Disease associated variation - GWASdb Chr Pos SNP ID(dbSNP 142) Ref Alt Ori SNP ID P-value Drug Name Drug Anno GWAS Trait HPO ID DO ID AA Type Trait or Drug 2 54995746 rs2116441 A G rs2116441 8.58E-04 PROPYLTHIOURACIL RECEPTORS, G-PROTEIN-COUPLED|TASTE RECEPTORS, TYPE 2 Taste perception HPOID:0000223 DOID:0050155 T intron GWASdb_drug 2 55082530 rs1371021 C T rs1371021 9.42E-04 ALDOSTERONE BIOLOGICAL MARKERS|NATRIURETIC PEPTIDE, BRAIN|RENIN Blood pressure, CVD RF and other traits (body mass index (BMI), waist:hip ratio, renin activity in plasma, aldosterone concentration in plasma, BNP levels in plasma, alcohol consumption) HPOID:0011025 DOID:10763 G intron GWASdb_drug 2 55087887 rs1371020 C T rs1371020 0.0007356 INFLIXIMAB|ADALIMUMAB|IMMUNOGLOBULIN G TUMOR NECROSIS FACTOR-ALPHA|ANTIRHEUMATIC AGENTS|ANTIBODIES, MONOCLONAL, HUMANIZED|TNFR-FC FUSION PROTEIN|ANTIBODIES, MONOCLONAL|RECEPTORS, TUMOR NECROSIS FACTOR Anti-TNF treatment response in rheumatoid arthritis (by DAS-28 score change at 3 months) HPOID:0001370 DOID:7148 G,A intron GWASdb_drug 2 55087887 rs1371020 C T rs1371020 7.36E-04 LEUCOVORIN|METHOTREXATE SLCO1B1 PROTEIN, HUMAN|ORGANIC ANION TRANSPORTERS Methotrexate clearance (acute lymphoblastic leukemia) HPOID:0006721 DOID:9952|DOID:12603 G,A intron GWASdb_drug 2 54957416 rs6732751 G A rs6732751 7.22E-05 Bipolar disorder, affective HPOID:0007302 DOID:3312 G intron GWASdb_trait 2 54957416 rs6732751 G A rs6732751 6.84E-04 Acute lung injury HPOID:0002088 DOID:850 G intron GWASdb_trait 2 54957773 rs7582640 C T rs7582640 4.77E-04 Acute lung injury HPOID:0002088 DOID:850 C intron GWASdb_trait 2 54958830 rs6708082 A G rs6708082 1.23E-04 Bipolar disorder, affective HPOID:0007302 DOID:3312 A intron GWASdb_trait 2 54958830 rs6708082 A G rs6708082 4.77E-04 Acute lung injury HPOID:0002088 DOID:850 A intron GWASdb_trait 2 54959092 rs6740110 C G rs6740110 1.36E-04 Bipolar disorder, affective HPOID:0007302 DOID:3312 C intron GWASdb_trait 2 54959092 rs6740110 C G rs6740110 4.77E-04 Acute lung injury HPOID:0002088 DOID:850 C intron GWASdb_trait 2 54959690 rs10169439 T C rs10169439 4.17E-04 Acute lung injury HPOID:0002088 DOID:850 T intron GWASdb_trait 2 54959862 rs6545440 A T rs6545440 4.77E-04 Acute lung injury HPOID:0002088 DOID:850 A intron GWASdb_trait 2 54960680 rs13428703 G A rs13428703 4.65E-04 Acute lung injury HPOID:0002088 DOID:850 G intron GWASdb_trait 2 54962352 rs6752720 G A rs6752720 8.29E-04 Acute lung injury HPOID:0002088 DOID:850 G intron GWASdb_trait 2 54962723 rs6753004 C A rs6753004 8.29E-04 Acute lung injury HPOID:0002088 DOID:850 C intron GWASdb_trait 2 54964021 rs10194108 A G rs10194108 6.20E-04 Acute lung injury HPOID:0002088 DOID:850 A intron GWASdb_trait 2 54972648 rs13401661 C T rs13401661 8.69E-05 Pancreatic cancer HPOID:0006725 DOID:1793 T intron GWASdb_trait 2 54975471 rs2631835 T C rs2631835 9.92E-05 Multiple complex diseases HPOID:0000118 NA T intron GWASdb_trait 2 54976770 rs1848924 A G rs1848924 2.05E-04 Multiple complex diseases HPOID:0000118 NA T intron GWASdb_trait 2 54987142 rs12615703 C A rs12615703 3.92E-04 Multiple complex diseases HPOID:0000118 NA A intron GWASdb_trait 2 54991442 rs17046292 A T rs17046292 6.51E-04 Multiple complex diseases HPOID:0000118 NA A intron GWASdb_trait 2 54991712 rs4671975 G A rs4671975 4.78E-04 Multiple complex diseases HPOID:0000118 NA A intron GWASdb_trait 2 54995746 rs2116441 A G rs2116441 1.00E-04 Multiple complex diseases HPOID:0000118 NA T intron GWASdb_trait 2 54995746 rs2116441 A G rs2116441 8.58E-04 Taste perception HPOID:0000223 DOID:0050155 T intron GWASdb_trait 2 55019723 rs165051 C G rs165051 9.51E-04 Multiple complex diseases HPOID:0000118 NA G intron GWASdb_trait 2 55034113 rs2578715 C T rs2578715 1.66E-06 Height HPOID:0000002 NA A intron GWASdb_trait 2 55034113 rs2578715 C T rs2578715 2.30E-05 Height HPOID:0000002 NA A intron GWASdb_trait 2 55038830 rs2631837 A G rs2631837 1.09E-07 Height HPOID:0000002 NA G intron GWASdb_trait 2 55038830 rs2631837 A G rs2631837 8.19E-06 Height HPOID:0000002 NA G intron GWASdb_trait 2 55042463 rs2567839 A G rs2567839 9.59E-05 Height HPOID:0000002 NA A intron GWASdb_trait 2 55042463 rs2567839 A G rs2567839 7.89E-05 Height HPOID:0000002 NA A intron GWASdb_trait 2 55046042 rs2567840 C T rs2567840 8.38E-05 Height HPOID:0000002 NA A intron GWASdb_trait 2 55052493 rs10197243 C T rs10197243 1.50E-05 Urinary metabolites HPOID:0000079 DOID:557 C intron GWASdb_trait 2 55052949 rs17046387 T G rs17046387 2.75E-04 Type 2 diabetes HPOID:0005978 DOID:9352 T intron GWASdb_trait 2 55063113 rs1549840 C T rs1549840 4.68E-04 Multiple complex diseases HPOID:0000118 NA G intron GWASdb_trait 2 55066310 rs10173697 T C rs10173697 4.00E-05 Type 2 diabetes HPOID:0005978 DOID:9352 T intron GWASdb_trait 2 55072474 rs2116435 G A rs2116435 6.33E-05 Heart Rate HPOID:0005150|HPOID:0001645|HPOID:0001644|HPOID:0011704|HPOID:0005110 DOID:10273 T intron GWASdb_trait 2 55073464 rs4613325 G A rs4613325 3.07E-04 Alzheimer's disease HPOID:0002511 DOID:10652 G intron GWASdb_trait 2 55074429 rs12465327 C A rs12465327 9.38E-05 Suicide attempts in bipolar disorder HPOID:0007302 DOID:3312 A intron GWASdb_trait 2 55075394 rs2165006 T C rs2165006 1.64E-04 Suicide attempts in bipolar disorder HPOID:0007302 DOID:3312 A intron GWASdb_trait 2 55076441 rs6545449 T C rs6545449 3.05E-04 Suicide attempts in bipolar disorder HPOID:0007302 DOID:3312 T intron GWASdb_trait 2 55077061 rs12713278 A G rs12713278 1.20E-04 Suicide attempts in bipolar disorder HPOID:0007302 DOID:3312 A intron GWASdb_trait 2 55079242 rs4671979 G T rs4671979 9.34E-05 Suicide attempts in bipolar disorder HPOID:0007302 DOID:3312 T intron GWASdb_trait 2 55079388 rs13033818 C T rs13033818 2.80E-04 Suicide attempts in bipolar disorder HPOID:0007302 DOID:3312 C intron GWASdb_trait 2 55079454 rs13033668 A G rs13033668 4.56E-04 Suicide attempts in bipolar disorder HPOID:0007302 DOID:3312 A intron GWASdb_trait 2 55079654 rs2033411 A T rs2033411 1.12E-04 Suicide attempts in bipolar disorder HPOID:0007302 DOID:3312 A intron GWASdb_trait 2 55081376 rs12713280 C T rs12713280 6.00E-06 Economic and political preferences HPOID:0000118 NA C intron GWASdb_trait 2 55082903 rs7596552 T G rs7596552 1.44E-05 Suicide attempts in bipolar disorder HPOID:0007302 DOID:3312 T intron GWASdb_trait 2 55084583 rs10496033 C T rs10496033 8.00E-06 Suicide attempts in bipolar disorder HPOID:0007302 DOID:3312 T intron GWASdb_trait 2 55086183 rs10188555 T C rs10188555 7.73E-06 Suicide attempts in bipolar disorder HPOID:0007302 DOID:3312 T intron GWASdb_trait 2 55087887 rs1371020 C T rs1371020 5.06E-04 Suicide attempts in bipolar disorder HPOID:0007302 DOID:3312 G,A intron GWASdb_trait 2 55087887 rs1371020 C T rs1371020 0.0007356 Anti-TNF treatment response in rheumatoid arthritis (by DAS-28 score change at 3 months) HPOID:0001370 DOID:7148 G,A intron GWASdb_trait 2 55087887 rs1371020 C T rs1371020 7.36E-04 Methotrexate clearance (acute lymphoblastic leukemia) HPOID:0006721 DOID:9952|DOID:12603 G,A intron GWASdb_trait 2 55091029 rs2358155 C T rs2358155 1.81E-04 Suicide attempts in bipolar disorder HPOID:0007302 DOID:3312 C intron GWASdb_trait 2 55091223 rs6545450 A C rs6545450 5.43E-04 Suicide attempts in bipolar disorder HPOID:0007302 DOID:3312 A intron GWASdb_trait 2 55091375 rs2006878 G A rs2006878 2.90E-04 Suicide attempts in bipolar disorder HPOID:0007302 DOID:3312 C intron GWASdb_trait 2 55092926 rs723975 G A rs723975 2.96E-05 Personality dimensions HPOID:0012075 DOID:1510 G intron GWASdb_trait 2 55093784 rs17417731 T A rs17417731 2.75E-04 Suicide attempts in bipolar disorder HPOID:0007302 DOID:3312 T intron GWASdb_trait 2 55093859 rs4671981 C G rs4671981 2.91E-05 Personality dimensions HPOID:0012075 DOID:1510 C intron GWASdb_trait 2 55097549 rs11677058 A G rs11677058 6.76E-05 Cognitive test performance HPOID:0100543 DOID:1561 A,G intron GWASdb_trait 2 55103265 rs13385982 G T rs13385982 2.07E-04 Alcohol dependence HPOID:0000707 DOID:0050741 T intron GWASdb_trait 2 55111689 rs2163618 G A rs2163618 3.04E-04 Alcohol dependence HPOID:0000707 DOID:0050741 A intron GWASdb_trait 2 55127601 rs10171653 A G rs10171653 0.0000923 Carotid intima media thickness HPOID:0005344 DOID:1936 G intron GWASdb_trait 2 55133564 rs7355716 G A rs7355716 1.47E-04 Acute lymphoblastic leukemia (childhood) HPOID:0006721 DOID:9952|DOID:12603 A intron GWASdb_trait 2 55134309 rs4671992 C T rs4671992 9.22E-04 Suicide attempts in bipolar disorder HPOID:0007302 DOID:3312 T intron GWASdb_trait 2 55144103 rs2304685 C G rs2304685 8.49E-04 Bipolar disorder HPOID:0007302 DOID:3312 G intron GWASdb_trait 2 55153731 rs10176018 A G rs10176018 3.98E-04 Suicide attempts in bipolar disorder HPOID:0007302 DOID:3312 A intron GWASdb_trait 2 55156630 rs6726292 G A rs6726292 1.00E-06 Obesity (extreme) HPOID:0001513 DOID:9970 A intron GWASdb_trait 2 55176112 rs13394146 C T rs13394146 5.43E-04 Suicide attempts in bipolar disorder HPOID:0007302 DOID:3312 T intron GWASdb_trait 2 55181893 rs10746530 G A rs10746530 1.25E-04 Scoliosis HPOID:0010674 DOID:0080010 A intron GWASdb_trait 2 55182968 rs11898145 C A rs11898145 5.23E-05 Orofacial clefts HPOID:0000202 DOID:0050567 C intron GWASdb_trait 2 55183627 rs7584992 G A rs7584992 1.62E-05 Height HPOID:0000002 NA G intron GWASdb_trait 2 55185862 rs17046514 G A rs17046514 1.70E-05 Urinary metabolites HPOID:0000079 DOID:557 G intron GWASdb_trait 2 55186229 rs12623902 T C rs12623902 7.04E-04 Obesity (extreme) HPOID:0001513 DOID:9970 T intron GWASdb_trait 2 55186394 rs17346629 A C rs17346629 7.04E-04 Obesity (extreme) HPOID:0001513 DOID:9970 C cds-synon GWASdb_trait 2 55188195 rs6741304 G A rs6741304 4.96E-04 Obesity (extreme) HPOID:0001513 DOID:9970 G intron GWASdb_trait

Disease associated variation - GWAS Central Study Name Source Marker Accession Chromosome Marker Start Marker Stop Alleles Gene Section P-value -log(p-value) GWAS of prostate cancer rs2165006 2 55075394 55075394 intronic 0.964263 0.015804497351517 GWAS of prostate cancer rs2631837 2 55038830 55038830 intronic 0.924558 0.0340658391939973 GWAS of prostate cancer rs6713115 2 55012202 55012202 intronic 0.907967 0.041929935596032 GWAS of prostate cancer rs17345167 2 55031023 55031023 intronic 0.827619 0.0821695476094473 GWAS of prostate cancer rs164854 2 54992282 54992282 intronic 0.783949 0.105712189533695 GWAS of prostate cancer rs165052 2 55021758 55021758 intronic 0.771181 0.11284367891954701 GWAS of prostate cancer rs930185 2 55057961 55057961 intronic 0.756194 0.12136677285715 GWAS of prostate cancer rs17046380 2 55041322 55041322 intronic 0.743564 0.128681644962297 GWAS of prostate cancer rs993362 2 55053174 55053174 intronic 0.742724 0.129172542289921 GWAS of prostate cancer rs2588512 2 55192082 55192082 intronic 0.680014 0.167482146028825 GWAS of prostate cancer rs2116436 2 55007205 55007205 intronic 0.674655 0.170918256649872 GWAS of prostate cancer rs4671992 2 55134309 55134309 intronic 0.660453 0.180158082768483 GWAS of prostate cancer rs6761960 2 55015764 55015764 intronic 0.655845 0.183198788061283