PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus CBX1 USP17L2 19615732 biogrid,intact exp P P P P P P P P P P P P P P P P P P P P USP17L7 USP17L2 19615732 biogrid,intact exp USP17L2 SUDS3 21239494 biogrid exp P P P P P P P P P P P P P P P P P P P P CDC25C USP17L2 20228808 biogrid exp P P P P P P P P P P P P P P P P P P P P SET USP17L2 19615732 biogrid,intact exp P P P P P P P P P P P P P P P P P P P P H2AFX USP17L2 24704006 biogrid exp P P P P P P P P P P P P P P P P P P P P USP17L2 LGMN 24610907 biogrid exp P P P P P P P P P P P P P P P P P P P USP10 USP17L2 23023127 pred P P P P P P P P P P P P P P P P P P P P USP46 USP17L2 23023127 pred P P P P P P P P P P P P P P P P P P P P USP12 USP17L2 23023127 pred P P P P P P P P P P P P P P P P P P P P DLG1 USP17L2 23023127 pred P P P P P P P P P P P P P P P P P P YOD1 USP17L2 23023127 pred P P P P P P P P P P P P P P P P P P P P USP17L2 USP15 23023127 pred P P P P P P P P P P P P P P P P P P USP17L2 BAP1 23023127 pred P P P P P P P P P P P P P P P P P P P P USP17L2 USP9X 23023127 pred P P P P P P P P P P P P P P P P P P P USP2 USP17L2 23023127 pred P P P P P P P P P P P P P P P P P P P RFWD3 USP17L2 23023127 pred USP17L2 USP33 23023127 pred P P P P P P P P P P P P P P P P P P P USP17L2 USP22 23023127 pred P P P P P P P P P P P P P P P P P P P P USP17L2 USP7 23023127 pred P P P P P P P P P P P P P P P P P P P P USP9Y USP17L2 23023127 pred RPL24 USP17L2 23023127 pred P P P P P P P P P P P P P P P P P P P P USP17L2 CYLD 23023127 pred P P P P P P P P P P P P P P P P P P P P USP17L2 USP44 23023127 pred P P P P P P P P P P P P P P P P P P P USP17L2 USP3 23023127 pred USP17L2 USP21 23023127 pred P P P P P P P P P P P P P P P P TRIM21 USP17L2 23023127 pred P P P P P P P P P P P P P P P P P P P P USP8 USP17L2 23023127 pred P P P P P P P P P P P P P P P

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q6R6M4 Q9H7L9 affinity chromatography technology 21239494 physical association X 2 Q6R6M4 Q9H7L9 pull down 21239494 direct interaction X 2 Q6R6M4 Q9H7L9 affinity chromatography technology 21239494 physical association X 2 Q6R6M4 Q9H7L9 affinity chromatography technology 21239494 physical association X 2 Q6R6M4 P0C7H9 affinity chromatography technology 19615732 physical association X 2 Q6R6M4 P30307-3 affinity chromatography technology 20228808 physical association X 2 Q6R6M4 P30307-3 affinity chromatography technology 20228808 physical association X 2 P0CG48 Q6R6M4 pull down 24704006 direct interaction X 2 Q6R6M4 P16104 enzymatic study 24704006 direct interaction X 2 Q6R6M4 P16104 affinity chromatography technology 24704006 physical association X 2 Q6R6M4 Q53XC6 enzymatic study 24610907 direct interaction X 2 Q6R6M4 Q53XC6 biochemical 24610907 colocalization X 2 Q6R6M4 Q53XC6 affinity chromatography technology 24610907 physical association X 2 Q6R6M4 affinity chromatography technology 19615732 physical association X 2 Q6R6M4 P83916 affinity chromatography technology 19615732 physical association X 2 Q6R6M4 affinity chromatography technology 19615732 physical association X 2 Q6R6M4 anti tag coimmunoprecipitation 19615732 physical association C 5 Q6R6M4 anti tag coimmunoprecipitation 19615732 physical association C 7

PPI - HINT Gene A Gene B PMID Method Quality USP17L7 USP17L2 19615732,19615732 0004,0007 HT CBX1 USP17L2 19615732,19615732 0004,0007 HT SET USP17L2 19615732,19615732 0004,0007 HT USP17L24|USP17L25|USP17L26|USP17L27|USP17L28|USP17L29|USP17L30 USP17L2 19615732 0007 HT USP17L7 USP17L2 19615732,19615732 0004,0007 HT CBX1 USP17L2 19615732,19615732 0004,0007 HT SET USP17L2 19615732,19615732 0004,0007 HT USP17L24|USP17L25|USP17L26|USP17L27|USP17L28|USP17L29|USP17L30 USP17L2 19615732 0007 HT H2AFX USP17L2 24704006,24704006 0004,0415 LC USP17L2 LGMN 24610907,24610907,24610907 0004,0415,0401 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9H7L9 Q6R6M4 SUDS3 USP17L2 0.569 21239494 Q6R6M4 O95760 USP17L2 IL33 0.376 26610488 Q99538 Q6R6M4 LGMN USP17L2 0.523 24610907 Q6R6M4 Q01105 USP17L2 SET 0.236 19615732 Q6R6M4 P83916 USP17L2 CBX1 0.236 19615732 Q6R6M4 P0C7H9 USP17L2 USP17L7 0.236 19615732 Q6R6M4 P16104 USP17L2 H2AFX 0.454 24704006 Q6R6M4 P30307 USP17L2 CDC25C 0.376 20228808 Q92769 Q6R6M4 HDAC2 USP17L2 0.376 26617781

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 IL33 USP17L2 MI:0045 experimental interaction detection MI:0461 interaction database DDX58 USP17L2 MI:0362 inference MI:1106 pathways database USP17L7 USP17L2 MI:0045 experimental interaction detection MI:0461 interaction database UBC USP17L2 MI:0045 experimental interaction detection MI:0461 interaction database H2AFX USP17L2 MI:0045 experimental interaction detection MI:0461 interaction database CDC25A USP17L2 MI:0362 inference MI:1106 pathways database CDC25C USP17L2 MI:0045 experimental interaction detection MI:0461 interaction database CBX1 USP17L2 MI:0045 experimental interaction detection MI:0461 interaction database SET USP17L2 MI:0045 experimental interaction detection MI:0461 interaction database USP17L24 USP17L2 MI:0045 experimental interaction detection MI:0461 interaction database USP17L2 HDAC2 MI:0045 experimental interaction detection MI:0461 interaction database USP17L2 LGMN MI:0045 experimental interaction detection MI:0461 interaction database USP17L2 IFIH1 MI:0362 inference MI:1106 pathways database USP17L2 SUDS3 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database USP17L2 RCE1 MI:0362 inference MI:1106 pathways database