P P P SH3D21 ARAF 23023127 pred G G G G G G G G G G G G G G G G G G G G G SH3D21 PLCG1 23023127 pred P GP G G GP P G GP GP G GP GP P GP GP GP P GP G GP P GP GP GP P P GP G SH3D21 PLCG2 23023127 pred GP G G GP P G GP GP G GP G P GP GP GP P G G GP G GP GP P P GP G SH3D21 SKAP1 23023127 pred G G G GP G G G G G G P GP G G G G G G G G P G G SH3D21 UBXN11 23023127 pred GP G G G P G GP P G GP GP P G GP GP P GP G GP P GP GP GP P GP G SH3PXD2B SH3D21 23023127 pred P GP G G G P G G GP G GP G P G G GP P GP G GP P GP G G P GP G SH3D21 ARHGEF19 23023127 pred G G G G G G SH3D21 MIA2 23023127 pred P P P P GP GP P P GP P P GP P P P G SH3D21 EPS8L2 23023127 pred P GP G P P GP G GP GP P G GP GP GP G GP P GP P GP P P GP G SH3D21 PIK3R1 23023127 pred P GP G G GP P G GP GP G GP GP P GP GP GP P GP G GP P GP GP GP P P GP G SH3D21 PSTPIP1 23023127 pred G GP G GP G P GP G G G G P G SH3D21 SH3GL1 23023127 pred P GP G G GP P G GP GP G GP GP P G GP GP P GP G GP P GP GP GP P GP G ARHGEF37 SH3D21 23023127 pred P GP G G G P G GP GP G GP G G GP GP P G GP GP G GP P GP G SH3D21 OSTF1 23023127 pred P GP G G GP P G GP GP G GP GP P GP GP GP P GP G GP P G GP GP P P GP G SH3D21 ARHGAP4 23023127 pred G G GP G P GP G G P SH3D21 ARHGEF6 23023127 pred GP G G GP P G G GP G GP GP P GP GP GP GP G G G G GP P G G SH3D21 LYN 23023127 pred P G G G GP P G G GP G G G P GP GP GP GP G GP P GP GP P P G G SH3D21 ARHGEF9 23023127 pred P GP G P P G GP GP G GP GP G G GP GP G GP GP P G P P G SH3D21 STAC3 23023127 pred G G G G G G G G G G G G SH3D21 SORBS3 23023127 pred G G G G P G GP GP G GP GP G GP GP GP G GP P GP GP GP P G G SH3D21 FCHSD2 23023127 pred P GP G G GP P G GP GP G GP GP P G GP GP GP G GP P P GP GP P P G G SH3D21 SQSTM1 23023127 pred P GP G G GP G G GP G GP GP P GP GP G P GP G GP P GP GP GP P P GP G SH3D21 UBXN7 23023127 pred P GP G G GP P G GP GP G GP GP P GP GP GP P GP G GP P GP GP GP P P GP G SH3D21 ABI3 23023127 pred G G G GP P G GP GP G GP G P GP GP GP G G G G GP GP P G SH3D21 SAMSN1 23023127 pred GP G GP P G P GP P P P GP GP GP P P P P GP P P P SH3D21 RIMBP3B 23023127 pred SH3D21 SLA2 23023127 pred G G G G G G G G G G G G SH3D21 NCK2 23023127 pred GP G G GP P G GP GP G GP GP P GP GP GP P GP G GP P GP GP GP P P GP G SH3D21 DDI1 23023127 pred P P P P GP GP P G P P GP SH3D21 NCF1B 23023127 pred SH3D21 ABL1 23023127 pred P GP G G GP P G GP GP G GP GP P GP GP GP P GP G GP P GP GP GP P P GP G SH3D21 SNX9 23023127 pred P GP G G GP P G GP GP G GP GP P GP GP GP P GP G GP P GP GP GP P P GP G SH3D21 UBL4B 23023127 pred P P P P P P P P P P P P P P P P P P P P SH3D21 UBC 23023127 pred SH3D21 RASA1 23023127 pred P G G G GP P G G G G G G G G GP G G GP G G G P G G SH3D21 ASPSCR1 23023127 pred P GP G P P G GP P G GP GP P GP GP GP P GP G GP P GP GP GP P GP SH3D21 HERPUD2 23023127 pred P GP G G GP P G GP GP G GP GP P GP GP GP P GP G GP P GP GP GP P P GP G SH3D21 CIDEA 23023127 pred G G G G G SH3D21 CTTN 23023127 pred P GP G G GP P G GP GP G GP GP P GP GP GP P GP G GP P GP GP GP P P GP G SH3D21 PPP1R13B 23023127 pred P GP G G GP P G GP GP G GP GP P GP GP GP P GP G GP P GP GP GP P P GP G SH3D21 BCAR1 23023127 pred P GP G P P G GP GP G GP GP P GP GP GP P GP G GP P GP GP GP P P GP G SH3D21 MAP3K11 23023127 pred P GP G G GP P G GP GP G GP GP P GP GP GP P GP G GP P GP GP GP P P GP G SH3D21 NPHP1 23023127 pred P P G P P GP P P P P P GP G P P P G P P GP SH3D21 NOXA1 23023127 pred P GP G G G P G G GP G GP GP G GP GP P GP G GP P GP G GP P GP G SH3D21 PIK3R2 23023127 pred G G G G G G G G G G G G G G G G G G G G G SH3D21 VAV3 23023127 pred P GP G G GP P G GP GP G GP GP P GP GP GP GP G GP P GP GP GP P P GP G SH3D21 PACSIN3 23023127 pred P GP P G GP P P GP P G GP GP P GP GP P GP GP GP P P G SH3D21 NSFL1C 23023127 pred P GP G G GP P G GP GP G GP GP P GP GP GP P GP G GP P GP G GP P P GP G SH3D21 CASS4 23023127 pred P P P P P P P P P P P P P P P GP P P P SH3D21 SRGAP2 23023127 pred G G G G G G G G G G G SH3D21 SH3RF2 23023127 pred P P P GP P P P P P P P P P P P GP SH3D21 ARHGAP26 23023127 pred P GP G G G P G GP GP G GP G P GP GP GP P GP G GP P GP G GP P GP G SH3D21 AMPH 23023127 pred G G G P G G GP G G G G GP GP G G G G G G SH3D21 BZRAP1 23023127 pred P GP G G GP P G GP GP G GP GP P GP GP GP P GP G P P GP GP GP P P P G SH3D21 MYO1E 23023127 pred P P G GP P G GP GP G GP GP P GP GP GP GP G GP P G G GP P GP G SH3D21 TEC 23023127 pred P P P P P P P P P P P P P P P P P P P SH3D21 RAD23B 23023127 pred P GP G G GP P G GP GP G GP GP P GP GP GP P GP G GP P GP GP GP P P GP G SH3D21 SPTAN1 23023127 pred P GP G G GP P G GP GP G GP GP P GP GP GP P GP G GP P GP GP GP P P GP G SH3D21 ARHGEF7 23023127 pred P GP G G GP P G GP GP G GP GP P GP GP GP P GP G GP P G GP GP P P GP G SH3D21 SH3BP4 23023127 pred P GP G P P G G GP G GP G P GP GP GP GP G GP P GP G GP P P GP G SH3D21 SH3RF3 23023127 pred P GP G G GP P G GP GP G GP GP P GP GP GP P GP G GP P GP GP GP P P GP G SH3D21 SASH1 23023127 pred P GP G G GP P G GP GP G GP GP P G G GP GP G GP P GP GP G P GP G SH3D21 FCHSD1 23023127 pred P P P P P P P P P GP P P P P G P P P P P P P P SH3D21 UBFD1 23023127 pred P GP G G GP P G GP GP G GP GP P GP GP GP P GP G GP P GP GP GP P P GP G SH3D21 LCK 23023127 pred G GP G G G G G GP G G G P SH3D21 AHI1 23023127 pred P GP G G G P G GP GP G GP GP P GP GP GP GP G GP P G G GP P P GP G SH3D21 PHF1 23023127 pred P GP G G GP P G GP GP G GP GP P GP GP GP P GP G GP P GP GP GP P P GP G SH3D21 PRMT2 23023127 pred GP G G GP P G GP GP G GP G GP GP GP P GP G GP P GP GP GP P GP G SH3D21 NCF2 23023127 pred G GP G G G P GP G G G G G G P G SH3D21 STAC 23023127 pred P GP G G GP P G GP GP G GP GP P GP GP GP P GP G GP P GP GP GP P P GP G SH3D21 GRB7 23023127 pred P GP G G GP P GP GP G GP GP P GP GP GP P GP G GP P GP GP GP P P GP G SH3D21 KALRN 23023127 pred P P G P P G P P G P P P P P GP P P P P P P P P P SH3D21 MAP3K9 23023127 pred P GP G P P G GP G GP GP P G GP GP P GP G GP P GP GP GP P P GP G SH3D21 SORBS2 23023127 pred P GP G P P G GP GP G GP G P GP GP GP P GP G GP P GP GP GP P P G SH3D21 NCK1 23023127 pred P GP G G GP P G GP GP G GP GP P GP GP GP P GP G GP P GP G GP P P GP G SH3D21 CD2AP 23023127 pred P GP G GP P G G GP GP GP P GP GP GP GP G GP P GP G GP P P GP SH3D21 SH3GL2 23023127 pred G P G G G GP GP G G SH3D21 MYO15B 23023127 pred SH3D21 MAPK8IP1 23023127 pred P P G P P G P P G P P P P P GP P G P P P P P P P GP SH3D21 STAC2 23023127 pred P GP G G GP P G G GP G GP G P GP GP GP P GP G GP P GP G GP P P GP G SH3D21 NOXO1 23023127 pred G G SH3D21 TP53BP1 23023127 pred P GP G G GP P G GP GP G GP GP P GP GP GP P GP G GP P GP GP GP P P GP G SH3D21 PARK2 23023127 pred P GP G P P G GP GP G GP P P G P GP P P G P GP GP GP P GP G SH3D21 TMUB2 23023127 pred P GP G G GP P G GP GP G GP GP P GP GP GP P GP G GP P GP GP GP P P GP G SH3D21 MATK 23023127 pred P P G G GP P P P P GP P GP GP GP P P P P P P P P P P SH3D21 SH3PXD2A 23023127 pred P GP G G GP P G GP GP G GP GP P G GP GP P GP G GP P GP GP GP P GP G SH3D21 MAP3K10 23023127 pred P P P P P P P P P P P P P P P P P P P P P SH3D21 UBXN2A 23023127 pred G G G G G G G G G G G G G G G G G G G G G SH3D21 CRKL 23023127 pred P G G G GP P G G GP G G G P GP GP GP GP G GP P G G GP P P G G SH3D21 FRK 23023127 pred P P P P P P P P P P P P P P P P P P P SH3D21 SOCS6 23023127 pred P GP G P P G GP GP G GP GP P GP GP GP P GP G GP P GP GP GP P P GP G SH3D21 PPP1R13L 23023127 pred P G G G GP P G GP GP G GP GP P GP GP GP P GP G GP P G G GP P P GP G SH3D21 UBXN2B 23023127 pred GP G G G G G GP G GP G P G GP G P G G G P G G GP P GP G SH3D21 GRAP2 23023127 pred P P P P P P P P P P P P P P P SH3D21 MLK4 23023127 pred P GP G G GP P G GP G GP GP P GP GP GP GP G GP GP GP P P GP G SH3D21 SUMO3 23023127 pred P GP G G GP P G GP GP G GP GP P GP GP GP P GP G GP P GP GP GP P P GP G SH3D21 HCLS1 23023127 pred G G G GP P G G G G G G P GP G GP G G G G G G P G G SH3D21 NGEF 23023127 pred P GP G P P G P GP G GP GP P GP GP GP GP P P P P GP P P GP G SH3D21 TDRD1 23023127 pred P P P P P P P P P P P P P P P P P P P P P GP SH3D21 RUSC2 23023127 pred P GP G P P G GP GP G GP GP P GP P GP P P G P P GP GP GP P P GP G SH3D21 FAF1 23023127 pred P GP G G GP P G GP GP G GP G P GP GP GP P GP G GP P GP GP GP P P GP G SH3D21 UBQLN1 23023127 pred P GP G G GP P G GP GP G GP GP P GP GP GP P GP G GP P GP GP GP P P GP G SH3D21 BAIAP2 23023127 pred P P G G GP P G GP P G GP GP P GP P GP P GP G GP P P P P P P GP G SH3D21 BAHD1 23023127 pred G G G G G G G G GP G G G G G G G G G G G G SH3D21 PEX13 23023127 pred P GP G G GP P G GP GP G GP GP P GP GP GP P GP G GP P GP GP GP P P GP G SH3D21 ABL2 23023127 pred P GP G G GP P G GP GP G GP GP P GP GP GP P GP G GP P GP GP GP P P GP G SH3D21 ABI2 23023127 pred G G G G G G G G G G G G G G G G G G G G G SH3D21 BIN1 23023127 pred P GP G G GP P G GP GP G GP GP P GP GP GP P GP G GP P GP GP GP P P GP G SH3D21 ASAP1 23023127 pred P GP G G GP P G GP GP G GP GP P GP GP GP P GP G GP P GP G GP P P GP G SH3D21 LASP1 23023127 pred G G G GP P G G GP G GP GP P GP GP GP P GP G GP GP G GP P P G G SH3D21 RUSC1 23023127 pred P GP G G GP P G GP GP G GP GP P GP GP GP GP G GP P GP GP GP P GP G SH3D21 RGS14 23023127 pred P GP G G G P G GP GP G GP GP P GP GP GP GP G GP P GP GP GP P P GP G SH3D21 PACSIN1 23023127 pred G P G G P G P GP G SH3D21 SNX18 23023127 pred P GP G G GP P G G GP G GP G P GP GP GP P G G GP P GP G GP P GP G SH3D21 SORBS1 23023127 pred P GP G G GP P G GP GP G GP GP P G GP GP P GP G GP P GP GP GP P GP G SH3D21 RAD23A 23023127 pred P GP G G GP P G GP GP G GP GP P GP GP GP P GP G GP P GP GP GP P P GP G SH3D21 TRIO 23023127 pred P GP G G G P G G GP G GP GP P GP GP GP P GP G GP P GP G GP P P GP G SH3D21 ABI1 23023127 pred P GP G G GP P G GP GP G GP GP P GP GP GP P GP G GP P GP GP GP P P GP G SH3D21 UBASH3A 23023127 pred P P G P P P SH3D21 ARHGEF16 23023127 pred P GP G G GP P G G GP G GP GP P GP GP GP P GP G GP P GP G GP P P GP G SH3D21 PIK3CA 23023127 pred P GP G P P G GP GP G GP GP P GP P GP P GP G P P GP GP GP P P GP SH3D21 SH2D1A 23023127 pred G SH3D21 MYO1F 23023127 pred G G G GP G G G G G GP G G G G G GP G P G G SH3D21 SRGAP3 23023127 pred P G G G G P G GP GP G GP G G G GP G G G G GP G G SH3D21 SH3YL1 23023127 pred P G G G G P G G GP G GP GP P GP GP GP GP G GP P GP G GP P GP G SH3D21 TMUB1 23023127 pred P GP G G GP P G GP GP G GP GP P GP GP GP P GP G GP P GP GP GP P GP G SH3D21 SH3GL3 23023127 pred G G G P G G G G G G G G GP GP G G G G P GP G SH3D21 NCF1C 23023127 pred SH3D21 YES1 23023127 pred P GP G G GP P G GP GP G GP GP P GP GP GP P GP G GP P GP GP GP P GP G SH3D21 SRMS 23023127 pred P P P P P P P P P P P P P P P P P P P P P P SH3D21 UBQLNL 23023127 pred P P P P P P P P G P P P P GP SH3D21 UBL4A 23023127 pred P GP G G G P G G GP G GP G G G GP GP G GP G G G P P G SH3D21 SUMO1 23023127 pred P GP G G GP P G GP GP G GP G P GP GP GP P GP G GP P GP GP GP P P GP G SH3D21 SUMO2 23023127 pred P GP G G GP P G GP GP G GP GP P GP GP GP P GP G GP P GP GP GP P P GP G SH3D21 NEBL 23023127 pred P GP G G G G GP GP G GP GP P GP GP G GP G G G G GP P P G G SH3D21 TRIP10 23023127 pred G G G G G G G G G G G G G G G G G G G G G SH3D21 BAG6 23023127 pred P GP G G GP P G GP GP G GP GP P GP GP GP P GP G GP P GP GP GP P P GP G SH3D21 RIMBP3C 23023127 pred P P P P SH3D21 VAV1 23023127 pred P GP G GP P G P P G P GP P GP GP GP GP G GP GP P P P P GP G SH3D21 SRGAP1 23023127 pred GP G P G G GP G GP GP G GP GP GP G G GP GP G SH3D21 SH3GLB2 23023127 pred GP G G G P G G GP G GP GP G GP GP G GP G G G P P GP G SH3D21 OTOR 23023127 pred P G G P G P P P P P P P P GP P P P GP P P P G SH3D21 SASH3 23023127 pred P G G G G P G G GP G G G P GP G GP GP G GP P GP G G P P GP G SH3D21 STAM2 23023127 pred P GP G G GP P G GP GP G GP GP P GP GP GP P GP G GP P GP GP GP P P GP G SH3D21 SH3RF1 23023127 pred G G G G G G G G G G G G G G G G G G G G G SH3D21 DBNL 23023127 pred P GP G G GP P G G GP G GP GP P GP GP GP P GP G GP P GP G GP P P GP G SH3D21 MAPK8IP2 23023127 pred GP G G GP P G GP GP G GP GP P GP GP GP GP G GP P GP GP GP P P GP G SH3D21 SH3GLB1 23023127 pred P GP G G GP P G GP GP G GP GP P GP GP GP P GP G GP P GP GP GP P P GP G SH3D21 ARID4B 23023127 pred P GP G G G P G G GP G GP G GP G GP GP G GP P G G G P GP G SH3D21 BAIAP2L1 23023127 pred P GP P P G P GP GP GP P P GP P P GP G GP P GP P GP P P GP SH3D21 BTK 23023127 pred G GP G G P GP G G P SH3D21 SH3KBP1 23023127 pred G G G GP P G G G G G G GP G GP G G GP G G G P G G SH3D21 SH3D21 23023127 pred P GP G G GP P G GP GP G GP GP P GP GP GP P GP G GP P GP GP GP P P GP G SH3D21 HERPUD1 23023127 pred P GP G G GP P G GP GP G GP GP P GP GP GP P GP G GP P GP GP GP P P GP G SH3D21 MYO15A 23023127 pred P G G G G P G G GP G GP G G GP GP P GP G GP G GP GP P GP G SH3D21 ITSN2 23023127 pred G G G G P G G GP G GP GP G GP GP GP G GP P G G GP P GP G SH3D21 FYB 23023127 pred G G GP G G G G G GP G G G G G G P SH3D21 TP53BP2 23023127 pred P GP G G GP P G GP GP G GP GP P GP GP GP P GP G GP P GP GP GP P P GP G SH3D21 RIMBP2 23023127 pred P P G P P G P P G GP P P G GP GP GP G P P P GP P P P P G SH3D21 SUMO4 23023127 pred P GP G G GP P G GP GP G GP GP P GP G GP P GP G GP P GP GP G P P GP G SH3D21 NCF4 23023127 pred G G GP G P GP G G G P SH3D21 NCF4 23023127 pred G G GP G P GP G G G P SH3D21 CRK 23023127 pred P G G G G G GP GP G GP GP G GP G GP G GP P GP GP GP P G G SH3D21 NCF1 23023127 pred P P P P SH3D21 BAIAP2L2 23023127 pred P P G P P GP GP P P P GP P P P P P P P GP P P P SH3D21 STAM 23023127 pred P GP G G GP P G GP GP G GP GP P GP GP GP P GP G GP P GP G GP P GP G SH3D21 ITK 23023127 pred G G G G G G G G G G G G G G G G G SH3D21 VAV2 23023127 pred P GP G G GP P G G GP G GP GP P G GP GP P GP G GP P GP GP P P GP G SH3D21 RIMBP3 23023127 pred SH3D21 MIA 23023127 pred P P P P G GP P P P P G GP G GP P G P P SH3D21 NFATC2IP 23023127 pred G G G G G G G G G G G G G G G G G G G G G SH3D21 UBASH3B 23023127 pred P P G G GP P G P P G P P P P P GP P GP P P P P P P P SH3D21 UHRF2 23023127 pred P GP G G GP P G GP GP G GP GP P GP GP GP P GP G GP P GP GP GP P P GP G SH3D21 USP14 23023127 pred P GP G G GP P G GP GP G GP GP P GP GP GP P GP G GP P GP GP GP P P GP G SH3D21 UBL7 23023127 pred P GP G G GP P G GP GP G GP GP P GP GP GP P GP G GP P GP G GP P P GP G SH3D21 FYN 23023127 pred GP G G GP P G G GP G GP GP GP G GP G G G G G G P G G SH3D21 DNMBP 23023127 pred P GP G G G P G GP GP G G G P G G GP P G G GP P G GP G P G G SH3D21 NEDD9 23023127 pred P GP G G GP P G GP GP GP GP P GP GP GP P GP G GP P GP GP GP P P GP G SH3D21 EFS 23023127 pred P G G G G P G G GP G GP P P G G GP P GP G GP P GP G G G G SH3D21 EPS8L3 23023127 pred G G G GP P G GP GP G P G P G GP GP P GP G G G GP GP GP G SH3D21 NEB 23023127 pred G P G G G P G G G G GP G P G SH3D21 MIA3 23023127 pred P GP G G GP P G GP GP G GP GP GP GP GP P GP G GP P GP G GP P P GP G SH3D21 SGSM3 23023127 pred P GP G G GP P G GP GP G GP GP P GP GP GP P GP G GP P GP G GP P P GP G SH3D21 NOSTRIN 23023127 pred P GP G P P G GP GP G GP GP P GP GP GP GP G GP P GP GP GP P P GP G SH3D21 EPS8L1 23023127 pred P GP G G G G GP GP GP GP G GP G GP G GP GP P G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants A4FU49 P00533 ubiquitin reconstruction 20029029 physical association X 2

PPI - HINT Gene A Gene B PMID Method Quality SH3D21 JUN 25609649 0006 HT SH3D21 JUN 25609649 0006 HT SH3D21 EGFR 20029029 0112 LC

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 SH3D21 EGFR MI:0045 experimental interaction detection MI:0461 interaction database SH3D21 JUN MI:0045 experimental interaction detection MI:0461 interaction database SH3D21 GOLGB1 MI:0362 inference MI:0461 interaction database